天主教藝術博物館位於大三巴牌坊後的聖保祿大教堂 (天主之母教堂) 遺址內。1990年至1996年間，澳門政府對聖保祿大教堂遺址進行考古、修復和再利用工程，並在昔日聖保祿大教堂主祭壇的位置，建造了墓室和天主教藝術博物館。墓室和博物館於1996年10月23日落成揭幕。
墓室中央為一座花崗岩墓穴的遺址，墓主很可能是聖保祿學院創始人范禮安神父。墓室兩側牆壁上的納骨龕內安放著日本和越南殉教者的骸骨。
天主教藝術博物館位於墓室西側，館內的展品是澳門多間教堂和修院收藏的天主教藝術精品，包括詮釋聖方濟各事跡的四幅油畫，以及耶穌受難像、聖像雕塑、禮拜器物等。其中最引人注目的是油畫《聖彌額爾大天神》。聖保祿大教堂1835年毀於一場大火，這幅油畫是聖保祿學院唯一留存至今的油畫藝術品。
The Catholic Art Museum is located in the ruins of St. Paul's Cathedral (Church of Mother of God) behind the Archway of the Great Three. Between 1990 and 1996, the Macao government carried out archaeological, restoration and reuse projects on the ruins of St. Paul's Cathedral, and built a tomb and a Catholic Art Museum on the former main altar of St. Paul's Cathedral. The tomb and museum were unveiled on October 23, 1996.
In the center of the tomb is the site of a granite tomb, and the owner of the tomb is likely to be Father Fan Li'an, the founder of St. Paul's College. The skeletons of Japanese and Vietnamese martyrs are placed in the ossuary on the walls on both sides of the tomb.
The Catholic Art Museum is located on the west side of the tomb. The exhibits in the museum are Catholic art collections from many churches and monastices in Macau, including four oil paintings interpreting the deeds of St. Francis, as well as statues of the Passion, icons, worship artifacts, etc. Among them, the most eye-catching is the oil painting "The Great God of St. Michael". St. Paul's Cathedral was destroyed in a fire in 1835. This oil painting is the only oil painting artwork of St. Paul's College that has survived to this day.
From Museu De Macau