Cancers of the lung
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- Опубліковано 31 лип 2024
- This is a short video describing the four most common carcinomas of the lung.
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ADDITIONAL TAGS:
Cancers of the lung
The most common carcinomas that originate in the lung parenchyma
Squamous cell carcinoma
Adenocarcinoma
Large-cell undifferentiated carcinoma
Small-cell carcinoma
Non-small-cell
carcinomas
Squamous cell carcinoma
Smokers (98%)
Often arises centrally/proximally in larger bronchi more than peripheral lung
Occurs in bronchi more than larynx and trachea bc flow more turbulent
Associated with hypercalcemia (secretes PTH-like cmpd); causing weakness, dehydration, AMS
Might see desmosomes and/or keratin accumulation (keratin pearls)
Can cause obstruction of airway, atelectasis, collapse of lung
Can invade lymphatics
Can cause clubbing
Squamous cell carcinoma
Adenocarcinoma
Large-cell undifferentiated carcinoma
Small-cell carcinoma
Adenocarcinoma
Most common carcinoma in nonsmokers (but 80% are smokers)
More likely to be peripheral than central/proximal
Might see glands and/or mucin production on histology
Hypertrophic osteoarthritis (HPO) triad has clubbing, long bone swelling, and arthritis
Adenocarcinoma in situ (formerly: "Bronchioloalveolar carcinoma" (BAC))
Lepidic growth pattern, replaces type I pneumocytes, but no invasion of interstitium
Can be solitary nodule, multiple nodules (multifocal, bilateral)
Presents as cough and dyspnea, again +/- mucinous
Squamous cell carcinoma
Adenocarcinoma
Large-cell undifferentiated carcinoma
Small-cell carcinoma
Large-cell undif. carcinoma
Large cells with prominent nuclei
No desmosomes, no keratin, no mucin staining
Expression analysis on cDNA microarray
Squamous cell carcinoma
Adenocarcinoma
Large-cell undifferentiated carcinoma
Small-cell carcinoma
Small-cell carcinoma
Exclusively smokers
Paraneoplastic syndromes:
Secretes hormones: ACTH (can cause Cushing’s), ADH (Na abnormality)
Eaton-Lambert (neurologic disorder)
Fast-growing, rapid progression, early metastases, often high stage at presentation
Highly responsive to chemo/rad treatment
Limited → Extensive staging as metastasis outside of hemithorax
High N/C ratios, frequent mitotic figures, high percentage of cells in division, salt and pepper chromatin, cells aren’t that small
Squamous cell carcinoma
Adenocarcinoma
Large-cell undifferentiated carcinoma
Small-cell carcinoma
This is really helpful lecture! Especially the pathology.
man how smart is this guy... awesome video
Very nice explanation. Thank you for the clear information.
So helpful! Thank you for the video :)
This is really helpful, thank you so much
Really helpful. Good job
Thank you. Very informed short presentation
Awesome! thanks a lot😄
very helpful. Thanks!
Thank you so much, it was really helpful
Very helpful, thank youuuu much❤️❤️❤️
hi could i get some sources
highly helpful
Thanks Medrevision
so heloful
Thanks🤓
No problem
Are small cell carcinomas also called oat cells?
yes
Why stop making videos ?
Wasnt helpful