Maja Divjak
Maja Divjak
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CAR-T Cells: Engineered Cancer Killers
The Peter MacCallum Cancer Centre is a unique Australian institution consisting of a world-leading cancer research program integrated within a world-leading cancer hospital.
Based on 25 years of research, we are the first site in Australia fully licensed to manufacture Chimeric Antigen Receptor (CAR)-T cells for treatment of blood cancers such as leukaemias and lymphomas. The process involves engineering a patient’s own T cells to express Chimeric Antigen Receptors, or CARs on the cell surface.
When the CAR-T cells are re-infused into the patient, they multiply rapidly and the CARs enable them to specifically seek and destroy cancer cells throughout the body. For some patients this has proven to be a miracle treatment when all other options have been exhausted.
This production explains how cancer cells can avoid detection by our immune cells. We then learn how our immune cells can be super charged by CAR-T technology to kill cancer cells and how this works at the molecular and cellular levels using 3D animation and ground-breaking microscopy techniques.
The production informs patients and the interested lay person about this unique technology and the great progress made by Peter Mac scientists into understanding cancer biology and developing revolutionary treatments, such as CAR-T cells, to combat cancer.
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Відео

Intro to Chimeric Antigen Receptors- Trailer for CAR-T Cells: Engineered Cancer Killers'
Переглядів 4432 роки тому
This animation is an introductory trailer for our soon to be released 3D animation, 'CAR-T Cells: Engineered Cancer Killers'. This production is a scientifically accurate explanation of this revolutionary new cancer treatment. The trailer gives a brief explanation of the structure of chimeric antigen receptors or 'CARs' and how these work to kill cancer cells. © Peter MacCallum Cancer Centre an...
What Goes Wrong in Cancer?
Переглядів 6 тис.4 роки тому
The Peter MacCallum Cancer Centre is a Melbourne institution and world leader in cancer research, treatment and diagnostics. It is Australia's only hospital solely dedicated to the overarching theme of cancer. Our award-winning Peter Mac biomedical animation reveals the invisible molecular world within our cells and how this finely tuned world can occasionally become disrupted, leading to cance...
The Role of p53 in Cancer
Переглядів 108 тис.4 роки тому
p53 is a sentinel protein recruited rapidly in response to DNA damage. p53 slides along the DNA until it finds a critical site, to which it binds. p53 then sends the message, to halt cell division until DNA is repaired, or If damage is too severe, the cell is destroyed. p53 is therefore known as the ‘guardian of the genome.’ A tiny change in p53 results in a structure that is unable to securely...
DNA Damage and Repair
Переглядів 65 тис.4 роки тому
DNA provides the blueprint to create proteins, which are the building blocks of our body. Remarkably, we are subject to vast amounts of DNA damage everyday due to environmental agents and even the byproducts of metabolism. This DNA damage can occur in a variety of different forms. Most of the time our cells do a very good job of dealing with DNA damage and have complex processes in place to rep...
The Role of KRas in Cancer
Переглядів 2,8 тис.4 роки тому
KRas is a protein that controls how often a cell divides. To do this it needs to be switched on before it can turn on cell division pathways. When no longer needed, it is then turned off. A tiny alteration in KRas leads to a protein that is always switched on. This means that the cell division pathways are also constantly switched on. In this situation, cells are more likely to multiply outside...
The Role of BRCA1 in Cancer
Переглядів 19 тис.4 роки тому
BRCA1 is an integral protein in the DNA repair pathway. Inherited alterations in the structure of BRCA1 cause interruption of the DNA repair process, which over time, lead to accumulation of more and more DNA damage in cells. This greatly increases the risk for cancer. Women afflicted with these inherited changes in BRCA1 face a lifetime of constant surveillance and medical intervention to figh...
Student Animation of Cell Division and Cell Death
Переглядів 5534 роки тому
This animation was created by students of Shepparton ACE and Shelford Girls' Grammar, Melbourne and is the result of an interactive workshop led by Dr Maja Divjak at the Arts Learning Festival 2019. artslearningfestival.com.au/. Using the same 3D software used in Hollywood cinema productions, students learnt to animate the processes of cell division and cell death. Biology meets art, meets digi...
Clostridium tetani and Tetanus
Переглядів 7 тис.7 років тому
Note: This production has been uploaded again to improve quality. Original views totalled 259. Please view at 720p Movement of our voluntary muscles is controlled by our central nervous system. This animation describes the process of infection with Clostridium tetani and how the toxin it releases interrupts nervous control of our muscles, leading to tetanus. This loss of muscle control causes t...
The Specialised Function of the Ciliated Epithelium
Переглядів 24 тис.8 років тому
Please view at 720p. This animation describes the normal function of the ciliated airway epithelium. Foreign bodies we inhale, such as dust, pollen and microbes become trapped in mucous, which is brushed up and out of the airways by the waving cilia. This animation was created for the Gene Technology Access Centre, Melbourne, Australia www.gtac.edu.au
Bordetella Pertussis and Whooping Cough
Переглядів 22 тис.8 років тому
Please view at 720p. This animation describes the process of infection of the airways by Bordetella Pertussis, a bacterium which causes whooping cough. It specifically details how the bacterium damages ciliated airway cells, impairing normal respiratory function, leading to the severe coughing fits characteristic of whooping cough. Vaccination is vital to protect against this highly contagious ...