Maja Divjak
Maja Divjak
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CAR-T Cells: Engineered Cancer Killers
The Peter MacCallum Cancer Centre is a unique Australian institution consisting of a world-leading cancer research program integrated within a world-leading cancer hospital.
Based on 25 years of research, we are the first site in Australia fully licensed to manufacture Chimeric Antigen Receptor (CAR)-T cells for treatment of blood cancers such as leukaemias and lymphomas. The process involves engineering a patient’s own T cells to express Chimeric Antigen Receptors, or CARs on the cell surface.
When the CAR-T cells are re-infused into the patient, they multiply rapidly and the CARs enable them to specifically seek and destroy cancer cells throughout the body. For some patients this has proven to be a miracle treatment when all other options have been exhausted.
This production explains how cancer cells can avoid detection by our immune cells. We then learn how our immune cells can be super charged by CAR-T technology to kill cancer cells and how this works at the molecular and cellular levels using 3D animation and ground-breaking microscopy techniques.
The production informs patients and the interested lay person about this unique technology and the great progress made by Peter Mac scientists into understanding cancer biology and developing revolutionary treatments, such as CAR-T cells, to combat cancer.
Переглядів: 2 752

Відео

Intro to Chimeric Antigen Receptors- Trailer for CAR-T Cells: Engineered Cancer Killers'
Переглядів 4492 роки тому
This animation is an introductory trailer for our soon to be released 3D animation, 'CAR-T Cells: Engineered Cancer Killers'. This production is a scientifically accurate explanation of this revolutionary new cancer treatment. The trailer gives a brief explanation of the structure of chimeric antigen receptors or 'CARs' and how these work to kill cancer cells. © Peter MacCallum Cancer Centre an...
What Goes Wrong in Cancer?
Переглядів 10 тис.4 роки тому
The Peter MacCallum Cancer Centre is a Melbourne institution and world leader in cancer research, treatment and diagnostics. It is Australia's only hospital solely dedicated to the overarching theme of cancer. Our award-winning Peter Mac biomedical animation reveals the invisible molecular world within our cells and how this finely tuned world can occasionally become disrupted, leading to cance...
The Role of p53 in Cancer
Переглядів 111 тис.4 роки тому
p53 is a sentinel protein recruited rapidly in response to DNA damage. p53 slides along the DNA until it finds a critical site, to which it binds. p53 then sends the message, to halt cell division until DNA is repaired, or If damage is too severe, the cell is destroyed. p53 is therefore known as the ‘guardian of the genome.’ A tiny change in p53 results in a structure that is unable to securely...
DNA Damage and Repair
Переглядів 66 тис.4 роки тому
DNA provides the blueprint to create proteins, which are the building blocks of our body. Remarkably, we are subject to vast amounts of DNA damage everyday due to environmental agents and even the byproducts of metabolism. This DNA damage can occur in a variety of different forms. Most of the time our cells do a very good job of dealing with DNA damage and have complex processes in place to rep...
The Role of KRas in Cancer
Переглядів 2,8 тис.4 роки тому
KRas is a protein that controls how often a cell divides. To do this it needs to be switched on before it can turn on cell division pathways. When no longer needed, it is then turned off. A tiny alteration in KRas leads to a protein that is always switched on. This means that the cell division pathways are also constantly switched on. In this situation, cells are more likely to multiply outside...
The Role of BRCA1 in Cancer
Переглядів 19 тис.4 роки тому
BRCA1 is an integral protein in the DNA repair pathway. Inherited alterations in the structure of BRCA1 cause interruption of the DNA repair process, which over time, lead to accumulation of more and more DNA damage in cells. This greatly increases the risk for cancer. Women afflicted with these inherited changes in BRCA1 face a lifetime of constant surveillance and medical intervention to figh...
Student Animation of Cell Division and Cell Death
Переглядів 5584 роки тому
This animation was created by students of Shepparton ACE and Shelford Girls' Grammar, Melbourne and is the result of an interactive workshop led by Dr Maja Divjak at the Arts Learning Festival 2019. artslearningfestival.com.au/. Using the same 3D software used in Hollywood cinema productions, students learnt to animate the processes of cell division and cell death. Biology meets art, meets digi...
Clostridium tetani and Tetanus
Переглядів 7 тис.7 років тому
Note: This production has been uploaded again to improve quality. Original views totalled 259. Please view at 720p Movement of our voluntary muscles is controlled by our central nervous system. This animation describes the process of infection with Clostridium tetani and how the toxin it releases interrupts nervous control of our muscles, leading to tetanus. This loss of muscle control causes t...
The Specialised Function of the Ciliated Epithelium
Переглядів 24 тис.8 років тому
Please view at 720p. This animation describes the normal function of the ciliated airway epithelium. Foreign bodies we inhale, such as dust, pollen and microbes become trapped in mucous, which is brushed up and out of the airways by the waving cilia. This animation was created for the Gene Technology Access Centre, Melbourne, Australia www.gtac.edu.au
Bordetella Pertussis and Whooping Cough
Переглядів 22 тис.8 років тому
Please view at 720p. This animation describes the process of infection of the airways by Bordetella Pertussis, a bacterium which causes whooping cough. It specifically details how the bacterium damages ciliated airway cells, impairing normal respiratory function, leading to the severe coughing fits characteristic of whooping cough. Vaccination is vital to protect against this highly contagious ...

КОМЕНТАРІ

  • @goodmantactics
    @goodmantactics 2 дні тому

    Thank you!

  • @JasonKing-m6m
    @JasonKing-m6m 9 днів тому

    I need to take some injections of P53 to keep my self right...

  • @eternalstudios4502
    @eternalstudios4502 18 днів тому

    Humanity is fixing in own imperfections.

  • @eternalstudios4502
    @eternalstudios4502 18 днів тому

    Are we gonna get one on Natural killer cells?

  • @eternalstudios4502
    @eternalstudios4502 18 днів тому

    This is cool

  • @charlesfranz9018
    @charlesfranz9018 Місяць тому

    Beautiful simulations

    • @majadivjak4538
      @majadivjak4538 Місяць тому

      The movement is animated, not based on simulation data, but pleased you like it.

  • @niecynatural9075
    @niecynatural9075 Місяць тому

    Thank you for explaining this oh so well i pray blessings upon you :)

  • @azca.
    @azca. 5 місяців тому

    Which programs are you using to make these? Unreal Engine? Unity?

    • @majadivjak4538
      @majadivjak4538 5 місяців тому

      Hi, I use Autodesk Maya for animation and Adobe After Effects for compositing. Recently I've moved towards Blender for animation.

    • @azca.
      @azca. 3 місяці тому

      @@majadivjak4538 Your animations are absolutely exceptional. You are one of the best animators I have seen in a long time. Your skill is very impressive. Thanks for the response!

  • @peters972
    @peters972 7 місяців тому

    What a great video! It’s not that often I find out something new these days there is quite a lot of recycling. But this was new to me! Thank you.

  • @PatientsPortal
    @PatientsPortal 7 місяців тому

    I just visited my friend in hospital day 36 at UCLA, who has the P53 mutation and Diffuse Large B-Cell Lymphoma (DLBCL). Seeing her strength firsthand, despite her white blood cell count being at 0.9, has been incredibly inspiring. It's true what they say: the best teacher is learning from a patient. My friend is the most resilient person I know, and their journey is a powerful reminder of the strength and courage in the face of adversity.

  • @Savagereviewer
    @Savagereviewer 8 місяців тому

    Thank you so much for your insights it's very good of you too show people this knowledge😊

  • @thasiyanamweso1575
    @thasiyanamweso1575 9 місяців тому

    Please make more videos on gene mutation

  • @محمدعليمهدلي-ح6ق
    @محمدعليمهدلي-ح6ق 9 місяців тому

    how do you make these animations doctor? I want to learn how do it

    • @majadivjak4538
      @majadivjak4538 9 місяців тому

      Hi there, I use Maya software, but Blender is free and easier to learn. Take a look at this course here: blender.scidart.com/

    • @محمدعليمهدلي-ح6ق
      @محمدعليمهدلي-ح6ق 9 місяців тому

      thanks so much@@majadivjak4538

  • @bio366geethasankar7
    @bio366geethasankar7 10 місяців тому

    🙏🏻

  • @ritadecassia9616
    @ritadecassia9616 10 місяців тому

    Sou brasileira e tô aqui😅😢

  • @robappleby583
    @robappleby583 11 місяців тому

    Surely just drinking bleach would solve it? Or bringing a very bright light inside the body?

  • @kriziamaealcid
    @kriziamaealcid 11 місяців тому

    thank you for those great, clear and informative animations!

  • @kriziamaealcid
    @kriziamaealcid 11 місяців тому

    i was having a hard time understanding how did the toxin cause spasm. i'm glad I saw this video. books make things so complicated and this animation really helped me understand everything. thank you for this video

  • @supportadmin7735
    @supportadmin7735 Рік тому

    does it really make all that noise?

    • @majadivjak4538
      @majadivjak4538 Рік тому

      No, there is no sound at the molecular level. The sound effects are to punctuate the action and direct the viewer's attention; it is purely artistic license. 😊

  • @batcactus6046
    @batcactus6046 Рік тому

    I love the little fixing and clicking noises.

  • @sahanasanu8964
    @sahanasanu8964 Рік тому

    Super

  • @katzinator5141
    @katzinator5141 Рік тому

    Is it possible to construct P53 proteins with some sort of protection from getting controlled by the cancer cell, if yes they need to be created in a way that the immune system doesn't recognize them as an virus or bacterium

  • @diwakar14
    @diwakar14 Рік тому

    Is the sound real?

  • @JonathanWirth-c3p
    @JonathanWirth-c3p Рік тому

    Have a goodnight production volunteer 😊

  • @SadiaAdnan-yp5dn
    @SadiaAdnan-yp5dn Рік тому

    These are all the beautiful and unbelievable creations of ALLAH.

  • @footballsteel4022
    @footballsteel4022 Рік тому

    Who didn't believe in god he shoud watch any mechanism of body physiology

  • @autismgranny
    @autismgranny Рік тому

    Fantastic video!!

  • @kanetao
    @kanetao Рік тому

    That rattle! I will never imagine DNA without that sound again.

  • @larrybethune3909
    @larrybethune3909 Рік тому

    Quick two part question. How does the introduction of the spike protein impact the ability of p53 to bind to and repair or destroy damaged DNA strands? And does this have an impact on pathosis' like breast cancer?

    • @Jo.King_
      @Jo.King_ Рік тому

      mRNA spike protein binds p53 and other cancer suppressor genes. It is very clear and very frightening that these vaccines have several elements to cause a perfect storm in cancer development in those patients lucky enough to have avoided heart attacks, clots, strokes, autoimmune diseases and other common adverse reactions to the Covid vaccines. To advise booster vaccines, as is the current case, is no more and no less than medical incompetence; to continue to do so with the above information is medical negligence which can carry a custodial sentence. No ifs or buts any longer. All mRNA vaccines must be halted and banned now." Angus Dalgleish

  • @isapinales-torres5160
    @isapinales-torres5160 Рік тому

    That was great

  • @MartinDlabaja
    @MartinDlabaja Рік тому

    Any chance we get "behind the scenes" for your awesome awesome animations?

    • @majadivjak4538
      @majadivjak4538 Рік тому

      Hi Martin, Thank you for your kind words! I'll be giving a talk at the Australian Centre for the Moving Image (ACMI) on Oct 25, if you care to join. See here: www.acmi.net.au/education/school-program-and-resources/the-intersection-of-art-and-science-using-3d-animation-to-tell-the-stories-of-biology/

    • @MartinDlabaja
      @MartinDlabaja Рік тому

      @@majadivjak4538 That is amating Maja! Your animations (and animations from Drew Barry) really inspired me to do my own projects like protein visualizers / molecular dynamics sim etc ... You two guys are my bioviz heroes! Also thanks for the link to conference, I am going to attend! Keep up fantastic and aesthetic work, care, M.

  • @inshajan7133
    @inshajan7133 Рік тому

    Allah is great

  • @prakharpandey8968
    @prakharpandey8968 Рік тому

    Thanks

  • @JBulsa
    @JBulsa Рік тому

    Instruct the cell that a new P53 is needed

  • @JBulsa
    @JBulsa Рік тому

    Inject photolayse into the bone and cleave the TT uvc bond with different wavelength of light?

  • @farahdeebakhan5322
    @farahdeebakhan5322 Рік тому

    Wow what an amazing animation

  • @idk-it8pz
    @idk-it8pz Рік тому

    I'm sorry but this video is really creepy to the point that i actually cried while watching, that was terrifying

  • @Moon-ep2bb
    @Moon-ep2bb Рік тому

    mmmm, nerd rope

  • @BassNinja
    @BassNinja Рік тому

    My 5 year old has been for the last year or so interested in cells and knows more about than I do which is kinda sad

  • @DrHimanshiTheUnicorn
    @DrHimanshiTheUnicorn Рік тому

    Amazing amazing

  • @TimCrinion
    @TimCrinion Рік тому

    How do people discover this?

  • @FutureAIDev2015
    @FutureAIDev2015 Рік тому

    This is really cool. Does this type of immunotherapy have side effects?

    • @majadivjak4538
      @majadivjak4538 Рік тому

      Yes, it can do. Please see page 22 of this PDF that we give to patients www.petermac.org/component/edocman/car-t-cell-therapy-a-guide-for-patients-carers-and-families/viewdocument/218?Itemid=0

  • @thoughtgarden8090
    @thoughtgarden8090 Рік тому

    I don't know what your thought process was for the sound that you put on this video. But you should delete every sound file that you have because that is awful. Hands down one of the worst sound I've ever heard

  • @catdaddy5192
    @catdaddy5192 Рік тому

    Great are the ways of God!

  • @markwillentdion
    @markwillentdion Рік тому

    Future

  • @markwillentdion
    @markwillentdion Рік тому

    DNA ku, clonning DNA beku

  • @lisa-rouletlawfirm9307
    @lisa-rouletlawfirm9307 Рік тому

    Wow, thanks for sharing this!!! Exceptional explanation!

  • @lisa-rouletlawfirm9307
    @lisa-rouletlawfirm9307 Рік тому

    Excellent explanation, thank you!!!

  • @steveocvirek6671
    @steveocvirek6671 Рік тому

    Fantastic illustrations and mind blowing science. I never imagined the DNA repair process was that complex. Thank you so much for making that video!!!! Much appreciated.

  • @arturlyaptyap4926
    @arturlyaptyap4926 Рік тому

    The 21st century and scientists cannot figure out how to fix this gene so that the body can kill cancer cells itself. I have this gene and I have cancer and I want to be healthy

    • @HL-qv3yd
      @HL-qv3yd Рік тому

      I agree with you, so many good souls suffer from this disease, yet all over the world governments pouring money on war and going Mars instead put the money cure this bloody disease, I'm upset for that reason.

    • @daltonfreire6328
      @daltonfreire6328 Рік тому

      Fasting is the solution to the body promote self healing. Even at DNA level. It promotes autofagy, and can reverse any chronic disease, includind cancer. Unfortunately, the medications industry don't invest in researches about fasting, for financial reasons.

    • @SJ-wu9gx
      @SJ-wu9gx Рік тому

      Exactly my thoughts ..

    • @sagarikapati9612
      @sagarikapati9612 8 місяців тому

      My mom has this

    • @GNICHO
      @GNICHO 8 місяців тому

      Everyone has the p53. It is a gene that regulates cell proliferation. This means when a cell decides what to do with its energy potential, divide or die are the options. P53 regulates this, it is a gene which is part of your DNA. It’s how your DNA knows how to function, gene is like “key” or tool for your DNA. Deregulation of this cell can change the rate at which cells are created. When functioning properly in (remember when all this gene, put some have mutations) a human body it fights cancer, and viruses. It regulated any biological process related to the cell’s ability to reproduce. As cell may choose “Apotosis” and die, because it is corrupted. A cell would understand that it’s necessary to program its own death, due to it becoming a corrupted “file” in the body. Modulating this gene is difficult because it’s not so much amount turning it “up” or “down” it’s about getting it to regulate itself consistently where cell regulation is concerned. Hope this helps, best of luck.