Anticancer Drugs (Part-07)= Antimetabolites | Methotrexate Mechanism of Action | Anticancer Drugs
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- Опубліковано 23 лип 2020
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Excessive, abnormal and uncontrolled growth of body cell is called cancer. Cancer is the name given to a collection of related diseases. In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues. Many cancers form solid tumours, which are masses of tissue. Cancers of the blood, such as leukaemias, generally do not form solid tumours. Cancerous tumours are malignant, which means they can spread into, or invade nearby tissues. In addition, as these tumours grow, some cancer cells can break off and travel to distant places in the body through the blood or the lymph system and form new tumours far from the original tumour.
Unlike malignant tumours, benign tumours do not spread into, or invade nearby tissues. Benign tumours can sometimes be quite large, however, when removed, they usually don’t grow back, whereas malignant tumours sometimes do. Unlike most benign tumours elsewhere in the body, benign brain tumours can be life-threatening.
Metastatic cancer has the same name and the same type of cancer cells as the original, or primary, cancer. For example, breast cancer that spreads to and forms a metastatic tumour in the lung is metastatic breast cancer, not lung cancer.
Symptoms of cancer may be following found in patients with different cancers: fatigue, weight loss, pain, skin changes, change in bowel or bladder function, unusual bleeding, persistent cough or voice change, fever, lumps, or tissue masses.
Antimetabolites are drugs that interfere with one or more enzymes or their reactions that are necessary for DNA synthesis. They affect DNA synthesis by acting as a substitute to the actual metabolites that would be used in the normal metabolism (for example antifolates interfere with the use of folic acid) Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid; thus, competitive inhibition can occur, and the presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
Examples of cancer drug antimetabolites include, but are not limited to the following: (1) 5-Fluorouracil (5-FU) (2) 6-Mercaptopurine (6-MP)
(3) Capecitabine (4) Cytarabine (5) Floxuridine (6) Fludarabine
(7) Gemcitabine (8) Hydroxycarbamide (9) Methotrexate (10) Pemetrexed
(11) Phototrexate
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Such an awesome examples ...thank you sir for explaining it in an easy way...
My pleasure. Thank you for feedback
Got 15 out of 15..
Thanks for such a helpful lectures..
Great. Well done
Sir i scored 14/15 thank you sir for such candid explanation.
Good score
Thanku soo much sir ..
Really helped me alot ..
Respect from Pakistan . 🙏
Thank you so much
I got 14/15 , Thanku so much sir
Great
thank u so much sir
Thankyou so much for making pharmacology easy for us sir😍 stay blessed
Thanks alot
I got 14/15 thank you sir such an amazing lecture
Thank you
TQ sir ...15/15...
😊
Scored 15/15 very happy 😇 thank you sir for such a nice lecture 🙏
Very good. Proud of you
I got 15/15 😊
Thank you so much sir 🙏🙏
Very good
Sir, Mext or folic acid inka bodle me daoi he kya
Sir aap to sab logo doctor hi bana dege
Thank you so much sir... 👌👌👏👏👏👏👏👌👌
My pleasure
Chart and table good explanation 👌
Thank you
Sir I can't understood pseudoirrreversible inhibition.
Excellent Sir
Thanks a lot
I Scored
13/15
Good. Thank you
Score 13/15
Thank you sir🙏🙏
Good
today's score 14/15.. thank you sir..
Good
Today my total score 15/15...thank you sir🙏🙏🙏👍👍
Very good score. Keep going
1st one is salt and second one is sugar......
Tq so much sir🙏🙏
Are you sure ??
Not its very confusing.... may be its wrong or right
Even I can't say it exactly
Good work sir
Thank you
My score 14/15, you are great sir
Good
Thanku sir 😊
Welcome
Thank u so much sir.score 15/15
Most welcome
Thanks
My pleasure
Tqsmmm sir😍😍😍😍😍😍😍😍😍😍😍😍😍😍😍😍😍😍😍😍😍😍😍
My pleasure
Thank you sir
I got 13/15 .☺
Good score.
Sir, video on metabolism, clearance of drugs.
Metabolism is uploaded. Please check
Very good video sir sir Folinic acid mens folic acid
DescriptionFolinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. Purpose wahinhai
Sir, did u teach medicinal chemistry, physical pharmacy? If not any channel recommendation for these two..please😊
No I don't. And sorry i don't know about others because I have never searched
@@solutionpharmacy ok sir, thank you.
🙏🙏🙏🙏🙏🙏🙏🙏🙏
Sir plzzz help me to find the drug is prodrug or not in p'cology sir plzzz rply me
What??
@@solutionpharmacy sir mtlv hum ye pta kaise lga skte hain ki koi drug prodrug hai ya ni ...
Pragti Verma wo to aapko list me se yaad karna padega.
@@solutionpharmacy okk sir
Sir GPAT ke liye best books konsi he MCQ ki
GPAT Cracker
14/15👍
Good one
I have scored 14/15
Good score
Today's scored 15/15🙏🙏
Very good.
14/15 😎 ... thank u so much sir 😇
Good.
My score 13/15
Good score
Sir b.pharm final year ke liye mcq based video banaiye
Don't teach final teart
I think 1st one is Sugar and Second one is Salt...
Because Watching carefull, 1st One is crushed finely, but on second there are tiny crystal of salt. I may be wrong...
Even i am not sure without tasting. I had left it for night so it absob moisture and look alike
Please sir Kuch batao
Sir aap itna jyada likhe rhte hai aur itna deep me explain krte hai ki kya kya note kre dekh k dar lagta hai
Aapke college me kaise hota hai ? You can prefer less content channel also
@@solutionpharmacy sir jab koi teacher samjhate huye likhta rehta board pe bhle video 1 ghnte ki ho to wo baaten dimag me baith jaaati hai
Satyam Seth ok
sir Antineoplstic druges karo
Already done
Screen shot के लिये टाईम नही दिया सर्जी
👌🌹
Ha is baar galti se wo raha gaya. Really sorry. Baad me maine dekha but tab kuch kar nahi sakta tha
@@solutionpharmacy it's ok sir 🌹
Sir b pharma ki 1st year ka video upload karo na
Bhai yeh Cology ke Sir hai... Aur 1st Year me jyadatar +2 ka Syllabus hi hota hai. So I doubt tumhe syllabus ke according kahi bhi Video milegi. U have to search Topic wise...
भूत प्रेत Right
brij bhan i will not teach 1
Sir ss nai aaya aaj k topic ka
Means ??
Sir aaj screen shot k liye Time nai Diya Kya ??
Ha wo galti se raha gaya. Really sorry