paying thousands of dollars to attend a university just for my professor to assign this free video for us to watch, and then him getting pissed and saying he's overwhelmed w the amount of responsibility and work he has to do :) love that
Cant Express how easy and fun you have made it for me to understand Chemistry, I have always been strugggling with concepts, Every now and then i end up on your video and have always got satisfied after comprehending the concepts you have explained in a manner that anyone can understand:)
Just wanted to drop by and thank you for the amazing tutorials you've made for organic chem. You've definitely really helped me and many others grasp different concepts of this subject with such simplicity and ease through your great tutorials. Many thanks prof Dave :D
I was wondering in the second to last step it looks like the negatively charged oxygen takes on two protons to form water. Why does it take on 2 to make water instead of taking on 1 to become an alcohol group.
sometimes you can isolate the addition product, depending on the precise structure, but particularly at higher temperatures elimination is going to be favorable
Hi, I added some NaOH+ to my wastewater in order to raise to the pH to 7.0. However, an immediate discolouration of my wastewater occured. I suspect it to be due to aerobic oxidation leading to acetalhyde accumulation that leads to adol condensation. Does the adol condensation produce oligomers and polymers that may cause a darkening of aqueous solution? and am i correct in my thinking?
yikes! out of my wheelhouse. the only thing i can say is that enolate chemistry (aldol, etc.) can indeed lead to polymerization, but i can't say much about pH or color or anything like that.
+Wukeywukey sometimes you can stop at the aldol addition product (alcohol), but because of the entropic favorability of elimination it'll usually go to the condensation product, especially at higher temperatures.
Thanks!! Explained better than the instructor. However in the last ste, would H2O basic enough to take off the H+ from the alpha H of carbonyl? Isn't is supposed to be OH- instead?
Do these enolate ions with partial charge only occur in water solutions, or is it also possible to find them as solid molecules without water, or are they always part of a larger molecule?
I'm a bit confused coz my textbook says base is used for aldol condensation, and after watching this video I personally also think that using acid makes more sense. So which one is correct??? Thx in advance :D
Why do you have -OH2 after work-up? Should it not be -OH followed by base-catalyzed elimination and leaving of the -OH? Because water can leave by itself, no?
could be, but hydroxides won't protonate in basic conditions, that requires acid work up. if i remember correctly, the elimination probably happens during the workup itself, with just the addition happening while in basic conditions. but i'd have to double check!
@@ProfessorDaveExplains you'd have OH after protonating the oxide. The presence of the carbonyl group renders the alpha carbon mildly acid which would allow dehydration to occur
I agree, my book shows OH as the leaving group. Even though OH is considered a "bad" leaving group, the condensation product is conjugated and is the driving force behind the reaction. Plus losing a hydrogen and a water is overall losing H3O. Losing a hydrogen an OH is overall losing H20.
You know your stock is rising in the COVID era professor Dave b/c hundreds of professors are probably making their students watch your videos. Maybe I am one of the professors, maybe not :)
Hi sir...i m preparing fir jee.....coupd to recommened me some bokks for physics, chemistry and maths that would be helpful to me for understanding concepts
abhisao2312 If You don't find any video on one Channel - You should have the basic understanding that you can search ot on youtube instead of begging ! - search *Demjanov reaction Anytime Padhai*
can you do a practice problem video for aldol condensation reactions please? I'm going to take my orgo 2 exam on Monday so it won't help me but will surely help other students. Thank you.
I was not understanding this at ALL before I watched this video. You are a master of Ochem!
Yes
am I the only one that sings along in the intro lmao it's so frickin catchy, I always find myself humming it at random times
branding at its finest!
Professor Dave Explains IM SO HONORED!!! YOU REPLIED!!!
u not the only one ....thats some dope vibe by Dj Dave lol :)
c ram Same here dude 😝
Haha yes😂 I've promoted this channel literally everywhere because the intro is always stuck in my head and I keep singing it...
paying thousands of dollars to attend a university just for my professor to assign this free video for us to watch, and then him getting pissed and saying he's overwhelmed w the amount of responsibility and work he has to do :) love that
😂
Your explanations are perfect! It's fantastic how simply you illustrate every topic that we would otherwise find challenging to comprehend.
Cant Express how easy and fun you have made it for me to understand Chemistry, I have always been strugggling with concepts, Every now and then i end up on your video and have always got satisfied after comprehending the concepts you have explained in a manner that anyone can understand:)
Never knew chemistry involved logic and intuition up until this point
Please NEVER stop making these videos! They're so helpful.
can't stop won't stop don't stop!
@@ProfessorDaveExplains❤ Thanks professor
Chemistry exam tomorrow I am so gonna succeed, thanks to you !!!!
Everytime he says thx "for watching", I am actually the one ending up really greatful, I will definitely send him an e-mail once!
I understood more from this 5 minute video than an hour long lecture hats off
Thanks for keeping it short and simple. Other people's videos go off on tangents too often
Incredibly helpful and well delivered! Thank you. Subscribed.
He knows a lot about science stuff, Professor Dave explains..di ding ding ding✨
My orgo 2 final is in 1 hour. I feel so sad because I will miss visiting your channel every week.
you don't have to stop! there are many other subjects to learn, even if just for fun.
Professor Dave Explains I hope to do biochem next semester! Hopefully it will bring me back here! Thank you so much!!
Helpful for MCAT. Thanks!
Did you already take the MCAT, and if so, how did it go?
short, clear and to the point! mcat studying... thank you!
How'd the MCAT go?
one month of lectures < your videos
this is the best shit ever!!! keep up the good work. I'm definitely telling all my friends about your channel. Thumbs up!!
tell them to pretty please subscribe! woo!
sure sure!
The lecture is perfect only that the writings tend to block important information down
Got The Office vibe! This makes learning even better! :D
Just wanted to drop by and thank you for the amazing tutorials you've made for organic chem. You've definitely really helped me and many others grasp different concepts of this subject with such simplicity and ease through your great tutorials. Many thanks prof Dave :D
Wow nice video! Really well explained!
Thank you sir for getting me back on track! I forgot about that final hydrogen deprotonization👌
why are you so good?
U r always great in explaining everything ..thanks a lot
I was wondering in the second to last step it looks like the negatively charged oxygen takes on two protons to form water. Why does it take on 2 to make water instead of taking on 1 to become an alcohol group.
It was too fast for me so this video helped me: ua-cam.com/video/q6-FlFW01kM/v-deo.html
Finally someone asked the question I had in mind!
Dave, could you have also used the first resonance structure? The anion carbon attacking the carbonyl carbon?
+LT “Chargers” GFX you certainly can.
Wow awesome explanation...gives a thorough knowledge...i also sanged along the intro song...its catching...pls do videos for pg students
Chem Jesus!! thank you man. Been following you since organic chemistry one and now that I'm prepping for my mcat I still watch your videos. The best
Why, at the last step, does it not just form an OH-group, why does it form an double bond?
sometimes you can isolate the addition product, depending on the precise structure, but particularly at higher temperatures elimination is going to be favorable
Excellent explanations
I never get enough of your plad shirts
Hi, I added some NaOH+ to my wastewater in order to raise to the pH to 7.0. However, an immediate discolouration of my wastewater occured. I suspect it to be due to aerobic oxidation leading to acetalhyde accumulation that leads to adol condensation. Does the adol condensation produce oligomers and polymers that may cause a darkening of aqueous solution? and am i correct in my thinking?
yikes! out of my wheelhouse. the only thing i can say is that enolate chemistry (aldol, etc.) can indeed lead to polymerization, but i can't say much about pH or color or anything like that.
During acidic workup, why isn't an alcohol simply formed?
+Wukeywukey sometimes you can stop at the aldol addition product (alcohol), but because of the entropic favorability of elimination it'll usually go to the condensation product, especially at higher temperatures.
Wouldn't OH be a good leaving group in basic conditions instead of a formation of a formal positive charge.
absolutely, though we can show the condensation product forming during aqueous acidic workup if we like as well.
Thank you
shouldn't the aldol product be an aldehyde plus alcohol product? Please explain
Thanks!! Explained better than the instructor. However in the last ste, would H2O basic enough to take off the H+ from the alpha H of carbonyl? Isn't is supposed to be OH- instead?
+Jenna Zhang with acidic workup water will do! in acidic conditions water is a base and hydronium is an acid.
+Professor Dave Explains Ohhh right! Acidic condition should never use OH- to deprotonate. I see! Thanks again!!! Very helpful
Where did the aldehyde come from? Is that what Aldol condensation is, an aldehyde is necessary I'm assuming for this mechanism?
came from wherever! we can mix anything we want together when we do chemistry. for aldol condensation, you need an aldehyde or ketone.
Professor Dave Explains makes sense! Thank you for responding!
May i know why we don’t use the carbo anion to react further?
here the night before my 2nd year orgo2 mid-term
Hahaha looks like learning the mechanism of reaction would be a good investment
How did the water form and not OH after the protonation?
H+OH=HOH=H20
So easy to learn from this!! LOVE LOVE!
Do these enolate ions with partial charge only occur in water solutions, or is it also possible to find them as solid molecules without water, or are they always part of a larger molecule?
Thank you so much for this explanation!
Thanks for kindly explaining :)
Is Aldolization and aldol condensation the same process?
If i had prof like this.......
Ur explanation works like magic ,thanks . Can I hope to get a video on zener diode voltage regulator,plz.
I'm a bit confused coz my textbook says base is used for aldol condensation, and after watching this video I personally also think that using acid makes more sense. So which one is correct??? Thx in advance :D
aldol can be done in either basic or acidic conditions, in this clip i show the basic route.
Oic, thanks so much :))
THANK YOU SO MUCH. I was reading through my lab protocol and the explanation sounded like an alien language...this helps a lot!
Can you please explain where the second carbonate comes from during the addition? I can't seem to get i.
thanks!
+Nona Hovsepyan carbonate? no carbonates involved. feel free to email with questions!
Professor Dave Explains
Hi, where the proton came from at the end of the reaction, coul'd it be from the water?
yep water is most likely!
thanks!!
from Vietnam with love 😘
i love this channel too but if you think this 5 min video is better than all your lectures lmao it says as much about your class as about prof dave
Your videos are awesome, you're easy to learn from and explain things well.
Why do you have -OH2 after work-up? Should it not be -OH followed by base-catalyzed elimination and leaving of the -OH? Because water can leave by itself, no?
could be, but hydroxides won't protonate in basic conditions, that requires acid work up. if i remember correctly, the elimination probably happens during the workup itself, with just the addition happening while in basic conditions. but i'd have to double check!
@@ProfessorDaveExplains you'd have OH after protonating the oxide. The presence of the carbonyl group renders the alpha carbon mildly acid which would allow dehydration to occur
Hi Sir, why aldol condensation of ketone is difficult than aldehyde?
it's not! both are perfectly feasible. ketones are a little more sterically hindered though, that can sometimes be a factor.
Why wouldn't the O- only get protonated once to make an alcohol? What pushes it all the way through to condensation?
thermodynamics! especially if it's hot, elimination is favorable. but it's true, sometimes the addition product can be isolated.
Please make a video on Cannizzaro reaction!
I just wanted to say thank you, and I sincerely hope that I'm not too enolate.
😎
Thank you professor Subscribed
very well explained! makes it possible to study OC of one semester within one week!
thanks from Germany
Synthetic and clear!
unbelievable, you r too good
Sorry Sir I have an check last result OH group is not present sir
OH. O
| ||
/ \ / \ maybe sir
I agree, my book shows OH as the leaving group. Even though OH is considered a "bad" leaving group, the condensation product is conjugated and is the driving force behind the reaction. Plus losing a hydrogen and a water is overall losing H3O. Losing a hydrogen an OH is overall losing H20.
Can you please explain formation of mesytyline from acetone
Thank you
I finally get it... thank you!
I hereby declare you jesus of chemistry
All my friends know about you now
"Now, upon aqueous acidic workup..."
Umm, so?
Thank you so much 🙂🙂🙂
thanx alot..
the reaon of there is no alot of views because of the picture that put in the face of each video..keep going..
AAMC MCAT FL3 question 1
nice professor
Sir aap yha??????
You know your stock is rising in the COVID era professor Dave b/c hundreds of professors are probably making their students watch your videos. Maybe I am one of the professors, maybe not :)
very helpful and well made video thank you !
Can you upload a video on
all types of aldol condensations,please?
My OC teacher sucks😛
Great video....keep going
What is aqueous acidic workup
Hey professor,I had mailed you a question but you didn't reply?
In India we learn this Aldol Condensation
In our 12th grade of high school 😂
really!!💯💯
@@s9k328 yes
@@s9k328 you don't learn this in high school?
You are great !☺😊
Hi sir...i m preparing fir jee.....coupd to recommened me some bokks for physics, chemistry and maths that would be helpful to me for understanding concepts
In case of chemistry pls tell a book from which i can umderstand all exceptions
In case of physics tell me a book which could make be understand all concepts from basics to high level
sorry i'm not sure!
Ok thanks😊
Liked ur all videos...nice
im in high school n i have this stuff 😓
go to the mall
Thanks
Can you do an Aldol Addition
aldol addition is the first part of aldol condensation, it's in this clip.
Life saver!
Whats's a PKA?
-log Ka, measurement of acidity
no better way of learning chemistry from Jesus himself
Could you please do a video on polymers
in the biochemistry playlist i talk all about polymers! at least biopolymers.
+Professor Dave Explains plz naming reaction demjnov rearrangment
abhisao2312 If You don't find any video on one Channel - You should have the basic understanding that you can search ot on youtube instead of begging ! - search *Demjanov reaction Anytime Padhai*
can you do a practice problem video for aldol condensation reactions please? I'm going to take my orgo 2 exam on Monday so it won't help me but will surely help other students. Thank you.
Damn i hate those skelet formulas so much!
WHY!!!!! He looks like Jesus Christ already plus he helped me !! Oh my lord
U r looking like ranvir kapoor
what I am cooked
Thanks you Jesus Christ for explaining
thanks jesus
Thanks so much...
What are doing with ypur life bro
Um, I'm a science communicator.
Single handedly saving my organic chemistry grade, I'm not even kidding