FIGO 2023 New Endometrial Cancer Staging - تحديث هام جدا ومختلف تماما لمراحل سرطان الرحم
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- Опубліковано 10 вер 2024
- 2023 FIGO staging of cancer of the endometrium.
- Endometrial cancer is surgically staged and pathologically examined.
In all stages, include:
The grade of the lesion, and the histological type (Low grade - High grade)
Lympho-vascular space involvement (No LVSI - Focal LVSI - Extensive/substantial LVSI)
If available and feasible, molecular classification testing (POLEmut, MMRd, NSMP, p53abn) is encouraged in all patients with endometrial cancer (Good - Intermediate- Bad prognosis)
The performance of complete molecular classification (POLEmut, MMRd, p53abn, NSMP) is encouraged in all cases of endometrial cancer for prognostic risk-group stratification and as potential influencing factors of adjuvant or systemic treatment decisions.
Molecular subtype assignment can be done on a biopsy, in which case it need not be repeated on the hysterectomy specimen.
When performed, these molecular classifications should be recorded in all stages.
• Good prognosis: pathogenic POLE mutation (POLEmut)
• Intermediate prognosis: mismatch repair deficiency (MMRd)/microsatellite instability and no specific molecular profile (NSMP)
• Poor prognosis: p53 abnormal (p53abn)
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