The Genomic Revolution with Prof. Dr. George Church
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- Опубліковано 9 чер 2019
- Today on FYI - For Your Innovation we are joined by Dr. George Church for a high-level discussion with ARK’s genomics analysts, Simon Barnett and Manisha Samy, on the current and future status of the field of genetics.
Dr. Church is a pioneer of synthetic biology and an influencer in the field of genomics. He is a Professor of Genetics at Harvard Medical School, the Director of personalgenomics.org and a cofounder of a multitude of companies! His innovations have led to technological breakthroughs in the areas of next generation DNA sequencing and CRISPR gene editing, amongst many others.
Our conversation in this episode covers a wide range of topics within genomics including next generation oncology, the security and regulation of genetic information, gene editing and the increasing speed of the genomic revolution. Dr. Church really gives us the inside and expert scoop and how exciting things in his world are and how this may become more of a reality for all of us sooner than you think. For all this and more be sure to join us!
Key Points From This Episode
-Genomic Revolution: Cost decline and unlocking new possibilities in the field of genetics
-Obstacles that stand in the way of the zero dollar human genome
-Increasing population genomics as a means to more accurate tests
-The future of health care as new technologies converge
-Why we should not be underestimating the speed of the revolution
-What our ability to edit 13,000 sites in a single cell means in real terms
-The ultimate goal of the human genome project and creating a synthetic reference
-Our computational power in dealing with these huge amounts of data
-What these advances mean for the field of regenerative medicine
-The possible efficacy of CAR T in fighting solid tumors
-Competition, market leaders and driving down of prices of advanced products
-Some of the technologies in the genome field that excite Dr. Church the most
Tweetables
“There’s still a few remaining diseases that are not solved by vaccines and there are some synthetic biology solutions to those that may be even cheaper than vaccines.” - @geochurch [0:14:03]
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Disclosure: bit.ly/1C5DBVL
Dr. George Church is my hero, thanks for your amazing work!
Church is an absolute legend
true
Thanks. Great interview.
"One and done..." Ok. This is mind-bending. And I must respond on some level b/c of how powerfully what I just heard, moves me. " I am a critical care nurse with 30 years of bedside, real-life, first-hand, front-line miracle and tragedy.
The first thing I have to share is that all these years have been a challenge against cynicism because of how much of a price-fixing scam medicine has devolved into over the years (Politicians being 1000% to blame...all politicians).
The second thing I must share is that despite this, people like George Church - thankfully, keep that self-less drive to serve alive within...albeit sometimes only barely and in need of life-support.
That said, in his words and wisdom, I finally heard the glimmer of hope...I see the glimmer of light for the exit ramp - off this dead-end travesty we call "health care" in America. Finally, I see that way I ALWAYS knew it would take to thwart the greedy and hoarders; a mechanism that denied them monopoly, monopsony, and political fraud.
What Dr. Church is describing is (just like he states) the low cost holy grail that is so inexpensive - everyone can have it, but not profitable enough to allow anyone to manipulate it.
We are close - ever so close to equality will have its first true toehold.
When employers are no longer the brokers for our health care, all men are instantly created (treated) equal.
This day CANNOT come soon enough.
Thank you Dr. Church for your obvious genius and your obvious motivations. Peace.
ARKG anyone???
I will just DCA ARKG but have it a less percentage as compared to other ETFs and indiviudal stocks in my portfolio.
lots of it!
Regarding the 23m/ 37m mark, I understand the prevention approach, like screening potential mates to avoid Tay-Sachs or having your phone alert you of a virus in the room.. but except for a few single-gene Mendelian diseases, how does sequencing or knowing your DNA address prevent epigenetics and/or somatic dna issues that lead to disease? i.e. 'genetics only loads the gun.. the environment pulls the trigger'?
On the Space Show Podcast, George mentions that for age reversal he *adds* genes that were present when young (15m).. however, wouldn't the genes already be in the dna, and would just need to be enabled / expressed? And what does the delivery look like.. is it retro-virus , and how is controlled to go to the areas needed.. and what percentage of cells would need to be updated to be effective?
Also, if each DNA strand has 23 chromosomes / 3.2 billion base pairs, therefore a complete (clinical) sequencing has 6.4bn bp.. so when they say there are 20k+ coding genes, is that per strand? For example, on the After-On podcast, Obvious Ventures' Nan Li mentions that if every 3 letters is a codon therefore, the total number of gene combinations is 10^614 (for reference, the total number of atoms in the universe is 10^80). How is he arriving at 10^614?!
Prof Church is my man. With William Gibson'sk company names such as "Veritas Genetics" "Warp Drive Bio" and "Nebula Genomics" very fitting for an Ark-exponential-tech-interview.
ARK should consider re-posting this interview as a primer for all those interested in ARKG.
I got 60% of my portfolio in ARKG. I believe it.
I know im randomly asking but does anyone know of a tool to get back into an Instagram account??
I somehow lost the account password. I would appreciate any assistance you can offer me
@Xavier Tucker Instablaster ;)
@Jayce Jake Thanks for your reply. I found the site on google and im waiting for the hacking stuff atm.
Takes quite some time so I will reply here later with my results.
@Jayce Jake It worked and I actually got access to my account again. Im so happy!
Thank you so much, you saved my ass :D
So how does this help the average person? Im new to this field.
The questions that come to mind are, who will benefit and for what reason?
The sick, because they want health
I wish I can get my genes sequenced & edited at the same place right now. Where can I go?
Excellent talk. It is aging and genetic diseases we need to end. If we do not like the effect then remove the cause.
I am surprised that this discussion never referred to "inflammation;" the most implicated immune response in virtually all disease; "aging," the most consequential of them all. Perhaps his talks elsewhere will do so. I will certainly be on the look out for that.
@@grizzlymartin1 Senescent cells seem to be implicated in inflammation. Dasatinib and Quercetin works the same way in humans as it does in mice. Dasatinib has lost patent protection in Europe, and I think also in the US so it is very cheap about $50 for 10g.
@@higreentj Right. But not knowing more about genetic modification of these will be interesting to learn about going forward.
What does those drugs do that you mentioned?
@@johanjonasson4188 SENS believe there are seven causes of damage so we will need seven therapies to stop and reverse aging which SENS believe they will have in 2036. Japan has created a vaccine that would remove senescent cells. Fasting for at least three days removes senescent cells. Dasatinib and Quercetin also Fisetin are senolytics which remove senescent cells.
Captions are unavailable in English. Can these be added? Thanks.
When will ARK invest in senolytic development?
Exiting technology but there's something that always make me nervous about genetics
I would urge you not to exit technology, as it will be one of most profitable spheres of investment
P
Bought more ARKG after this lol
Good now just hold and buy more when people panic and sell
So crisp is the one?
It has been a while, I didnt listen to Church.
I wish i could find a doctor who understood this. I wish i could afford a doctor or just existing tests.
I'm confident the politicome and regulations will make everything I'd want inaccessible and expensive. Also "gain of function" govt minions will mess with all of this and us.
Educated and talented doctors are like good car mechanics... they are not easy to find!!!
I hope these "scientist" guys will soon be irreversibly deleted from the human race
why?
Pascal V You go first and we will follow !
@@Niamato_inc How many will follow?
You're pathetic
@@pascalv2794 oh, everyone - you just go m8