Thank you very mucy for making this video! I think having an example of what a professional thesis presentation online could help students with defending their thesis.
Once again congratulations on your successful thesis defense 🎉 I'm sure this material will be very useful for your fellow chemists to appreciate and learn from 😊
Congratulations! I had the misfortune of an older colleague (she was Assistant Prof.) trying to shut me up on some natural compound chemistry I had my graduation about saying "at least I published on this topic as opposed to you" ...printer noise... paper got wet with the sweat of my palms as I read my second year undergrad prep method published by the people I had to trust as supervisors and coworkers without even acknowledgement of my (back then) good self... while I was abroad. I understand paperwork between universities and alliances between Professors that last saw each other while college students were made for me to have this research topic that was their own... but then again, I nailed the prep approach by extrapolating some other method I found on a similar substrate. Just to make it clear I was living in whatever is inappropriate to call a lab at least compared to any home lab I pretty much had rather an institute (2800+ different chemicals I even heroically enforced the local DEA to return to me, but evil parents took care of quite a few). The point is that the incomparably superior plant material was brought to me by pure chance... this made a second grade biology/biochem student bringing a giant jar full of crystalline betulin, which was reported in literature but never extracted as other than amorphous. I felt like teaching the prestigious industrial chemistry Faculty how to properly use a soxhlet (top quality extractive hand picked by biologist who does a good distinction between the tissues and knowing what to choose) the crystals were obtained by the partial recovery of the solvent just by knowing when to stop (gut feeling, not that much science), the prep oxidation was found tested and implemented in my own lab with my own materials what I showed them was the most successful of my findings that just happened to beat their previous attempts regarding time, cost, labour and yield. My rest of the thesis had some amino triazoles attached to the newly formed oxo group that were not really easy to both prepare and analyse but everyone knew my dedication as at least something needed to be at a light reflux in order for me to sleep. The lady that printed the traumatic paper had no idea of her involvement since she did the HPLC and just that. I was losing the fight with my apparently limitless ego things never got good enough for me to get to defend or even write my thesis... there is no publication with my name on it up to date. Plenty of so far safe clandestine labs established by people I met and inspired, I sometimes have the magic of sending someone home with the gift of understanding most of what is needed to operate a chemical lab just by reading because I made them curious. I spoke the truth when told them I was aquainted with the basics of organic chemistry in two weeks. I have them references, and people know I'm not backing down on using them on whomever I deem worthy (mistakes included)
I have been watching your channel for a while and just wanted to say that it was got me though me first year chemistry course. Congrats Dr.ThatChemist !
Ahh good old fluorine shuch a viscous yet a very useful element in lots of ways,expected or not Hats off to you for this amazing thesis and congrats on getting that Ph.D
Congratulations for your Ph.D. Josh🎉 I've always wanted to learn more about fluorine organic chemistry, and now you give me a new motivation to apply for doctorate
Amazing Job, i'm glad the defence went well. I'm particularly happy to see a new method for making difluoromethyl ethers as in the past I searched for those and only found a sketchy electrochemical way and one using difluorocarbene, amazing job!
Congrats on the PhD. I'll give you the same advice I give others and my Father gave me when I got the PhD. And I quote, "Just because you have a PhD doesn't mean you know a damn thing".
My Dad was a PhD in hard living, totally proud of me. Remember the advice, it will slap you in the face one day when you least expect it. I also tell new PhDs, there is a post-PhD let down you will experience. @@exaviestivalet3393
Excellent, useful thesis. Well done Man,we always believed in you and still you managed to exceed expectations. Well done, well deserved and can't wait to read the entire thesis. And hey, I suppose Your girlfriend/ wife had a hand in choosing the suit but you still deserve a commendation - finally,a well chosen colour, interesting, yet classy combination. If I see one more black funeral suit with a grandparent's violently red (or worse, yellow) tie, during day, on adult dude that can afford different, I'll cry.
@@That_Chemist Interesting. One common PET tracer, 11C-deprenyl-D2, has the drawback of being metabolized into 11C-methamphetamine, which has horrible off-target binding. MDMA-F2 could be interesting even if useless in PET.
Awesome thesis! Fluorine is easily the most interesting halogen and chemical element to me. If I could go back 15 years ago with the knowledge and fascination I have with chemistry in my 30s I would have absolutely pursued it as my career rather than becoming a licensed electrician
Congratulations on that PhD dude!!! :D you inspire me to keep on with my chemistry undergraduate :') I'm looking forward to someday become a doctor too
2 Funny stories I got to share. I am a mine Eng (essentially the gollum of the engineering programs) and once I drank sulfur water, it didn’t taste too good. Second I accidentally licked HCl. I was trying to see if the rock was salt.
Just completed chem 2 in undergrad this semester and still have no idea anything that you're talking about. Will come back in 1.5 years after biochem and see if i get it then👍
Wow such a promising field to study, I wonder what effects thoes fluors induces in the galienic molecules. Realy proud of you Dr That, you are my role model :^) Curently not finding any master that is interresting, teaching some highscoolers to save for next year, I wonder if i will be able to get back at it and be a scolar like you one day.
You worked with elemental fluorine?!? You're a brave man. That being said, my chemistry teacher explained to me that fluorine just wants to get together with someone really bad. When it does, it's perfectly happy.
Great talk, I quite enjoyed it (and congratulations by the way)! I just wanted to ask briefly how common the difluoromethyl species (and particularly the ether variety) are in the medicinal chemistry literature? I can't say I see them terribly frequently, especially when compared to its trifluoromethyl sibling. Do they tend to have similar properties and/or activities (aside from generally being less stable) to that of trifluoromethyl species? Thank you, and congrats again!
I'm not a chemist but I find your channel really interesting. Congratulations on your doctorate, and allow me to say the little thionobenzodioxole diagram guys are really cute 🥺
Sincere congrats on your thesis! Is there a way to contact you directly? I have some problems regarding the -CF2H group and maybe you would know the answers
Congratulations. 🥳 Very cool chemistry. ☺ What other difluoro-compounds do you think will be of great interest in pharmaceutical research, looking forward into the future?
The only sucky thing is that the specific anthranilic acid completely messes up how well that step works - like I made a BDT with two fluorines on the ring, and the yield of that salt was 0.5% 💀
Congratulations on your Ph.D on selective fluorination of organics. That is a very challenging task. Im wondering if you tried microwave assist with your flourination?
Do you give two presentations, one for the public and one for the PhD committee? I'm assuming this is too general of a talk for the committee. We only have the students do one presentation including all the technical details but it is open to the public.
Me: Who needs to read a PhD thesis on fluorination? All I need to know about fluorination I learned from /Ignition/! Next chempolation: Discusses the discovery of my crispy and unselectively fluorinated remains in a vat of ClF3.
Congrats on actually doing it Joey! Now you are officially Dr Chemist!
Ty Niklas :)
@@That_Chemist you did it before tom too
Congratulations on your PhD Dr Chemist!
thank you for your help Mr Angry Factory Man :P
A completed thesis from a youtuber chemist, What kind of black magic is this ?
not wasting time with cubane
This is alchemy
More like yellow magic ...
@@kaboom4679I admit it, I laughed.
That's because the thesis is on chemistry instead of physics
Thank you very mucy for making this video! I think having an example of what a professional thesis presentation online could help students with defending their thesis.
I hope it helps!
Congratulations for the PhD , one of my mates is playing around with fluorination at the moment, I will let him know about this work
Congratulations once again on your PhD Mr Doctor That Chemist.
Thanks Chuck
So you got a doctorate in giving a molecule an F
Using S-tier chemistry
@@That_Chemist😄♥️
Awesome job! I didn’t understand most of it but proud of you for showing up and doing the work!
6:05 I felt this so much lmao, the more concise and straight to the point the better
lol same, when I practice with my self I do the same
Once again congratulations on your successful thesis defense 🎉 I'm sure this material will be very useful for your fellow chemists to appreciate and learn from 😊
Congratulations! Also, thanks to Organic 1 and Organic 2 (both partly with Sharpless in 1987) and your clear explanation, I mostly understood this.
Congratulations! I had the misfortune of an older colleague (she was Assistant Prof.) trying to shut me up on some natural compound chemistry I had my graduation about saying "at least I published on this topic as opposed to you" ...printer noise... paper got wet with the sweat of my palms as I read my second year undergrad prep method published by the people I had to trust as supervisors and coworkers without even acknowledgement of my (back then) good self... while I was abroad. I understand paperwork between universities and alliances between Professors that last saw each other while college students were made for me to have this research topic that was their own... but then again, I nailed the prep approach by extrapolating some other method I found on a similar substrate. Just to make it clear I was living in whatever is inappropriate to call a lab at least compared to any home lab I pretty much had rather an institute (2800+ different chemicals I even heroically enforced the local DEA to return to me, but evil parents took care of quite a few). The point is that the incomparably superior plant material was brought to me by pure chance... this made a second grade biology/biochem student bringing a giant jar full of crystalline betulin, which was reported in literature but never extracted as other than amorphous. I felt like teaching the prestigious industrial chemistry Faculty how to properly use a soxhlet (top quality extractive hand picked by biologist who does a good distinction between the tissues and knowing what to choose) the crystals were obtained by the partial recovery of the solvent just by knowing when to stop (gut feeling, not that much science), the prep oxidation was found tested and implemented in my own lab with my own materials what I showed them was the most successful of my findings that just happened to beat their previous attempts regarding time, cost, labour and yield. My rest of the thesis had some amino triazoles attached to the newly formed oxo group that were not really easy to both prepare and analyse but everyone knew my dedication as at least something needed to be at a light reflux in order for me to sleep. The lady that printed the traumatic paper had no idea of her involvement since she did the HPLC and just that. I was losing the fight with my apparently limitless ego things never got good enough for me to get to defend or even write my thesis... there is no publication with my name on it up to date. Plenty of so far safe clandestine labs established by people I met and inspired, I sometimes have the magic of sending someone home with the gift of understanding most of what is needed to operate a chemical lab just by reading because I made them curious. I spoke the truth when told them I was aquainted with the basics of organic chemistry in two weeks. I have them references, and people know I'm not backing down on using them on whomever I deem worthy (mistakes included)
I have been watching your channel for a while and just wanted to say that it was got me though me first year chemistry course. Congrats Dr.ThatChemist !
Glad to hear it :)
Ahh good old fluorine shuch a viscous yet a very useful element in lots of ways,expected or not
Hats off to you for this amazing thesis and congrats on getting that Ph.D
Dude I literally LOVE all of your videos. Plz keep em comin!
Thank you for sharing this 😊! This is truly a gem! I love it. As a chem nerd I really wanted these sorts of learning material
Glad you liked it :)
Congratulations for your Ph.D. Josh🎉 I've always wanted to learn more about fluorine organic chemistry, and now you give me a new motivation to apply for doctorate
You have officially earned the title of dr chemist
Amazing Job, i'm glad the defence went well. I'm particularly happy to see a new method for making difluoromethyl ethers as in the past I searched for those and only found a sketchy electrochemical way and one using difluorocarbene, amazing job!
Difluorocarbenes are like 95% of the literature
Dr. Chemist has a nice ring, congrats! I am not a chemistry guy by any means but your content makes it interesting. Well deserved.
Congrats on the PhD. I'll give you the same advice I give others and my Father gave me when I got the PhD. And I quote, "Just because you have a PhD doesn't mean you know a damn thing".
Those sound like the words of a person who is upset at the accomplishments of those who came after them. I’d never take that advice .
My Dad was a PhD in hard living, totally proud of me. Remember the advice, it will slap you in the face one day when you least expect it. I also tell new PhDs, there is a post-PhD let down you will experience. @@exaviestivalet3393
@@exaviestivalet3393 It's a reminder to stay humble. Chances are, you have a lot of knowledge in a very narrow part of the scientific spectrum.
Excellent, useful thesis. Well done Man,we always believed in you and still you managed to exceed expectations. Well done, well deserved and can't wait to read the entire thesis. And hey, I suppose Your girlfriend/ wife had a hand in choosing the suit but you still deserve a commendation - finally,a well chosen colour, interesting, yet classy combination. If I see one more black funeral suit with a grandparent's violently red (or worse, yellow) tie, during day, on adult dude that can afford different, I'll cry.
6:15
What's your lab's ETA on fluorinated MDMA hitting the streets?
Jokes aside, great presentation, great job, and congratulations!
TRIUMF decided to not pursue a project looking at 18F phenethylamines due to their general trend of binding to lots of receptors
@@That_Chemist Interesting. One common PET tracer, 11C-deprenyl-D2, has the drawback of being metabolized into 11C-methamphetamine, which has horrible off-target binding. MDMA-F2 could be interesting even if useless in PET.
Good luck on your thesis defense!
As far as i know he has defended already
Bless you
Congratulation! Well done! I actually listened to Prof. Britton's talk two months ago about total synthesis.Very interesting chemistry.
Congratulations! I'm working on my Master's thesis right now, and the idea of having to present my research is very intimidating. Excellent work!
Which of these fluorine compounds will turn my frogs the most gay?
Are you posting this for feedback and to check it for errors? Mad respect, Doctor.
That Dr. Chemist
This is so awesome, so damn proud of you!
Congratulations dude the PET applications are humongous
Very nice presentation, I feel remembered to my days at university. Congratulations to you PhD
*sneeze*
"I left that in"
I don't know why, but I found great amusement in that bit.
Congratulations once again. Hope to learn a lot from you.
Congratulations Man!
Please remember that current happiness might be temporary, but the fluorinated compounds are forever.
Awesome thesis! Fluorine is easily the most interesting halogen and chemical element to me. If I could go back 15 years ago with the knowledge and fascination I have with chemistry in my 30s I would have absolutely pursued it as my career rather than becoming a licensed electrician
Congrats on your PhD! Really nice and well made powerpoint. Explanations were easy to follow for a difficult subject. Thank you for that!
Glad it was helpful!
Congratulations! Very interesting presentation and work. Good Job, hope to see more details about your research.
So happy for your PhD congratulations! This was a very interesting thesis regarding fluorination, I can’t wait to see more material from you Dr. Chem!
holy shit congration DR CHEMIST!
Now I always thought that Sanford & Co meant Sanford and collaborators not Sanford and co-workers.
Congratulations on that PhD dude!!! :D you inspire me to keep on with my chemistry undergraduate :') I'm looking forward to someday become a doctor too
WOOHOO CONGRATS DR!!
Interesting work, great presentation, congratulations! You pitched that at the right level of detail for me, anyway.
Congratulations, Dr. Newton!!!
Love to see it, can’t wait to see some more from the PhD
CONGRATULATIONS DR. CHEMIST!!!
Wow congrats Dr Joey
Now you have one up on "explosions and fire"
3:04 Bless you :)
God I hope my research goes as well as yours (or at least yours seemed to have gone well!)
Congratulations Dr. That Chemist!! Amazing stuff!!🎉
2 Funny stories I got to share.
I am a mine Eng (essentially the gollum of the engineering programs) and once I drank sulfur water, it didn’t taste too good.
Second I accidentally licked HCl. I was trying to see if the rock was salt.
Big congrats the concept of writing a thesis is crazy to me props 🎉🎉🎉
its just a story tbh - a 5 paper sandwich
Great PhD! Very interesting work
What's the name of the leishmaniasis drug on your slide titled "Noteworthy Difluorobenzodioxoles"? Excellent work my guy congratulations!!!!!!!!
Just completed chem 2 in undergrad this semester and still have no idea anything that you're talking about. Will come back in 1.5 years after biochem and see if i get it then👍
Congratulations! 🎉
congratulations, doctor!!!
Congrats on the phd!
Excellent content 👍🏻
Congratulations Doctor🎉
Dropout: I used to think i could write a thesis in chemistry. Now I walk into a convenience store, and threaten, "Thesis a stick up!"
Thank you Dr Chemist. I was wondering how to fluorine
Congratss!!!
Wow such a promising field to study, I wonder what effects thoes fluors induces in the galienic molecules. Realy proud of you Dr That, you are my role model :^)
Curently not finding any master that is interresting, teaching some highscoolers to save for next year, I wonder if i will be able to get back at it and be a scolar like you one day.
I also just did my Viva. Getting diploma on 22. Woot!
You worked with elemental fluorine?!? You're a brave man. That being said, my chemistry teacher explained to me that fluorine just wants to get together with someone really bad. When it does, it's perfectly happy.
Yay!! Now you and explosions and fire are officially smart 🎉
Congratulations. Excellent work. I wonder if I can get ppt version of this?
Congratulations!!!!
He is now officially That Doctor.
Awesome work man and congrats on the PhD!
Question: Have you tried the difluoromethyl procedure on aryl alcohols? Thanks!
the reagent is super messy with phenols - not clean EAS reactions either, like red tars and lots of spots by TLC (I tried lots of things)
Congratulations to Dr. ThatChemist
Congrats on making it! Will you be sharing your thesis in the near future? I'd be curious to read some of it.
Great talk, I quite enjoyed it (and congratulations by the way)! I just wanted to ask briefly how common the difluoromethyl species (and particularly the ether variety) are in the medicinal chemistry literature? I can't say I see them terribly frequently, especially when compared to its trifluoromethyl sibling. Do they tend to have similar properties and/or activities (aside from generally being less stable) to that of trifluoromethyl species? Thank you, and congrats again!
I'm not a chemist but I find your channel really interesting. Congratulations on your doctorate, and allow me to say the little thionobenzodioxole diagram guys are really cute 🥺
thanks :)
YES congrats!
When are we getting the fluoriated compounds tierlist
Sincere congrats on your thesis! Is there a way to contact you directly? I have some problems regarding the -CF2H group and maybe you would know the answers
Send me a dm - I’d be happy to help
♥️♥️♥️♥️Very interesting! Thank you so much✨🍀
Glad you liked it :)
Congrats !
Congratulations
Great work. Do you have a link to the article? Would love to study it in broader detail.
I’ll link to my Google scholar profile so that you can check out any of my published work scholar.google.ca/citations?user=mSBZhIYAAAAJ&hl=en
Yay you are doctor ThatChemist now
This is gonna make explosions&fire mad lol
Naw he was cool and nice
@@That_Chemist but... But... Yellow!!!!
How did you make the structures? ChemDraw? It looks really clean, congratulations on your PhD!
Yeah chemdraw! We have the template available in the TC discord resources channel
Congratulations. 🥳 Very cool chemistry. ☺ What other difluoro-compounds do you think will be of great interest in pharmaceutical research, looking forward into the future?
I actually find the benzyne CS2 step to be highly elegant
The only sucky thing is that the specific anthranilic acid completely messes up how well that step works - like I made a BDT with two fluorines on the ring, and the yield of that salt was 0.5% 💀
Behold, that Dr. Chemist
Congratulations on your Ph.D on selective fluorination of organics. That is a very challenging task. Im wondering if you tried microwave assist with your flourination?
I didn’t - this would be worth examining though, especially as 18F-radiolabeling is concerned
RIP AgF purification section
Any plans to 'rebrand' (?) into _That PhD (Chemist)_ now?
This sounds like a lot spicy reagents going downrange.
Remember! *NEVER* mention the secret handshake! Future plans?
Dude this is great research, thanks for posting. Where did you do grad school?
Flourine is scary
Do you give two presentations, one for the public and one for the PhD committee? I'm assuming this is too general of a talk for the committee. We only have the students do one presentation including all the technical details but it is open to the public.
did you have tier lists in your thesis presentation? )
But what about the wookies under nucleophilic attack?!
Me: Who needs to read a PhD thesis on fluorination? All I need to know about fluorination I learned from /Ignition/!
Next chempolation: Discusses the discovery of my crispy and unselectively fluorinated remains in a vat of ClF3.