I have a real problem with hypothetical "chemists" that follow a paper like as cake recipe, but never characterize their products or intermerdiates. n truth, they don't know what they made or what path they followsed to make it.
Love video! It is not often we see uranium coordination chemistry :) Just a practical note: alumina is a lot heavier than silica, so it does not form a slurry. Probably you observed that yourself. In labs, everyone I talked to just dry-pack it, as it sediments faster than you can pour it, and it is heavy enough that it does not dusts everywhere like silica. For the future, just pour how much you need, and flow solvent through the column (if needed, use what came from the column again once or twice). A lot better working in the alumina case. Can not wait for your next video!
UVC LEDs do exist but they're very rare and hard to obtain, likely that UV lamp is a fake UVC lamp and only making UVA, it didn't look like UVC which should be almost entirely invisible. You'll need a special fluorecent lamp for UVC
Are you sure the "UV-LED" actually puts out the right spectrum? Oftentimes those UV led chips put out light more in the UVA range, UVC chips are pretty hard to make and expensive (and currently only exist down to a certain wavelength). For quite many reactions in photochemistry, as long as the lower wavelengths do not produce a particularly nasty byproduct in your specific reaction, I think currently mercury lamps are the best option. Also you get very high Lower-Wavelength-UV output compared to the higher NM wavelengths so the lighting time can be lower.
I was thinking the same thing. The light looked purplish instead of blueish. The LED chips themselves look like the typical kind and not the all-metal type for UVB/C.
@@TheOpticalFreakhopefully when doing uranium chemistry you don't smell anything. I'd hope the fume hood is working well enough to block anything coming out.
I don't even know you but I swear I love you, the way you draw each step of the reactions saves me headaches to fully understand the reaction. Keep doing this man, i love it.
While working in a lab can be very enjoyable, hearing someone say a couple liters through column cromatograph (saying takes a couple seconds) is so much more fun than taking all that, perhaps in 10-20ml and doing TLC or whatever. In literature breaking K with glass is no problem, one can always say "Added x amount of K with crushed glass imbedded" and everyone keeps wondering if the glass is an essential catalyst or what :D To meaasure small amounts of products it is always possible to make a solution of it and evaporate it in a smaller measured container. I did that when I once had only 1mg of stuff to synthesize with and there is no other way to measure it but in a tiny container. Measuring the products was way more fun! :D
Filtering hot solvent always seems like a bad idea to me, especially during crystallization. I recommend filtering the benzene, then adding the hexanes. Also, next time you place in the freezer to get crystals put it in the freezer in an insulated container, like a styrofoam box full of packing peanuts, to slow the rate of cooling to a couple days.
in like the 2010s i remember reading about uranium sandwich scaffolds that were showing really good promise for improving the magnetic resolution/density on hard drives. they were having issues though trying to get to a practical curie temp above room temperature but it was my understanding that the F and D blocks of uranium could give you either really dense and descrite 1's and 0's or very stable 1's and 0's when compared to typical hard drive tech. obviously SSD's made this a mute point but at the time ssd's were like 5-10$ / gig and had questionable longevity/stability. here we are now though.
Perhaps the photo-reaction failed in part due to the UV source? I’m a super nerd with lightning, and I can tell you all LED bulbs that advertise UVC are fake. There is exactly 1 company in the world right now that I know of that is producing true deep UV LEDs in the 260nm range, and those diodes are almost $10,000 a watt at the moment. Most LEDs sold as “UV” are 395nm UV as well, which isn’t exactly great for most applications that call for long wave UV. Perhaps trying that reaction with a filtered 365nm UV LED source (which have become readily available and cheap over the past few years) or, if you are allowed, a low pressure mercury sterilizing bulb, would yield much better results.
3:30 maybe there is an inert liquid you could submerge the reactant in and submerge the uv light as well under stirring? Or perhaps the reaction requires the reactant to be sprayed/atomized under uv light
Loved the video, great chemistry! When you are loading your alumina next time, don't try to make a slurry, that only really works with silica, just add the alumina dry then pack with solvent :) Also some sand on top once you have loaded your sample means you can be a bit more careless when topping up with eluent
In the methylation of the amine, why does it complete on its own like that? I thought the imminium has to be reduced by borohydride or something. Excelent video, keep it up, its really a wonder to look at.
nope, these molecules can't make the strained cubane, it can form a benzene with attached cyclobutane, just the cyclooctatetraene, or break apart into multiple components.
As some other people are saying, that UV lamp is most likely fake. If it was using UVC leds the inside of those 5050 (i think) chips would be gold plated instead of dark red. Most UVC lamps glow sky blue but check with a UVC test card to be sure.
I don't have the most experience but I'm familiar with the technique of opening ampuoles where you score a ring around one end to get a cleaner crack. Alternatively maybe you could crack it open after cooling it in a freezer, so the potassium is harder?
How do you dispose of benzene? Responsibly? The Halliburton method of pouring it out on the ground when nobody is looking is the only method I’m familiar with. Which seems not so great.
You can get UVC led lights at 255 and 270nm peak emissions from certain types of pandemic madness phone disinfecting devices. They usually have s 405nm or blue LED on the board as well. Also mercury vapor lamps are rather cheap, the ones that make ozone give all bands of UV light.
Are you not afraid to mix NaN3 with chloroform? They are know to for explosive triazidomethane, it might not be an issue, but i would choose another solvent if possible.
why did you do the eschweiler clarke? you could have just methylated the amin with CH3I and you would get the quaternary ammonium salt or am i missing something?
There are multiple problems when starting with a primary amine to make a quat salt via CH3I. The first thing is the formation of salt as a byproduct which cannot be removed with the acetone wash, and since the product is a salt too it makes it more complicated. Also. I have heard of experience of others that tested this on many substrates and that it works poorly. The salt potentially hinders the reaction. In this case I was just following the literature, but I did think of doing CH3I triple methylation and I was adviced against it.
It could have been the lamp that was the problem in the first step. There are many fake UV-C LED lamps out there. I would stay away from them for UV-C and use an old-fashioned mercury discharge lamp, which they still make very cheaply for disinfection.
![Making [1.1.1]Propellane](http://i.ytimg.com/vi/iTlRvQuIyqE/mqdefault.jpg)
![Making [1.1.1]Propellane](/img/tr.png)
This is maybe the most advanced chemistry anywhere on UA-cam.
All the more to love it. He's sloppy yet refined.
I have a real problem with hypothetical "chemists" that follow a paper like as cake recipe, but never characterize their products or intermerdiates. n truth, they don't know what they made or what path they followsed to make it.
Showing full reaction mechanisms just makes the video so much better
Agreed, I feel like I start to get a more intuitive understanding of how it's gonna work
I 100% agree with this statement, I absolutely love his channel. He definitely gained a new Patreon today
"Mom can we get a rotovap?"
"No we have a rotovap at home"
Rotovap at home: 2:28
genius contraptions thou 😅
lmao
Bro literally made a uranium sandwich
Nom nom irradiaaaa........👻
Why does "an uranium " not roll of the tongue?
Even tho it is wrong "a uranium sandwich " feels better
Tasty……and you’ll never lose it in the dark..
@@scottbruner9266don’t worry even with your eyes closed you’ll get helium nucleus flying in that indicates you the position of the sandwich
@@koukouzee2923Because it should a uranium sandwich.
Love video! It is not often we see uranium coordination chemistry :)
Just a practical note: alumina is a lot heavier than silica, so it does not form a slurry. Probably you observed that yourself. In labs, everyone I talked to just dry-pack it, as it sediments faster than you can pour it, and it is heavy enough that it does not dusts everywhere like silica. For the future, just pour how much you need, and flow solvent through the column (if needed, use what came from the column again once or twice). A lot better working in the alumina case.
Can not wait for your next video!
Thanks for the tip, I will do that next time
thank you for always explaining the reaction mechanisms. You are awesome!
I gotta say, this is the best organic chemistry content out there, you're really killing it esspecially with the reaction mechanisms
I KNEW IT! Screaming IS a completely normal procedure in chemistry!
I love how you do videos on reactions that aren't always shown on UA-cam. Its really interesting and educational! Love it
UVC LEDs do exist but they're very rare and hard to obtain, likely that UV lamp is a fake UVC lamp and only making UVA, it didn't look like UVC which should be almost entirely invisible. You'll need a special fluorecent lamp for UVC
Also UVC does not really penetrate. I don't think it can be done in solid phase.
I was about to say this. That lamp would have cost a couple hundred bucks if they were UVC LEDs. Dead giveaway - no metal package for the LEDs
These mechanisms be keeping me alive
Are you sure the "UV-LED" actually puts out the right spectrum? Oftentimes those UV led chips put out light more in the UVA range, UVC chips are pretty hard to make and expensive (and currently only exist down to a certain wavelength). For quite many reactions in photochemistry, as long as the lower wavelengths do not produce a particularly nasty byproduct in your specific reaction, I think currently mercury lamps are the best option. Also you get very high Lower-Wavelength-UV output compared to the higher NM wavelengths so the lighting time can be lower.
I was thinking the same thing. The light looked purplish instead of blueish. The LED chips themselves look like the typical kind and not the all-metal type for UVB/C.
Indeed if you don't smell ozone, then it's not UV-C!!
@@TheOpticalFreakhopefully when doing uranium chemistry you don't smell anything. I'd hope the fume hood is working well enough to block anything coming out.
I’m so early that even Ariana had tears left to cry
Great video! I love that you explain the reactions in detail, it really allows for a deeper understanding of what's happening in each reaction.
I don't even know you but I swear I love you, the way you draw each step of the reactions saves me headaches to fully understand the reaction.
Keep doing this man, i love it.
While working in a lab can be very enjoyable, hearing someone say a couple liters through column cromatograph (saying takes a couple seconds) is so much more fun than taking all that, perhaps in 10-20ml and doing TLC or whatever.
In literature breaking K with glass is no problem, one can always say "Added x amount of K with crushed glass imbedded" and everyone keeps wondering if the glass is an essential catalyst or what :D
To meaasure small amounts of products it is always possible to make a solution of it and evaporate it in a smaller measured container. I did that when I once had only 1mg of stuff to synthesize with and there is no other way to measure it but in a tiny container. Measuring the products was way more fun! :D
Undergrad here, showing mechanisms is really helpful. Pls keep doing it. Also quoting named reactions
This is seriously impressive. I was groaning at just the first step of the reaction. This is tough stuff.
I feel like hes slowly edging towards to making a nuclear bomb with these videos
My new creation: the Organonuclear type. Fully legal for household extermination of undesired critters.
@@Chemiolis Polonocene?
Bro is about to turn into chemiolisheimer
Omg. Uranium doesn’t always = bombs.
Filtering hot solvent always seems like a bad idea to me, especially during crystallization. I recommend filtering the benzene, then adding the hexanes. Also, next time you place in the freezer to get crystals put it in the freezer in an insulated container, like a styrofoam box full of packing peanuts, to slow the rate of cooling to a couple days.
MONDAY LEFT ME BROKEN🤩🎶
Alumina column and a soxlet! Awesome video and awesome chemistry Chemiolis!
in like the 2010s i remember reading about uranium sandwich scaffolds that were showing really good promise for improving the magnetic resolution/density on hard drives. they were having issues though trying to get to a practical curie temp above room temperature but it was my understanding that the F and D blocks of uranium could give you either really dense and descrite 1's and 0's or very stable 1's and 0's when compared to typical hard drive tech. obviously SSD's made this a mute point but at the time ssd's were like 5-10$ / gig and had questionable longevity/stability. here we are now though.
Thank you for not dealing out another blow to the guy doing chemistry in down under and yet went for physics..
I have no fucking idea what I'm watching but it's great
Perhaps the photo-reaction failed in part due to the UV source? I’m a super nerd with lightning, and I can tell you all LED bulbs that advertise UVC are fake. There is exactly 1 company in the world right now that I know of that is producing true deep UV LEDs in the 260nm range, and those diodes are almost $10,000 a watt at the moment. Most LEDs sold as “UV” are 395nm UV as well, which isn’t exactly great for most applications that call for long wave UV. Perhaps trying that reaction with a filtered 365nm UV LED source (which have become readily available and cheap over the past few years) or, if you are allowed, a low pressure mercury sterilizing bulb, would yield much better results.
Best content! I love your explanations and full detailed mechanism!
Much awaited video finally here
You aren't really partying til the International Atomic Energy Agency knocks on your door
wonderful format of video!
Loving it
Keep doing what you’re doing man love these videos
Great video 👍🔝
That is an outstanding achievement. My sincere congratulations. Thank you for your wonderful channel and interesting videos. Just ❤ U, bro!
That move with the tumbler was so cool ngl
Amazing video
are there any videos which show the intended use and how things such as the various glass attachments you use work? such as the part at 7:47
7:45 got me, too many deepfried insta reels from friends
So cool I can't wait to see next video
3:30 maybe there is an inert liquid you could submerge the reactant in and submerge the uv light as well under stirring? Or perhaps the reaction requires the reactant to be sprayed/atomized under uv light
This is so informative!!! Fantastic video; I love this kind of content!🌻🌼🐝
00:00 Yoooo, fellow chemistry Wikipedia rabbit hole enjoyer! Found the most messed up molecules this way.
thank you for always explaining the reaction mechanisms. You are awesome!. This is so informative!!! Fantastic video; I love this kind of content!.
Outstanding video!
Marvelous 🎉🎉
Loved the video, great chemistry! When you are loading your alumina next time, don't try to make a slurry, that only really works with silica, just add the alumina dry then pack with solvent :) Also some sand on top once you have loaded your sample means you can be a bit more careless when topping up with eluent
Love your videos man, any plans in the future to make Adamantane?
He already has made it
Amazing as always!
Everyone's a badass chemist until they need to break open a glass ampule of something... xD
Holy shit that's one hell of a synthesis.... wow. Right on
You getting a 107% yield reminds me of Explosions&Fire’s hydrogen peroxide video
0:10 god bless you nineteen sixties
You’ve got yourself a AIVD subscription!
Greatest collab in history
The Dutch counterpart to the CIA?
@@douro20 Yessir
In the methylation of the amine, why does it complete on its own like that? I thought the imminium has to be reduced by borohydride or something. Excelent video, keep it up, its really a wonder to look at.
The formic acid acts as the reducing agent, donating a Hydride and producing CO2.
@@kpunkt98 wow, never thought imminium was strong enought to oxidize formic acid to CO2. Super cool
Thanks alot for the explanation
@@ingensvidcz5390 as far as i know it's a concerted mechanism, where both the hydride and proton are transferred at once, lowering the barrier.
17:03 If it got UV treatment, would it be the derivative of cubane？
nope, these molecules can't make the strained cubane, it can form a benzene with attached cyclobutane, just the cyclooctatetraene, or break apart into multiple components.
@@Chemiolis so sad
Uranium sandwich! 😋
Thorocene is next. This time with +4 being the most stable.
Why not put the uvc lamp into the beaker in the rollers after scraping it?
2:20 that is genius
kids can turn F*ing rocks into F*ing diamonds
@Chemiolis you can't turn f*ing rocks into f*ing diamonds cause you are not a f*ing kid LOL
As some other people are saying, that UV lamp is most likely fake. If it was using UVC leds the inside of those 5050 (i think) chips would be gold plated instead of dark red. Most UVC lamps glow sky blue but check with a UVC test card to be sure.
I don't have the most experience but I'm familiar with the technique of opening ampuoles where you score a ring around one end to get a cleaner crack. Alternatively maybe you could crack it open after cooling it in a freezer, so the potassium is harder?
You are a fucking god.
Love it!!!!!
How do you confirm your product? Do you run nmr or ftir ? Or any chemical tests
Love your videos! Does the di-acid keep you from using Diphenylphosphoryl Azide for the acid to amine step?
Can you do quinuclidine and then make a compound with it?
the meme interjections we’re a little jarring but other than that, really enjoyed this video!
If I may suggest a video topic, I would love for you to synthesize MOF-5, a metal-organic framework used in hydrogen storage.
why not use CH3I on the amine groups from the start to get to the ammonium instead of doing the Eschweiler-clarke first?
How do you dispose of benzene? Responsibly? The Halliburton method of pouring it out on the ground when nobody is looking is the only method I’m familiar with. Which seems not so great.
Mmm yummy. Now time for the taste test
The chemistry you've accomplished here is very impressive! And to think you did all this to make "Hulk-Juice." 😉🖖
are you sure that lamps makes the right uv?
I heard led have a hard time making it
You can get UVC led lights at 255 and 270nm peak emissions from certain types of pandemic madness phone disinfecting devices. They usually have s 405nm or blue LED on the board as well. Also mercury vapor lamps are rather cheap, the ones that make ozone give all bands of UV light.
The rolling beaker heat gun coating was so cool, I wish it had worked. It seems like photons are the WORST chemistry lab partners.
Are you not afraid to mix NaN3 with chloroform?
They are know to for explosive triazidomethane, it might not be an issue, but i would choose another solvent if possible.
I'm only marginal interested in chemistry, but this molecule looks exactly like two drones sandwiched together. Or like an Octodrone 😄
Gordon Ramsay to Uranium atom: WHAT ARE YOU?
tutorial on getting yellowcake from coffinite ore?
Amazing!!!
Next time you might want to try spreading out the alpha trans-cinnamic acid more and using a mercury UV source instead.
how does it taste like
What a delicious uranium sandwich
Is there a reason why the photoaddition wasnt done in solution? that seems to be the best way to get homogenous reaction.
UV wont penetrate properly and in solution it has no alpha polymorph so it would make a mix of all isomers
why did you do the eschweiler clarke? you could have just methylated the amin with CH3I and you would get the quaternary ammonium salt or am i missing something?
There are multiple problems when starting with a primary amine to make a quat salt via CH3I. The first thing is the formation of salt as a byproduct which cannot be removed with the acetone wash, and since the product is a salt too it makes it more complicated. Also. I have heard of experience of others that tested this on many substrates and that it works poorly. The salt potentially hinders the reaction. In this case I was just following the literature, but I did think of doing CH3I triple methylation and I was adviced against it.
It could have been the lamp that was the problem in the first step. There are many fake UV-C LED lamps out there. I would stay away from them for UV-C and use an old-fashioned mercury discharge lamp, which they still make very cheaply for disinfection.
will you make creatine?
I
\/
from dicarboxilic compound B to diamine is 1 step
The UV lamb may degrade plastic and rubber parts ob the equipment you used.
Uranocene is strongly air sensitive. Should Run the reaction between COT2- and UCl4 in argon atmosphere or inside the glovebox.
Interesting use of a rock tumbler lol.
😎 i like your ghetto sort-of rotovap ❤
Uranium cinnabons?
Lmao loved the diy rotovap, nice one
next time aspirate the dry powder so it is a free flowing powder with a way to make it air borne so all the surfaces are exposed to the UV
spicy
So in short: when the double bond reforms, shit happens
uv-c from led is kinda impossible they do exist but its hard and expensive
That was creepy 7:44 😂
Kinda sad the polymorph thingy didn't work-out.
epic