Michael Fralick
Michael Fralick
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PCR vs culture vs antigen test: everything you need to know in 5 min
PCR vs culture vs antigen test: everything you need to know in 5 min by Hania Siddiqui. Hania is an MSc candidate at the university of toronto and team member at fralicklab.com & cube-ontario.github.io
Переглядів: 56

Відео

SGLT2i: Everything you need to know in 5 minutes
Переглядів 226Місяць тому
www.sglt2rx.com/ www.glp1-rx.com/ References [1] www.nejm.org/doi/full/10.1056/NEJMoa1504720 [2] www.nejm.org/doi/full/10.1056/NEJMoa2107038 [3] www.nejm.org/doi/full/10.1056/NEJMoa2022190 [4] www.nejm.org/doi/full/10.1056/NEJMoa2107038
Ozempic (semaglutide): Everything you need to know in 5 minutes
Переглядів 206Місяць тому
www.glp1-rx.com/ fralicklab.com References www.nejm.org/doi/full/10.1056/NEJMoa2403347 www.nejm.org/doi/full/10.1056/NEJMoa2306963 www.nejm.org/doi/full/10.1056/NEJMoa2307563 www.nejm.org/doi/full/10.1056/NEJMoa1607141
Confounding: Everything you need to know in 5 minutes!
Переглядів 1342 місяці тому
Brought to you by www.fralicklab.com Check out jrnowl.com to stop wasting your time when trying to find journal submission requirements! Higher level teaching point: Confounder is a common cause* of the exposure and outcome and not on the causal pathway. *Markers of a common cause also fall in that bucket. For age to be a confounder it does not have to cause anything but it is a marker for othe...
Stats 101 for med students: everything you need to know in 7 minutes
Переглядів 2473 місяці тому
95% CI: everything you need to know in 5min - ua-cam.com/video/5eAGXsY9LSI/v-deo.html p values: everything you need to know in 5 min - ua-cam.com/video/jZdMYUT1R6Y/v-deo.html Jrnowl.com - a free resource to waste less time when you are submitting manuscripts for publication tinystats.github.io/teacups-giraffes-and-statistics/index.html Thank you to Katarina Zorcic (Queen's University medical st...
Bias: everything you need to know in 5 min!
Переглядів 3236 місяців тому
Brief video to introduce and define bias. Past videos include: - 95% confidence interval: ua-cam.com/video/5eAGXsY9LSI/v-deo.html - p values: ua-cam.com/video/jZdMYUT1R6Y/v-deo.html - RCTs: ua-cam.com/video/cfymxVWy8YY/v-deo.html www.jrnowl.com/ Follow on twitter - @fralickmike
Tight vs liberal glycemic control: 3min summary
Переглядів 787 місяців тому
www.nejm.org/doi/full/10.1056/NEJMoa2304855 cardiotrialfiles.substack.com/
Intro to 95% confidence intervals: 6 min crash course
Переглядів 1,2 тис.7 місяців тому
[1] Great resource here: tinystats.github.io/teacups-giraffes-and-statistics/index.html [2] www.jrnowl.com follow along on twitter @fralickmike
Lecture: crash course from pragmatic to adaptive RCTs
Переглядів 1559 місяців тому
Here is the unabridged version of a lecture I gave on October of 2023 at Mount Sinai Hospital in Toronto, Ontario. www.jrnowl.com trialfiles.substack.com/ fralicklab.com/
P values: everything you need to know in 5 min
Переглядів 1,5 тис.10 місяців тому
Jrnowl.com - a free resource to waste less time when you are submitting manuscripts for publication NEJM Evidence stats stat - ua-cam.com/video/85lLfUHmmYQ/v-deo.html&ab_channel=NEJMGroup Episheets - www.rtihs.org/episheet
3 min RCT: once weekly insulin!!
Переглядів 53610 місяців тому
Twitter: FralickMike The Rounds Table Podcast: podcasts.apple.com/ca/podcast/the-rounds-table/id826703161 JRNOWL: www.jrnowl.com/ www.nejm.org/doi/full/10.1056/NEJMoa2303208
RCT in 3min: SGLT2s improve hemoglobin in CKD!
Переглядів 19511 місяців тому
Twitter: FralickMike The Rounds Table Podcast: podcasts.apple.com/ca/podcast/the-rounds-table/id826703161 JRNOWL: www.jrnowl.com/ evidence.nejm.org/doi/full/10.1056/EVIDoa2300049
Thrombocytopenia - everything you need to know in 3min
Переглядів 252Рік тому
This is a brief 3min crash course on thrombocytopenia meant for medical trainees and generalists (e.g., internists, family doctors). fralicklab.com/
Preventing critically low hemoglobin: 3minute overview
Переглядів 127Рік тому
This video is intended for staff and trainees at St Michael's hospital in Toronto to provide a primer on a new decision support tool. The tool aims to decrease the number of blood transfusions and critically low hemoglobin values
RCT in 3min: Goals of Care Conversations
Переглядів 89Рік тому
Link to article: jamanetwork.com/journals/jama/fullarticle/2805346 Twitter: FralickMike The Rounds Table Podcast: podcasts.apple.com/ca/podcast/the-rounds-table/id826703161 JRNOWL: www.jrnowl.com/
So you want to start an RCT: everything you need to know in 16min
Переглядів 259Рік тому
So you want to start an RCT: everything you need to know in 16min
NG tubes - everything you need to know in 5 minutes
Переглядів 173Рік тому
NG tubes - everything you need to know in 5 minutes
RCT in 3min: CLEAR trial of bempedoic acid
Переглядів 295Рік тому
RCT in 3min: CLEAR trial of bempedoic acid
3min RCT: RSV vaccine for older adults!
Переглядів 121Рік тому
3min RCT: RSV vaccine for older adults!
RCT in 3min: Hydrocortisone in Severe CommunityAcquired Pneumonia
Переглядів 1 тис.Рік тому
RCT in 3min: Hydrocortisone in Severe CommunityAcquired Pneumonia
3 min RCT: IRONMAN - IV iron for heart failure
Переглядів 360Рік тому
3 min RCT: IRONMAN - IV iron for heart failure
ECG crash course in 7min for nurses and medical students
Переглядів 1,4 тис.Рік тому
ECG crash course in 7min for nurses and medical students
A crash course on types of RCTs: Everything you need to know in 6min!
Переглядів 673Рік тому
A crash course on types of RCTs: Everything you need to know in 6min!
3 min RCT: NOSTONE Trial HCTZ for recurrent kidney stones
Переглядів 316Рік тому
3 min RCT: NOSTONE Trial HCTZ for recurrent kidney stones
3min RCT: DELIVER Trial
Переглядів 297Рік тому
3min RCT: DELIVER Trial
Anemia crash course: everything you need to know in 3min
Переглядів 594Рік тому
Anemia crash course: everything you need to know in 3min
Run in phases for clinical trials: everything you need to know in 2min
Переглядів 726Рік тому
Run in phases for clinical trials: everything you need to know in 2min
3min RCT: CLASSIC trial
Переглядів 145Рік тому
3min RCT: CLASSIC trial
3min RCT: Psilocybin for depression
Переглядів 122Рік тому
3min RCT: Psilocybin for depression
3min RCT: chlorthalidone vs hctz
Переглядів 623Рік тому
3min RCT: chlorthalidone vs hctz

КОМЕНТАРІ

  • @TheProblembaer2
    @TheProblembaer2 2 дні тому

    Wonderfull, thank you so much!

  • @abhijithasok4314
    @abhijithasok4314 22 дні тому

    This is the reason why the side effects for Statin were under reported.

  • @heenajariyal6620
    @heenajariyal6620 Місяць тому

    Tirzepatide from Eli Lilly

  • @nesrinaa4844
    @nesrinaa4844 2 місяці тому

    THANK YOU

  • @danielaperezvasquez3340
    @danielaperezvasquez3340 3 місяці тому

    Omg!! This was perfect thanks!

  • @jananys3156
    @jananys3156 3 місяці тому

    thank you so much for this video helped me with my journal club!

  • @ghadah9120
    @ghadah9120 3 місяці тому

    Michael, the man that you’re!! Thank you from the bottom of my heart.

  • @frankpeprah6198
    @frankpeprah6198 3 місяці тому

    Very informative

  • @josephinechikapa9587
    @josephinechikapa9587 4 місяці тому

    Thank you for this lecture it is really helpful

  • @FROSTHAWK247
    @FROSTHAWK247 4 місяці тому

    I am a masters student studying social work and even when the focus of the research is different the process of calculating these scores is more or less similar. This video was a great deal of help and extremely digestible, thank you so much!

    • @Fralickmike
      @Fralickmike 4 місяці тому

      That’s very kind of you. And I’m glad you found it helpful !

  • @frankvanschellen4980
    @frankvanschellen4980 4 місяці тому

    thank you for this great explanation! Is there also a possibility when having 3 treatment groups to calculate propensity scores with the same strategy?

    • @Fralickmike
      @Fralickmike 4 місяці тому

      You’re most welcome. There is but that gets complicated fast! If there are 3 groups and one is the ref then I do two pair wise comparisons to the ref. Hope that helps.

  • @dr.tomadragos-medicreziden1806
    @dr.tomadragos-medicreziden1806 4 місяці тому

    DB RCT are the best! Thank you for the content! Why should i listen to other trials if they are vulnerable to biases?

    • @Fralickmike
      @Fralickmike 4 місяці тому

      Sometimes double blind trials is not feasible and sometimes not possible. also, unblinded RCTs are still very useful. but they are just prone to some biases that double blinded trials are not

  • @josefoso15
    @josefoso15 4 місяці тому

    Fantastic! Nicest explanation of PSM ever

  • @akshitbhalla874
    @akshitbhalla874 5 місяців тому

    Thank you so much for making this video!

    • @Fralickmike
      @Fralickmike 5 місяців тому

      My pleasure. Thank you for your kind words!!

  • @augustinechukwunta680
    @augustinechukwunta680 5 місяців тому

    Great video - well explained

  • @augustinechukwunta680
    @augustinechukwunta680 5 місяців тому

    Great video - you made it so easy to understand

    • @Fralickmike
      @Fralickmike 5 місяців тому

      thank you very much!!

  • @osashruf
    @osashruf 5 місяців тому

    Great vid! Would love to see a crash course on Kaplan-Meier/survival analysis

    • @Fralickmike
      @Fralickmike 5 місяців тому

      Great idea. Will work on that one in the future for sure

  • @yoshtisune
    @yoshtisune 6 місяців тому

    Can you talk about confidence intervals in depth? I’m having a hard time trying to interpret it

    • @Fralickmike
      @Fralickmike 6 місяців тому

      Yes here is recent video on it. ua-cam.com/video/5eAGXsY9LSI/v-deo.htmlsi=58K48FXROpUEm4is

  • @stanislavlegkovoy2119
    @stanislavlegkovoy2119 6 місяців тому

    thanks, pretty clear

  • @svenkreutzer5617
    @svenkreutzer5617 6 місяців тому

    Great, thanks!

  • @silverlight7938
    @silverlight7938 6 місяців тому

    Really helpful, I wanted to ask What is the difference between Propensity score matching and Case control matching (SPSS)?

    • @Fralickmike
      @Fralickmike 6 місяців тому

      Case control matching is unrelated. Here is great resource on everything you need to know about case control studies sphweb.bumc.bu.edu/otlt/MPH-Modules/EP/EP713_Case-Control/

  • @user-uu7co5li9v
    @user-uu7co5li9v 6 місяців тому

    Thanks for the clear explanation!

    • @Fralickmike
      @Fralickmike 6 місяців тому

      My pleasure. Thank you for watching

  • @flori2611
    @flori2611 7 місяців тому

    THANK YOU SO MUCH

    • @Fralickmike
      @Fralickmike 7 місяців тому

      My pleasure. I’m happy you enjoyed it

  • @ericyeh4315
    @ericyeh4315 7 місяців тому

    genius! deeply appreciate this video! helpful for med students drowned by statistical terms

  • @A_Psych_Nurse
    @A_Psych_Nurse 7 місяців тому

    Hi Michael, Appreciate this breakdown, despite most of it going over my head. When you say these statistical methods do not mimic RCTs, what exactly does that mean? How closely do we get to the results of a RCT using this method, and has this method been verified against the findings of RCTs? The reason I'm asking this is b/c I came across a cohort article comparing adolescents who took antipsychotic medication vs. those who didn't, and compared how they were doing 5 years later. The article suggests, after using IPTW, that antipsychotic medication in those w/ their first episode of psychosis, actually makes for a worse 5 year outcome. I'm skeptical though b/c it's a cohort study and no randomization was done. The authors acknowledge this weakness, and then state that the Stabilized IPTW is used to eliminate the possibility that those with worse psychosis were the ones who were given an antipsychotic medication. (I think this is the most probable explanation for why those who were given AP medication fared worse. . .simply b/c they already were experiencing more profound psychosis and so we would expect them to be doing worse at a 5 year follow-up). Seems super fishy to me. . .any thoughts here are appreciated, thx.

    • @Fralickmike
      @Fralickmike 7 місяців тому

      You are totally right to be skeptical. There’s no way to answer this Q “how close do we get to the results of a RCT”. It would be like asking how much does this glass of wine taste like a beer. They are two different things. To learn more about why RCTs are so powerful and what randomization achieves (that no cohort study can) here is link to my 6min crash course on RCTs: ua-cam.com/video/oQt8jR5RgVQ/v-deo.htmlsi=cpMn3c6YQnWYj3wv

    • @A_Psych_Nurse
      @A_Psych_Nurse 7 місяців тому

      awesome, thank you for the insanely prompt and helpful response Michael!@@Fralickmike

  • @yutingchen9701
    @yutingchen9701 7 місяців тому

    great video!

  • @ishikahalder799
    @ishikahalder799 8 місяців тому

    🤩

  • @user-oj2bu6sv3n
    @user-oj2bu6sv3n 8 місяців тому

    Very good lesson except that you are extremely fast. I wish you could slow down your pace

    • @Fralickmike
      @Fralickmike 8 місяців тому

      Thank you for feedback. Note you can slow the speed to 0.75 or 0.5 to slow it down

  • @ajkovic914
    @ajkovic914 9 місяців тому

    Thank you so much. Plz make more videos especially about meta-analysis

    • @Fralickmike
      @Fralickmike 9 місяців тому

      Thank you for your kind words!!

  • @jamesharte8390
    @jamesharte8390 9 місяців тому

    excellent breakdown and synopsis. Thank you.

  • @girlthatcooks4079
    @girlthatcooks4079 9 місяців тому

    There are 3 scores as 0.6, would it be fair/unbiased to match with random 2 only?

    • @Fralickmike
      @Fralickmike 9 місяців тому

      that is a good question. you are right that it would be ok to pick at random. In some studies people match "many to one". so you could keep all 3. But the "ideal" approach is 1:1 based on prior studies.

    • @girlthatcooks4079
      @girlthatcooks4079 9 місяців тому

      @@Fralickmike Thank you!!

  • @ruiz_aeg
    @ruiz_aeg 9 місяців тому

    I learnt so much. Such a good presenter. Thank you!

    • @Fralickmike
      @Fralickmike 9 місяців тому

      Thank you! That’s very kind of you

  • @articulatepro4449
    @articulatepro4449 9 місяців тому

    This lecture coul even solve a particular question... kept rigmaroles coming...

  • @taifshah9003
    @taifshah9003 9 місяців тому

    you are so stupid, while giving a lecture, avoid your shit chatting with people

  • @datadoctor10
    @datadoctor10 10 місяців тому

    Thanks for the video

  • @yuyangzhu6822
    @yuyangzhu6822 11 місяців тому

    Thank you for the video!! saved me when I got totally lost in my intermediate pharmacoepidemiology class 😂

  • @sushiman972
    @sushiman972 11 місяців тому

    Doing an analysis on a controlled trial you were involved in just feels like cheating. But super helpful video, Thank you!

  • @DrogbaPT454
    @DrogbaPT454 Рік тому

    Great summary. I think the only point that I would have added on patient baseline was highlighting the fatc that all patients were statin intolerant (and they signed a informed consent)

  • @MA-dd9dd
    @MA-dd9dd Рік тому

    Thank you for uploading

  • @ivytruong4997
    @ivytruong4997 Рік тому

    how do you set the 20% margin on the forest plot?

  • @rajmacwan665
    @rajmacwan665 Рік тому

    Thank you Dr. Fralick for this video!! Can you please post your talk about everything you need to know about statistics ? Thanks again

    • @Fralickmike
      @Fralickmike Рік тому

      Yes you are right that is a long overdue talk. I will work on it next

  • @addisalemtsegaye1271
    @addisalemtsegaye1271 Рік тому

    Thank you

  • @ec.juanfranulcuangolee3294

    Thank you dear teacher. Excellent, in spite of it wasn't in Spanish or without subtitles

  • @marjorieaijeelucero1149
    @marjorieaijeelucero1149 Рік тому

    I cannot emphasize how helpful this lecture is. Thank you for making this available. Topics like these are very hard for me to understand on live face-to-face/online lectures. I need to pause a bit, rewind a bit to catch the concepts. THANK YOU!

    • @Fralickmike
      @Fralickmike Рік тому

      Thanks that’s very kind of you!!

  • @chadibenchakroun6465
    @chadibenchakroun6465 Рік тому

    Can you please explain the slide at 5:10? Why don't we have the same number of persons, means...? Is it just that we do not take into account people without a match?

  • @user-yw1ul4xq1g
    @user-yw1ul4xq1g Рік тому

    Very helpful video for rookies like me😊

  • @TheVishu27
    @TheVishu27 Рік тому

    One of the best 👍💯

  • @khadeijahussain6000
    @khadeijahussain6000 Рік тому

    Great lecture Michael! can anyone help me understand how to use the Newcastle Ottawa scale a little better? The questionnaire seems pretty straightforward but I'm not sure if I am interpreting it correctly.

  • @hpthelegend
    @hpthelegend Рік тому

    Very informative video😊 I will suggest the channel to my colleagues too

    • @Fralickmike
      @Fralickmike Рік тому

      thank you!!

    • @georgestone6807
      @georgestone6807 Рік тому

      Can u make a video how to critical analyze clinical trials , the interpretation is so varied Will appreciate that

  • @alsonyang230
    @alsonyang230 Рік тому

    Thank for the concise videos that explain the overall concept very well. It was very easy to understand. There are 3 implementation details during the matching phase (at 5:00) hoping you could clarify. 1. After we get the score, if there are two rows with scores 0.5 in control group (where `SGLT2 = No`), should both of them be matched to row 3 in treatment group? 2. In the real world, the score would rarely be exactly the same if we allow infinite decimal. How do you consider a match? Would there be an arbitrary numeric difference allowed? 3. If there are two rows in treatment with score 9.15 and 9.18 (row A and B), and two rows in control with score 9.16 and 9.25 (row C and D). Would row A and B both be matched to C? Or would row A matched to C as they are have the smallest difference, then row B has to be matched to D?

    • @Fralickmike
      @Fralickmike Рік тому

      The stats section of this article will help answer your Qs www.acpjournals.org/doi/10.7326/M19-2610