NF-κB pathways, Part 1: The canonical pathway of NF-κB activation

NF-κB transcription factors can be activated by different pathways. The canonical NF-κB pathway starts with the activation of the TNFα receptor. The activated receptor recruits several intracellular proteins that pass the signal on to a multiprotein complex made up of NF-κB and other proteins. The signal leads to the degradation of NF-κB-inhibiting proteins and thus to the dissociation of NF-κB and its translocation into the nucleus, where it activates the expression of anti-apoptotic genes.
#onkoview, #nf-kappab, #tnfalpha, #pathways, #genes, #expression, #multiprotein, #proteins, #genes

[@semihanadegbite3255]

So P65 and P50 do not need to get phosphorylated to activate the Nf-kB pathway, just IkBa that needs to?

[@indiabiologyexplains5013]

yes, this is because when IkBa is tagged for degradation, the NLS(nuclear localization signal) signal domain of Nf kappa B is activated, making it migrate to the nucleus. The only thing that is preventing this is IkBa because it blocks the NLS domain on Nf kappa B.

[@JonathanWirth-c3p]

Have a good day. Productions. 😊