Normally, I don't comment on any UA-cam videos but this time I couldn't resist myself to appreciate this amazing piece of work. I guess nobody could have explained pharmacology topics better than you. Thanks a million sir. And you are a life saver!
You are making us rich with such nice explanation of a huge subject, thank you brother. Pls continue to make such videos. Many many thanks and good wishes.
Well, the one should be really thankful because i've been struggling going really slow with my study .. now am very happy .. this is a huge aid .. it would've been harder without your lectures .. Thank you
your videos always inspire me to learn more and more. I really feel great after watching your videos. your outstanding videos are a great relief for my confusion, especially at pharmacology subjects. Thank you !!
My dear partner died last year almost certainly due to kidney failure. She was aged 86 and had been prescribed Furosemide for several years. This was intended to treat her oedema (ankle swelling), and her ascites (extended abdomen). The Furosemide was not a "cure" for either condition, although it might have had a mitigating effect. But I believe that it was the direct cause of her kidney failure which caused her to die earlier than she would have otherwise. I believe that diuretics should be prescribed only for short periods of time, if at-all. Apart from causing ultimate mortality the other side-effect is to reduce the quality of the patient's life to less than zero. My partner became a wretched prisoner in her home. This was because she needed constant access to the toilet, so she was unable to go far from her front door. What is the point of prescribing a medication whose side-effects are more distressing than the condition it is intended to treat? (I have never heard of anyone dying from oedema). I know nothing about medical science, but that is not necessary. For whatever reasons diuretics stimulate the kidneys into "overdrive". Surely this amounts to an abuse, and we should not be surprised when negative consequences arise. When physicians prescribe diurects their patients are entitled to receive a warning that their death may be one of the side-effects.
Great lesson. Would like make a suggestion. Loop diuretics are very unlikely to cause hyponatremia. The thiazides have a much higher propensity to cause hyponatremia. Loop diuretics can in-fact cause/contribute to hypernatremia. Also, they have a role in the treatment of hyponatremia caused by SIADH.
I wanna start with Thank you for providing amazing lectures for free. The content you create are one of the best i've ever seen. Just wanna point that in the minute 35:06, you inverted a sign in the equation for the AG formula. You put AG = Na + (Cl + HCO3) instead of AG = Na - (Cl + HCO3)
I've read physiology reference, lippincott and alot of sources to understand the real mechanism of these drugs but nothing has persuaded me as ur video All the love to u man
loop diuretics act on the loop of henle Na K 2 Cl transporter type I has the sulfa groups: Furesemide. Bumetanide. toresemide type II no sulfa grp: Ethacrynic acid leads to loss of great volume of water na and cl. helps in reducing bp, bv, Fluid overload: corrects Ascites, Pulmonaey or peripheral edema eliminiation of toxins by flushing out a lot of water adverse effects Hypovolemia, hyponatremia, hypochloremia,hypokalemia metabolic alkalosis hyperuricemia, hyperglycemia Acute Interstitila Nephritis
The best of the best , 42 minutes of pleasure. Keep going , many thanks to you . I just have one notice in the minute 35:14 , the anion gap is NA - (Cl + HCO3 ).
you are a sorce of inspiration and all I can say is to thank you and ask you please to keep going with giving of extraordinary work in a remarkable outstanding amazing way... all love ❤❤
Found 2 mistakes: 1. Loop diuretics inhibit the renal elimination of lithium. so they shouldn't be used in lithium intoxication 2. The Ototoxicity is result of a increase of potassium and change of potential in the endolymph (not decrease), what decreases is the potential which results in dysfunction of the hair cells. its mostly reversible.
I m lil bit confused..why more water retain in lumen cause in the interstial space between ascending loop of henly and pct thier is less ammount of na+ ,cl- than how water won't go to interstial space cause as per I know gradients go low concentration to heigh concentration...plz answer
Thank you for your videos, they are really helpful. Do you think that it could be mentioned the fact that loop diuretics are much less likely to cause hyponatremia than theiazic diuretics?
A question: If we block the Na/K/2cl channel, then, like other ions, K+ is also not entering into the cuboidal cells. Doesn't it mean that K+ will be high in the lumen as Loop-Diuretics are blocking them from entering through the channel?
NO! if you go through those channels there are two channels first one is NA+K+2Cl ions transport channel which moves these ions into cell from lumen if you talk tell now it makes sense if we give drug (channel inhibitor) the K+ reabsorption will reduce but those drug wil also inhibit the K+ absorption just because of that K+ level will reduce in the lumen and so on
Thank you soo much for this video! One question: if loop diuretics could possibly cause hyperglycemia, why should we give patients D50(and also insulin)?
This man has saved my medlife. You are a saviour. Thank you for existing. You are literally the Best physiology Teacher ever.
same for me he is my hero❤️
Normally, I don't comment on any UA-cam videos but this time I couldn't resist myself to appreciate this amazing piece of work. I guess nobody could have explained pharmacology topics better than you. Thanks a million sir. And you are a life saver!
You just saved me, i was about to cry because I didn’t understand diuretics and you made it so easy and fun💚
You are making us rich with such nice explanation of a huge subject, thank you brother. Pls continue to make such videos. Many many thanks and good wishes.
My instructor recommended this. At first I thought why 43 mins, it too much. But no I get it now. You’re talented my friend.
Well, the one should be really thankful because i've been struggling going really slow with my study .. now am very happy .. this is a huge aid .. it would've been harder without your lectures ..
Thank you
The best 43mins of my education thank you
Man u are so genius
U deserve " Nobel Prize"
My hypertension case study is going to be so much better on account of this video. Thanks for the pointers.
your videos always inspire me to learn more and more. I really feel great after watching your videos. your outstanding videos are a great relief for my confusion, especially at pharmacology subjects.
Thank you !!
Best pharmacologic video ever ❤️❤️
My dear partner died last year almost certainly due to kidney failure. She was aged 86 and had been prescribed Furosemide for several years. This was intended to treat her oedema (ankle swelling), and her ascites (extended abdomen). The Furosemide was not a "cure" for either condition, although it might have had a mitigating effect. But I believe that it was the direct cause of her kidney failure which caused her to die earlier than she would have otherwise.
I believe that diuretics should be prescribed only for short periods of time, if at-all. Apart from causing ultimate mortality the other side-effect is to reduce the quality of the patient's life to less than zero. My partner became a wretched prisoner in her home. This was because she needed constant access to the toilet, so she was unable to go far from her front door. What is the point of prescribing a medication whose side-effects are more distressing than the condition it is intended to treat? (I have never heard of anyone dying from oedema).
I know nothing about medical science, but that is not necessary. For whatever reasons diuretics stimulate the kidneys into "overdrive". Surely this amounts to an abuse, and we should not be surprised when negative consequences arise. When physicians prescribe diurects their patients are entitled to receive a warning that their death may be one of the side-effects.
i uave watched few videos on ytb, n only ur video make me undesrtand mechanism of diuretic. thank u my hero
you making very complicated scientific concepts very simple, thanks man, thanks big Time.
this is so helpfull specially during online classes a big Thank You for all the work you are doing
Great lesson. Would like make a suggestion. Loop diuretics are very unlikely to cause hyponatremia. The thiazides have a much higher propensity to cause hyponatremia. Loop diuretics can in-fact cause/contribute to hypernatremia. Also, they have a role in the treatment of hyponatremia caused by SIADH.
Thank you so much!! Made the concept crystal clear👍🏻
🙏🙏you are a real hero for students 🙏😘
I wanna start with Thank you for providing amazing lectures for free. The content you create are one of the best i've ever seen.
Just wanna point that in the minute 35:06, you inverted a sign in the equation for the AG formula. You put AG = Na + (Cl + HCO3) instead of AG = Na - (Cl + HCO3)
I've read physiology reference, lippincott and alot of sources to understand the real mechanism of these drugs but nothing has persuaded me as ur video
All the love to u man
Best Teacher ever 🧡
loop diuretics
act on the loop of henle Na K 2 Cl transporter
type I has the sulfa groups: Furesemide. Bumetanide. toresemide
type II no sulfa grp: Ethacrynic acid
leads to loss of great volume of water na and cl.
helps in reducing bp, bv, Fluid overload: corrects Ascites, Pulmonaey or peripheral edema eliminiation of toxins by flushing out a lot of water
adverse effects
Hypovolemia, hyponatremia, hypochloremia,hypokalemia
metabolic alkalosis
hyperuricemia, hyperglycemia
Acute Interstitila Nephritis
You are truly God sent. Thank you very much.
Best teacher ever!!
Before I watch, the first thing I must do is liking and commenting 😘
Awesome . This man is a genius!
The best of the best , 42 minutes of pleasure. Keep going , many thanks to you . I just have one notice in the minute 35:14 , the anion gap is NA - (Cl + HCO3 ).
LOL 5:36 to 5:50 , That fine and salty moment made me become a patreon
you are a sorce of inspiration and all I can say is to thank you and ask you please to keep going with giving of extraordinary work in a remarkable outstanding amazing way... all love ❤❤
best teacher ever .. please sir make more videos on anatomy also
Thank you so much, you are blessing to many students - I enjoy your videos.
loving so far
I love every time you teach. The best explanation and so much detail
Well explained...... I hape more videos on Pathology and pharmacology will be available soon
Thank you so much sir
Love & respect from India 🙏🏻
Thank you so much sir 🙏
Love from India
Man .....you are the best!!
Literally Best and outstanding as always...
Great conscept of making us understand counter cutmrrent multiplyer
Found 2 mistakes:
1. Loop diuretics inhibit the renal elimination of lithium. so they shouldn't be used in lithium intoxication
2. The Ototoxicity is result of a increase of potassium and change of potential in the endolymph (not decrease), what decreases is the potential which results in dysfunction of the hair cells. its mostly reversible.
Tysm zach for such clear explanation!👏
Super video sir
Loved it 🤟🏻✌🏻
It’s always fun watching your videos
Bless you, you just saved my arse for an exam in 36 hours! :-D
You're awesome Zach! Thank you!
You are saving my life in all the ways #thank u zach and team
I m lil bit confused..why more water retain in lumen cause in the interstial space between ascending loop of henly and pct thier is less ammount of na+ ,cl- than how water won't go to interstial space cause as per I know gradients go low concentration to heigh concentration...plz answer
You are the best bro !!
if there were hundred like buttons on this video i would have liked it a hundred times because he makes my life easier
Extraordinary brother. Pls continue making videos
Amazing explanation!!
amazing unparallel i have never see any lecture like u sir please sir upload vedio on medicine
just wow!!!! super explanation doctor. thank you very much.
I love watching your videos😍 It was amazing as always 🤓👏🏼👌🏻
just amazing, thanks a lot prof. Just like in physiology, do more on pharmacology.
Superb explanation 👌
for god sake man you are the best 😘😘
Thank you for the explanation!
Crazy man!!! what a amazing explanation!!!
I am a great fan of you sir❤️
You are great..❣️❣️
Perfect. Amazing. Thank you very much
Please do more pharmacology videos 🙏
Your are the Best. Du bist der beste
Great Sir thanks you keep it up
This is awesome! Thanks
Si es que te amo por favor, me vas a salvar farmacología
Thank you for your videos, they are really helpful. Do you think that it could be mentioned the fact that loop diuretics are much less likely to cause hyponatremia than theiazic diuretics?
Thank you!!
Thank u so much u made it really easy 😍
A question: If we block the Na/K/2cl channel, then, like other ions, K+ is also not entering into the cuboidal cells. Doesn't it mean that K+ will be high in the lumen as Loop-Diuretics are blocking them from entering through the channel?
I wondered the exact same thing, didn't understand that part
NO! if you go through those channels there are two channels first one is NA+K+2Cl ions transport channel which moves these ions into cell from lumen if you talk tell now it makes sense if we give drug (channel inhibitor) the K+ reabsorption will reduce but those drug wil also inhibit the K+ absorption just because of that K+ level will reduce in the lumen and so on
Amazing amazing amazing ❤️❤️❤️❤️
Greats from Egypt
Thank you! You are the best!
Thank you!! Finally i get it.
Thanks janee
I can’t thank you enough
Can diuretics cause slow stomach releasing
Thank you soo much for this video!
One question: if loop diuretics could possibly cause hyperglycemia, why should we give patients D50(and also insulin)?
These are given only for hyperkalemic patients..,to stabilize the heart from dysrhythmia.
Super nice video!
Thank you so much brother
Thank you sir
Awesome sir👌
Loved it!!!!...thank you so much
Hypocalcemia causes Tetany. Tanks for showing me Loop diuretics cause hyperglycemia.
🙏🙏Proff Zach
anion gap=Na-(Cl+Hco3)
So so good thanks
Thank you so much
This is amazing , thank u so muchhhhh♥️♥️♥️♥️
Thank u Sir,u r as good as always
God bless you honestly truly
I loveeeeeeeee urrrrr channellllll uuuu are amaziiiiiinggggg
Freaking legend again. I love that explanation on how Loop Diuretics cause metabolic alkalosis and hypokalemia!
Thank you so much 😊 ❤️❤️
nice work
Love it sir ❤️
Thank you man! Inspired.. Keep up!
Great video!
nice job man
thank you soooooo much
nice sir very helpful