What are the side effects of Lecanemab?

The most common side effects of Lecanemab are infusion-related reactions. The side effects occur in one out four patients, and tend to be mild-to-moderate in severity. Symptoms include fever, chills, flushing, or blood pressure changes. Patients who develop these symptoms can be premedicated for future doses as prevention.
Other possible adverse events are Amyloid Related Imaging Abnormalities (ARIA). There are two types of ARIA. ARIA-E represents edema, meaning swelling of the brain. ARIA-H represents hemorrhage or bleeding.
Patients that carry two copies of a gene called APOE4 are at higher risk of ARIA. For this reason, UCLA screens all patients for the gene. UCLA does not recommend treatment for patients with two copies of the gene, nor in people who take blood-thinners such as Warfarin, Apixaban, or Rivaroxaban because they increase the risk of bleeding.
To learn more about Alzheimer’s disease treatment and care at UCLA, please speak with your primary care doctor or call the UCLA Amyloid Infusion Core at [phone].
You can also visit our website to find a provider, schedule an appointment, and learn more about treatment and care options: www.uclahealth.org/medical-se...