Cancer and the immune system: how Immune cells destroy cancer (video mocroscopy)

How does our immune system protect itself from cancer? Using video microscopy, cancer researchers are investigating how the body's own immune cells destroy tumor cells and how cancer cells defend themselves against them.
The tutorial is based on results from peer-reviewed Nature paper published in 2021 (Nat Commun. 2021 Sep 1;12(1):5217. doi:10.1038/s41467-021-25282-3).
Links:
You can find the original publication here: www.nature.com....
0:00: Intro
0:14: T cells in muscle tissue
0:24: Destruction of a tumor cell by T cells
0:52: Animation: The effect of granzyme B and 53BP1 in the tumor cell
1:32: Cell death by nuclear fragmentation (apoptosis)
1:43: Cooperating T cells
2:34: Outro
In the tutorial you will learn how tumor cells are attacked and destroyed by the T cells of the body's own immune system.
The process of this destruction can be easily observed in cell and tissue cultures.
Granzyme B is released during the attack. This process activates nucleases in the nucleus of the cancer cell, which cut up the genetic material.
The tumor cell tries to repair the DNA damage with the help of the DNA repair protein 53 BP1.
But after several injuries, the tumor cell gives up and dies. The process is particularly efficient when several T cells cooperate.
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This tutorial is a project of the German Cancer Foundation, the German Cancer Society (DKG) and the Department of Experimental Cancer Research (AEK) of the DKG.
Visit us at at www.krebsgesellschaft.de/german-cancer-society.html and at www.aek-congre...