CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis

To cite: Papadimitriou TI, Singh P, van Caam A, et al. CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletion. Annals of the Rheumatic Diseases Published Online First: 18 December 2023. doi: 10.1136/ard-2023-224827
Read the full article here: dx.doi.org/10.1...
Objective: Cytotoxic T cells and natural killer (NK) cells are central effector cells in cancer and infections. Their effector response is regulated by activating and inhibitory receptors. The regulation of these cells in systemic autoimmune diseases such as systemic sclerosis (SSc) is less defined.
Conclusions: Together, the findings imply costimulatory molecules as key regulators of cytotoxicity-driven pathology in systemic autoimmune disease, yielding CD7 as a novel target for selective depletion of pathogenic cells.