This is a good question and distinguishing collapsing glomerulopathy and crescentic glomerulonephritis can be challenging in practice and when looking at a glomerulus in isolation. The cells that you see here within the Bowman's space are visceral epithelial cell that have undergone hyperplasia and hypertrophy. In general, the features that help us favor a collapsing glomerulopathy include reabsorption droplets as seen in the previous image. In a crescentic glomerulonephritis we would expect to see glomerular basement membrane breaks, karyorrhexis, and fibrinoid necrosis, as well as red blood cell casts in the biopsy.
Excellent presentation. I love this series. Please, keep up the great work.
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Great case and presentation. At 2:41 is that not a cellular crescent? If not what are the cells at the Bowman capsule? Thanks
This is a good question and distinguishing collapsing glomerulopathy and crescentic glomerulonephritis can be challenging in practice and when looking at a glomerulus in isolation. The cells that you see here within the Bowman's space are visceral epithelial cell that have undergone hyperplasia and hypertrophy. In general, the features that help us favor a collapsing glomerulopathy include reabsorption droplets as seen in the previous image. In a crescentic glomerulonephritis we would expect to see glomerular basement membrane breaks, karyorrhexis, and fibrinoid necrosis, as well as red blood cell casts in the biopsy.