Therapeutics Initiative
Therapeutics Initiative
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Відео

Dr Daniel Kadlec: Common Errors in Meta-Analyses & Metaregressions in Strength+Conditioning Research
Переглядів 5821 день тому
TI Methods Speaker Series: Common Errors in Meta-Analyses and Meta-Regressions in Strength & Conditioning Research. Presented by Dr. Daniel Kadlec on 23 October 2024.
Dr. Mohsen Alayche: Evaluating prospective study registration & result reporting of trials in Canada
Переглядів 81Місяць тому
TI Methods Speaker Series: Evaluating prospective study registration and result reporting of trials conducted in Canada from 2009 to 2019. Presented by Dr. Mohsen Alayche on 25 September 2024.
Dr. Caspar J. Van Lissa: Text Mining Systematic Reviews: New Directions for Qualitative Research
Переглядів 883 місяці тому
TI Methods Speaker Series: Text Mining Systematic Reviews: New Directions for Qualitative Research Synthesis. Presented by Dr. Caspar J. Van Lissa on 31 July 2024.
Dr. Jennifer Petkovic: Equity in Evidence Synthesis
Переглядів 794 місяці тому
TI Methods Speaker Series: Equity in Evidence Synthesis. Presented by Dr. Jennifer Petkovic on 26 June 2024.
BC Provincial Deprescribing Series Webinar #7
Переглядів 2475 місяців тому
BC Provincial Deprescribing Series Webinar #7. Presented by Dr. Shawn Gill, Dr. Marrison Marwood, and Dr. Shayna Henry on 12 June 2024
Dr. Larissa Shamseer: Preprints: Catalyzing Equity and Integrity in Scientific Discourse
Переглядів 555 місяців тому
TI Methods Speaker Series: Pre-prints: Catalyzing Equity and Integrity in Scientific Discourse. Presented by Dr. Larissa Shamseer on 29 May 2024.
Dr. Mark Horowitz: Antidepressant withdrawal effects and how to safely stop them
Переглядів 13 тис.6 місяців тому
TI Best Evidence Webinar: Antidepressant withdrawal effects and how to safely stop them. Presented by Dr. Mark Horowitz on 8 May 2024.
Matthew B Jané: Artifact corrections for effect sizes
Переглядів 976 місяців тому
TI Methods Speaker Series: Artifact corrections for effect sizes. Presented by Matthew B Jané on 24 April 2024.
Prof. Stephen Senn: Research synthesis is older than you think. Some early pioneers of meta-analysis
Переглядів 2087 місяців тому
TI Methods Speaker Series: Research synthesis is older than you think. Some early pioneers of meta-analysis. Presented by Professor Stephen Senn on 27 March 2024.
BC Provincial Deprescribing Series Webinar #6
Переглядів 1 тис.8 місяців тому
BC Provincial Deprescribing Series Webinar #6. Presented by Dr. Juan Maria Rubio Lopez and Sadie Quintal on 13 March 2024
Dr Jessica Otte, Dr Aaron Tejani: Becoming an evidence detective - Critical appraisal for clinicians
Переглядів 1188 місяців тому
TI 2023 Annual Conference: Becoming an evidence detective - Critical appraisal for clinicians. Presented by Dr. Jessica Otte and Dr. Aaron Tejani on October 14, 2023.
Dr. Javier Bracchiglione: Overlap of primary studies in overviews
Переглядів 1438 місяців тому
TI Methods Speaker Series: Overlap of primary studies in overviews. Presented by Dr. Javier Bracchiglione on 28 February 2024.
Dr. Josh Levin: What is Portrait Online?
Переглядів 358 місяців тому
What is Portrait Online? Presented by Dr. Josh Levin.
Dr. Tom Perry: Case-based polypharmacy
Переглядів 2108 місяців тому
TI 2023 Annual Conference: ACase-based polypharmacy. Presented by Dr. Tom Perry on October 14, 2023.
Dr. Cait O'Sullivan and Dr. Vincent Wong: Bupropion - A discussion of its efficacy and safety.
Переглядів 1699 місяців тому
Dr. Cait O'Sullivan and Dr. Vincent Wong: Bupropion - A discussion of its efficacy and safety.
Dr. Tom Perry: Using simple pharmacokinetics to optimize prescribing
Переглядів 1149 місяців тому
Dr. Tom Perry: Using simple pharmacokinetics to optimize prescribing
Dr. Wade Thompson: Statin deprescribing for older adults
Переглядів 7569 місяців тому
Dr. Wade Thompson: Statin deprescribing for older adults
Dr. Anshula Ambasta: Approach to rational laboratory test utilization
Переглядів 13610 місяців тому
Dr. Anshula Ambasta: Approach to rational laboratory test utilization
Dr. Rita McCracken and Dr. Wade Thompson: Is any sleep medication ever a good idea?
Переглядів 23410 місяців тому
Dr. Rita McCracken and Dr. Wade Thompson: Is any sleep medication ever a good idea?
Dr. Colin Dortmuth: Likelihood ratio meta-analysis
Переглядів 7211 місяців тому
Dr. Colin Dortmuth: Likelihood ratio meta-analysis
Dr. Guylène Thériault: Is screening misunderstood?
Переглядів 71111 місяців тому
Dr. Guylène Thériault: Is screening misunderstood?
BC Provincial Deprescribing Series Webinar #5
Переглядів 155Рік тому
BC Provincial Deprescribing Series Webinar #5
Eitan Agai: Addressing challenges for applying systematic review methods using AI
Переглядів 91Рік тому
Eitan Agai: Addressing challenges for applying systematic review methods using AI
Krystle Amog: Right Review tool: development, evaluation and application
Переглядів 85Рік тому
Krystle Amog: Right Review tool: development, evaluation and application
Dr. Tom Hardwicke: Improving science through meta-research
Переглядів 132Рік тому
Dr. Tom Hardwicke: Improving science through meta-research
A brief introduction to using Portrait Online. Presented by Alecz Reyes and Arrietty Song
Переглядів 41Рік тому
A brief introduction to using Portrait Online. Presented by Alecz Reyes and Arrietty Song
Dr. Carole Lunny: Introduction to a new risk of bias tool for network meta-analysis
Переглядів 167Рік тому
Dr. Carole Lunny: Introduction to a new risk of bias tool for network meta-analysis
BC Provincial Deprescribing Series Webinar #4
Переглядів 297Рік тому
BC Provincial Deprescribing Series Webinar #4
Dr. David Juurlink: Relieving pain in the era of fentanyl
Переглядів 582Рік тому
Dr. David Juurlink: Relieving pain in the era of fentanyl

КОМЕНТАРІ

  • @LoraineBatchelor-yl2uw
    @LoraineBatchelor-yl2uw 9 днів тому

    Desperate to come off my sertraline. I have been on them for nearly 8 years and cannot get off them. Struggling at the moment as i ran out of my 25mg and forgot to reorder them. I slowly came down from 150mg last year. I get as far as 25mg but have had no help to get lower. Initially I tried on my own this time asked GP help but she told me to from 100mg take it every other day and so on. No help after 25mg . I am beginning to think I will never get off them. I used to struggle in the winter, (still do) so would take st John's wort through the winter and could come off them easily. However since being put on antidepressants after my marriage break up every time I have tried to stop I end up on a higher dose , then a higher dose and the cycle continues. All suicidal thoughts etc has always been when I am on them or stopped them. I never had problems in that way prior to taking them. They the meds are ruining my life

  • @compassionateconversations441
    @compassionateconversations441 10 днів тому

    Thank you so much for putting this information out to the world. I refer clients to this video so they can: a) learn about the withdrawal effects of coming off of psychotropics and b) how they can manage withdrawal very gradually to minimize these effects.

  • @0hhwhoisshe
    @0hhwhoisshe 10 днів тому

    Dr, you are the best. Thank you for your enlightment.

  • @1111sage
    @1111sage 12 днів тому

    Thank you so much for your honest open approach ❤

  • @jacklane6076
    @jacklane6076 17 днів тому

    Such sympathy for this lady, must have been a frightening experience for her. Living with Epilepsy is no joke, I have been taking Phenytoin and Tegretol for 46 years, thankfully, I have never experienced toxicity. I hope the lady remains now in a stable condition😘

    • @ClarkIsraeli
      @ClarkIsraeli День тому

      46 years on Phenytoin without toxicity. So can we say that the people who have complaints about Dilantin is because they were taking the medication at toxic levels?

  • @cpodgorelec
    @cpodgorelec 19 днів тому

    Bravo. Standing ovation. Very interesting and important information. 🌷 South Australia

  • @kjgarner9186
    @kjgarner9186 22 дні тому

    I have to say after trying to stop one recently and then getting back on half after too many zaps and anxiety, I think we should remember that some anxiety and the depression may be associated the fact that we’ve realized we’ve been ‘screwed so to speak’ by no one telling us anything. Also, we’ve realized this isn’t gonna be easy. So I agree that exercise is good to help with that part. Great info !!! Not giving up 😊

  • @lifeAfterSSRIs
    @lifeAfterSSRIs 26 днів тому

    I was able to quit sertraline with zero withdrawals thanks to exercising and drastically reducing sugar consumption. I had tried to quit sertraline at least 7 times over the course of 13 years, and had horrible withdrawals every time. When i finally succeeded, I was on my diet and exercise regimen and simply ran out of my medication because of procrastination. The withdrawals were completely gone. It was an unexpected result. I've been off the medication for four years now.

    • @1111sage
      @1111sage 12 днів тому

      You have been bless I've been on sertraline and other ssri 30+ years ...off sertiline 2 weeks Today was hell on earth. Anxiety Angery frustration

    • @1111sage
      @1111sage 12 днів тому

      Also no suger weight loss more exercise last few days no Engery

    • @lifeAfterSSRIs
      @lifeAfterSSRIs 5 днів тому

      @@1111sage I would definitely recommend getting into the diet and exercise FIRST, while you're still taking the medication. And make sure you're working with a doctor! Don't do it alone!

  • @Adrem37733
    @Adrem37733 Місяць тому

    These drugs should be banned from the market.

  • @oanavoiculescu3505
    @oanavoiculescu3505 Місяць тому

    Can you suddenly lose muscle in Prozac withdrawal?

  • @JamilaLoubrielModelActress
    @JamilaLoubrielModelActress Місяць тому

    That’s my old psych ! He knows his stuff !! Somebody def needs to call this OUT!! I’m here for it !!!

  • @DavidCurryFilms
    @DavidCurryFilms Місяць тому

    God only knows why the liquid form is the prescibed way to taper off. I had to beg my PCP to see a psychiatric pharmacist to get liquid... even then 1mg changes from 10-9-8 are drastic and painful. Those shit heads told me to keep going on just 5mg when alternating 10-5 put me in crisis 😭.

  • @arthurmurfitt7698
    @arthurmurfitt7698 Місяць тому

    Dr. Mark Horowitz is a beacon of light in the darkness… 🙏🏻❤

  • @mudbutton2
    @mudbutton2 2 місяці тому

    I was put on 10mg of Lexapro by my GP as I was going through a stressful life event, some 12 years ago. I was never told about coming off, how long to stay on, or what it was like to stop. About three years later I tapered off and felt OK until a stressful event soon after stopping, whereupon I had worse anxiety and panic than I had before I went on the drug. So I went back on. I later had my dose increased to 20mg by a psychiatrist. I'm tired of the side effects (tinnitus, a bit of weight gain and I just hate taking drugs which I think I'm only on because I can't get off. ) I tapered off once again several months ago and was feeling ok but once again another life stressor soon after threw me into anxiety and panic. I think I just had not adapted and had maybe tapered too fast. I am tapering very slowly now, and hope to be free of this drug in maybe a year or so. I'm in no hurry because no way do I want to feel the terrible discontinuation effects, which are downright dangerous. Think very carefully and get proper advice before starting psych drugs.

  • @woodyshade
    @woodyshade 2 місяці тому

    Do side effects go away after few weeks or they are permanent?my doc says they won t subside.

  • @ashleynanos57
    @ashleynanos57 2 місяці тому

    Youre truly amazing. Thank you for this and for sticking up for all these people who are gas lit by their doctors. The world needs more of this.

  • @AngelWings-uu7rh
    @AngelWings-uu7rh 2 місяці тому

    Dr are clueless. I was also told relapse. I was assaulted and hospital put me on AD

  • @janetmorrison2710
    @janetmorrison2710 2 місяці тому

    Why aren't the Dr's following what you are saying as I have mentioned this to my Dr's and they refuse to follow your suggestions on how to come off peroxitine also been told they don't prescribe lower doses like drops ect.Can you give me answers to this.

  • @vincemarshall8550
    @vincemarshall8550 3 місяці тому

    brilliant video that gives me some hope ,been on 20mg citalopram for 11 years thinking i was permanently screwed by anxiety ,looks like i have a fight on my hands but at least theres a strategy i can follow ,thank you Dr Mark

  • @claireh.7605
    @claireh.7605 3 місяці тому

    You have to schedule and wait for an appointment and then you have to have the skills to discuss things with a doctor: why wasn’t this info given when this med was prescribed? Had I known you need patience and diligence to quit, I would have been started it!!

  • @vincemarshall8550
    @vincemarshall8550 3 місяці тому

    thanks for this ,i finally found a word for the description of what im feeling when i try to withdraw from ssri,s .......akathisia ,its so insidious but at least i have a name for it

  • @dtseringdorje
    @dtseringdorje 3 місяці тому

    After taking dopes called as antidepressant you are left fucked up even more than before treatement. Who profits on you...? Figure it out before professionals tell you do what you are told and take your pills for your own good.

  • @monamour3414
    @monamour3414 3 місяці тому

    I have been trying to taper again off of Cymbalta for 2 years. I am going through hell with severe anxiety and panic sensations. It's a nightmare! Been using a compounding pharmacy and they haven't been using a hyperbolic taper. I really need help!

    • @susanmorgan4151
      @susanmorgan4151 3 місяці тому

      You sound like me. I'm so sorry. I'm 14 months off at this point. Expect to experience "windows and waves" . Getting enough sleep is imperative. For me , SMALL doses of Marijuana helps. But each person responds differently. ....so be careful with any medication. I found my body/brain responds differently to most meds , then before withdrawing from SSRI's. So again , be careful . You can do this.❤

  • @nicolascamacho319
    @nicolascamacho319 3 місяці тому

    Damn psychiatrists.... they destroy lifes. I wish I have never met one of them

  • @nanadoodlez4209
    @nanadoodlez4209 3 місяці тому

    I'm so grateful to find your videos and learn about your studies. I believe this is vitally important. I've been following protocol from Facebook support group, Cymbalta hurts Worse. The moderators are so compassionate and very wise, especially Maria Pastoor. (who I saw you interviewed at beginning of July 2024). I began my taper from 60 mg capsule. After 20+ years of taking it I began my taper on 7/21/2020 (I find creating a spreadsheet to document my progress and symptoms has been very helpful). presently I am only taking 2mg/daily, although I take 1/2 dosage twice a day, because Cymbalta has an extremely short half-life of 12 hours & every 3 weeks I know I won't be able to sleep well for 3-5 days, experience hot flashes, anxiety, spiky headaches, pain & numbness down arms and legs. I started this withdrawal at age 69 and I'm now 73. Listening to this presentation has given me hope that I'm not beginning dementia, although it could be possible as both my mother and older sister had dementia. At my age it's hard to determine if the taper is to blame for my decline in my physcial and mental health. I fear hospitalization because in the US, they don't allow you to bring your own medications & they dispense it from their pharmacies. They don't recognize or understand the delicate balance with counting out tiny beads and that I must have Breckenridge as manufacturer. Back in 2020, no one understood the micro-dosing to taper. I've had a couple of weird episodes and would not go to the ER because of this fear. My pharmacist who fills my scripts laughed at me the first time I tried explaining what I intended to do, but in the past 4 years, she has become much more informed. My family Physician argued with me about the proper method but has agreed to continue prescribing it for me. I would probably be dead or institutionalized if it wasn't for this peer group, Cymbalta Hurts Worse. Keep up the research. There are at least 40,000 of us who are deeply grateful!!!

  • @Jazzy0316
    @Jazzy0316 4 місяці тому

    I’m on venlafaxine SSNRI for 2 months and I’m stopping. I don’t want to go any further and risk something like this happening. After stopping for a week I feel Nauseous, tired, dizzy, and headaches , I don’t think 2 months is considered longterm

    • @dianemorrell9638
      @dianemorrell9638 3 місяці тому

      @@Jazzy0316 you're right. 2 months is enough to change brain chemistry. I am finishing a 4 year taper from 30 years of effexor. It messes with serotonin doesn't fix anything. So happy you are trusting your gut.

  • @Jazzy0316
    @Jazzy0316 4 місяці тому

    I’m on venlafaxine SSNRI for 2 months and I’m stopping. I don’t want to go any further and risk something like this happening. After stopping for a week I feel Nauseous, tired, dizzy, and headaches

  • @jiririnagl302
    @jiririnagl302 4 місяці тому

    Nice i have only 75 and 50 mg tablets of Effexor in my country, thats it. :D gues im fucked.

  • @janiebobs
    @janiebobs 4 місяці тому

    I am off Citalopram after 16+ years. I am so short fused and swear readily. I have been off one month. Still have brain zaps, heightened emotions generally. I would say the anger/reactionary behaviours are tge worst symptoms. Worse than crying readily and zapping. From all I havecheard it could be a very long time before the withdrawal symptoms abate! There are not many success stories, if any, to help keep you going either which is almost ominous!.

    • @shellyschmidtRE
      @shellyschmidtRE 3 місяці тому

      I went off Citalopram 4 weeks ago, after 25 years. I'm still having withdrawals. My biggest physical distressing symptom is dizziness, and equilibrium issues....which cause nausea. Are you getting better? I am pretty much homebound.

    • @janiebobs
      @janiebobs 3 місяці тому

      I am determined to keep going. I still have somewhat 'immediate emotions ', but certainly more clarity of thought!

    • @tchillism
      @tchillism 3 місяці тому

      I was on Lexapro for 16 years as well. Tapered for six weeks. It’s been 2 1/2 months and I feel moderately depressed. I can still function fairly well, but I know the way I feel is not normal. Has anyone else thought about going back on their medication’s and then tapering according to his recommendations? Or having been off for 2 1/2 months maybe it’s better just to see the withdrawals through to the end..

    • @shellyschmidtRE
      @shellyschmidtRE 3 місяці тому

      @@tchillism You say you are functioning… Was there a time within those 2 1/2 months that you were not functioning? Did you steadily feel better during those 2 1/2 months? I tapered really quick at the direction of my doctor, about 3 1/2 weeks, I was on citalopram for many years. Equilibrium is the hardest part for me as it keeps me pretty much homebound. I am at four weeks since my last dose. I can feel my anxiety creeping in, especially in the mornings. I have generalized anxiety disorder, no depression. However, all of this has caused me to feel a bit depressed. I'm just wondering if you can tell me how you felt through the 2 1/2 months. As far as going back on your medication, I wonder about that each day as well, however, at this point I just feel like maybe pushing through to see where my baseline is Would be the better choice. Since I don't have depression, my doctor would like to see me go on Buspar for my anxiety, however, I'm pretty gun shy now about taking anything. If I did decide to try that, I think I would still want to see where my baseline is. I just need to be able to get out of my house and function.

    • @janeekitchen7727
      @janeekitchen7727 3 місяці тому

      @@tchillism Only you know you...but for me at 67 i want to try and see it through. I actually am thinking for clearly. x

  • @artealain
    @artealain 4 місяці тому

    Is this talk available to download and print out. I would really like to give it to my new doctor.

    • @drug_evidence
      @drug_evidence 3 місяці тому

      Thank you for your interest in Dr. Horowitz's presentation. The transcript is viewable by clicking on the description of the presentation (just below the video recording on UA-cam). Dr. Horowitz may also be contacted through his website for more information: markhorowitz.org/contact/

  • @joeallan3706
    @joeallan3706 4 місяці тому

    im lucky, i quit paxil 30mg after being on it over 20 years cold turkey about 2 months ago and had no withdrawal. whenever i attempted to before it was awful. after 7 days without it i was like "oh crap i didnt take my paxil for week! and i feel fine, im just going to quit" i feel so much better off that stuff. i have emotion now! and not just flat affect, its like i was living in black and white and the color is back now

  • @juliesaadwellness
    @juliesaadwellness 4 місяці тому

    Wow - the second case study! It’s shocking. I’m so angry on behalf of that young woman. No one listened to her at all.

  • @SEOExpertSojib
    @SEOExpertSojib 4 місяці тому

    You are uploading videos constantly but your contact not getting views or subscribers. Because there is some SEO problem. You should fix your content title, description, and tags. Make all things SEO friendly then your video will gain more views & your channel will grow. Let's discuss how we can enhance your channel's performance! I'm waiting for your response.

  • @vicklassen7227
    @vicklassen7227 4 місяці тому

    Dr could you please help. My husband tried to go off Effexor and then went back on, but for a week took double his dose. He ended up in er because of suicidal ideation. They said to go back down to his regular dose and he would be fine. He’s not fine. Inthe hospital again and now they put him on remron? Spelling wrong. Now it’s been 3 weeks and he is still unable to work, he can barely eat, can’t do anything. What do i do? The dr wants to put him on more drugs. I’m so afraid, please please help.

    • @vicklassen7227
      @vicklassen7227 4 місяці тому

      ​@@TheresaR.Amen Jesus is King. What dose of mitazapine are you on if you don't mind me asking

    • @1111sage
      @1111sage 12 днів тому

      @Theresa R I wish I had the knowledge to help I was on effor XL for years it has a horrible effect coming off it and on it . All I can say if this helps you, is. He is being monitored in hospital. Any bad happens he is where everything is near to help him . Try to get some rest knowing this ❤

  • @icydev
    @icydev 4 місяці тому

    Very well said Dr Mark You, Dr Josef hottering. Bob whittaker, have all been life saving to me. I have been taking this drugs all the anti psychotics, benzos, mood stabilizers , SNRi etc from last 20 years and was still not improving and had cold turkeyed several times only to suffer the withdrawals with vengeance . But after going through your seminars , from the last 9 months have started the taper of 10% of the last dose and the wds are hell but manageable bcoz i am simultaneously reducing 3 drugs i.e Lamtrrgiene (mood stabilizers), Prozac (SSRI) and Duloxietene (snris). Have decided to go slow now as i have reached the 25% of my original dose on all 3 tabs. also taking omega 3 and vi- d and vit B12 supplements

  • @Snowflake1374
    @Snowflake1374 5 місяців тому

    I’m 9 months off zoloft 15 years use. Too fast taper by Dr. Severe WD. Feels like injury in my brain. Is there any hope? Will I be disabled for years. Cant work. Pain in my body. Feels like I lost myself and my life.

    • @icydev
      @icydev 4 місяці тому

      Hi @Snowflake1374 Sorry to hear that u are going through the worst of wirhdrawals, it has happened to me too several times as doctors used to rapidly taper me of Ads very quickly in a month and after 2-3 months used to suffer from sever withdrawals that i coludnt even get up from my bed and then again after 4 months of sufferings used to start on new drugs and the cycle repeated. In your case i wld recoomed that as u are already of the drug for 9 months, have seen in a video by Dr josef (he also makes very informative videos on withdrawals) that to reinstate the drug at 50%, so in your case restart at 25mg )hopefully ur symptons will decerse quicly and from there on start reuding the dosage by 10% of previous dose evey 1 month, so for 1st month it wld be 22.5mg, then 2nd month 20.5mg and so on , so it wld take around 30 months to get off the drug but it will surely take u out of the unimagianbele hell of withdrawal. hope it helps.

    • @susanmorgan4151
      @susanmorgan4151 3 місяці тому

      It's horrible. Yes , there IS hope. For me , having people in my life who "get it" is helpful. Talking about what you are going through helps. I would say be prepared mentally for a long withdrawal, but know it DOES get better. It does. A diet high in fat , low to no carbs or sugar seems to help me. Eat clean. Lots of water. Your brain is healing. ❤❤❤

    • @Snowflake1374
      @Snowflake1374 3 місяці тому

      @@susanmorgan4151 ❤️Thanks. Unfortunately, I don't have anyone who "gets it". Did you take them long term?

  • @whatevs1700
    @whatevs1700 5 місяців тому

    Please come back to Australia and set up a clinic here… Melbourne specifically… please 🙏

    • @nikeetamchutchison1547
      @nikeetamchutchison1547 5 місяців тому

      I would definitely see him if he was back here and would even travel from Sydney to Melbourne 100%

  • @mazymonroe8749
    @mazymonroe8749 5 місяців тому

    What length of time after your last dose is considered a protracted withdrawal? I'm 19 months off and still experiencing acute withdrawal symptoms 😢

    • @icydev
      @icydev 4 місяці тому

      Hi If u have tapered quicly, u will surely have nasty withdrawals and if u have tapered at 10% of last dose , the wds are quiet manageable and tapeeing shld continue to the ;ast of 0.01mg. if u are still having acute symptons means u havent withdrawaled prodperly. so my advice wild be start form the 25% of the dose from when u started tapering and start tapeing at the recommedned speed. hopefully u will have manageable wds. hope this helps

    • @dianemorrell9638
      @dianemorrell9638 4 місяці тому

      So terrible isn't it? Thing is time heals. Biochemistry is different for everyone and changes can happen quickly too.

    • @mazymonroe8749
      @mazymonroe8749 4 місяці тому

      2 years to withdraw! That is not too fast!​@@icydev

    • @mazymonroe8749
      @mazymonroe8749 3 місяці тому

      @@icydev I did a harm reduction taper over a long period of time so it has nothing to do with that. It has occurred because of long term use. It can take the brain a long time to heal and function without the meds!

  • @cheryl8956
    @cheryl8956 5 місяців тому

    I commend you for sticking your neck out challenging these drug companies. Your videos are inspiring, thank you.

    • @cpodgorelec
      @cpodgorelec 19 днів тому

      This gentleman is a hero. 😊

  • @cheryllryan8440
    @cheryllryan8440 5 місяців тому

    38 years paxil and xanax and one week hospital to get off. Swear truth. Last October. Now what ??.

  • @susanmorgan4151
    @susanmorgan4151 5 місяців тому

    THANK YOU!❤

  • @karenpeart5997
    @karenpeart5997 5 місяців тому

    I have only been taking mirtazapine for 2 months , and i want to stop ( as i can not tolerate the side effects anymore ) I tried to stop but i got to day 3 and the withdrawal was horrific , feel terrible taking them a d terrible trying to get off tgem ( was put on them becauses of anxiety ( they do not really help , not very good with medication)

  • @arquipaje8441
    @arquipaje8441 5 місяців тому

    I´ve been tapering down from 5mg Lexapro, 10% reductions every two months, and now currently on 2.95mg. This is not medical advice to anyone, but taking the following supplements daily has helped quite substantially in tackling withdrawal symptoms: Vitamin D with K2: 4000units (morning) Vitamin C: 1gram (liposomal) (morning) Omega 3: 800mg EPA + 400mg DHA (at night) Magnesium Glycinate: 120mg (at night) Magnesium Threonate: 122mg (morning) Chaga Powder: 2g serving (served with tea, afternoon) Symptoms are mild the first three weeks after each reduction, then relatively normal functioning the following five weeks (with 1 or 2 miserable days)

    • @snowps1
      @snowps1 5 місяців тому

      How are you reducing the dosage? I have 5 mg pills. Are you just shaving them down? I went cold turkey and it's been 3 months and I'm starting to feel really miserable. I think I need to start it over and wean down but I don't know the best way to do it when I have pills.

    • @Liz-hc4um
      @Liz-hc4um 5 місяців тому

      Thank you for sharing this. I am back up to 5 in readiness to reduce. I went too fast and although no ‘neuro’ symptoms I was impatient, irritable, with bursts of anger and easily startled. I’m thinking of trying 4.5 mg next ( I have the liquid formulation). I am also going to stop trying to do this in secret because it’s been just awful for my relationship. I am also interested to hear that you’re doing this every too months…

    • @snowps1
      @snowps1 5 місяців тому

      @@Liz-hc4um oh my, I've also been doing it in secret and should just fess up to my husband. I'm so grouchy and moody now.

    • @arquipaje8441
      @arquipaje8441 5 місяців тому

      @@snowps1 I live in Chile, and we don´t have either liquid formulations available in the market, or compounding pharmacies that can prepare very small, specific doses of escitalopram. The only alternative I had was to buy the available 10mg Lexapro, which can be easily cut in half because of the notch on the reverse, and then shave each 5mg piece down with an always sharp scalpel to the desired doses. For this, I had to buy a 0.001mg precision scale. It is tedious as hell, and requires time and dedication to make sure you get constant doses. It´s the only way. I went cold turkey from 5mg to 0mg back in January 2011, and I was miserable for about a year and a half before going back to 10mg. I definitely would not recommend that!

    • @snowps1
      @snowps1 5 місяців тому

      @@arquipaje8441 thanks for the tips! I did pretty much stop cold turkey off 5mg and it's been a very rough couple of months, especially the wild mood swings!

  • @CarmenOrtiz440
    @CarmenOrtiz440 5 місяців тому

    Psychedelics definitely have potential to deal with mental health symptoms like anxiety and depression, I would like to try them again but it's just so hard to source out here

    • @JamesFJohnson
      @JamesFJohnson 5 місяців тому

      I’ve been researching on psychedelics and it’s benefits to individuals dealing with Anxiety, Depression, ADHD and from my findings, they really work and I’ve been eager to get some for a while but its been difficult to get my hands on them.

    • @AlbertoTorres894
      @AlbertoTorres894 5 місяців тому

      The Trips I've been having really helped me a lot. I’m now able to meditate and I finally feel in control of my emotions and my future and things that used to be mundane to me now seem incredible and full of nuance on top of that I'm way less driven by my ego and I have alot more empathy as well

    • @LucyFernandez628
      @LucyFernandez628 5 місяців тому

      I was having this constant, unbearable anxiety due to work stress. Not until I came across a very intelligent mycologist. He saved my life honestly

    • @Rogerseegren271
      @Rogerseegren271 5 місяців тому

      ​@@AlbertoTorres894I feel the same way too. I put too much on my plate and it definitely affects my stress and anxiety levels. I am also glad to be a part of this community.

    • @AnaSolano190
      @AnaSolano190 5 місяців тому

      ​@@LucyFernandez628Does he deliver to various locations?

  • @Me-fs5mi
    @Me-fs5mi 5 місяців тому

    Execelent presentation Mark. Especially the graphs ( VISUALS)......they are true for most taperings I imagine. How would a graph look for those who have successfully stopped the drugs? For younger people who have a fighting chance? What might success look like?

  • @JasonBrown-dd7dj
    @JasonBrown-dd7dj 5 місяців тому

    Thanks Mark, doctors need to recognise this if they knew the damage they can and have done to patients they wouldnt be quick to prescribe.Opiates,benzos ,gabapentinoids and antidepressants can be really damaging.Informed consent thats all patients advocate for.Your a genius in your field of work.Theres people in psych wards that are ill cos these meds victims.

  • @nicolasmezaconcha7686
    @nicolasmezaconcha7686 5 місяців тому

    Thank you for your excellent presentation, Javier

  • @shahnazali4000
    @shahnazali4000 5 місяців тому

    Please can you guide me how to taper successfully Closopine. The doctor initially put my nephew at 450 mg. He withdrew by himself reducing it by 100mg. i.e 350 mg. Thereafter 25mg every 8 weeks or more. He wants to completely ween off this medication. The psychologist is refusing to his tapering. Where can he get help, to overcome withdrawal symptoms ...esp. suicidal symptoms, as this has happened when earlier he was put on Risperidon , which actually causes suicides...PLEASE HELP !

  • @janebond8342
    @janebond8342 5 місяців тому

    This is why I NEVER take pharmaceuticals

    • @MathematicsStudent
      @MathematicsStudent Місяць тому

      That's the wrong takeaway: if you get sick, and there is good evidence behind using a medicine that has been preacribed to you, and the risks outweigh the benefits in your case, then you absolutely should take it. Otherwise you risk dying from a treatable disease, or living with a condition that can be vastly improved. I say this as someone who has tried and failed to taper off SSRIs. The problem is you have to follow the actual scientific evidence, which the guidelines don't always do. I will take a doctor who is extremely knowledgable about the latest state of the evidence every day of the week. I mostly get frustrated with doctors who (usually through no fault of their own) are not current with their knowledge of actual state of the evidence. The dream would be to have everyone treated by a combo clinician/researcher with a nonstressful work load who is able to think, read, and deeply analyze every case.

  • @pradeepdatta2168
    @pradeepdatta2168 5 місяців тому

    Excellent presentation.Dr Horowitz may kindly also do presentations on tapering by elderly patients as their cases are different from other adults ie < 65 years.