I was literally in depression since last 3 days because I couldn't understand this topic.....I went through Physiology to Medicine books....but was a hell lot confused....Then I saw your videos about pressure,compliance and DLCO....I was relieved....No one can explain like you...I repeat no one....I just can't thank you enough.....Wish to meet you once in my life.....Lots of love and respect...From India🙏🙏🙏🙏
i was searching for a mnemonic for PLUMMER VINSON and your video came up about the italian wife . hahaha it was amazing. already subscribed earlier to your channel but i dont receive updates so i hit the bell icon . keep making the amazing videos
You say Transpulmonary pressure is the actual pressure that tends to inflate the lungs but on the other side you say it is a recoil pressure. If it tends to collapse the lungs then how it will distend the lungs? Can't get this point?? Plz help
Beautifully explained 😊 thank you so much!! Also that "A stupid student might suggest to insert a needle..oh oh shut up"😂😂how did you know that I was exactly thinking the same LMAO 🤣🤣
Can someone tell me how come Transmural pressure and Intrapleural pressure have the same quantity but different sign if the Transmural pressure equals the difference of the Intrapulmonary and the Intrapleural pressure. So, for instance if Intrapleural pressure is -6 and Intrapulmonary pressure is -1 or +1 we get respectively +5 or +7 for the Transmural pressure. ???
Hey, first of all, thanks for the videos! I have a question, at minute 4:58, what happens with Boyle´s law? How is it possible that lung volume increases and at the same time increases the pressure?
Because you’re connecting the pleura to the atmosphere. Then, if a valve forms, it becomes positive because air is coming in but not out (like the valve in the car’s tires)
I once had an old man for substitute teacher in high school. Substitute teachers don't teach anything but stay in classroom as a guardian. But I never forgot what he said about learning! He said:" If you make learning fun, it is easier to learn"! So, you not only teach objective matter; but indirectly, you help us learn easier by making us laugh. So, you are doing more than teaching. You are making life fun. Thank you so much! I can picture you in a comedy show on TV! "Laughter is the best medicine"!
hey medicosis , your each and every concept taught actually makes sense , thankyou for making physiology actually senseful , wish my professors also watch this video😏😑🤥
I was watching this video on 2x and I started cracking up when he was doing the breathing sounds... thank you @Medicosis Perfectionalis for making awesome videos! They are so helpful, funny and interesting to watch all at the same time!
During inspiration, the intrapulmonary pressure becomes negative so that the air can move in. At the same time, the chest wall is expanding which means an outward force on the chest wall. If the lungs and chest wall are moving in the same direction, how can the intrapleural pressure become MORE negative during inspiration? Or is it that even though the lungs are expanding, the pressure is actually in the opposite direction?
Great video! I do have one question, when the chest wall expands making intrapleural pressure move from -5 to -7, why does the pressure stay at -7 even when the lung expands with air? Wouldn't the lung's expansion move it closer to the chest wall and increase the pressure as air rushes in?
Hello and thank you for this video :) quick question: you 're saying that the intrapleural and the transpulmonary pressures are always equal and of opposite charges, but doesn't that happen ONLY when the alveolar pressure equals zero? Like at 10.04 Pip is around -6, Pa=-1 and so Ptp=-1-(-6)=5. (and not 6).
1-Your videos are wonderful specially biochimistry playlist it helped me a lot thx 2- our teacher asked us why the intrapleural pressure is negative from the beginning (he wasn't talking about its variations)
So you explained beautifully the concept of intrapleural and intrathoracic pressures . My question is that if pressure in any intrathoracic structure like ivc trachea esophagus must be equal to intrapleural pressure then why does the esophagus looks a *bit collapsed* than trachea on CAT scan images .Like you explained intrapleural pressure is the same in the esophagus ..
Hello, there is a feeling of pressure, tightness and shortness of breath in the upper lobe of the right lung, which has become chronic, a tomography was taken, nothing came out, what else can I do?
During inspiration, the chest wall expands, but so do the lungs, so where the lungs and chest wall moving opposite direction that makes the intraplural pressure more -ve ?
may i ask question is the Intrapleural pressure necessary for alveoli ? if we just cancel the Intrapleural pressure is the ventilation will absolute lost ? in case the answer is yes ، so how we kapt the lung out side the body in case of lung transplant
According to the third law of Newton: Every action has an equal and opposite reaction. So, the recoil pressure is the mirror image of the transmural pressure. Hope it helps!
I never usually comment on youtube videos, but had to make an exception. Throughout school and my undergrad degree I struggled with this concept- now I fully understand it. THANK YOU!
U are a heaven sent angel.. for this topic i have spent months and no luck! so i finally gave up.. decided to give it one last shot & ur video popped up in suggestion... u r AMAZINGGGGGG!! i have shared ur channel to all the places and social sites ... u totally deserve this!
I get transmural pressure is what actually inflates the lungs, great. Makes sense if the lungs were one big airbag, but it’s not. I just don’t see how it relates to individual alveoli. If alveoli want to “recoil” and chest wants to expand(spring), that’s fine. It would require neg. intrapleural pressure around all the alveoli and transmural pressure differential around each alveoli...Structurally doesn’t make sense. What am I missing?
I don't think boyle's law makes sense here. Boyle's law is applicable for a fixed mass of gas. But in case of the lung, air volume of particular mass is not changing. Rather mass of air is increasing in inspiration and decreasing on expiration. It's just that the vacuum sucks up more MASS of air (which means more volume). The mass is not fixed here. So I don't think boyle's law is the appropriate term to use here. Correct me if I am wrong.
With regards to intrapleural/intrathoracic pressures, is it true that both positive pressure mechanical ventilation and non-invasive PPV (CPAP & BIPAP) will sort-of inverse the curve? I.e. the intrapleural pressure will now be more positive during inspiration and less positive during expiration. I know that this is true for mechanical ventilation, but I am wondering if CPAP has the same effects on intrapleural/intrathoracic pressure?
As you expire air out volume of lungs decrease and pressure will increase it increases to +1 (means 761mmhg ) and because of high pressure air goes out of your lungs ....till the pressure of lung reaches to 0 ( means 760mmhg)
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I was literally in depression since last 3 days because I couldn't understand this topic.....I went through Physiology to Medicine books....but was a hell lot confused....Then I saw your videos about pressure,compliance and DLCO....I was relieved....No one can explain like you...I repeat no one....I just can't thank you enough.....Wish to meet you once in my life.....Lots of love and respect...From India🙏🙏🙏🙏
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i was searching for a mnemonic for PLUMMER VINSON and your video came up about the italian wife . hahaha it was amazing. already subscribed earlier to your channel but i dont receive updates so i hit the bell icon . keep making the amazing videos
Thanks, bro...Welcome to the Medicosis tribe 😊😊
Thanku so much... its very help full..
Amazing explanation! I love the humour you put into it as well
Thank you so much 😊
You say Transpulmonary pressure is the actual pressure that tends to inflate the lungs but on the other side you say it is a recoil pressure. If it tends to collapse the lungs then how it will distend the lungs? Can't get this point?? Plz help
Beautifully explained 😊 thank you so much!!
Also that "A stupid student might suggest to insert a needle..oh oh shut up"😂😂how did you know that I was exactly thinking the same LMAO 🤣🤣
Haha 😂
But How would you measure the pressure with a needle?
Thanku sir concept cleared
Awesome 👏
At mid inspiration how does the volume increase and pressure increase as well?
علي الحرام عظمة😘
Why chest wall tends to expand ?and i m not clear with intrapleural pressure
It has to do with its physical design and orientation in space...It's like a spring that spirals outwards.
Can someone tell me how come Transmural pressure and Intrapleural pressure have the same quantity but different sign if the Transmural pressure equals the difference of the Intrapulmonary and the Intrapleural pressure. So, for instance if Intrapleural pressure is -6 and Intrapulmonary pressure is -1 or +1 we get respectively +5 or +7 for the Transmural pressure. ???
Tysm :)
U R sooooooo amazing😣🔥🔥🌺
Hey, first of all, thanks for the videos! I have a question, at minute 4:58, what happens with Boyle´s law? How is it possible that lung volume increases and at the same time increases the pressure?
the lung volume increases so the pressure decreases i think you misheard it
why in a stab wound the pressure in pleura won't be positive but atmospheric?
Because you’re connecting the pleura to the atmosphere.
Then, if a valve forms, it becomes positive because air is coming in but not out (like the valve in the car’s tires)
@@MedicosisPerfectionalis great thanks!
@@MedicosisPerfectionalis but doesn't a stab wound always lead to a valve formation therefore positive pressure?
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Not always, otherwise all doctors would be able to diagnose it early on, which is not the case.
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Medicosis Perfectionalis of course Sir :)
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Great job, I had been trying to find a good explanation of this. You not only explained it, but it was interesting and funny.
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I pressed the like button before even watching. I'm sure it's perfect as always💞💞💞
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What is your name bro..?
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I once had an old man for substitute teacher in high school. Substitute teachers don't teach anything but stay in classroom as a guardian. But I never forgot what he said about learning! He said:" If you make learning fun, it is easier to learn"!
So, you not only teach objective matter; but indirectly, you help us learn easier by making us laugh. So, you are doing more than teaching. You are making life fun.
Thank you so much!
I can picture you in a comedy show on TV!
"Laughter is the best medicine"!
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Very nicely explained, No words to appreciate your efforts ....This video deserves much more likes.....
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Heyy! Thank you so much.. this was soo helpful to me asi have my exam tom. love you loads for this wonderful video.. you are a great teacher!❤
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hey medicosis , your each and every concept taught actually makes sense , thankyou for making physiology actually senseful , wish my professors also watch this video😏😑🤥
I was watching this video on 2x and I started cracking up when he was doing the breathing sounds... thank you @Medicosis Perfectionalis for making awesome videos! They are so helpful, funny and interesting to watch all at the same time!
I really like when students laugh...It means a lot.
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During inspiration, the intrapulmonary pressure becomes negative so that the air can move in. At the same time, the chest wall is expanding which means an outward force on the chest wall. If the lungs and chest wall are moving in the same direction, how can the intrapleural pressure become MORE negative during inspiration? Or is it that even though the lungs are expanding, the pressure is actually in the opposite direction?
me answer the wrong answer and getting called stupid is the highlight of this video.
this is brilliant explanation tbh, everything became so simplify and easier to understand. props to you!!
Thanks a million 😊😊😊😊
Easy explanation 😉 I am from Egypt ,but l loved your video and understood it 💜 it was so amazing one 😍
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Great video! I do have one question, when the chest wall expands making intrapleural pressure move from -5 to -7, why does the pressure stay at -7 even when the lung expands with air? Wouldn't the lung's expansion move it closer to the chest wall and increase the pressure as air rushes in?
Same question 🤦🏿♀️did you get the answer?
Very very excillent for this vidio thank you thank you👍👍👍👌👌
My pleasure 😇
Hello and thank you for this video :) quick question: you 're saying that the intrapleural and the transpulmonary pressures are always equal and of opposite charges, but doesn't that happen ONLY when the alveolar pressure equals zero? Like at 10.04 Pip is around -6, Pa=-1 and so Ptp=-1-(-6)=5. (and not 6).
same question
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1-Your videos are wonderful specially biochimistry playlist it helped me a lot thx
2- our teacher asked us why the intrapleural pressure is negative from the beginning (he wasn't talking about its variations)
Thank you so much 😊
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So you explained beautifully the concept of intrapleural and intrathoracic pressures .
My question is that if pressure in any intrathoracic structure like ivc trachea esophagus must be equal to intrapleural pressure then why does the esophagus looks a *bit collapsed* than trachea on CAT scan images .Like you explained intrapleural pressure is the same in the esophagus ..
Finalmente entiendo claramente estos conceptos lo cual me ayuda mucho a entender la mecánica ventilatoria. Thank you so much!
:)
Hello, there is a feeling of pressure, tightness and shortness of breath in the upper lobe of the right lung, which has become chronic, a tomography was taken, nothing came out, what else can I do?
I am again speechless here... WWWWowww
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okay. I officially love this channel. Thank you so much!
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At 5:29 the diagram of lung inspiration says +1 and -1 for expiration lung diagram. This is a mistake? Or i couldn’t understand someone
During inspiration, the chest wall expands, but so do the lungs, so where the lungs and chest wall moving opposite direction that makes the intraplural pressure more -ve ?
Correction _ At 7.00 , visceral pleura is inner and parietal pleura is outer one .
Nupoor Rautkar listen carefully. Sir is correct there
@@jessicakaushal3327 read books babe
He said inside of CHEST WALL = outer pleura and outside Of LUNG 🙄 =inner pleura
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I was afraid he was going to hypervantilate.
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may i ask question
is the Intrapleural pressure necessary for alveoli ?
if we just cancel the Intrapleural pressure is the ventilation will absolute lost ?
in case the answer is yes
، so how we kapt the lung out side the body in case of lung transplant
What about patients that have undergone pleurectomy? How does this affect the venous return and such?
I love how you explain the subject and make it such a piece of cake for me .....thank you soo much 👏👏
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If you ever write a textbook called A Humorous Review of Medical Physiology, by Medicosis Perfectionalis, I will buy.
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why does the transmural pressure responsible for lung inflation? Isn’t it the same as recoil pressure?
According to the third law of Newton: Every action has an equal and opposite reaction. So, the recoil pressure is the mirror image of the transmural pressure. Hope it helps!
Gosh you just saved a Med student in South Korea, no cap. Luv ya, ur videos are qay better than physiology books and other confusing lectures🙏🙏🙏
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Keep going ..You can simplify the information in a very great way 🤩
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What do you mean when yu state the positive intrapleural pressure will push the mediastinum to the negative side?
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I never usually comment on youtube videos, but had to make an exception. Throughout school and my undergrad degree I struggled with this concept- now I fully understand it. THANK YOU!
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oh my god I hate these graphs got me XD 4:13
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Also why is intrapleural and intrapulmonary pressure the same amount?
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Omg you taught it like it was a piece of cake tysm❤
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So far it was so much Confusing, Thanks to you made it easier to understand about basics ....
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Aye man God bless you for the work you're putting in. How can I get access to your notes?
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My notes are available at: www.medicosisperfectionalis.com/
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heaven sent angel.. for this topic i have spent months and no luck! so i finally gave up.. decided to give it one last shot & ur video popped up in suggestion...
u r AMAZINGGGGGG!! i have shared ur channel to all the places and social sites ... u totally deserve this!
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I get transmural pressure is what actually inflates the lungs, great. Makes sense if the lungs were one big airbag, but it’s not. I just don’t see how it relates to individual alveoli. If alveoli want to “recoil” and chest wants to expand(spring), that’s fine. It would require neg. intrapleural pressure around all the alveoli and transmural pressure differential around each alveoli...Structurally doesn’t make sense. What am I missing?
I don't think boyle's law makes sense here. Boyle's law is applicable for a fixed mass of gas. But in case of the lung, air volume of particular mass is not changing. Rather mass of air is increasing in inspiration and decreasing on expiration. It's just that the vacuum sucks up more MASS of air (which means more volume). The mass is not fixed here. So I don't think boyle's law is the appropriate term to use here.
Correct me if I am wrong.
In the photo u mistakenly put +1 in inspiration and -1 in expiration shouldn't it be the opposite (in minute ua-cam.com/video/0g4d1F7QOfE/v-deo.html)
You’re right!
Thank you!
My pleasure!
With regards to intrapleural/intrathoracic pressures, is it true that both positive pressure mechanical ventilation and non-invasive PPV (CPAP & BIPAP) will sort-of inverse the curve? I.e. the intrapleural pressure will now be more positive during inspiration and less positive during expiration. I know that this is true for mechanical ventilation, but I am wondering if CPAP has the same effects on intrapleural/intrathoracic pressure?
So is transmural pressure highest at the end of inspiration?
Great ! Thanks a lot ..which app are u using
If the alveolar pressure is at 0 at the end of inspiration, how does it change/go into +1 during expiration? I am still not fully clear on that.
As you expire air out volume of lungs decrease and pressure will increase it increases to +1 (means 761mmhg ) and because of high pressure air goes out of your lungs ....till the pressure of lung reaches to 0 ( means 760mmhg)
May be you understand now ......
it is cool, very clear and helpful video, and always be my fav channel
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