We will discuss real-time nucleation in weakly coupled, high-temperature quantum field theories (QFTs), with a particular focus on the effects of off-equilibrium plasma on nucleation rates. We begin with an overview of high-temperature nucleation, highlighting its similarities and differences with the well-known scenario of vacuum tunneling. A key feature of the thermal system is its division into two quasi-classical components: nucleating fields and thermal particles interacting with the nucleating bubbles. To compute the nucleation rate, we construct a Hamiltonian description for the system consisting of the fields and off-equilibrium particles. We derive the form of the off-equilibrium corrections to the nucleation rate and demonstrate that Langer's paradigm, augmented with these QFT-specific corrections, holds over Linde's thermal rate. We also establish a connection to Euclidean (imaginary-time) treatments of thermal nucleation, particularly with the effective field theory approach. Additionally, we find that the off-equilibrium effects of bosonic particles are subdominant to those arising from the corresponding off-equilibrium bosonic fields. This presentation is primarily based on the article arXiv:2403.07987.