Clarification: THC is Schedule II for Syndros, one formulation of THC, but aside from this product, THC is Schedule I Sodium oxybate (a salt of GHB) is also listed as Schedule III even though GHB is Schedule I
THCA is federally legal though funny enough. And turns into good ole delta 9 thc through simply heating it up. Also 11 OH thc which is what your body metabolizes ingested delta 9 into is also legal federally.
Well one was created to get you high and the orher was developed fornuse within hospitals. Thats why. Not daying its right nut thats how they view it. One can be regulated in their minds but the other cant. But hey man we needa chante a lot begor we can change peoples minds on drugs lol
At least some states are getting it right. In terms of toxicity at least, psilocybin has a very good safety profile. The only real concern is proper safety practices while under the influence, which is also true for many different legal or prescription substances.
The reason fentanyl is schedule 2 is because it's very good in surgery of emergency situations as a painkiller still mushrooms shouldn't even really be on the schedule
I think a tierlist about the most dangerous drugs or the safest drugs would be far more interesting. Because if it is legal or not doesn't really tell you much at all about the substance sadly.
@@DotDotDottt Its more because meth and fentanyl have medical uses that it seems that way, but I think some studies on mushrooms being a treatment for depression have come out, so might change someday.
@@DotDotDottt Weed is considered schedule 1 according to the dumbass US system. Reagan and his political allies made sure to make LSD, shrooms, and weed were schedule one to go after the hippy, black, and Latino population. Lock them up for their preferred drug of choice and they can't vote. Its the same reason they made crack much more illegal than cocaine.
How would you rate safety? If you use Therapeutic Index as a measure of safety, paracetamol is less safe than fentanyl. To be fair when fentanyl is dosed correctly it's a pretty safe drug. Unfortunately volumetric dosing is extremely hard using powders
Just another reminder that the scheduling of psychedelics under the controlled substances act has very little to do with science, and everything to do with Richard Nixon's hatred for hippies. Even back then, there was tons of promising research on the use of psychedelics for the treatment of a variety of mental health issues, but that research was shut down when the drugs were made schedule 1. Only now, 50 years later, has that research been resumed.
"We knew we couldn’t make it illegal to be either against the war or black, but by getting the public to associate the hippies with marijuana and blacks with heroin, and then criminalizing both heavily, we could disrupt those communities. We could arrest their leaders, raid their homes, break up their meetings, and vilify them night after night on the evening news. Did we know we were lying about the drugs? Of course we did."
They've been seen as very good medications for PTSD, no other drugs are really used for PTSD other than antidepressants which DOESN'T WORK for PTSD at least for most people.
There is no good reason why we shouldn’t know everything there is to know about these substances. We already know so much about alcohol, caffeine, and nicotine, so why not everything else? Because some weirdo decided that it’s better to separate African Americans and Hispanics from Caucasian communities? If they really are that dangerous, then we should be doing mountains of research and testing to learn even more about them, not completely halt it for a completely backwards reason. Stupidest shit I’ve ever seen
That was clear when they made marijuana a Schedule 1 drug "Marijuana is a Schedule I substance under the Controlled Substances Act, meaning that it has a high potential for abuse, no currently accepted medical use in treatment in the United States, and a lack of accepted safety for use under medical supervision." www.dea.gov/sites/default/files/2020-06/Marijuana-Cannabis-2020_0.pdf
@@ExtraThicccSome countries in Europe have lax drug regulation. That is not the same as "Europe has no drug regulation at all". Most of these substances still are very much illegal in European countries.
@@rfmerrillnot even lax drug policy either really, there’s still strict enforcement and penalties for vast majority of drugs and even cannabis legalisation propositions usually face heavy pressure to drop or water down by France particularly, because of perceived threats to single market. It will be interesting to see European experiences in legalisation with German and Czechia pursuing it for cannabis and whether it does actually lead to more ambitious legalisation attempts
It totally makes sense that the most dangerous drug, marijuana, is in the strictest Schedule I, while substances like fentanyl, meth and cocaine, which do have medical applications, face less restrictions in Schedule II. Tobacco and alcohol, the drugs that cause the least amount of death and serious illness, can be bought at the grocery store, which makes sense for these relatively harmless substances.
I’m in the Marines, and during a class about casualty care under fire, I asked our corpsman if they can do anything for pain relief on the battlefield before they get the casualty to an aid station, such as if someone lost a leg to a mine or something. He told me that in combat, corpsmen actually carry fentanyl and ketamine in their med bags for that purpose. I was kinda shocked to find out that 2 very infamous drugs actually have a purpose on the battlefield.
@@Zorro9129 lmao compared to any other war time and/or military substance testing it most definitely was. hitler even tweaked on it for fun at the olympics. WW2 was no holds barred for all new kinds of drugs and torture. it doesn't hold a candle to a medic carrying fentanyl on the field today
Scheduling is some made up BS by politicians. If a molecule exists naturally or synthetically, it should be fair game. I'm neither using or condoning the use of anything, just saying.
Fun fact- Bobby Kennedy's wife was severely depressed, and through LSD treatment at the time, she was supposedly able to find remission. He was the only bearcat who spoke out against its placement as schedule 1. It always makes me sad to see LSD and psilocybin scheduled, and cannabis, too. Knowing how much medical value they all have saddens me, being that there have been 50+ years where their medicinal use could not be studied :( most people don't know that LSD, at one time, was the most prescribed and used treatment for depression
It's almost insulting how the US government, if it truly believed mescaline to be "dangerous", would allow Native Americans to "harm" themselves with the substance legally 😅😅😅
They’re all schedule I bcuz they were the drugs of choice for the counter culture movement of the 60s. They made young ppl stand up and say “Why are we fighting a war for old men who don’t care about us?” And then the CIA used Charles Manson, LSD and the LaBianca murders as a psyop to discredit the hippie movement(they nipped that in the bud,no pun, as quick as they could) which was very much about peace and was steering the US economy away from hyper-capitalism. Pretty much all our problems today can be attributed to covert govt operations, corporations, their lobbyist and the politicians who take their money smh….
I did my master's thesis on GHB. GHB actually has a low-affinity target being the GABA-B receptor, owing its depressant effects. It does however also have a high-affinity target involved in neuromodulation, and might have a neuroprotective effect under certain conditions. I believe a lot more about this will be uncovered in the next few years.
@@highbread817It is used in high doses, twice a night to induce sleep. A stimulant is used during the daytime to keep said narcoleptic awake, in combination with nighttime GHB. GHB induces a deep, replenishing sleep but causes wakefulness once the drug wears off. It is a very effective sedative but it does not last a full night, hence the twice nightly dosing.
As far as I know, the mechanism for the treatment of narcolepsy still remains unknown. The following thing is pure speculation on my part, but since narcolepsy can't be treated with other GABA-B agonists, it might instead have to do with GHB's effects on the high-affinity binding site.
It’s interesting you mention it being neuroprotective. Could you elaborate a bit, or link a paper, I’d love to read up more on it! I’ve read about it being neurotoxic to GABA neurons via oxidative stress, though I assume that would be in the setting of high and repeated dosing
read some history, its interesting. when the US go their hands on LSD for the first time pharmaname Delysid. You could just get this stuff in vials. LSD was used in therapy in US believe it or not between 50 and 60 and doctors and therapist said it was great. but then the US got scared that the soviets would get their hands on it so they bought sandoz whole inventory and then some of pure LSD 25 10KG amd started the project MKULTRA, and also started sor eeading lsd in cali where it soon became popular and hippies were made. The US hated the hated the hippies because of the counterculture and were against the vietnam war so us banned LSD and didnt want anyone to use it as a medicine anymore (big pharma lobbying)
Anything that makes your population question the system and control you have them under, or otherwise makes them realize how absurd the constructs we have as a society are, is dangerous. The government is not concerned that you’ll hurt yourself or jump out of a window when you take acid; they’re more concerned that it’ll cause social discourse
Heroin is still commonly used as a painkiller in UK hospitals. I have been injected with it. I had some crazy hallucinations and dreams when I was on it. I kept seeing a dog's tail wagging at the end of my bed like a dog was there but it's body hidden. The pain was gone though but it made me feel a bit sick aswell.
They gave me Fentanyl post-op in the US. Same thing. Waking dreams. They sent me home with Hydrocodone. I was happy to have the drugs, but once the pain subsided I has happy to NOT take the drugs. I can tolerate the side effects of opiates but don't enjoy them. Alcohol honestly gives a better buzz but I don't like that on a regular basis either. I *can* get addicted to things, for example nicotine (which I quit with great difficulty) and caffeine which I still use every day.
2-3 years ago I took some really strong morphine tablets, my back was hurting to the point i literally wanted to die, the pain went away after a few minutes and it was like heaven but i couldn't pee for 2 days. All this because of one single wrongful deadlift, be careful guys
Schedule 1 is basically substances banned from medical use out of tradition or similarly arbitrary reasons, no matter how small or large their potential is. Case and point: THC, which made Weed fall into the same schedule as Heroin (or even worse, since Heroin has very limited medical use!), as well as making any UN member who legalizes weed break UN treaties.
@@dirtysploof5890 since the high isn't "enjoyable" it's allowed to be otc for ppl who need it regularly for allergies. regardless the danger is still unremarkable and can have lasting damage but that doesn't matter to pharmaceutical companies
@@dirtysploof5890 I'd guess one of two reasons: 1) Anticholinergics had an important military and civil use as antidotes against nerve agent chemical weapons, as these drugs have the opposite effect of a nerve agent 2) there is no minority group who uses anticholinergics recreationally and who was suppressed for reasons beyond my understanding (racism)
The whole schedule is a mess. Cannabis is still schedule I at the Federal level. Ultimately the whole war on drugs was started with the prohibition of cannabis and a desire to arbitrarily prosecute ethnic minorities. Look up Harry Anslinger, he’s the racist prick who gave it all a start.
A lot of the schedule 1 drugs are there because of a mixture of racism and the vietnam war; the US couldnt put you in jail for protesting against the war so they just banned all the drugs the people protesting against the war (mainly black people and hippies were targeted) took, and then made the UN make them illegal internationally too.
L-meth has a specific exception in the inhaler formulation. The big difference though, as you may well know, is it's much more selective for norepinephrine release over dopamine, while d-meth is more balanced. That means, while it'll wake you up, it'll make your heart pound, blood vessels constrict, etc, and probably hardly be more fun than drinking ten cups of coffee if taken orally. The inhaled dose is tiny. But it works! Actually quite nuanced of the DEA for once.
Isn't benzadrine l-amphetamine, and didn't they used to put benzedrine in those? Jerome Howard was addicted to them, they say. Either way, amphetamine is a shitty high if you're already manic and have more fun with downers. I believe they call crystal made with l-meth "crank."
This reminded me of benzedrex inhalers, which contain the psychoactive and fully legal stimulant drug propylhexedrine. It’s pretty terrible for you but it’s incredible just how many inconsistencies there are in the controlled substances act, I can think of 3 substances off the top of my head that are legal yet very psychoactive (and sometimes much more dangerous than a lot of the schedule I drugs)
@@MnemonicHeadTrip Just cannabis alone being Schedule I makes many, many psychoactive drugs in comparison more dangerous. The psychedelics as well. Meth and Cocaine are Schedule II
As a former psychonaut(many years sober now) whose less interested in getting high and more interested in the chemistry of drugs, there are SO many compounds I’d love to hear a chemist’s take on. I don’t care about the legality of recreational drugs, but I’d like to hear you explain how they work and what they’re doing in the body, as someone with your knowledge and speaking ability can convey these concepts in a way that’s so much more digestible to the layman than just reading about them. There’s so many drugs I’d like to suggest, but instead I’d just like to ask that you do another video on “recreational drugs” that goes more into the chemistry of them rather than just their legalities. Also there’s a huge scene of psychonauts on the internet so a video like that would do really, really good on your channel just as this one did😁
I’m glad to see you educating people on the CSA. It’s one of those things most people don’t have much of a grasp on. The most important thing to understand about it is that it is insanely outdated. A single five tier descriptor does not even begin to encompass the complexity and nuances of drugs/medicines. When will those boomers repeal the CSA? Or at least rewrite it?
Have you read Pihkal or Tihkal, by Alexander Shulgin? They are mixtures of a love story, an encyclopedic list of phenethylamine/tryptamine derivatives with syntheses, and testing notes.
@@justanaverageguy912 Most unique thing I’ve ever tried for sure. So clear headed, but visual and still psychedelic. The 36 hour duration was a little annoying though. And the books were the best introduction to psychedelics one could ask for!
its funny how they schedule stuff, like fentanyl and thc being on the same class, and psilocybin and heroin on the same class (istg my name isnt a reference to magic mushrooms, it just came to be that i named myself shroomlord then started looking into psychedelics like shrooms)
Thc is schedule 1 except for one kind, he clarified in a comment. But it's crazy how a drug widely known for medical use and recreationally legal in some states has "no" medical uses at all according to the government and is scheduled higher than fetynal, a drug that killing a ton of citizens
The fun part is that analog laws actually only cover Schedule I and Schedule II, meaning that many drugs like Xanax, Valium, and Ketamine (Schedules IV and II) have legal analogs even if drugs like Heroin, Meth, and LSD (Schedules II and I) don’t.
was just surfing around weird designer drugs and saw you have a video on related and thought "yea figures he's got it tier'd out per usual" before i noticed the upload date! lol
Curious that it’s Mdpv that gets associated with bath salts in the us - U.K. and Europe in general, the term gets used for cathinones as a whole on Reddit etc., especially 4-mmc which has almost a legendary reputation especially after the late 2000’s dip in md availability
@@douglassmalls6934 remember when they blamed bath salts on the guy who went psychotic and attacked and ate a homeless man's face? Turns out he only had THC in his system and ever since cathinones got a bad rep smh.
Would have been cool to see a tier list not just based on scheduling by the federal government. Like including a ratio of death/overdose per person, and how many people these substance are affecting, and lastly the potential legal consequences of use.
Sodium Oxybate must be my favorite - raw material sampling being my primary responsibility I've been around 1000s of kgs of it at a time in our pharmaceutical plant; Fentanyl - we work with various types of fentanyl and fentanyl derivate injections and are also setting up fentanyl synthesis unit; Ketamine - worked with ketamine injections. (Not to mention some minor one I encounter on a regular basis, like pseudoephedrine, diazepam, alprazolam, zopiclone.)
It would be nice if you were to do another one of these but then a weigh off between overdosis potential, long term effects and medical use (even ones which arent proven like micro dosing of lsd)
Couple notes; 1. THC is still schedule 1 - despite the accepted medical uses 2. Federally there's no exceptions for religious uses of peyote - and the SCOTUS has determined that it cannot be discrimination if the expectation applies to everyone such as laws.
I scratched my cornea and the doc used cocaine eyedrops for pain relief in the clinic and man i wanted to hug him the relief was immediate 😂 lubricating eyedrops did the trick at home
The fact that MDMA is schedule 1 makes no sense, it's less damaging than weed (which is literally legal nowadays in quite some US states) and current studies on it suggests it can be used to treat depression. It also doesn't meet the requirement for potential of abuse and addiction that goes with schedule 1.
Please make a follow up video to this one where instead of just putting them in the tiers that the government has said theyre in, you put them in the order you think it should be labeled.
The picture at 4:46 is of the wrong type of poppy: natural opiates like morphine and codeine are derived from the opium poppy (papaver somniferum), while the picture seems to be of a corn poppy (papaver rhoeas), which doesn't produce these alkaloids.
I think it should have been a matris , 1-5 for how adictive / abused it is and 1-5 for the medical usefull nes so fentenal would score 25 and would end up in s tier
I don't know how relevant this is, but the FDA is currently researching psilocybin as a treatment for ADHD. Microdoses of course, but still interesting
The law arounds these compounds only applies to USA. Psychedelic therapy has been approved in Australia, and changes in legislation have permitted clinical trials in the UK.
That picture is not actually opium poppy (Papaver somniferum), but Papaver bracteatum, from which thebaine (and hence oxcodone, e.g.) is derived, but not morphine. Yes I know mm-maybe that's intentional.
I will not confirm the amount of different psychedelic compounds on this list that may or may have not been ingested. It may or may not have been every psychedelic on the list. It may have been all of them. Perhaps off the list It might also have included ibogaine.
lol in my research lab the DEA halted our order of piperidine for a while due to its potential for being used to make fentanyl, and now, actually looking at the structure of fentanyl, that does kinda make sense
Lol my lab had a ton of trouble acquiring hydroiodic acid because I guess it's useful in making meth. We were on the verge of simply making it ourselves.
in a recent surgery I had a ketamine injection in my arm...and then the last words I remember before the anaesthesia kicked in was "and here comes some fentanyl"
I saw an article about MDMA being used in trials as a treatment for PTSD and Depression in veterans. One guy suffered from PTSD for 8 years, and signed up for a trial in 2014. After 3-5 treatments he was no longer suffering from PTSD.
I recommend you try out where I get my stuff from as they ship discreetly worldwide. they are specialist on Shrooms psychedelics psilocybin Lsd Vape Pens and other psychedelic stuffs..
I think it's pretty misleading to say that a schedule I drug is "more illegal" than the other drugs. The sentencing guidelines and laws around each substance vary, and don't usually line up with the scheduling. Even though fentanyl is a lower schedule than THC, you are going to have a much worse time in court if you are caught with 50 doses of fentanyl than 50 doses of THC. Really the only place a schedule I drug will act as "more illegal" is in a research setting or for doctors. The CSA scheduling is messed up, and should be changed, but this video just adds to the confusion IMO :(
Hey, I just checked, and THC is still schedule 1 despite being the active ingredient in the FDA-approved medication Marinol. Various important and knowledgeable people have recommended that it be moved to a different schedule, but the DEA remains obstinate and illiterate.
I genuinely have no idea how LSD and Mushrooms are likely for abuse 🤣 Ive never met a single person who used psychedelics that didn't just spend 14 hours on their couch doing nothing when taking it
A note about tier lists, the left to right order of the items in a given tier are significant, with the leftmost items being a higher rank than the rightmost items. so no need for placing items between two tiers, just put them at the right end of the items in the tier.
Mescaline is like, stupid easy to get ahold of because you can just buy some of the cactuses that have it and then just get it from there. You can get it from the damn internet, or a home and garden store!
Man I lost some friends to ketamine, every day more and more ppl Ik are hitting special k. Really sad, it’s only more recently it’s being looked at more seriously. It’s been a long time coming, the K craze started 2-3 years ago because of how criminally easy it is to get. Not as bad as opiates but we need to take it seriously. When I say lost I mean mentally they’ve died, I left home for 6 months for work by the time I came back one of my closer friends was gone. Mid 20s losing all his hair, living in a hotel, all his relationships were crumbling, lost jobs etc. It was hard to see.
@@zekiz774 y-hydroxybutyric acid or y-butyrolactone are probably the easiest ones to synthesize of them all. Its crazy that y-aminobutyric acid, NaNO2, HCl, and a water-immiscible solvent are all that's used
ive seen the videos they do this... it makes me sick. its like seeing people go to buy poison and knowingly drink to their deaths.... funnily enough my brain doesn't psychologically apply this to alcohol which is worse.... the only difference is you would have to drink 1 litre of vodka which is very harsh which would slow your breathing right down to a point of being near death... you would knowingly be doing it as the more and more you drink the blinder you get to a point you lose that ability codeine... you drink a little.. and your already high. its pointless to have more
commenting now in case he forgot to mention GHB is somehow both schedule 1 (high abuse and no medical use) and schedule 3 (medium abuse and yes medical use) at the same time
well, he alluded to it but didnt mention it. yeah, it is literally in both schedules at the same time, just in the other one as "sodium oxybate" (the sodium salt, which, as chemists, we know is really the same thing) schrodinger's drug: both has no medical use and medical use, and high abuse and medium abuse at the same time!
One thing really fun about having to take controlled substances as medication is being treated like a convicted criminal every time you go to the doctor. I had one doctor that made me take a drug test, EVERY TIME I got my ADHD meds refilled
Meanwhile nobody bats an eye if you buy Alcohol or get a Benzo script. Both notorious for deadly withdrawals and higher addiction rates/potential and harm. But Addy, is what people freak out about lmao
because theres none such thing as a fda approved fentanyl pill. it only comes in a slow release path 99.9% of the time. rarely there is a sub lingual spray ive seen used for end stage cancer called subsys. the advantage of fentanyl is that you can use it in extremely low mass amounts as an IV anesthetic and your body will never get overwhelmed trying to metabolize it so an anesthesiologist can easily turn off the fentayl IV after a surgery is done and you will quickly metabolize all of the remaining amount in your blood before the sedation wears off. try that with morphine and you have to use such a high mass amount to achieve pain control that they will be floating on cloud 9 for 4 hours after they wake up. and yes surgeons have to use strong opioid pain killers when people are sedated because otherwise people twitch/squirm and move around when your making incisions, especially with the electrical burning type cutting instruments. just like how its a subconscious reflex to move your hand off of a hot stove and your body will do so faster than you could otherwise because the part of the body that actually does the thinking/sends the move away signal is in your spine. there are reasons to these things but everyone is so internet sophomoric now days, there just incorrect reasoning that gets amplifies infinitely
" This is also used to treat depression, although those effects are temporary. " well, it seems most of the chemicals in this list can be used to temporarily treat depression.
They got around the GHB thing by saying "oh uh well this specific salt has medical uses". Even though for every other drug, all salts or the base drug are illegal. OH, and there's nothing special about the sodium salt of GHB, the potassium salt would work just as well medically. Also the idea that GHB has ever been used as a date rape drug is absurd. I'm sure there are some rare cases - but anyone who has ever tasted GHB knows the taste is extremely strong. It actually got it's popularity in the body building community as it gives much better sleep than benzos etc, and some steroids can disrupt sleep. The date rape thing was just mass hysteria because you can't be woken up from GHB sleep - it puts you into a deep sleep for ~4 hours, then you get a dopamine rebound when you wake up and feel super awake and happy. It was the same with Rohypnol (flunitrazepam), it's just a benzo that has particular affinity for the sub-receptors that cause sleep. Except the one problem you'd face trying to use it as a date rape drug is that it's only soluble in oil... in an alcoholic or normal drink it'd just form an obvious powder at the bottom. The real date rape drug is alcohol, by a huge margin. And the second most reported date rape drug (coming in at
Interesting thing about 1,6-Diacetomorphine it's metabolized so fast by the body that you will almost always find its metabolite 6-monoacetomorphine (6-MAM) And since it's most often cut with fentanyl; if a 6-MAM panel is needed then a fentanyl panel is ordered as well (forensic tox).
I missed some drugs like, Methylphenidat, Oxicotin, Promethazin, Benzodiazepine. But nice Video even if it is a bit short. edit: Could someone explain the difference of GHB and GABA? In terms of structure, they are almost the same.
The U.S. Gov: "Schedule 1 if the drug has no known medical use" Also the U.S. Gov: "We're gonna make it impossible for you to do scientific research on drugs for medical use, and we're never reading your findings, anyways"
The correct IUPAC name for LSD is N,N-diethyl-d-lysergamide. "LSD," d-lysergic acid diethylamide, was the term employed prior to the adoption of the IUPAC nomenclature. Of course, those of us intimately familiar with its unique properties, refer to it as the "Holy Acid." :)
Great video! I love having the chemistry perspective. Annoying legal perspective, but perhaps the tier list would be a bit more evenly-spread throughout the tiers if you also included factors like sentencing guidelines & prosecution rates, so it isn’t just the schedule classification that determines “how illegal” but also the level of punishment. Basically, how illegal does the government think it is and therefore how much they want you to be punished for it. Just a thought - but very informative video.
Fentanyl should only be administered by a health professional at a clinic and or hospital. If methadone, a drug that is supposed to stop opiate use, is to only be administratored in a medical setting, why isn’t Fentanyl? The problem all started when they started sending patients home with this stuff!
Unpopular opinion alert!: I'm not here to say that all drugs need to be legal, but I really don't think the people taking them are the problem. In a nutshell, it's a problem with not allowing people to get the treatment they need so they self medicate. Some people self medicate with alcohol, some people do it with green leaf. Treatment should not include going to prison for possession when you have an addiction problem. That only perpetrates the problem. Treatment should be fine out why they use, get them the help they need, weather that's a therapist, the right medical treatment, etc.(I know there are other problems with the street drug sometimes being cheaper too thanks to the lack of healthcare or poor healthcare) TLDR; treat the problem at its root. Shaming people and putting people in prison for a mental problem like addiction, isn't treating the problem; it only perpetuates the problem.
Psilocybin is legal in some states, and mushroom therapy is allowed in many states as a legit medical treatment, so despite its schedule 1 stature, it should probably be in between 1 and 2 if not entirely in 2.
Can you explain those old videos where they dose a spider and see what different webs it's spins under the influence of different compounds? If spiders have limited receptors in comparison to mamals, why would these drugs have any discernable effect? When I google it (cannabis for example), the explanation is "spiders don't have cannabis receptors, but cannabis has other compounds that fuck that spider up" This does not satisfy me. Love your channel. Keep it up man!
There was a hilarious video about spiders on drugs that I saw a while ago. You’ll die laughing when you see what the crack spider does 🤣 I’m sure it’s on UA-cam
While I don't have the answer I'll do what everyone feels compelled to do and speculate a bit. Plants evolve to have the chemical composition they do based on pressure from natural selection. Likely there was some minor evolutionary pressure from guarding against various bugs. And so it happens to have an effect on spiders as well. It's a very human-centric (or at least mammal-centric) view to think that just because plants have effects we might enjoy, that's why those effects exist.
@Gameboygenius I appreciate the reply. I think that explanation is self evident. It's ostensibly why we have any relationship with the compounds, having evolved alongside them. The gap I'm trying to fill is in relation to the spiders' limited receptors in comparison to a more genetically complicated organism, such as vertebrae. Given the popularity among cannabanoid receptors being a key influence in getting wrecked off weed, I would imagine we would have a better understanding of the isolated psychoactive compounds and its influence on different nervous systems. Even if their are compounds in drugs that exclusively interact with spiders(or whoever), you'd think we would have stumbled over them by now.
what is wrong with people, i have adhd, and yes it is annoying, but fucking METH???!!!! Hell nah, i think the people making this legal took enough for the two of us lmao
Clarification: THC is Schedule II for Syndros, one formulation of THC, but aside from this product, THC is Schedule I
Sodium oxybate (a salt of GHB) is also listed as Schedule III even though GHB is Schedule I
THC is actually Schedule III for Marinol as well
Pin this!
THCA is federally legal though funny enough. And turns into good ole delta 9 thc through simply heating it up. Also 11 OH thc which is what your body metabolizes ingested delta 9 into is also legal federally.
@@DrewWalton I thought I did pin it, but apparently I didn't - I have now
Well one was created to get you high and the orher was developed fornuse within hospitals. Thats why. Not daying its right nut thats how they view it. One can be regulated in their minds but the other cant. But hey man we needa chante a lot begor we can change peoples minds on drugs lol
The fact that mushrooms are more illegal than fentanyl show how bad the drug scheduling system failed 😂
Yup.....
Also casually labelling a natural neurotransmitter as Schedule I
At least some states are getting it right. In terms of toxicity at least, psilocybin has a very good safety profile. The only real concern is proper safety practices while under the influence, which is also true for many different legal or prescription substances.
The reason fentanyl is schedule 2 is because it's very good in surgery of emergency situations as a painkiller still mushrooms shouldn't even really be on the schedule
@@_shadow_1 yeah im all for legalizing psychedelics, but i think people should follow a course on how to take them before
I think a tierlist about the most dangerous drugs or the safest drugs would be far more interesting. Because if it is legal or not doesn't really tell you much at all about the substance sadly.
yeah because based off he schedule system, meth and fentanyl are technically "safer " then shrooms or acid/ which is obviously absurd
@@DotDotDottt Its more because meth and fentanyl have medical uses that it seems that way, but I think some studies on mushrooms being a treatment for depression have come out, so might change someday.
@@DotDotDottt Weed is considered schedule 1 according to the dumbass US system. Reagan and his political allies made sure to make LSD, shrooms, and weed were schedule one to go after the hippy, black, and Latino population. Lock them up for their preferred drug of choice and they can't vote. Its the same reason they made crack much more illegal than cocaine.
How would you rate safety? If you use Therapeutic Index as a measure of safety, paracetamol is less safe than fentanyl.
To be fair when fentanyl is dosed correctly it's a pretty safe drug. Unfortunately volumetric dosing is extremely hard using powders
@@wittoist overdose dose, overdose rate, death rate, addiction potiental, side effects etc
Just another reminder that the scheduling of psychedelics under the controlled substances act has very little to do with science, and everything to do with Richard Nixon's hatred for hippies. Even back then, there was tons of promising research on the use of psychedelics for the treatment of a variety of mental health issues, but that research was shut down when the drugs were made schedule 1. Only now, 50 years later, has that research been resumed.
The god darned kids are basically adults how dare they protest and not get shipped to Vietnam.
It must have been the drugs lol
"We knew we couldn’t make it illegal to be either against the war or black, but by getting the public to associate the hippies with marijuana and blacks with heroin, and then criminalizing both heavily, we could disrupt those communities. We could arrest their leaders, raid their homes, break up their meetings, and vilify them night after night on the evening news.
Did we know we were lying about the drugs? Of course we did."
They're such a promising anti-depressant!
They've been seen as very good medications for PTSD, no other drugs are really used for PTSD other than antidepressants which DOESN'T WORK for PTSD at least for most people.
There is no good reason why we shouldn’t know everything there is to know about these substances. We already know so much about alcohol, caffeine, and nicotine, so why not everything else? Because some weirdo decided that it’s better to separate African Americans and Hispanics from Caucasian communities? If they really are that dangerous, then we should be doing mountains of research and testing to learn even more about them, not completely halt it for a completely backwards reason. Stupidest shit I’ve ever seen
The DEA shouldn't be setting arbitrary regulations. It's like letting cops make laws.
ATF does the same thing
That was clear when they made marijuana a Schedule 1 drug "Marijuana is a Schedule I substance under the Controlled Substances Act, meaning that it has a high potential for abuse, no currently accepted medical use in treatment in the United States, and a lack of accepted safety for use under medical supervision." www.dea.gov/sites/default/files/2020-06/Marijuana-Cannabis-2020_0.pdf
don’t you love bureaucracy?
Anyone who sets the regulation will be arbitrary though.
@@Moneymaker864shut up bro ever heard of checks and balances or judge jury and executioner?
This schedule system is in large part responsible for the drug epidemic.
Europe solved this by not having drug regulation at all and having free rehab and drugs for addicts
@@ExtraThicccSome countries in Europe have lax drug regulation. That is not the same as "Europe has no drug regulation at all". Most of these substances still are very much illegal in European countries.
Overall, this statement is correct
@@ExtraThicccthat is very wrong
@@rfmerrillnot even lax drug policy either really, there’s still strict enforcement and penalties for vast majority of drugs and even cannabis legalisation propositions usually face heavy pressure to drop or water down by France particularly, because of perceived threats to single market. It will be interesting to see European experiences in legalisation with German and Czechia pursuing it for cannabis and whether it does actually lead to more ambitious legalisation attempts
It totally makes sense that the most dangerous drug, marijuana, is in the strictest Schedule I, while substances like fentanyl, meth and cocaine, which do have medical applications, face less restrictions in Schedule II. Tobacco and alcohol, the drugs that cause the least amount of death and serious illness, can be bought at the grocery store, which makes sense for these relatively harmless substances.
exactly!!!!!!!!!!!!!!!!!! holy shit tell them> tjats exactly what they dont know alrady!!!
Good point, but I'd wager that tobacco and alcohol have ruined more lives than all those other ones just because of how common they are...
@@nephi246he’s joking about how ridiculous it is
@@nephi246 you're on the spectrum aren't you?
Ok
I’m in the Marines, and during a class about casualty care under fire, I asked our corpsman if they can do anything for pain relief on the battlefield before they get the casualty to an aid station, such as if someone lost a leg to a mine or something. He told me that in combat, corpsmen actually carry fentanyl and ketamine in their med bags for that purpose. I was kinda shocked to find out that 2 very infamous drugs actually have a purpose on the battlefield.
Just wait until you hear about what WW2 soldiers received.
@@Zorro9129 well they also carried meth for funsies so idk if WW2 is the best example
@@Heroo01 It had a purpose, not just "for funsies" so yes it's a good example.
@@Zorro9129 lmao compared to any other war time and/or military substance testing it most definitely was. hitler even tweaked on it for fun at the olympics. WW2 was no holds barred for all new kinds of drugs and torture. it doesn't hold a candle to a medic carrying fentanyl on the field today
Ketamine has been used as anesthetic since its inception. It’s actually one of the safest and widely used anesthetics.
Would've been funnier on 4/20, but still finally a new tier list
yeah sorry they take so long 😬
@@That_Chemist It's a time consuming process! You give us the best content
@@soundspark No its 9/10
Scheduling is some made up BS by politicians. If a molecule exists naturally or synthetically, it should be fair game. I'm neither using or condoning the use of anything, just saying.
@@steamhearteyestimezones exist...
you should make a video on how to synthesise all of these for educational purposes 😊
asking for your dog i assume? xD
YAY MORE WATCHLIST MATERIAL 😁
This glows
He prolly knows somthing more abt heroine when he said "by some chemical process"
@@maximwynant1865 It's extremely easy to synthesis heroin from opium poppy.
Fun fact- Bobby Kennedy's wife was severely depressed, and through LSD treatment at the time, she was supposedly able to find remission. He was the only bearcat who spoke out against its placement as schedule 1. It always makes me sad to see LSD and psilocybin scheduled, and cannabis, too. Knowing how much medical value they all have saddens me, being that there have been 50+ years where their medicinal use could not be studied :( most people don't know that LSD, at one time, was the most prescribed and used treatment for depression
It's almost insulting how the US government, if it truly believed mescaline to be "dangerous", would allow Native Americans to "harm" themselves with the substance legally 😅😅😅
They’re all schedule I bcuz they were the drugs of choice for the counter culture movement of the 60s. They made young ppl stand up and say “Why are we fighting a war for old men who don’t care about us?”
And then the CIA used Charles Manson, LSD and the LaBianca murders as a psyop to discredit the hippie movement(they nipped that in the bud,no pun, as quick as they could) which was very much about peace and was steering the US economy away from hyper-capitalism. Pretty much all our problems today can be attributed to covert govt operations, corporations, their lobbyist and the politicians who take their money smh….
No it wasn't lol
Having worked in pharmacy for 7 years, as far as im concerned the schedules are just how that chemical passes the DEA's vibe check
Maybe you tell us what things do get us on a vibe but aren't enforced? (writing from Canada) 🇨🇦🌴
@@n1chirin depends what you're looking for. Lots of awesome legal grey market drug companies in Canada
I did my master's thesis on GHB. GHB actually has a low-affinity target being the GABA-B receptor, owing its depressant effects. It does however also have a high-affinity target involved in neuromodulation, and might have a neuroprotective effect under certain conditions.
I believe a lot more about this will be uncovered in the next few years.
Such a strange drug. Only had a couple of experiences... but can you explain how it helps narcolepsy? Must be very low dose
@@highbread817It is used in high doses, twice a night to induce sleep. A stimulant is used during the daytime to keep said narcoleptic awake, in combination with nighttime GHB. GHB induces a deep, replenishing sleep but causes wakefulness once the drug wears off. It is a very effective sedative but it does not last a full night, hence the twice nightly dosing.
As far as I know, the mechanism for the treatment of narcolepsy still remains unknown.
The following thing is pure speculation on my part, but since narcolepsy can't be treated with other GABA-B agonists, it might instead have to do with GHB's effects on the high-affinity binding site.
Methamphetamine also potentially has a nueroprotective effect when used in low doses like 5mg from the study I read a while back.
It’s interesting you mention it being neuroprotective. Could you elaborate a bit, or link a paper, I’d love to read up more on it! I’ve read about it being neurotoxic to GABA neurons via oxidative stress, though I assume that would be in the setting of high and repeated dosing
How in the world did they come to the conclusion that LSD has a high potential for abuse?
What else was the USA doing round about this time? And that's the reason
read some history, its interesting. when the US go their hands on LSD for the first time pharmaname Delysid. You could just get this stuff in vials. LSD was used in therapy in US believe it or not between 50 and 60 and doctors and therapist said it was great. but then the US got scared that the soviets would get their hands on it so they bought sandoz whole inventory and then some of pure LSD 25 10KG amd started the project MKULTRA, and also started sor eeading lsd in cali where it soon became popular and hippies were made.
The US hated the hated the hippies because of the counterculture and were against the vietnam war so us banned LSD and didnt want anyone to use it as a medicine anymore (big pharma lobbying)
good point. Fuck the Vietnam war@@stuartcommon4651
It made the youth oppose the war, clearly it's dangerous
Anything that makes your population question the system and control you have them under, or otherwise makes them realize how absurd the constructs we have as a society are, is dangerous. The government is not concerned that you’ll hurt yourself or jump out of a window when you take acid; they’re more concerned that it’ll cause social discourse
Heroin is still commonly used as a painkiller in UK hospitals. I have been injected with it. I had some crazy hallucinations and dreams when I was on it. I kept seeing a dog's tail wagging at the end of my bed like a dog was there but it's body hidden. The pain was gone though but it made me feel a bit sick aswell.
Captain cat hallucinating a dog?!?
@@maxlosergor Yeah a dog ! And lots of other really weird stuff.
They usually call it diamorphine these days, since the name Heroin is a liiiiiiiiiiittle tainted. But yeah, it's still used in cases of severe pain
They gave me Fentanyl post-op in the US. Same thing. Waking dreams. They sent me home with Hydrocodone. I was happy to have the drugs, but once the pain subsided I has happy to NOT take the drugs. I can tolerate the side effects of opiates but don't enjoy them. Alcohol honestly gives a better buzz but I don't like that on a regular basis either.
I *can* get addicted to things, for example nicotine (which I quit with great difficulty) and caffeine which I still use every day.
Glad you did'nt see a baby at the ceiling that turns its head 180°
2-3 years ago I took some really strong morphine tablets, my back was hurting to the point i literally wanted to die, the pain went away after a few minutes and it was like heaven but i couldn't pee for 2 days. All this because of one single wrongful deadlift, be careful guys
Ah urinary retention. My favorite. Here’s your cath!😁
Why I quit deadlift plenty of other good back excersises
@clydedoris5002 there sure is, maybe I'm dumb but I've always loved doing deadlifts.
@@bonlappen3000same it just feels so good to lift so much.
Best piss i have ever had was after morphine. God that was painful. Far more than the original injury.
Schedule 1 is basically substances banned from medical use out of tradition or similarly arbitrary reasons, no matter how small or large their potential is. Case and point: THC, which made Weed fall into the same schedule as Heroin (or even worse, since Heroin has very limited medical use!), as well as making any UN member who legalizes weed break UN treaties.
Lets talk about anti-cholonergics being 100% legal and otc lmao DPH should be banned if weed is
@@dirtysploof5890 since the high isn't "enjoyable" it's allowed to be otc for ppl who need it regularly for allergies. regardless the danger is still unremarkable and can have lasting damage but that doesn't matter to pharmaceutical companies
@@dirtysploof5890 I'd guess one of two reasons:
1) Anticholinergics had an important military and civil use as antidotes against nerve agent chemical weapons, as these drugs have the opposite effect of a nerve agent
2) there is no minority group who uses anticholinergics recreationally and who was suppressed for reasons beyond my understanding (racism)
Thank god no one in the USA are getting arrested anymore for just possession of THC
we love a man who thinks@@frtzkng
I'm mad how shrooms are classified as an addictive substance it's not addictive in the slightest
america is a kleptocracy ran by out of touch geriatrics. there are people in congress that are only than the television. this place is fucked.
The whole schedule is a mess. Cannabis is still schedule I at the Federal level.
Ultimately the whole war on drugs was started with the prohibition of cannabis and a desire to arbitrarily prosecute ethnic minorities.
Look up Harry Anslinger, he’s the racist prick who gave it all a start.
Same with LSD. Not at all addictive. Not like opiates or euphoric stimulants are.... not even close.
A lot of the schedule 1 drugs are there because of a mixture of racism and the vietnam war; the US couldnt put you in jail for protesting against the war so they just banned all the drugs the people protesting against the war (mainly black people and hippies were targeted) took, and then made the UN make them illegal internationally too.
I couldn’t imagine being addicted to the taste of ground up dirt and bunghole 😂😂😂😂
L-meth has a specific exception in the inhaler formulation. The big difference though, as you may well know, is it's much more selective for norepinephrine release over dopamine, while d-meth is more balanced. That means, while it'll wake you up, it'll make your heart pound, blood vessels constrict, etc, and probably hardly be more fun than drinking ten cups of coffee if taken orally. The inhaled dose is tiny. But it works! Actually quite nuanced of the DEA for once.
Isn't benzadrine l-amphetamine, and didn't they used to put benzedrine in those? Jerome Howard was addicted to them, they say. Either way, amphetamine is a shitty high if you're already manic and have more fun with downers. I believe they call crystal made with l-meth "crank."
This reminded me of benzedrex inhalers, which contain the psychoactive and fully legal stimulant drug propylhexedrine. It’s pretty terrible for you but it’s incredible just how many inconsistencies there are in the controlled substances act, I can think of 3 substances off the top of my head that are legal yet very psychoactive (and sometimes much more dangerous than a lot of the schedule I drugs)
@@MnemonicHeadTrip Please; elaborate. ::furious note taking::
That's because of the efforts of large pharmaceutical companies. When you find "nuance", you can bet Big Pharma is involved.
@@MnemonicHeadTrip Just cannabis alone being Schedule I makes many, many psychoactive drugs in comparison more dangerous. The psychedelics as well. Meth and Cocaine are Schedule II
Psychedelics are just an amazing discovery. It's quite fascinating how effective they are for depression and stress..saved my life.
Me tooooo
@JordanRakeyou literally cannot abuse it. There is nothing to abuse about it. That's like saying some people abuse water
@Babarakrimbel4884you can order a chocolate bar online with shrooms in it they will literally ship to your door
@@Cornflakes691 this entire thread are bots talking to each other trying to promote a scam, you'll see threads like this on any video about shrooms
Hey! An emotionally healthy society does not serve the greater good of our economy!
You should make a list for the most dangerous drugs and see how it compares
As a former psychonaut(many years sober now) whose less interested in getting high and more interested in the chemistry of drugs, there are SO many compounds I’d love to hear a chemist’s take on. I don’t care about the legality of recreational drugs, but I’d like to hear you explain how they work and what they’re doing in the body, as someone with your knowledge and speaking ability can convey these concepts in a way that’s so much more digestible to the layman than just reading about them.
There’s so many drugs I’d like to suggest, but instead I’d just like to ask that you do another video on “recreational drugs” that goes more into the chemistry of them rather than just their legalities. Also there’s a huge scene of psychonauts on the internet so a video like that would do really, really good on your channel just as this one did😁
I’m glad to see you educating people on the CSA. It’s one of those things most people don’t have much of a grasp on. The most important thing to understand about it is that it is insanely outdated. A single five tier descriptor does not even begin to encompass the complexity and nuances of drugs/medicines.
When will those boomers repeal the CSA? Or at least rewrite it?
whenever this generation becomes their age probably
@@afnltv5988 The government won't last that long hopefully.
A min of silence for how hard these laws backfired
Have you read Pihkal or Tihkal, by Alexander Shulgin? They are mixtures of a love story, an encyclopedic list of phenethylamine/tryptamine derivatives with syntheses, and testing notes.
FANTASTIC Books. Alexander Shulgin was a genius and one of the most brilliant chemists to ever touch the study.
DOC is wild.
@@justanaverageguy912 Most unique thing I’ve ever tried for sure. So clear headed, but visual and still psychedelic. The 36 hour duration was a little annoying though.
And the books were the best introduction to psychedelics one could ask for!
Came here to say this, found your comment first
Tihkal tierlist soon
Will never forget one of my Ochem exams had a question about MDMA
My Ochem2 professor told us to how to synthesize heroin for one lecture lmao. Ended up taking her for a senior level medchem course
My high school teacher actually had a question about C10H15N on a test.
I’m glad I subscribed so I can learn how to speed run capital punishment 👍🏻
its funny how they schedule stuff, like fentanyl and thc being on the same class, and psilocybin and heroin on the same class (istg my name isnt a reference to magic mushrooms, it just came to be that i named myself shroomlord then started looking into psychedelics like shrooms)
Thc is schedule 1 except for one kind, he clarified in a comment. But it's crazy how a drug widely known for medical use and recreationally legal in some states has "no" medical uses at all according to the government and is scheduled higher than fetynal, a drug that killing a ton of citizens
The fun part is that analog laws actually only cover Schedule I and Schedule II, meaning that many drugs like Xanax, Valium, and Ketamine (Schedules IV and II) have legal analogs even if drugs like Heroin, Meth, and LSD (Schedules II and I) don’t.
was just surfing around weird designer drugs and saw you have a video on related and thought "yea figures he's got it tier'd out per usual" before i noticed the upload date! lol
clutch timing
Curious that it’s Mdpv that gets associated with bath salts in the us - U.K. and Europe in general, the term gets used for cathinones as a whole on Reddit etc., especially 4-mmc which has almost a legendary reputation especially after the late 2000’s dip in md availability
Bath salts does refer to many cathinones but MDPV is the most well known "Bath salt" in the US due to the media hysteria around it a few years ago
@@douglassmalls6934or A-PVP
@@douglassmalls6934 remember when they blamed bath salts on the guy who went psychotic and attacked and ate a homeless man's face? Turns out he only had THC in his system and ever since cathinones got a bad rep smh.
@@douglassmalls6934 Few? That shit was 10+ years ago.
Would have been cool to see a tier list not just based on scheduling by the federal government. Like including a ratio of death/overdose per person, and how many people these substance are affecting, and lastly the potential legal consequences of use.
Sodium Oxybate must be my favorite - raw material sampling being my primary responsibility I've been around 1000s of kgs of it at a time in our pharmaceutical plant;
Fentanyl - we work with various types of fentanyl and fentanyl derivate injections and are also setting up fentanyl synthesis unit;
Ketamine - worked with ketamine injections.
(Not to mention some minor one I encounter on a regular basis, like pseudoephedrine, diazepam, alprazolam, zopiclone.)
Saying fentanyl is used in “some medical procedures” is a funny way of saying I give it to like every patient in the ICU lol
It would be nice if you were to do another one of these but then a weigh off between overdosis potential, long term effects and medical use (even ones which arent proven like micro dosing of lsd)
Couple notes;
1. THC is still schedule 1 - despite the accepted medical uses
2. Federally there's no exceptions for religious uses of peyote - and the SCOTUS has determined that it cannot be discrimination if the expectation applies to everyone such as laws.
From what I can gather, THC specifically is Schedule II; cannabis itself is Schedule I.
@JJPMaster Not how it works weed is illegal federally and still in some states they test for thc
@@CosmicFire88 See the pinned comment
@@JJPMaster That's Synthetic THC
I scratched my cornea and the doc used cocaine eyedrops for pain relief in the clinic and man i wanted to hug him the relief was immediate 😂 lubricating eyedrops did the trick at home
Found this out after my mate told me to rub coke on my gums.. honestly wasn’t very pleasant, I can see how it’s used as a local anesthetic though
The fact that MDMA is schedule 1 makes no sense, it's less damaging than weed (which is literally legal nowadays in quite some US states) and current studies on it suggests it can be used to treat depression. It also doesn't meet the requirement for potential of abuse and addiction that goes with schedule 1.
I'd love to see you make a sequel and add on to the list with some more obscure and lower tiered substances
Please make a follow up video to this one where instead of just putting them in the tiers that the government has said theyre in, you put them in the order you think it should be labeled.
The picture at 4:46 is of the wrong type of poppy: natural opiates like morphine and codeine are derived from the opium poppy (papaver somniferum), while the picture seems to be of a corn poppy (papaver rhoeas), which doesn't produce these alkaloids.
I'd say it's Papaver bracteatum
lol i wanst the only one to notice its a turkish poppy
also papaver orientale actually has some oripavine
@@martinivers489 hard to tell, could be bracteatum or orientale
I think it should have been a matris , 1-5 for how adictive / abused it is and 1-5 for the medical usefull nes so fentenal would score 25 and would end up in s tier
"alexa, add something to my shopping list"
*the fact that shrooms, LSD, and MDMA are ranked higher than coke, meth, and fentanyl*
fucking crazy
Damn, schedule 1 for mushrooms is pretty rough
I don't know how relevant this is, but the FDA is currently researching psilocybin as a treatment for ADHD. Microdoses of course, but still interesting
The law arounds these compounds only applies to USA. Psychedelic therapy has been approved in Australia, and changes in legislation have permitted clinical trials in the UK.
He said that within the first minutes of this video. Thanks Einstein.
Yeah, if you wanna shell out $10,000 a session. Trust me, most people ARE NOT getting psychedelic therapy done in AU.
That picture is not actually opium poppy (Papaver somniferum), but Papaver bracteatum, from which thebaine (and hence oxcodone, e.g.) is derived, but not morphine. Yes I know mm-maybe that's intentional.
Getting um acktually’d by a botanist 😭
@@That_Chemist Actually, I am a philosopher...
Modus ponens
Cogito ergo philosopher
@@That_Chemistwingardium leviosa
I will not confirm the amount of different psychedelic compounds on this list that may or may have not been ingested. It may or may not have been every psychedelic on the list. It may have been all of them. Perhaps off the list It might also have included ibogaine.
Psychedelics being schedule 1 and claiming “no medical benefits” is absurd.
wonder how many less suicides there wouldve been between now and lets say the 70s if they had finished the research and started prescribing it
lol in my research lab the DEA halted our order of piperidine for a while due to its potential for being used to make fentanyl, and now, actually looking at the structure of fentanyl, that does kinda make sense
Lol my lab had a ton of trouble acquiring hydroiodic acid because I guess it's useful in making meth. We were on the verge of simply making it ourselves.
In Poland one of most controlled substances was acetic anhydride because of, well, use for certain poppy related chemical reactions on the street ;)
Piperidine can be used to make many drugs actually. Even PCP I believe
BTW: THC is still Schedule I. It's bullshit, but it is.
Edit: I see you addressed this in the comments.
Honey wake up, the drug tier list just dropped
i learned years ago that if you just believe hard enough laws aren’t a thing
Should have made the tier chart based effects, side effects, and damage that the drugs cause
do another part 2 with more obscure and unheard of drugs and research chemicals.
He arguably can't since research chemicals aren't scheduled
in a recent surgery I had a ketamine injection in my arm...and then the last words I remember before the anaesthesia kicked in was "and here comes some fentanyl"
I saw an article about MDMA being used in trials as a treatment for PTSD and Depression in veterans. One guy suffered from PTSD for 8 years, and signed up for a trial in 2014. After 3-5 treatments he was no longer suffering from PTSD.
I recommend you try out where I get my stuff from as they ship discreetly worldwide. they are specialist on Shrooms psychedelics psilocybin Lsd Vape Pens and other psychedelic stuffs..
Dude is on telegram and Instagram
@pham_smart11
I think it's pretty misleading to say that a schedule I drug is "more illegal" than the other drugs. The sentencing guidelines and laws around each substance vary, and don't usually line up with the scheduling. Even though fentanyl is a lower schedule than THC, you are going to have a much worse time in court if you are caught with 50 doses of fentanyl than 50 doses of THC. Really the only place a schedule I drug will act as "more illegal" is in a research setting or for doctors. The CSA scheduling is messed up, and should be changed, but this video just adds to the confusion IMO :(
psilocybin is legal in the state of Oregon for therapeutic use.
In Colorado it’s legal to use and share, but not to sell yet
shrooms mdma and lsd being in the same tier as heroine is crazy
My man out here asking the real questions
That monopoly Jail symbol thumbnail be hitting different
Hey, I just checked, and THC is still schedule 1 despite being the active ingredient in the FDA-approved medication Marinol. Various important and knowledgeable people have recommended that it be moved to a different schedule, but the DEA remains obstinate and illiterate.
Yeah pretty shocking that he fucked that one up since it's the most ridiculous one
The THC in marinol is synthetic and there's different forms of THC such Delta 8 THC and Delta 9 THC
I genuinely have no idea how LSD and Mushrooms are likely for abuse 🤣 Ive never met a single person who used psychedelics that didn't just spend 14 hours on their couch doing nothing when taking it
The fact that meth and weed are in the same tier doesn’t sit right with me.
A note about tier lists, the left to right order of the items in a given tier are significant, with the leftmost items being a higher rank than the rightmost items. so no need for placing items between two tiers, just put them at the right end of the items in the tier.
Ketamine is nuts. I was hit by a car٫ and have three days missing from my memory. Woke up in the hospital confused as hell.
Mescaline is like, stupid easy to get ahold of because you can just buy some of the cactuses that have it and then just get it from there. You can get it from the damn internet, or a home and garden store!
psilocybin is too. It's legal to sell it for microscope use only. So you can buy the culture from legitimate businesses then grow it yourself.
It’s actually legal too grow psilocybin mushrooms in Colorado
It is worth noting that CBD and Delta-8 THC ARE legal due to hemp's inclusion in the farm bill.
all the drugs someone that isn't me doesn't have of course.
another banger Mr. Chemist. I will be watching and eating popcorn
Watching this while taking organic chemistry is crazy, like understanding those structures and them not being just doodles anymore is wild
For real
I'd love a "Which Drugs are the Most Dangerous" tierlist, I think it would be a fun comparison
Goblin has a vid on this
Man I lost some friends to ketamine, every day more and more ppl Ik are hitting special k. Really sad, it’s only more recently it’s being looked at more seriously. It’s been a long time coming, the K craze started 2-3 years ago because of how criminally easy it is to get. Not as bad as opiates but we need to take it seriously. When I say lost I mean mentally they’ve died, I left home for 6 months for work by the time I came back one of my closer friends was gone. Mid 20s losing all his hair, living in a hotel, all his relationships were crumbling, lost jobs etc. It was hard to see.
Why people would take tranq in the first place is beyond me
Can you cover their (the drugs) syntheses with common household chemicals? Asking for a friend who needs it for eduvational purposes...
no
There’s an archive full of this kind of chemistry. You’ll have to look around for it if you want to learn about this kind of stuff
Most of them are quite hard to synthesize. The easiest would be GHB or Methamphetamine, but it’s still hard to do it from only OTC chemicals.
@@zekiz774 y-hydroxybutyric acid or y-butyrolactone are probably the easiest ones to synthesize of them all. Its crazy that y-aminobutyric acid, NaNO2, HCl, and a water-immiscible solvent are all that's used
This gives me the same vibes of "what hole does the triangle block go? That's right, the square hole."
in the uk, codeine can be bought over the counter at any chemist unrestricted
ive seen the videos they do this... it makes me sick. its like seeing people go to buy poison and knowingly drink to their deaths....
funnily enough my brain doesn't psychologically apply this to alcohol which is worse....
the only difference is you would have to drink 1 litre of vodka which is very harsh which would slow your breathing right down to a point of being near death... you would knowingly be doing it as the more and more you drink the blinder you get to a point you lose that ability
codeine... you drink a little.. and your already high. its pointless to have more
commenting now in case he forgot to mention GHB is somehow both schedule 1 (high abuse and no medical use) and schedule 3 (medium abuse and yes medical use) at the same time
well, he alluded to it but didnt mention it. yeah, it is literally in both schedules at the same time, just in the other one as "sodium oxybate" (the sodium salt, which, as chemists, we know is really the same thing)
schrodinger's drug: both has no medical use and medical use, and high abuse and medium abuse at the same time!
One thing really fun about having to take controlled substances as medication is being treated like a convicted criminal every time you go to the doctor.
I had one doctor that made me take a drug test, EVERY TIME I got my ADHD meds refilled
Meanwhile nobody bats an eye if you buy Alcohol or get a Benzo script. Both notorious for deadly withdrawals and higher addiction rates/potential and harm. But Addy, is what people freak out about lmao
They make you test for the medication you have to ensure you are actually taking it and not selling it. They aren't testing for other drugs.
@@admiral7599 the strength of effects from benzos are much less than that of amphetamines, benzos also don’t cause euphoria
@@admiral7599benzos are also extremely hard to get for most people nowadays due to DEA pressure since about 2019
Blows my mind how fentanyl is sched 2 and heroin is sched 1.
Ironically the Ed/Ld of morphine is 2, heroin is 4.5 and fentanyl is only 0.2.
because theres none such thing as a fda approved fentanyl pill. it only comes in a slow release path 99.9% of the time. rarely there is a sub lingual spray ive seen used for end stage cancer called subsys. the advantage of fentanyl is that you can use it in extremely low mass amounts as an IV anesthetic and your body will never get overwhelmed trying to metabolize it so an anesthesiologist can easily turn off the fentayl IV after a surgery is done and you will quickly metabolize all of the remaining amount in your blood before the sedation wears off. try that with morphine and you have to use such a high mass amount to achieve pain control that they will be floating on cloud 9 for 4 hours after they wake up. and yes surgeons have to use strong opioid pain killers when people are sedated because otherwise people twitch/squirm and move around when your making incisions, especially with the electrical burning type cutting instruments. just like how its a subconscious reflex to move your hand off of a hot stove and your body will do so faster than you could otherwise because the part of the body that actually does the thinking/sends the move away signal is in your spine. there are reasons to these things but everyone is so internet sophomoric now days, there just incorrect reasoning that gets amplifies infinitely
Thats because its not based on dangerousness but medical usefulness.
" This is also used to treat depression, although those effects are temporary. "
well, it seems most of the chemicals in this list can be used to temporarily treat depression.
They got around the GHB thing by saying "oh uh well this specific salt has medical uses". Even though for every other drug, all salts or the base drug are illegal. OH, and there's nothing special about the sodium salt of GHB, the potassium salt would work just as well medically.
Also the idea that GHB has ever been used as a date rape drug is absurd. I'm sure there are some rare cases - but anyone who has ever tasted GHB knows the taste is extremely strong. It actually got it's popularity in the body building community as it gives much better sleep than benzos etc, and some steroids can disrupt sleep. The date rape thing was just mass hysteria because you can't be woken up from GHB sleep - it puts you into a deep sleep for ~4 hours, then you get a dopamine rebound when you wake up and feel super awake and happy.
It was the same with Rohypnol (flunitrazepam), it's just a benzo that has particular affinity for the sub-receptors that cause sleep. Except the one problem you'd face trying to use it as a date rape drug is that it's only soluble in oil... in an alcoholic or normal drink it'd just form an obvious powder at the bottom.
The real date rape drug is alcohol, by a huge margin. And the second most reported date rape drug (coming in at
Interesting thing about 1,6-Diacetomorphine it's metabolized so fast by the body that you will almost always find its metabolite 6-monoacetomorphine (6-MAM)
And since it's most often cut with fentanyl; if a 6-MAM panel is needed then a fentanyl panel is ordered as well (forensic tox).
This inspired me to look into what structure my antidepressants have. I kinda sucked at chemistry, but I do love a sick molecule structure.
I missed some drugs like, Methylphenidat, Oxicotin, Promethazin, Benzodiazepine. But nice Video even if it is a bit short.
edit: Could someone explain the difference of GHB and GABA? In terms of structure, they are almost the same.
GHB has a hydroxyl group while GABA has an amino group on the 4th carbon
Thank you, I phrased it wrong. What I meant is why is GABA not a Drug but GHB is? They go on the same receptors and so on. @@limmuquan4796
Is it a bad omen that I'm on all 3 of these: OxyContin, promethazine, and multiple benzodiazepines...
@@benjaminsmekens2344 nope I'm on them to and more 😅
The U.S. Gov: "Schedule 1 if the drug has no known medical use"
Also the U.S. Gov: "We're gonna make it impossible for you to do scientific research on drugs for medical use, and we're never reading your findings, anyways"
The correct IUPAC name for LSD is N,N-diethyl-d-lysergamide. "LSD," d-lysergic acid diethylamide, was the term employed prior to the adoption of the IUPAC nomenclature. Of course, those of us intimately familiar with its unique properties, refer to it as the "Holy Acid." :)
Odd that these chemicals are included in the CSA but Alcohol and Nicotine aren’t. Or even Caffeine.
...it's 50 to 100 times more potent than morphine.
EXCUSE THE F*CK OUT OF ME, HOW STRONG?!
THEY ARE ALL LEGAL IN OREGON! AND IT ISN'T GOING WELL!
Same with Vancouver BC Canada. And soon to be toronto Ontario.
Great video! I love having the chemistry perspective. Annoying legal perspective, but perhaps the tier list would be a bit more evenly-spread throughout the tiers if you also included factors like sentencing guidelines & prosecution rates, so it isn’t just the schedule classification that determines “how illegal” but also the level of punishment. Basically, how illegal does the government think it is and therefore how much they want you to be punished for it. Just a thought - but very informative video.
Fentanyl should only be administered by a health professional at a clinic and or hospital. If methadone, a drug that is supposed to stop opiate use, is to only be administratored in a medical setting, why isn’t Fentanyl? The problem all started when they started sending patients home with this stuff!
Crazy how benzos can kill you in so many ways and ruin your life but its schedule 4. Meanwhile there's Fuckin weed in Schedule 1 😂😂
Unpopular opinion alert!: I'm not here to say that all drugs need to be legal, but I really don't think the people taking them are the problem.
In a nutshell, it's a problem with not allowing people to get the treatment they need so they self medicate. Some people self medicate with alcohol, some people do it with green leaf. Treatment should not include going to prison for possession when you have an addiction problem. That only perpetrates the problem. Treatment should be fine out why they use, get them the help they need, weather that's a therapist, the right medical treatment, etc.(I know there are other problems with the street drug sometimes being cheaper too thanks to the lack of healthcare or poor healthcare)
TLDR; treat the problem at its root. Shaming people and putting people in prison for a mental problem like addiction, isn't treating the problem; it only perpetuates the problem.
That's the opposite of an unpopular opinion
Look at all these ppl in the comments that think they're _soo_ smart & know everything there is to know.
Psilocybin is legal in some states, and mushroom therapy is allowed in many states as a legit medical treatment, so despite its schedule 1 stature, it should probably be in between 1 and 2 if not entirely in 2.
Idk why, but the title genuinely made laugh😂
Can you explain those old videos where they dose a spider and see what different webs it's spins under the influence of different compounds? If spiders have limited receptors in comparison to mamals, why would these drugs have any discernable effect?
When I google it (cannabis for example), the explanation is "spiders don't have cannabis receptors, but cannabis has other compounds that fuck that spider up"
This does not satisfy me.
Love your channel. Keep it up man!
That is a great question - I think ThoughtEmporium should test it!
There was a hilarious video about spiders on drugs that I saw a while ago. You’ll die laughing when you see what the crack spider does 🤣 I’m sure it’s on UA-cam
@That_Chemist Could you put him in touch with me? I'm willing to supply the spiders, and enough cannabis to complete the experiment several times.
While I don't have the answer I'll do what everyone feels compelled to do and speculate a bit. Plants evolve to have the chemical composition they do based on pressure from natural selection. Likely there was some minor evolutionary pressure from guarding against various bugs. And so it happens to have an effect on spiders as well. It's a very human-centric (or at least mammal-centric) view to think that just because plants have effects we might enjoy, that's why those effects exist.
@Gameboygenius I appreciate the reply. I think that explanation is self evident. It's ostensibly why we have any relationship with the compounds, having evolved alongside them. The gap I'm trying to fill is in relation to the spiders' limited receptors in comparison to a more genetically complicated organism, such as vertebrae.
Given the popularity among cannabanoid receptors being a key influence in getting wrecked off weed, I would imagine we would have a better understanding of the isolated psychoactive compounds and its influence on different nervous systems. Even if their are compounds in drugs that exclusively interact with spiders(or whoever), you'd think we would have stumbled over them by now.
what is wrong with people, i have adhd, and yes it is annoying, but fucking METH???!!!! Hell nah, i think the people making this legal took enough for the two of us lmao
Desoxyn is the brand name and it does have valid uses for narcolepsy and espescially treatment-resistant adhd.