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The ‘width’ is a misnomer, because it is calculated from the MCV, meaning it is actually a measure of the distribution of volume rather than width. Other causes of an increased RCDW include haemolytic fragmentation, sickle cell anaemia, agglutination, cytotoxic chemotherapy, chronic liver disease, myelodysplasia, dimorphism.
Great job. I would just like to add that the there are 2 ways of measuring the RDW. One Is the way you presented which is known as RDW-CV and it is a calculation. It is calculated by dividing the standard deviation of the mean cell size boy the MCV and then multiplying by 100 to get a percentage. The other is RDW-SD which is the actual measurement of the width of the red cell distribution curve. Normal range for adults is 40 - 55 fL. RDW-SD is considered to be a better reflection of the variation in cell size since it is an actual measurement and is not influenced by the MCV.
Hello the sentence when you say (RDW is elevated in nutritional anemia but normal in genetic anemia) is incorrect because thalassemia is a genetic disorder and the RDW is elevated The RBC distribution width (RDW) is elevated (reflecting anisocytosis) in untreated β-thalassemia major, but it is often normal in β-thalassemia minor.
Your explanation was great so I'm going to watch your whole hematology course even though I already took it last year! Thank you! keep it up! PS: love your neat handwriting.
Thank you very much! Your videos are very helpful. You are better than my Hematology Uni professor. ( I always wait for the last few seconds when you say something funny🤣. )
You have been a GREAT help to me....my RDW is elevated and I thought it was something that I could not correct...thank goodness I ran across your video☺
Thank you 🙏 Make sure to interpret the result in light of th the entire case (history, symptoms, signs, other lab tests) with the help of a good doctor!
Thank you very much sir your are very helpful and amazing God bless you for this channel and working 💐💐💐💐♥️💖 Your are the best one I interact with you 💕💕💕 Please sir make videos about ecg because I love your explanation
If the condition (e.g., IDA) is not detected early (e.g., for more than 4 months, given the RBC lifespan is 120 days), is it possible for the RDW to be normal if, for example, all the RBCs are small?
hai as an medico your video is in detail to explain the RDW but in the microcytic and macrocytic anemia why the RDW is increased ? if you explain in clear way i would recommned my freined also hope you will do good videos mate >>>
Thanks for your comment. RDW is elevated due to the fact that it takes the bone marrow a while to provide new sales, and these cells will be variable in size because the deficiency will be more severe in that late leave form cells. At first, there is sufficient iron or B12, so the bone marrow can produce relatively normal cells, but as time goes by, the bone marrow will become deficient in iron/ or B12, and shortage occur. So the cells become more abnormal. This variability is what causes anisocytosis and causes the RDW to rise. Hope it helps, and thank you for your support!
I did my blood test on first month of pregnancy and my blood test resulted 26.3 MCH and 18.3 RDW is it normal ? My hb and other factors are in normal range
Hello...can someone start to recover from an anemia cause high RDW? Because 3 months before my little one anemic ...after taking iron rich foods her HB raised to 12.8 ...but her RDW and platelets goes up....what is the reason...?
I am confused if this patient has thalassemia or Iron deficiency. The patient from Northern Europ I think thalassemia is hereditary in that part of the world. I need help with this one Thank you RBC Case Study # 1 A 65-year-old female of northern European origin with progressive shortness of breath and fatigue for the past 6 months has a history of hemorrhoids and described occasional bright red blood after her bowel movements. She did not mention any additional changes in color or consistency. She was post-menopausal and had no history of abnormal menstrual bleeding in the past. She mentioned that she took over the counter multivitamins but mentioned no other medications. Her physical examination noted pale conjunctiva and skin with no jaundice. No organomegaly was noted. A CBC was drawn, but the main analyzer was down, so only the following results were provided: WBC 5.6 X 109/L RBC 3.55 X 1012/L HGB 7.4 gm/dL HCT 24.5% PLT 439.0 X 109/L Manual differentiation of leukocytes was unremarkable with all values within normal limits. A snapshot of her peripheral blood picture is provided. 1. Calculate the RBC indices and indicate their significance. MCV: Hct /RBC x 10= 69.0 (normal range 80- 100 fL MCH: Hgb/RBC x 10= 20.8 (normal range 27-31 pg). MCHC: Hgb/Hct x 100= 30.2 (normal range 32%-36 %). 2. What is the significance of the blood following bowel movements? Do you believe this is related to her hematology findings? 1. What follow up tests would be most useful for the diagnosis of this patient? 2. Do you believe these findings will be normal? increased?
Hi! I was thinking the same. I got the idea that if the RDW is low it just means that cells share a very similar size but I don't know if I'm right. Did you find the answer?
so it's connected to iron deficiency? I was doing a blood test while I was on an iron pill treatment and it showed normal iron levels(prob because I was taking iron pills), but the RDW was high (17.8) ... I've been taking them for 4 months now and stopping taking them for just one day will make my hands freeze and lose dexterity, so I know I have to keep taking them ... after I finishing with the iron pills, how much time do I have to wait before taking a new blood test, so that it shows my real iron levels?
You said that RDW is increased in nutritional deficiencies but not in genetic conditions impacting RBCs. That confuses me because isn't the RDW increased in hereditary spherocytosis?
RDW measures the variation of sizes in rbcs. Low RDW means that all your RBCs are about the same size. So the lower the value the more similar their size is :)
Thank you so much for this explanation. Does B-12 deficiency cause the same symptoms as iron deficiency anemia? Does high RCW even need treatment? Thanks again!
Great question...Look, there are common findings; for instance anemia signs& symptoms (fatigue, pallor, murmur, angina, shortness of breath, dizziness, exercise intolerance...etc) occur in both conditions...Also, both conditions have high RDW. However, some symptoms occur only in one condition and not the other, for instance; iron deficiency has Pica, restless leg syndrome, koilonychia.... B12 deficiency has neurological symptoms (ataxia, motor weakness, sensory deficits).... RDW per se is not a problem, the underlying disease (iron deficiency or B12 deficiency) is the actual problem, and this needs treatment. Hope it helps!
Mine is low so I’m catching while passing by midpoint.... the iron one is shrinking so shows all the same but gradually the iron is going to continue to drop creating an increase in the difference... correct?
My RBC 4.67 SUPPOSE BE BETWEEN 3.77 - 5.28 SO GOOD .... MY RDW 11 SUPPOSE BE 11.7-15.4. So RDW IS LOW I have watched 3x but I’m not catching this addressed Thx
💊🦠 Antibiotics Lectures: www.medicosisperfectionalis.com/products/courses/antibiotics/
💉 📜 My Notes, cases and courses www.medicosisperfectionalis.com/
😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119
📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis/
As a fresh resident in Hematology, I'm finding this whole playlist SO helpful. You're saving me here. Thank you!
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My rdw sd is 42 is it abnormal??
@@anannyadesai1706 yes
@@MedicosisPerfectionalis k😂yizsuygsjhzjsatz haly
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I wish you could see me stand up and clap for this video. It is explained so so so well. Hopefully you are a professor of some kind.
+Casey B You made my day. Thanks a lot for your kind words! No, I am just a student:)
Medicosis Perfectionalis I’m a nursing student and this made me feel more confident about studying these labs!
+Casey B Great to hear that! I wish you the best of luck!
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Medicosis Perfectionalis
I m from Iraq (Arabic language )
BUT
I understand what's you say
Thanks teacher
Oh, Woooow! Welcome...Great to have great people here! Thank you so much!
I'm watching more videos for you
Use more common words to understand what non-native users say I really understand most of what you say is quiet and fun
Can you give me an example, please?
The ‘width’ is a misnomer, because it is calculated from the MCV, meaning it is actually a measure of the distribution of volume rather than width. Other causes of an increased RCDW include haemolytic fragmentation, sickle cell anaemia, agglutination, cytotoxic chemotherapy, chronic liver disease, myelodysplasia, dimorphism.
RDW is influenced by poikilocytosis
It also happens in spheroytosis
Love how you broke down this topic to make it so easy to digest. Thank you!
Great job. I would just like to add that the there are 2 ways of measuring the RDW. One Is the way you presented which is known as RDW-CV and it is a calculation. It is calculated by dividing the standard deviation of the mean cell size boy the MCV and then multiplying by 100 to get a percentage.
The other is RDW-SD which is the actual measurement of the width of the red cell distribution curve. Normal range for adults is 40 - 55 fL. RDW-SD is considered to be a better reflection of the variation in cell size since it is an actual measurement and is not influenced by the MCV.
Thank you ! I was going to post a question to the two but you have articulated this very well.
I love your teaching. You would make a great instructor!
Thank you so much!
Hello the sentence when you say (RDW is elevated in nutritional anemia but normal in genetic anemia) is incorrect because thalassemia is a genetic disorder and the RDW is elevated
The RBC distribution width (RDW) is elevated (reflecting anisocytosis) in untreated β-thalassemia major, but it is often normal in β-thalassemia minor.
My English is pretty basic and even I understood everything! So good structured, simple and clear explanation, thank you very much!👍🏻
Your explanation was great so I'm going to watch your whole hematology course even though I already took it last year! Thank you! keep it up!
PS: love your neat handwriting.
WooooooooW! Love it! I am so happy right now...You made my day!
Thank you very much! Your videos are very helpful.
You are better than my Hematology Uni professor. ( I always wait for the last few seconds when you say something funny🤣. )
Thank you so much 😊
I appreciate you!
Great, you answered my question regarding what causes the small size of RBC.
Perfect 👌 Thanks for watching!
Simple and easy and that is a mark of how excellent you are , Thank you.
Thank you so much 😊
you are the best study coach in the entire universe . we are blessed to have you .
Thank you 🙏
What if your RDW distribution width is low? Mines got flagged on a blood test as being too low 🤔 what could cause that ? Is that even an issue?
I have decided to watch ur whole series of lecture on Anaemia.. I have watched starting 3 lectures and I m ur fan now.. Thank u soooo much😘😘
Awesome 👏
Please let me know if you have any questions!
Sure👍
😊😊
You have been a GREAT help to me....my RDW is elevated and I thought it was something that I could not correct...thank goodness I ran across your video☺
Thank you 🙏
Make sure to interpret the result in light of th the entire case (history, symptoms, signs, other lab tests) with the help of a good doctor!
Thank you very much sir your are very helpful and amazing God bless you for this channel and working 💐💐💐💐♥️💖
Your are the best one I interact with you 💕💕💕
Please sir make videos about ecg because I love your explanation
Thanks a lot!
4:10
*it happens gradually*
(Music intensifies in the background)
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medicosis should I tell you after each video that I love you. you are incredibly good
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you are amazing keep it up :)
Thank you 😊
WOOWW THIS IS SO EASY TO UNDERSTAND!
Clear, simple, and amazing explanation. Thank you so much.
Thanks a million, dear, for your continuous encouragement!
RDW should be below 12.9, as per studies done recently
I have Q. How patient can have low mcv , normal RDW same time.
Why doesnt a change in mcv affect to increase the RDW always
Great video as always. I always look out for a Medicosis perfectionalis thumbnail when i search for a yt video on a topic!
Thank you!
I like the way U talk
it's entertaining
thanx
Thank you for that :)
Me too its really interesting. .
Thanks a ton!
If the condition (e.g., IDA) is not detected early (e.g., for more than 4 months, given the RBC lifespan is 120 days), is it possible for the RDW to be normal if, for example, all the RBCs are small?
This is what's happening to me right now, and I've been trying to figure out why. Thanks!
You’re welcome...I wish you speedy recovery.
Thank you so much for this video! Explained very well!
Thank you for this easy explaniation!
You're very welcome!
@MedicosisPerfectionalis you said that the RDW is normal in genetic anemia, so will it also be normal in sickle cell anemia? (5:36)
sir please tell me about rdw in anaemia of chronic disease.Also please tell the treatment of anaemia of chronic disease
What is low RDW then, i still dont understand. What causes the patients to have low RDW
Best ever explained variations in RDW
Deep thanks & appreciations
If Iron deficiency causes microcytair anemia (the diameter of the blood cell decreases), why does the RDW still increase?
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RDW is elevated in nutritional anemia but normal in genetic anemia: how about cases of SCA? and isn't it a genetic cause?
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Thanks a ton 😍
Thank you from IRAQ ❤️
So I am curious, I don't think this was covered, but what would cause, or be the significance of, low RDW with low RBC? Thanks :)
RDW is only clinically significant when it's increased in value.
Low rdw have no meaning in medical science?
It might have a meaning but it’s not clinically or practically significant...If you have read otherwise, please let me know
@@MedicosisPerfectionalis thank you for responding!
Sure
hai
as an medico your video is in detail to explain the RDW but in the microcytic and macrocytic anemia why the RDW is increased
?
if you explain in clear way i would recommned my freined also
hope you will do good videos mate >>>
Thanks for your comment.
RDW is elevated due to the fact that it takes the bone marrow a while to provide new sales, and these cells will be variable in size because the deficiency will be more severe in that late leave form cells. At first, there is sufficient iron or B12, so the bone marrow can produce relatively normal cells, but as time goes by, the bone marrow will become deficient in iron/ or B12, and shortage occur. So the cells become more abnormal.
This variability is what causes anisocytosis and causes the RDW to rise.
Hope it helps, and thank you for your support!
Great, you're great dude, thank you so much for your cool content
Thank you so much!
Please help me by sharing my videos with others!
Too good. Eloquent.
Thank you ☺️
Thank you legend
Thank you!
Thank you!! Very useful and clear explanation 🩸
Hi :) if the deficiency is chronic (>120 days) will the RDW become normal again in nutritional anemia ?
I did my blood test on first month of pregnancy and my blood test resulted 26.3 MCH and 18.3 RDW is it normal ? My hb and other factors are in normal range
Mcv is normal 81 and RDW-CV IS LOW 9. WHAT DOES IT MEAN. PLEASE TELL ME
what a shame my lab teacher coudnt explain what RDW was correctly, thanks for the video !!
Hi, if the RDW is ready normal but the PDW is reading low on a CBC what does that mean?
Hey, what is RDWR , actually according to my medical report my RDWR is 73 but it's range is only till 54, what does that mean?
Amazing explanation🥰
Thank you 🙂
Hello...can someone start to recover from an anemia cause high RDW? Because 3 months before my little one anemic ...after taking iron rich foods her HB raised to 12.8 ...but her RDW and platelets goes up....what is the reason...?
concept was nicely explained
That’s why we’re here!
Just explained my missed UWorld question :) thank you!
My pleasure...Keep it up 👏
It's like factory production depends on raw material supply..
Indeed 😉
wow Very comprehensive
+Fahmi Ramzy Thanks a million!
I really do appreciate that!
I am really proud of you
Continue such videos of day to day medical practice and don't forget rare syndromes
God bless you
+Fahmi Ramzy Thanks again!
Sure, I will
Do you know what does it mean if RDW can't be measured in Hgb SC anemia?
Hi
What about RDW in sickle cell anemia, autoimmune anemia and thalassemia major??
Am not a science student... Your vid is great.. My iron and B12 is good... Just the MCHC is low - 30.7 g/dl and the RDW sd is high - 46.3 fl
Thanks...Honesty, I don’t know...Please talk to your doctor.
@@MedicosisPerfectionalis thnx for the reply
My pleasure 😇
I am confused if this patient has thalassemia or Iron deficiency. The patient from Northern Europ I think thalassemia is hereditary in that part of the world. I need help with this one
Thank you
RBC Case Study # 1
A 65-year-old female of northern European origin with progressive shortness of breath and fatigue for the past 6 months has a history of hemorrhoids and described occasional bright red blood after her bowel movements. She did not mention any additional changes in color or consistency. She was post-menopausal and had no history of abnormal menstrual bleeding in the past.
She mentioned that she took over the counter multivitamins but mentioned no other medications.
Her physical examination noted pale conjunctiva and skin with no jaundice. No organomegaly was noted. A CBC was drawn, but the main analyzer was down, so only the following results were provided:
WBC 5.6 X 109/L
RBC 3.55 X 1012/L
HGB 7.4 gm/dL
HCT 24.5%
PLT 439.0 X 109/L
Manual differentiation of leukocytes was unremarkable with all values within normal limits. A snapshot of her peripheral blood picture is provided.
1. Calculate the RBC indices and indicate their significance.
MCV: Hct /RBC x 10= 69.0 (normal range 80- 100 fL
MCH: Hgb/RBC x 10= 20.8 (normal range 27-31 pg).
MCHC: Hgb/Hct x 100= 30.2 (normal range 32%-36 %).
2. What is the significance of the blood following bowel movements?
Do you believe this is related to her hematology findings?
1. What follow up tests would be most useful for the diagnosis of this patient?
2. Do you believe these findings will be normal? increased?
I need to see the peripheral smear that's mentioned.
Thalassemia is found along in Southeast Asian countries.
What if RDW decreases? I find it hard to search for the answer, please help me, thank you!
Hi! I was thinking the same. I got the idea that if the RDW is low it just means that cells share a very similar size but I don't know if I'm right. Did you find the answer?
@@jhinsonmoreira8203 obviously that's what it means, but it shouldn't have any clinical significance
I think you're genius !thanks a million that's very helpful
Excellent explanation.. thank u
Absolutely
So people with sickle cell anemia should have high Rdw?
so it's connected to iron deficiency? I was doing a blood test while I was on an iron pill treatment and it showed normal iron levels(prob because I was taking iron pills), but the RDW was high (17.8) ... I've been taking them for 4 months now and stopping taking them for just one day will make my hands freeze and lose dexterity, so I know I have to keep taking them ... after I finishing with the iron pills, how much time do I have to wait before taking a new blood test, so that it shows my real iron levels?
Rdw elevated in reticulocytosis secondary to hemorrhage?
Plz do you have certain materials for studying for ascp exam ?? For mls ..thanks
You said that RDW is increased in nutritional deficiencies but not in genetic conditions impacting RBCs. That confuses me because isn't the RDW increased in hereditary spherocytosis?
By genetic disease, I meant the thalassemias
This helped me a lot, Thank you
My pleasure 😇
Hello, extremely amazing video thanks a lot. However i was wondering, what might cause RDW below the normal range and is it something to worry about?
RDW measures the variation of sizes in rbcs. Low RDW means that all your RBCs are about the same size. So the lower the value the more similar their size is :)
Your lecture is great Dr, thank you so much. My RDW is above normal, I was wondering will drinking alcohol such as red wine daily influence the RDW?
Thanks 🙏
I don’t know 🤷♂️
My rdw sd is 42. Is it abnormal??
What can i do im having high rdw sd and cv normal hgb,rbc,mcv and mchc...
Thanks
Correlation between high RDW and Monocytes?
A5ß
so anisocytosis is only transient until a new stable state of chronic deficiency is achieved?
how does low iron makes cells less in size ,does low iron helps cells to replicat
What will happen to RDW in sickle cell anemia ?
It depends…I will guess that RDW will often be within normal range.
Rome didn't fall in one day, neither did the bone marrow, God tier quote😁
You are the new messiah. All hail to you Mr Medicosis
Wow 🤩
Thank you ☺️
Thank you very much
My pleasure 😇
yu are great. keep it up. thanks
Thanks a million, Sir!
Great video. Thank you
My pleasure! Thanks for watching!
Amazing amazing amazing thanks alot
How about hereditary spherocytosis? I also learned the RDW should be elevated?
It's possible, but this is not a major clue while diagnosing hereditary spherocytosis.
In the previous video you said the RBCs are microcytic or marco according to the MCV , and now you say it’s according the RDW
More explanation please?
It’s according to MCV
Thank you so much for this explanation. Does B-12 deficiency cause the same symptoms as iron deficiency anemia? Does high RCW even need treatment? Thanks again!
Great question...Look, there are common findings; for instance anemia signs& symptoms (fatigue, pallor, murmur, angina, shortness of breath, dizziness, exercise intolerance...etc) occur in both conditions...Also, both conditions have high RDW. However, some symptoms occur only in one condition and not the other, for instance; iron deficiency has Pica, restless leg syndrome, koilonychia.... B12 deficiency has neurological symptoms (ataxia, motor weakness, sensory deficits)....
RDW per se is not a problem, the underlying disease (iron deficiency or B12 deficiency) is the actual problem, and this needs treatment.
Hope it helps!
Thank you so much!
@@MedicosisPerfectionalis yes it helps me too
Awesome 👏
Thank you 🙏
You’re very welcome
Very great videos.. Makes hematology mush more easy. Thank you
What’s name of program used in these videos
Thanks 🙏
Walker Patricia Lopez Anthony Rodriguez Nancy
This is really helpful
wow this was very helpful thank you!
My pleasure 😇
Sir , could u plz explain the clinical importance of mch and mchc ? When do we need it ?
They are only significant in iron deficiency and in spherocytosis.
MCHC: low in iron deficiency.
MCHC: high in spherocytosis.
Thank you
My pleasure 😇
Mine is low so I’m catching while passing by midpoint.... the iron one is shrinking so shows all the same but gradually the iron is going to continue to drop creating an increase in the difference... correct?
My RBC 4.67 SUPPOSE BE BETWEEN 3.77 - 5.28 SO GOOD .... MY RDW 11 SUPPOSE BE 11.7-15.4. So RDW IS LOW
I have watched 3x but I’m not catching this addressed
Thx