Steam Sterilization or Autoclaving, Basic concepts Part 01 of 02

This video is about Steam Sterilization or Autoclaving - Basic concepts Part 01 of 02
TimeStamps
00:28 What is sterilization
02:05 What is steam Sterilizer
03:22 What items to be sterilized
06:14 Steam Sterilizer basic principles and concepts
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#PharmaGyan
#Steamsterilization
#Autoclave
Sterilization is necessary for the complete destruction or removal of all microorganisms (including spore-forming and non-spore forming bacteria, viruses, fungi, and protozoa) that could contaminate pharmaceuticals or other materials and thereby constitute a health hazard.
Disinfection : a process that will eliminate infective organisms.
Sterilization - A process used to render a product free of
viable organisms with specified probability. - PDA TR1
“Sterilization is an absolute term and implies the total
destruction of all forms of microbial life in terms of their
ability to reproduce” - G. Sykes
• “Validated Process used to render a product free of all
forms of viable microorganisms” - ISO
Steam sterilization is achieved by exposing the items to be sterilized with saturated steam under pressure. Steam enhances the ability of heat to kill microorganisms by reducing the time and temperature required to denature or coagulate proteins in the microorganisms.
Steam Sterilization Principles?
6 factors are particularly critical to assure successful steam sterilization:
Time
Temperature
Moisture
Direct steam contact
Air removal
Drying
Hello, Friends welcome to my channel "PharmaGyan" Learn about Pharmacy, Pharmaceutical companies, regulatory guidelines, Documentation procedures, SOPs, How to videos on various operating procedures, Quality Assurance, Quality control, R&D, Pharmaceutical validation and qualification guidelines and procedures etc.

[@RizwanKhan-yn6vh]

What is the disinfectant load and
What is the warm up cycle
What is the hot leck test
What is the sip filter
What is the filter integrity
What material required for autoclave
HPHV prosess
Steam sterilizer

[@PharmaGyan]

Disinfectant load - item used for Disinfectantion and cleaning
Warm up cycle - simply to heat the Autoclave chamber
Hot Leak Test - leak test done after warmup cycle or empty cycle, leak test in hot chamber
SIP of Vent Filter by steam Sterilization
Filter Integrity - to check that filter is free from damages and blockages, it should be integral
HPHV process - involves high pressure and high vacuum pulses to achieve Sterilization
You can watch our more videos on steam Sterilization process to understand better

[@BrandBabuSoni]

Aap bahut achhe se samjhate hai sir

[@PharmaGyan]

Thanks dear

[@nileshbhusari5559]

Thank you ,good demonstrated.

[@PharmaGyan]

Thank you

[@sarabesaksahu2475]

Auto clave me vlt ka pass minute kya hai

[@sushmasreebondela945]

Do we need to qualify sterilizer as per production temperature or 1°C less than production temperature?

[@PharmaGyan]

No, it should be qualified as per the pre determined process parameters or else you need to develop the qualification cycles prior to qualify any load.

[@sushmasreebondela945]

@@PharmaGyan During the cycle development which one we need to consider from the above two?

[@PharmaGyan]

Production temperature

[@sarabesaksahu2475]

Auto clave me vacuum fail ho jaane par kya karte hai

[@PharmaGyan]

Check the ports sealing gaskets etc which may lead to air infiltration

[@hemantkabdwal2604]

👍👍👍👍

[@kishoresutar4175]

My question is why only general standard temp for steam sterilization is 121•c ,
But if we use more than that it will do Complete our process fast

[@PharmaGyan]

Yes you can do it but first you need to evaluate the impact of high temperature on the materials which you are sterilize.
An increase in temperature will reduce the time duration.

[@PharmaGyan]

Thank you

[@anujkumarjha7534]

ua-cam.com/users/shortsCibCM-t9zDY?feature=share

[@aruvasaikumar9368]

Pvl

[@sarabesaksahu2475]

Auto clave me vlt two minute se zyada aa raha hai to kya karana padta hai

[@PharmaGyan]

2 minute se jyada matlab
VLT measurements time me ni hota pressure me hota h
Clarify your question dear

[@chanduk1991]

Brother how to stop in middle of this machine

[@ajit2584]

Why 121.1 required..

[@PharmaGyan]

Its a std temperature you can change as per your requirements

[@TinkuKumar-uv3yh]

हिंदी में नही।हैं

[@aruvasaikumar9368]

Bottles

[@SONUKUMAR-ti8kq]

D-Value samaj nhi aaya

[@PharmaGyan]

We will try to prepare a separate video on D value along with calculation of D value