I'm not even into chemistry but your videos remind me of stuff I learnt in high school. I understand them just enough to be intrigued by what you are explaining. Simply knowing nomenclature and having a vague sense of chemical mechanics plus regularly lurking on science/chemistry videos makes it somehow digestible even if I don't get the more advanced stuff. I think that's the power of the fast paced "review" format, you don't get bored through it even though you don't understand everything and you aren't scared of going through it again to catch more stuff. The point is not to make sure you understood 100% of it after first watch but to make you want to learn more about it. I think your videos have great potential for the people like me who went through the era of scientific content creators on youtube. We watched a lot of stuff on a lot of topics so we are kinda used to hear about the technical stuff but at the same time these same content creators never commit to saying the big bad scientific words and going through the litterature. I think your channel is on a great spot for that, to go clearly through litterature, processes and chemistry shenanigans but not explaining things like your viewers are 5yo. I definitely think there is a good part of the audience of science channels that is actually hungry for more advanced knowledge. But at the same time they are not ready to commit to 1-2h long black board lectures recorded with a mediocre camera. We might not be millions of viewers but we are definitely interested and commited to it.
@@ThatChemistOld I must precise that I have found your channel only recently so I haven't gone through your old videos yet. Though I should ask, do you have the first 4 lectures? Your uploads start at Lecture 5, i'm not sure if that is intended or not. Thanks for these videos!
really enjoying your videos, super informative and helpful, is there any chance you will be covering the synthesis of heteroaromatics such as the Hantsch synthesis of pyridine
Maybe in the future - Phil Baran has a really good lecture series on UA-cam which is basically the authoritative resource in addition to his book “the portable chemists consultant”
In example at 13:01, will we get two products depending on which carbon forms the bond with the carbocation and then ketone forms on the one which broke bonds?
I will launch my self on 14:28, Si-O bond are very strong due to a Si-O pi overlaping (empty p orbital of Si) the electron of lone pair of the O are more delocalised on the Si and are not able to stabilize the partitial positive charge caused by the withdrawing effect of the O-atome pulling electron density toward him. Really not sure about this. On scale of 1-10, i'm 6 sure and you ?
I guess this does make sense - I would think of carbon as being more electronegative than silicon, which would make me thing that this behaves more like a typical ether would, but it might just be that the aza-baeyer-villiger reactions have different migratory aptitudes
Can you present something on instalation of fluorovinyl fragments either via heck-type coupling or any other ideas for fluoroolefin synthesis?? Just picking your brain🤗
if it does invert (which I have a hard time telling from the paper it comes from), it can be rationalized through a more complex understanding of 1,2-shifts - Clayden has a good phys chem description. I'm not 100% confident that I didn't just make an error.
I might - it's fairly specific though - I think Phil Baran discusses it in his heterocycle course, but I couldn't find the video with a quick google search
@@ThatChemistOld No No Sir I am Saying about Inductive Effect, Mesomeric Effect, Hyperconjugation, Electromeric Effects and Inductomeric Effect. Actually I am a High School Student from India where we are Introduced to Organic Chemistry in Class 11th and 12th We are required to study Physics, Chemistry and Mathematics for cracking JEE Exam for getting Admission for Higher Education in Colleges and Universities
Currently I am in Class 12th and Studying Stereo Isomerism in Organic Compounds and then would Proceed with Organic Reaction Mechanisms and Haloalkanes and Haloarenes
@@ThatChemistOld You are transferring an electron rich bond onto a potential poor one.. similar to bayer-villger mech with transfer into oxonium ion...better to explain using that analogy
If you had any advice for someone who was maybe interested in making a selenium derivative of a compound where you would have a nitrogen (2 amine) and oxygen (ether) version, what would you say and is it worth it, project supervisor said don't go there but what do you think?
@@peterwanyama2391 Sorry, this a strawman. I do very much appreciate different accents - I hardly notice any accent at all in this video actually. However, it's quite irritating and frankly a bit disrespectful (no offense to ThatChemist here!) to the chemists that came before us to botch their names, even if they are from different countries. This name is not unpronounceable. In fact, the 'i' and 'g' in Wittig are pronounced the same here. Also, I am aware that the pronounciation of names is often difficult to find. (In this case a simple google search would provide you with it, but I acknowledge this is not generally the case.)
Make sure you subscribe to the new channel where all the new videos will be posted! ua-cam.com/channels/0nEDA3uRd5YuvBfMwQNteg.html
bro doing more classes than my actual professors, luv u
I’ve gotta show everyone how much they (the professors) are slacking off
I'm not even into chemistry but your videos remind me of stuff I learnt in high school. I understand them just enough to be intrigued by what you are explaining. Simply knowing nomenclature and having a vague sense of chemical mechanics plus regularly lurking on science/chemistry videos makes it somehow digestible even if I don't get the more advanced stuff. I think that's the power of the fast paced "review" format, you don't get bored through it even though you don't understand everything and you aren't scared of going through it again to catch more stuff. The point is not to make sure you understood 100% of it after first watch but to make you want to learn more about it.
I think your videos have great potential for the people like me who went through the era of scientific content creators on youtube. We watched a lot of stuff on a lot of topics so we are kinda used to hear about the technical stuff but at the same time these same content creators never commit to saying the big bad scientific words and going through the litterature. I think your channel is on a great spot for that, to go clearly through litterature, processes and chemistry shenanigans but not explaining things like your viewers are 5yo.
I definitely think there is a good part of the audience of science channels that is actually hungry for more advanced knowledge. But at the same time they are not ready to commit to 1-2h long black board lectures recorded with a mediocre camera. We might not be millions of viewers but we are definitely interested and commited to it.
Thank you! I appreciate your insight!!!
@@ThatChemistOld I must precise that I have found your channel only recently so I haven't gone through your old videos yet. Though I should ask, do you have the first 4 lectures? Your uploads start at Lecture 5, i'm not sure if that is intended or not. Thanks for these videos!
@@D3CD95 ua-cam.com/channels/0nEDA3uRd5YuvBfMwQNteg.html
@@D3CD95 I just fixed the playlist so that they should still be part of the list now
@@ThatChemistOld Great thanks!
really enjoying your videos, super informative and helpful, is there any chance you will be covering the synthesis of heteroaromatics such as the Hantsch synthesis of pyridine
Maybe in the future - Phil Baran has a really good lecture series on UA-cam which is basically the authoritative resource in addition to his book “the portable chemists consultant”
In example at 13:01, will we get two products depending on which carbon forms the bond with the carbocation and then ketone forms on the one which broke bonds?
I will launch my self on 14:28, Si-O bond are very strong due to a Si-O pi overlaping (empty p orbital of Si) the electron of lone pair of the O are more delocalised on the Si and are not able to stabilize the partitial positive charge caused by the withdrawing effect of the O-atome pulling electron density toward him.
Really not sure about this.
On scale of 1-10, i'm 6 sure and you ?
I guess this does make sense - I would think of carbon as being more electronegative than silicon, which would make me thing that this behaves more like a typical ether would, but it might just be that the aza-baeyer-villiger reactions have different migratory aptitudes
More asymmetric synthesis content please ! Chemistry king
I haven't even revised regular Baeyer Villeger oxidation.
Fortunately I have a video on that too!
@@ThatChemistOld Thanks bro.
Can you present something on instalation of fluorovinyl fragments either via heck-type coupling or any other ideas for fluoroolefin synthesis??
Just picking your brain🤗
For the first problem at the start of the video, could you brominate the indole with NBS, then do a sonigashira coupling with acetylene?
Yeah that should work, but you would probably use TMS-acetylene practically
MORE LECTURES! MORE LECTURES!
Share them with people, so that they get even more exposure!
Oof... I have been calling them all beckmann rearrangement this whole time.
Can you explain why the configuration of the tertiary carbon in the first example was changed ?
if it does invert (which I have a hard time telling from the paper it comes from), it can be rationalized through a more complex understanding of 1,2-shifts - Clayden has a good phys chem description. I'm not 100% confident that I didn't just make an error.
based on the compound's given name in the paper, the structure is correct (based on chemdraw's convert structure to name)
just bombed a question on my orgo 2 final and it's still bugging me. any chance you'd cover the pictet-spengler reaction in a future video?
I might - it's fairly specific though - I think Phil Baran discusses it in his heterocycle course, but I couldn't find the video with a quick google search
Can you make a Series of Electronic Effects in Organic Chemistry ??
Please
Hammett parameters?
@@ThatChemistOld No No Sir
I am Saying about Inductive Effect, Mesomeric Effect, Hyperconjugation, Electromeric Effects and Inductomeric Effect.
Actually I am a High School Student from India where we are Introduced to Organic Chemistry in Class 11th and 12th
We are required to study Physics, Chemistry and Mathematics for cracking JEE Exam for getting Admission for Higher Education in Colleges and Universities
Currently I am in Class 12th and Studying Stereo Isomerism in Organic Compounds and then would Proceed with Organic Reaction Mechanisms and Haloalkanes and Haloarenes
Can you provide any another way to connect with you other than UA-cam Comment Section (Like- Telegram, Instagram, etc.)
@@shreesclassroom2963 I would still consider these as influencing Hammett parameters - I will cover it at some point in a future video!
You are doing good work as this is how organic chemistry should be taught. Please let me know if I can help you in any way.
Thank you!
At 8:56 you did a poor job explaining why the carbon bearing the carboxylic acid migrated
It is true - it was an ad hoc explanation
@@ThatChemistOld You are transferring an electron rich bond onto a potential poor one.. similar to bayer-villger mech with transfer into oxonium ion...better to explain using that analogy
Would you do a video on on synthetic routes to natural Products like argiotoxins (polyamine spider toxins) or bromo phenols(from marine sponges) ?
perhaps
@@ThatChemistOld AYYY😎
Can you get the indole nitrile in the practice problem by reducing indole aldehyde to alcohol, refluxing with hcl, then react with cyanide?
its an alkyne, not a nitrile, and adding in a cyanide would give you an indole with a 1-carbon extension
Got it! I'm still learning triple bond chemistry
If you had any advice for someone who was maybe interested in making a selenium derivative of a compound where you would have a nitrogen (2 amine) and oxygen (ether) version, what would you say and is it worth it, project supervisor said don't go there but what do you think?
Join the discord and DM me a scheme of what you mean discord.gg/bqAC6dVF
Please don't call the good man a villager, it's /vɪlɪgəɹ/ or something of the sort, but please don't say the g as /dʒ/...
It's probably a Canadian accent issue
Might be, but it's not like the 'g' in 'get' is particularly hard to pronounce either :p
Still appreciate the video very much
Please appreciate the accent of people from different origin. Just focus on the chemistry
@@peterwanyama2391 Sorry, this a strawman. I do very much appreciate different accents - I hardly notice any accent at all in this video actually. However, it's quite irritating and frankly a bit disrespectful (no offense to ThatChemist here!) to the chemists that came before us to botch their names, even if they are from different countries. This name is not unpronounceable. In fact, the 'i' and 'g' in Wittig are pronounced the same here.
Also, I am aware that the pronounciation of names is often difficult to find. (In this case a simple google search would provide you with it, but I acknowledge this is not generally the case.)