Calcium & IP3 Pathway

[@shontamanning7960]

Explained this better than my professor!!!

[@hussainbiology]

Thanks Shonta for appreciation.. Really glad to know that it helps.

[@thicccnoodle5887]

Your 4 minute videos literally sum up my hour long lectures

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@haylynn_tan]

Thank you for the explanation, it is so straight to the point that helps me understand the concept now. Now I can do for my finals better, well I hope so. But still thank you , you are life saver

[@hussainbiology]

Glad to hear that it helps..........Always here to Help you...................

[@ishmail61]

what a legend, made it so clear with beautiful accompanying diagrams.

[@hussainbiology]

Thanks brother for appreciation.... Glad to know that it helps

[@cliffordwilliams9597]

Beautiful concept, amazingly illustrated! Thank you so much!

[@hussainbiology]

thanks for appreciation..Glad to know that it helps

[@theangkorwatt3468]

Thank you for explaining better than my proffessor. :)

[@hussainbiology]

thanks for appreciation..Glad to know that it helps ✌️

[@iris-hb9qs]

my textbook was extremely confusing and unclear, so this video was super helpful! thank you.

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@bambathiam6221]

Thank you, the most simplified answer among all videos about PLC.

[@hussainbiology]

Thanks for appreciation...Glad to know that it helps.

[@teslaonlineschool-theschoo9475]

Amazing explanation... thank you very much.

[@hussainbiology]

Thanks Imthaz for appreciation.... keep sharing and supporting

[@ritikchaudhary2200]

Now the doubt is clear. Thank you sir.

[@hussainbiology]

Keep watching

[@mg2172]

thank you so much for explaining this!! pls keep up the amazing work!

[@hussainbiology]

thanks Maggie for appreciation..Glad to know that it helps

[@miinddaud1469]

Very Well explained... Excellent 👌 thank you...

[@carolinedacus3998]

Thank you for all of your videos! They never disappoint!

[@evamadaan4933]

You are helping a lot 🌸.. Your videos are just awesome 🙌🙌👏👏

[@hussainbiology]

thanks Eva for appreciation... Glad to know that it helps ✌️

[@alevelsdemystified3410]

1.Signalling molecule ie first messenger binds with G coupled transmembrane receptor.
2.Binding induces a conformational change in the receptor.
3.Conformational change in G coupled transmembrane receptor, effects a change in intermediary G protein attached to its intracellular end.
4.Alpha subunit of G protein let's go off its attached GDP and instead binds with GTP.
5.Alpha subunit gets activated moves along the length of the plasma membrane to reach a specific membrane phospholipase called Phospholipase C.
6.Phospholipase C gets activated travels along the membrane to reach its specific substrate PIP2 which is Phosphoinositol diphosphate (a particular phospholipid)
7.PLC cleaves PIP2 to produce IP3 ie Inositol tris phosphate and DAG(diacyl glycerol)
8.So in previous step secondary Messenger has been made... IP3 leaves membrane and goes to the Cytoplasm where it does its Thang! 😂

[@hussainbiology]

Loved the commentary....

[@alevelsdemystified3410]

@@hussainbiology hopefully that's not sarcastic
I actually just wrote down all the stuff.. I heard from ur video...for processing purposes. Hopefully u don't mind.

[@hussainbiology]

No not at all.....😊😊

[@milipal7364]

it was very helpful, beautifully explained. Thanks!

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@rubyyxlc3936]

You made it so simple thank you!

[@hussainbiology]

thanks for appreciation......Keep supporting

[@kaulickmitra6898]

Beautiful way of explanation

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@morgansasser7496]

Dude seriously thank you so much! I usually understand this material right off the bat but my teacher made this seem so far out there complicated... anyways, thanks to you I’ll pass Biochem! :))

[@hussainbiology]

Thanks Morgan for appreciation......Glad to know that it helps.... All the best for exams

[@bojjavenkatanarasai9432]

Again it's my pleasure to have Ur video

[@hussainbiology]

Thanks for ur kind words

[@shaimarifaie2605]

I wonder if my teacher's were so good! :-(
Thank you!
Great help!

[@hussainbiology]

Thank you so much for appreciation , and i am really glad to know that it helps.....Keep supporting

[@Anne-kg7ee]

It was a masterpiece explanation 🔥🔥🔥🔥thanks it was so helpful 💯
And please go on ❤️❤️❤️❤️

[@hussainbiology]

thanks for appreciation.. Glad it helps ✌️

[@christianfasiku5071]

This is nice and concise. Nice work!

[@riyadmansour5237]

Thanks a lot i was struggling!❤️

[@hussainbiology]

thanks for appreciation..Glad it helps

[@drahsanjavaid9076]

Phhhaast Messengeuuurs 🤔
Nice Explanation Btw 👍

[@hussainbiology]

thanks for appreciation.....

[@ishaadas_]

Much helpful😊

[@tradingworld865]

Keep it up bro 🙂 may Allah give u more success ⭐✨

[@hussainbiology]

thanks for appreciation..Glad it helps ✌️

[@lyalo5717]

Thank you verrrrrry very much very helpful you made it so easy 👏👏👏

[@hussainbiology]

Thanks Lya for appreciation.... glad to know that it helps

[@north_pakistan_]

Great Hussain bai

[@hussainbiology]

thanks bhai

[@drsaharabdulkarim8996]

thank you so much
if you dont mind speak a bit slower in your future videos that will be highly appreciated other than that you are really great

[@hussainbiology]

And from here , i thank you so much.......InshaAllah in future videos i will try to slow down a bit.........

[@tostitosfritos1748]

Just slow down the video it should help

[@ysynapse364]

if he were to talk slower I might die of old age

[@louiceize]

Very well explained thanks !

[@hussainbiology]

thanks for appreciation..Glad it helps

[@shivaninegi5868]

Thanks it is very useful video for quick learning in xam time☺

[@hussainbiology]

Appreciate ur words Shivani...... Really Glad to know that it helps......

[@wenger9461]

great explanation my brother!

[@hussainbiology]

thanks brother for appreciation.....

[@someone_has_found_the_trea2734]

I watched this video @0.75 speed😁
But no doubt this is the best.

[@hussainbiology]

Thanks Anushka for appreciation.....
U know , i am tired of saying to others who complain , that play it at 0.75x.
But u are too smart to play it without complaining... Thanks

[@someone_has_found_the_trea2734]

@@hussainbiology thanku. my pleasure.

[@hussainbiology]

You are welcome.. Anushka...Keep sharing and supporting

[@chesirarizkiagreatia2541]

Thank you so much your video really helps me. i love the animation,great work!

[@hussainbiology]

I really appreciate your support........

[@SonuBotany]

Is IP3 break zono pellucida protein into PIP2 and DAG????

[@ramchandrasuthar2848]

Very nice sir
Great shot

[@sheebazafer5476]

Can I write this if they ask " discuss the role of phospholipase-c" ??

[@hussainbiology]

You can write the Calcium Pathway directly......
But point the bold points abt the role of Phospholipase C :
1.The Phospholipase c has an enzymatic activity to cleave Phospholipids.
2.The Phospholipase C has a role in Signalling Transduction Pathways like in IP3 Signalling pathway where the Phospholipase c cleaves the PIP2 to IP3 and DAG.
4.So another role of PLC is the production of secondary messengers in the form of IP3 and DAG.
5.IP3 drives IP3/Calcium Signalling Pathway.
6.DAG membrane bound messenger drives PKC mediated pathways.
And after all these points you can illustrate the role of PLC in IP3 pathway

[@pzahariew]

Thank you very much for what you are doing! =)

[@hussainbiology]

Thanks buddy for appreciation..Glad to know that it helps.

[@nourhane2247]

Thanks a lot🙏

[@jonahday6344]

This was so helpful my man!!

[@pandiaye94]

Ramadan Mubarak to all my muslim brothers and sisters!!!

[@hussainbiology]

Ramadan Mubarak....

[@Zehra-9809]

Can anyone tell me that it's for chemistry or for biology I'm confused little bit...

[@hussainbiology]

it is for biology ( to be specific then it is in Biochemistry )

[@vilotoliwotsa9294]

Does this pathway occurs in plant ??

[@Toufeque]

Video on effects of calcium release.

[@minakshiwanjari4139]

Good seminar

[@hussainbiology]

Thanks for appreciation...

[@justmeemi6350]

Perfect!! Thank you so much!

[@murukeshtimetvm4119]

Thank you ❤️

[@hussainbiology]

most welcome

[@jyotikumari-vc4ep]

Just in 5 mins🔥

[@hussainbiology]

Yes

[@mima8960]

thank u sir it's such an amaizing explication but I have a question if u don't minde : who activate the PKc is it calcium-calmodulin complex or it is DAG who did it ?
and thank u again

[@hussainbiology]

Thanks for appreciation....I am glad to know that it helps....
For your question i can say it is the increased concentration of DAG in the cell that Signals the activation of PKC and most of the Research papers still state that it is ambiguous ,how PKC is activated....
Thanks again....

[@mima8960]

Thak u sir ....
So I just want to know for a last time 😅😅what is the major effect of high concentration of calcium-calmodulin inside the cells ????

[@hussainbiology]

Major Effect i can say is that when the Calmodulin gets activated by binding of Calcium ions then after that the conc of The complex increases which in turn activates many Kinases and Phosphatases im accordance with the pathway to be initiated.....hope u get some help.......
Thanks again

[@mima8960]

Hussain Biology thank u I m eternally grateful for your help sir and I wish u all the best and more success teachers like u are not easy to find.

[@hussainbiology]

It is my pleasure to help you out..........I am always here to help you.....
Thanks for ur support 😊😊

[@drsultansaudagar2733]

classic video...👍👍👍

[@hussainbiology]

Thanks Dr...............

[@kyliebrown5082]

great vid very helpful thanks

[@hussainbiology]

Glad to hear that it helps......And thanks for appreciation......Kylie

[@kamrankhan-en1if]

Sir what is angiogenesis pathway in pl3 ? reply me , i have exame after 2 days

[@hussainbiology]

That is mediated through VEGF-A .....
VEGF-A is received by VEGFr2 receptor on cell which then activates on dimerization.
And in the next step PLC gamma is activated which then drives formation and activation of IP3 .
Then IP3 does same what is shown in this pathway ( calcium release)
Which finally aids in Angiogenesis.

[@wedme6379]

What is IPC? Is it Interferon producing cell?

[@abcdefghijklmno1009]

Such a good video

[@chatreechai-adisaksopha4355]

Thank you so much.

[@hussainbiology]

you are welcome ✌️

[@bharatt.v.5060]

It's okay..but not all about it.. must write DAG in the diag.

[@stitidash7511]

Nice handwriting

[@hussainbiology]

Thanks Stiti....

[@shwethakrishna3716]

Nice sir

[@hussainbiology]

thanks Shwetha for appreciation....😊

[@shwethakrishna3716]

Your vedios makes concept very clear... Thanks a lot sir ji

[@hussainbiology]

You are welcome...... Keep sharing and supporting ✌️

[@shwethakrishna3716]

Sure sir

[@immanyaby9028]

short and clear.thanks

[@hussainbiology]

Thanks Imma for appreciation....Glad to know that it helps....

[@thermotronica]

Loved it !!!

[@hussainbiology]

Thanks bro.....

[@mariabulley6142]

Very helpful!

[@hussainbiology]

Thanks Maria :)

[@strawberrylala5529]

🙌🏽🙌🏽🙌🏽🙌🏽🙌🏽

[@hussainbiology]

Thanks for appreciation......

[@8887koko]

Thank you T.T

[@hussainbiology]

Thanks for appreciation....Glad to know that it helps

[@suepreme1876]

amazing, thank you

[@hussainbiology]

And i thank you for ur kind support......

[@itzbreex3]

made sooooo much sense! thank you for making this video!! :)

[@hussainbiology]

Glad to hear that it helps.......and thank you so much for appreciation

[@yogayantra]

yes, it's excellent, but so fast. I changed the settings for the speed... but now the words were less clear,

[@hussainbiology]

thanks for appreciation..And next time i will make sure I speak slowly

[@yogayantra]

@@hussainbiology thank you so much

[@عبدالكريم-ص8ظ6ي]

Where is the PDF of this video I want it ❤

[@danielaramos4089]

amazing

[@hussainbiology]

Thanks Daniela for appreciation....

[@sourireunique]

thank you sooo much!!!!

[@hussainbiology]

Thanks Jbid for appreciation....

[@prayfortruejustice]

Super!

[@hussainbiology]

thanks for appreciation

[@mAsElFsOoZ]

thank you so much

[@mohameddrici4887]

thank you

[@hussainbiology]

Glad to know that it helps....

[@latifabouabdallah6746]

Biiiiig thumbs up

[@hussainbiology]

thanks for appreciation...Glad to know that it helps

[@rahiejaan9492]

Thanku sir

[@hussainbiology]

You are welcome Rahie...Keep sharing and supporting

[@sagarsharma3419]

Thanku so much

[@hussainbiology]

Glad to know that it helps,,,, thanks for feedback

[@fatimaaffany6749]

thank you!!!

[@hussainbiology]

really glad to know that it helps.....

[@sftdopamine868]

Mercii

[@hussainbiology]

Thanks buddy

[@salsabilali5585]

Thank u!!!!

[@hussainbiology]

Glad to Know that it helps.......Keep supporting..

[@rajivsupra2011]

good man

[@hussainbiology]

Thanks buddy

[@abhi15geet]

Shadi me Jana hai kya... Ji itna jaldi jaldi Smjha rha hai

[@arslansulemani194]

jani thora aihsta bola kro
by the way thanks

[@brothersgamerz4700]

.

[@vitekskala]

If only this video was in English

[@abhi15geet]

Abe dhire dhire samjhaya kar...

[@AM-gc2wu]

Thank you