Fatty Liver Pathophysiology

www.sciencewithsusanna.com has diagrams, notes, and practice questions.

[@schuggy4408]

The best explanation on UA-cam for Fatty Liver. Thank you for making this.

[@ryanparker6903]

Brilliant! This is the first time I have seen someone explaining what is actually happening with the cells in the liver when they become fatty. Thank you!

[@agusscontesse]

youre a life saver. ive been working on this school project about fatty liver disease and no matter how much info i gathered i wast able to fully understand the topic until i came across this video. thank you so much.

[@wholefoodplantbasedmama5398]

that was brilliant! Love the way you teach. I showed my students who are in my whole food plant based no oil course. They wanted to know about this.
Well done!

[@eliaskemist717]

I had been lazy, short-tempered and drained every minute back them. In accordance with my medical doctor, I got fatty liver, that was an ailment I haven`t heard since. It was only 2 months ago that we found fatty liver treatment solution 4FattyLiverTreatment.blogspot.com as we were looking for ways to resolve the problem. I caught to it religiously and have lost 17 lbs already. I am a new individual because of this!

[@alexjulius69]

It's kinda in reverse. You develop insulin and leptin resistance from the fatty liver and other organs covered in fat. Insulin resistance doesn't lead to increased lipolysis, it's the complete opposite, it leads to more of deliponovogenesis in the body (fat making). This is why everyone who's above 20% body fat percentage pretty much have insulin resistance accompanied with leptin resistance. And that's why it's so easy for them to get fatter.

[@alexanderelsen9397]

Lovely explanation, I hate it when other people do this whole alcohol causes fatty liver disease, without explaining anything. They just skip to the result without explaining the process, when the process is the important bit.

[@daudyusufirbad1940]

Thank you very much. It is indeed remarkably competent. Way to go doctor!

[@FrancisFurtak]

Thanks for explaining this. Brings in a whole different way of looking at what I put into my system! Good video!

[@RR-wq3pq]

I thought the adipose cell was a fried egg! Thank God 🙏 I love my eggs

[@liposatreagu604]

I experienced having fatty liver for five years. The medical doctors recommended me to take medications and pills like there wasn`t any other way. I felt like that was the last of me and I was so down. I came across this fatty liver treatment: FattyLiverRemedy9.blogspot.com I had the best experiences with it.

[@_Tree_of_Life_]

You have really nice handwriting :)

[@srbijapodlupom9907]

This is glorious, I been tryin to find out about "liver problem treatment" for a while now, and I think this has helped. Have you heard people talk about - Bachalaswin Better Body Rule - (just google it ) ? Ive heard some incredible things about it and my partner got amazing success with it.

[@carlreynolds5657]

Here's a great treatment for fatty liver if you're interested: hootadvice.com/best-fatty-liver-treatment/
. .

[@karenbetancourt2744]

Winner of a video, I've been looking for "what does having a fatty liver mean" for a while now, and I think this has helped. Have you ever come across - Jeyebastian Venlena Blaster - (Have a quick look on google cant remember the place now ) ? Ive heard some pretty good things about it and my cousin got cool success with it.

[@mdmonowar7339]

Just wonderful, been searching for "how to take care of your fatty liver" for a while now, and I think this has helped. You ever tried - Jeyebastian Venlena Blaster - (just google it ) ? Ive heard some super things about it and my co-worker got great success with it.

[@davidsebastianvegas3534]

This was great, thanks, been searching for "liver problems fatty liver" for a while now, and I think this has helped. Ever heard of - Jeyebastian Venlena Blaster - (do a google search ) ? Ive heard some super things about it and my m8 got amazing success with it.

[@venkatibethi98]

Gorgeous presentation, amazing to keep all the information in one slide.... Makes simpler to understanding what really happens in the liver.

[@danmarquez3971]

GREAT tutorial!!This was very educational, clear, and even relaxing! I love this style of training!

[@DrNiteshRaj]

SUPERB,,VERY NICELY EXPLAINED THANKS

[@AnthonyPerez-fu1eh]

Very informative, so descriptive I’ve downloaded to study for my own educational understanding
Thank you, thank you, thank you Anthony

[@webstuff56]

excellent explanation-- thank you!

[@Bhanu_Dasaraju]

Thank you so much for such a simple explanation

[@hattienuff1405]

Excellent presentation 👍
Thank you !

[@mermer58]

Fantastic explanation!! Thank you so much. I've had a symptom that I believe indicated fatty liver for about 10 years. Doctor has just now ordered enzyme test and maybe ultrasound.

[@nasranaizi2714]

Great Job!! Thank you!
A couple of observations:
1. While it is true that insulin resistance stimulates lipolysis and may contribute to liver fat accumulation, NAFLD often precedes the onset of insulin resistance and may be a key factor in its etiology.
2. For further illustration of fructose hepatic toxicity I suggest you watch a video titled "why sugar is as bad as alcohol" on the WIL channel (What I Learned).

[@mermer58]

In my own case, NAFLD did not proceed insulin resistance.

[@PorkChopFriedRice]

This helped me a lot with science research. Thank you!

[@toniencheff4046]

Thank you so much. I was recently diagnosed. I had polycystic ovaries which are associated with insulin resistance. I had ovarian cancer which was associated with the ovary problem. Good news: I love my am coffee. Bad News: I love my fruit juice. Growth news: I am discovering my inner athlete.

[@dfinite1111]

Thank you for a clear explanation, on this complicated physiology! Much appreciated!

[@navpreetsingh2393]

Please reply please please, I'm suffering from this but i never drink alcohol and don't smoking. Actually i was loved to eat fast foods like champs , burgers , kurkre . I had eaten 3-3 packets in a day daily , I think i ate it 1 week daily kurkre,lays burgers. But now I'm changed totally i give up fast food 1 month passed . I'm skinny . Please reply i want to do excessive and i do it sometime what now i will do it daily. I love to do agriculture work like i do ploughing with hoe but i tired then i give up but now i got motivation please reply is it good. My mother compell me to eat fruits like guava and orange because we have tress please reply

[@htetoo4274]

I am so glad that I have found your videos on youtube. your explanation helps me a lot. thank you.

[@shalinidatta1889]

Nicely explained with appropriate cartoons. Excellent !!!

[@df6148]

11:05 is this why people store fat EVEN in a caloric deficit if your constantly eating things like Candy and Juice that make you spike insulin’s. Is it triggering the fat save cell response?
Answer: 13:18

[@Franzellcon]

if all teachers are like you...

[@salomealfred6160]

MUCHAS GRACIAS!! no hablo inglés, pero me ayudo mucho el vídeo

[@edwardwong654]

I am starting to love these videos. Can someone explain or breakdown how INSULIN prevents the adipose from storing fat, but if the adipose are IR, then the adipose refuses to store the fat, and instead fatty acids go up in the blood, where they are taken by hepatocytes, which then stores them as fat in the liver? Did I get that right? Thanks.

[@agp9844]

I am very fortunate to have found your video, I am taking some classes on this subject and I am looking for all the information about the different perspectives from different people that I can. There is so much information on the liver and the way it functions and how what you put in your body is metabolized in your liver including prescription drugs. I have found so much conflicting information on the effects of statins, natural dietary supplements and foods that have been proven to be the most important part of a healthy diet that I have been overwhelmed with my research. I may just have to write a thesis on the subject of the different theories and studies that have been done. There is very differing views and opinions depending on where the person was educated , the country they went to medical school in and if they were taught natural medicine as an alternative to the pharmaceutical drugs that are pushed by their educators in a few countries such as the United States for the ability for profit potential in their future medical practices that require the patients to return to the medical office on a regular basis to get the prescription drugs refilled and allow the medical practice to create a reoccurring revenue stream.

[@kvcrao7472]

WONDERFUL EXPLANATION - K V CHALAPATI RAO GUNTUR , AP , INDIA

[@ShahabSheikhzadeh]

What I don't understand from a pathology perspective is, can say, oils you put in your hair, does that cross the blood brain barrier and get processed by the liver?

[@rifkamisbahsyarifah8563]

great explaination. i am going to presentate about fatty liver tomorrow, this video pretty helps me.

[@alexjulius69]

You develop fatty liver from fructose and alcohol. Fatty liver leads to insulin and leptin resistance. These two lead to easier fat gain and obesity. And so on.

[@zazakh7804]

Thank you so much! It was explained clearly and for the first time I understood it completely.

[@claremangawhai1650]

Thank you sooo much for this excellent explanation of Fatty Liver Pathophysiology. Much appreciated :)

[@archiecooper5146]

I encountered having fatty liver for five years. All of the doctors ever wanted to do was give me pills and all kinds of medications. The medical doctors made it sound like a death sentence and it hit me hard. I came across this fatty liver treatment method 4FattyLiverCure.blogspot.com I got the best experiences with it.

[@brettzachar6570]

Talented artist, and excellent presentation. Thank you.

[@ahmedalmasry9575]

Is it a reversable disease or inreversable

[@user-co3nl8go6c]

Thanks! please can you make videos on subjects like systemic patholgy and surgery topics like hernia , ulcers etc ! your explanations are excellent!

[@susannaheinze]

Prakhar Gupta thank you for your encouraging comment! I will add these topics to my list of upcoming videos. when you say systemic pathology do you mean sepsis? thanks again for taking the time to comment.

[@cmmconstrictors5971]

so when your getting a stiffness feeling in the liver from steatosis its to late to be cured ??

[@arcelenegumabay1322]

The liver is a very strong and enduring organ of the body. It regenerates and heals itself when damaged. However, due to genetics or sedentary lifestyle, the liver kept continuously damaging which leads to cirrhosis. You can't feel the stiffness of your liver but your liver becomes stiff when cirrhosis occurs. Cirrhosis is the irreversible scarring of the liver. This cannot be cured because it is irreversible. The only solution for this is liver transplant. Hope this helps

[@alexjulius69]

Just stop making the situation worse. No refined sugar and no alcohol. And then delay breakfast for as long as possible when you wake up. Our body prioritizes using visceral fat in our organs first -- including liver fat, when it's absent of food.

[@anntonetteselga4136]

Thanks for knowledge..its very helpful to my reports..😁😁

[@jamilrehman1810]

amazing explanation.

[@birhanabdulkadir6616]

Nice explanation. Thank you.

[@JesseGelatnis]

It's very informative. But it upsets me that it doesn't mention if the scarring is irreversible. Is it?

[@AmitDatta1976]

exactly super handwriting artist ... you also have a great voice

[@ParsaAfghan]

Thanks for your time and comprehensive while simple explanation. I enjoyed it and learn from it.

[@ExcelMale]

Great simple explanation. Thank you

[@preethysatheesh1976]

A lot of informations in a single sheet, waiting for the rest.

[@jjbbreitenbach]

Susanna, Could you produce a video on Primary Biliary Cholangititis?
Thank you!

[@waltcrawford6153]

Great video, I was just diagnosed with NASH and have been taking Xeljanz for Ulcerative Colitis. Do you know of any drug interactions that may cause NASH?

[@pamelajob2261]

Herbal medicine is 100% guarantee of Fatty liver disease cure, the reason why most patient are finding it difficult to cure Fatty liver is because they believe on medical report, drugs and medical treatment which is not helpful to cure Fatty Liver disease. Natural Roots & herbs are the best remedies which can easily eradicate Fatty Liver so herbal medicine is the best remedies for Fatty Liver disease . I was once a patient of Fatty Liver disease now I give thanks to spiritual Dr. Auchi on UA-cam channel…

[@awemdo]

Nice explanation,,thanks alot✌️♥️

[@Junjo11]

Well detailed. Thank you....this will help me to heal my fatty liver.

[@shivanichhabra1166]

Thank you sir for advice. I remember last year, my uncle was suffering from fatty liver disorders and he visited to
many hospitals and doctor but he didn’t get well. Then he visited t planet ayurveda and he is well and fit after using
fatty liver care pack

[@eoindowning8125]

Many thanks for the clear and concise explanation

[@patwilliams5608]

Thanks. Beautiful handwriting btw!

[@etoile2185]

Thank you for a simple and great explanation 🙏

[@ABC-fv7ow]

superb 🎉

Thanks a lot! That's so good explanation :)

[@francesp1423]

Awesome video!

[@susannaheinze]

Thank you for the nice comment!

[@linjoy9627]

So I've ended up with a diagnosis of NAFLD after having my gallbladder removed and my liver disected from my duodenum (not sure how they got glued together? previous abdominal surgery??)
As an anaesthetic nurse I've always tried to be healthy, never drinking alcohol or if I did only on holidays abroad as I was" on call" for emergency surgery, during most of my working week.
I'm luck there is no scarring and to have a colleague who's a Professor in bariatric surgery from gastric banding to bypass care for me.
My weights only ever fluctuated since menopause and not to the obese level's. I've mainly managed to keep my weight down to being perhaps a stone overweight. I'm vegetarian that doesn't eat fish/seafood (can't get my head round why people think that fish or seafood dosen't count as being alive???) So the thing that's given me the fatty liver is fruit juice - I went through a phase a few years ago drinking ton's of mango juice, never realising that it was damaging my liver- also I'm a non smoker.
WE health professionals really need to re-educate the public on the damages done by eating and drinking what we assume is healthy!! I know that bottle water can be dangerous for someone with high blood pressure because some of the levels of sodium/saline both = salty water can be dangerously high in salts. One only needs 18 tiny grains of salt per day to live, unless your stuck in the middle of a dessert somewhere the temperatures are above 35 deg when you REALLY do need the extra salt to replace whats lost through perspiration.

[@madeehazafar5782]

Explained very beautifully

[@emmywee6040]

Great explanation!

[@jilligain3409]

Would a lipid storage disease show up in the biopsy as different? Also, what about if the patient has an excess of estrogen, such as pcos?

[@judylee1860]

Last evening I took melatonin gummies. Internally things did not go well. I just looked at the bottle to see the #1 ingredient in the gummies is glucose. Sigh....
Thank you for these informative videos.

[@stnsafira]

maybe at the end of the video you can zoom out the camera to fit in the whole paper, just as the summary :)

[@susannaheinze]

siti anissa Safira that is an excellent suggestion. I should have done that! I will be making a point of doing that more. thank you for the comment!

[@kavtech_midi]

how about belly fat/overweight, where is comes from?the proccess?

[@markomeara7962]

@Susannaheinze, my question is: Is it carbohydrate, glucose or dietary fatty acids are behind Fatty Liver Disease? Thank you

[@dianthas3498]

Mark O'Meara Sugars, carbohydrates. Not fat.

[@mourilshah2054]

@@dianthas3498 fat as well leading to Non Alcoholic Fatty Liver disease

[@dianthas3498]

All the credible sources I have seen, consistently only point to dietary sugar and carbs.

[@mourilshah2054]

@@dianthas3498 www.google.com/url?sa=t&source=web&rct=j&url=medicalxpress.com/news/2018-11-high-fat-diet-effects-liver.amp&ved=2ahUKEwjVpa3osqrlAhWTj-YKHftuDAYQFjAMegQICBAB&usg=AOvVaw2VF3mYFBVmcH_2xWj2ErZ5&cf=1
www.google.com/url?sa=t&source=web&rct=j&url=www.ncbi.nlm.nih.gov/m/pubmed/31037218&ved=2ahUKEwjVpa3osqrlAhWTj-YKHftuDAYQFjAKegQIARAB&usg=AOvVaw27k70NkURVcanEjMQPdjaT

[@dianthas3498]

@Mouril Shah. There are dificulties in each of the studies noted. I read the cited article for the first study, and for the second, I went on from the abstract to read the published study. The diets and animals studied were disclosed in the second study. In that study, mice were used, and although I have heard a little about mouse dietary needs and metabolism, I am unable to comment helpfully on tha issue, or its relevance to humans. Additionally, the characterization of the diet as high fat is somewhat misleading, particularly with regard to the presence of a lower but significant amount of carbohydrates as well. This is important in light of concerns that the combination of carbohydrates and fat may be particularly deleterious. As I am not a nutritional biochemist or specialist researcher, I would refer you to videos of Robert Lustig MD, Stephen Phinney MD PhD, and Gobor Erdosi for starters.

[@joshuahuihui5913]

gosh this is scary, why didn't you talk about the cure or what we can do to stop progression of this or how to reverse it?

[@Truth_puzzle]

Hi.. You talked about liver capacity.. I was wondering if we can measure this capacity with something.. Like total liver metabolism rate.. Or total amount of fatty acids the liver can handle per something...

[@medicalschool8615]

Brilliant

[@Rene-uz3eb]

Regarding my theory of cancer being structural perfused glue when cells are dying too quickly: interestingly liver cirrhosis is the case when liver cells die due to toxicity, but the liver cells being unique in how quickly they can grow and regenerate, liver failure results from too much scar tissue from all the die off. Conversely, in liver cancer, the toxicity presumably is so great that hepatocytes cannot keep up with outgrowing cell death so that only cancer cells will do the trick.

[@Tohamaalghirbia]

Thanks for the info. Much appreciated

[@glitteringworld3064]

Thank you god for suggesting this video to me

[@abdiwahabmohamed3990]

very helpful explanantion

[@1a2b3c4.]

Great graphics.
You should teach medicine.

[@sarangas8688]

What are the special stain used to confirm fatty change

[@dannyg652]

i love you haha. great info you explain stuff well.. deff subbed

[@angelicahernandez3148]

Very simple and beauty. Thanks

[@noahyoung8728]

I experienced having fatty liver for five years. The medical doctors recommended me to take medications and pills like there wasn`t any other way. I felt like that was the last of me and I was so down. I came across this fatty liver treatment: FattyLiverRemedy9.blogspot.com I had the best experiences with it.

[@baltazarlyimo9664]

,,,oohh,,,great info,,,,thanks madam....

[@krissyfabz5867]

great video!

[@davedeaton1595]

Love your video. Thank You!

[@professionalhermit4592]

So, what is being done to classify fructose as a toxin (maybe above certain concentration) as a food additive, given the expected doses people consume collectively. Our libertarian society has allowed government to do that with alcohol and other chemicals in the food supply. Doctors need to be vocal about this. The average person in America, chasing their ad-driven dreams of a good life, suffers from rational ignorance about food aditives, has little option for better food stuff on a budget, has no time to off set their low aerobic activity levels from their better paying office job (coding no doubt). And is systematically killing themselves and teaching their kids to do the same.

[@consciousphilosophy-ericva5564]

How long does this take to progress in those who drink alcohol?

[@MedicEne]

Brilliantly explained!

[@susannaheinze]

Thank you for the encouragement! I made this video at a viewer's request and I wasn't sure what depth of information to put. I ended up trying to keep it very simple. I'm glad you found the information helpful. Please let me know if there are additional video topics you would like me to make.

[@stellatartisio157]

susannaheinze

[@foreignchipatlin8972]

where can i get the notes of above subject?????please help

[@yusufnasr3861]

Thanks شكرا 👏👏👏

[@HealthBeautyTips101]

how to reverse fatty liver

[@channel1Dsila]

Thank u ❤️

[@mchan2141]

Nice vid

[@user-mq8bv1fj4d]

Thanks⭐️⭐️⭐️⭐️⭐️
Amazing!

[@greenapplejuice23]

badass audio

[@morrisamooti]

love this

[@SalmanKhan-uf8tl]

I started taking the medication I bought from DOCTOR OKUNABA channel on UA-cam and surprisingly it was working gradually & in 9days everything changed, I'm utterly Excited because you cured my liver disease Naturally & I pray that God Strengthens you Doctor Okunaba

[@claire99ism]

How to reverse insulin resistance please?

[@delosangelesgomezlugo8383]

Thanks for the Video clip! Sorry for the intrusion, I would appreciate your opinion. Have you heard about - Millawdon Fatty Liver Trick (Sure I saw it on Google)? It is a good one of a kind product for learn how to reverse fatty liver minus the headache. Ive heard some incredible things about it and my old buddy Taylor finally got excellent success with it.

[@planetayurvedaseo9624]

agr kisi ko fatty liver ki problem ho gai ho to ap planet ayurveda ka yakrit -phllanthus churna v us kr sakte ho .

[@nigelnyoni8265]

Fatty Liver Diseases
.
Caused by drugs, alcohol, and bad diet.
Simple Steatosis = Fat accumulation & peri-venular fibrosis.
. Nuclei are squashed at corner if cell instead of comfortably in centre. Fat macro vesicles are visible.
.
Continued bad habits result in inflammation (Steato-hepatitis = fatty liver disease): liver cell necrosis results in inflammation, Mallory body formation, fibrosis.
Blood levels of liver enzymes become elevated.
Collagen fibres (scarring) replace the necrotised cells, making liver stiff, and decreases it's function. **Caffeine decreased scar formation.
Fibros-scan (special kind of ultrasound) will indicate degree of steatosis and level of scarring
.
Continued damage results in Liver cirrhosis. Fibrosis. Hyperplastic nodule formation. Shrunken liver overall.
.
**Steatosis and hepato-steatitis are reversible, but cirrhosis is not.
.
Rate of fatty acid input (uptake + synthesis within liver) to liver > fatty acid output (FA oxidation + lipid secretion via VLDLs out of liver) from liver => steatosis.
.
Steatosis:
Hepatocyte takes in excessive lipids.
Hepatic lipase breaks TAGs into fatty acids.
Within blood plasma, lipoprotein containing TAGs + protein are floating about. Hormone Sensitive Lipase hydrolases TAGs to form Free FAs which are uptaken into hepatocyte.
In normal conditions, hepatocyte resynthesises TAGs from these FFAs, or breaks then down in FA oxidation.
In steatosis, FFAs are synthed into TAGs to an excessive extent.
.
Adipose tissue transports FAs in lipoproteins which are broken down into FFAs which are taken up into the liver.
.
Dietary fat and glucose and ethanol all contribute to FFA development and synthesis, resulting to excessive TAG synth in liver forming lipid venules (rather than FFAs being oxidised).
Excess energy (high FAs or Glucose) is detected by Peroxisome Proliferative Activator Receptor alpha (PPAR alpha) which is a nuclear receptor protein. On detecting high FAs or Glucose, it will increase Beta oxidation of FAs to rid ourselves of excess fat.
If PPAR alpha is defective in sensing, FAs accumulate in liver.
PPAR gamma stimulates decreased fat oxidation causing steatosis.
......................
Fatty Liver Diseases can be Alcoholic or Non-alcoholic:
Alcoholic:
Ethanol =Alcohol DeHydrogenase=> Acetyl Aldehyde =Aldehyde DeHydrogenase=> Acetic acid => Acetyl CoA
*Withbeach reaction, NAD+ is reduced to NADH
Acetyl CoA can be used to synthesis FAs within the liver. Excess FAs result in excess TAG synth in liver.
.
Hepatocellular steatosis results form excess NADH (causing shunting of normal substrates from metabolism into FA synth. High NADH tells body to make FAs)
.
Impaired assembly and secretion of lipoproteins in liver.
Peripheral catabolism of fat.
..
Non-alcoholic Fatty Liver Disease (diet induced)
High intakenof dietary fat, Fructose can cause it. (fructose enters many pathways to produce Phosphatidic acids or Acetyl CoA which are used to make TAGs)
High fat uptake, reduced fat secretion, increased fat storage, reduced lipoprotein secretion in liver will raise Fat content of hepatocytes.
...
Metabolic Syndrome (non -alcoholic fatty liver disease)
Caused by any 3 of the 5 following:
Central Obesity, Hypertension, Dyslipidemia, Impaired glucose tolerance, insulin resistance

[@kernakoni5210]

Great work Dr igho you are a true definition of a well honoured herbal doctor, i wonder what might have become of me, it I hadn't come across your UA-cam channel, Thank you for curing me off my disease with your Herbal medication, God bless you Sir.

[@mynovels9802]

Thanks 💖💖

[@dimasrahadian]

I got NASH. How to fix it

[@reaganrebello2067]

Dont eat oil food .alchol .dont take sugar intakefor 4 months n maitin you weight n tell me after 10month

[@reaganrebello2067]

After 4month

[@sidmichael1158]

How to remove nafl?

[@JulieWallis1963]

Sid Michael Fajardo diet, change your diet.

[@alexjulius69]

Don't consume fructose that's found in processed sugar, or fructose syrup that's found in many processed foods. And then delay breakfast when you wake up for as long as possible. The longer you fast, the better, as when you're fasting, that's when you run out of glycogen and your body has to break down triglycerides (fats) to supply your body with energy. And your body prioritizes using visceral fat first, before going into the adipose cells. That means it prioritizes using fat from your liver first.

[@sidmichael1158]

@@alexjulius69 thanksss

[@alexjulius69]

@@sidmichael1158 Welcome

[@bedrosdaoudian8927]

Sorry... But are you a doctor or a medical student... ? I was actually SHOCKED when you said that "cirrhosis" is reserved for alcoholic liver disease... This reflects how little medicine you know... Actually cirrhosis is severe disruption in liver structure that results in symptoms of liver failure... So it's no longer a silent liver disease. NASH is an intermediary stage between steatohepatosis and cirrhosis in fatty liver... NASH will be followed by cirrhosis if proper management is not started. Cirrhosis occurs in any disesase that causes severe damage to the liver including Viral Heptatis, drug induced hepatitis... And is definitely not restricted to alcohol induced damage. I highly recommed that you redo the video with the proper editing... Hope to research a topic better before you present it. Good Luck

[@Biomeducated]

Exactly, cirrhosis is end-stage liver disease and can come from many etiologies. Also noticed the same mistake. Still, the animation is nice though. But indeed, if (bio)medical students are watching, hope they read the comments...