94P Pathogenesis of Rheumatoid Arthritis, RA

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  • Опубліковано 8 тра 2013
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    The joint inflammation in RA is immunologically mediated, and there is a clear genetic predisposition to the disease, but the initiating agent or agents and the precise interplay between genetic and environmental variables are not yet understood. It is proposed that the disease is initiated, in a genetically predisposed individual, by activation of CD4+ helper T cells responding to some arthritogenic agent, possibly microbial, or to some self-antigen.

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