Відео

Thank you!

Wow this is amazing 😃

Well explained 👍

Very good educational summary!

Does this affect platelet count?

thank you sir you have helped me a lot

Thank you!!!

Great presentation & easy to follow. What temperature is considered low or high? Same for PH? I'm curious because patients with body temperature regulation issues seem to be more prone to anxiety and shortness of breath

Great review! Many thanks 🤩

Thank you ♥️

Excellent

Very well explained... Thank you 🙏🙏

Thank you so much

Thanks for simplifying this Buddy

Loved how comprehensive it is. Subscribed already. 👍 But you should have discussed hemoglobin synthesis in details :(

Thank you very much Sir.....Very nice and easy to understand.

It is a beautifully detailed video with a comprehensive and easy to understand explanation! Truly grateful for such an amazing video!

Very good explanation and presentation keep it up💞💞👏

Briliant

Please ... make another video which includes SUBSTRATES. Giving a classic example from each category would be wonderful!

This makes it easier to understand. Thank you! ❤️

I am really glad that Dr Madida herbal supplement that I found out on UA-cam and used didn't alone cure me of my HHSV but also worked for my wife too, she is cured of her human herpes virus .

Great video, keep up the good work! This deserves more views, I would recommend using smzeus . c o m to help grow your channel!

Recommended watching speed: x1.25 00:00:07 - Introduction 00:00:18 - MCR definition of Microcytic Anaemia 00:00:26 - TAILS mnemonic for causes of microcytic anaemia 00:00:46 - Logical way of understanding the causes of microcytic anaemia 00:01:10 - What causes of the microcytosis (small cells) + reason 00:02:08 - Listing the composition of haemoglobin to understand the causes of microcytic anaemia 00:04:22 - What are the 2 most common anaemias in the world? 00:04:43 - Iron Deficiency Anaemia (IDA) introduction + pathological definition 00:04:55 - IDA: most common causes 00:05:22 - IDA: other causes of IDA classified by 3 general causes 00:05:46 - IDA: causes of reduced iron absorption 00:06:26 - IDA: causes of increased anabolic state 00:06:33 - IDA: causes of increased iron loss 00:06:50 - IDA: stages of iron deficiency and why IDA can be both NCNC and MCHC 00:09:01 - IDA: specific clinical features 00:10:06 - IDA: differential diagnosis 00:10:27 - IDA: investigations + explanation of each investigation result 00:14:35 - IDA: the important relationship between ferritin and TIBC 00:15:47 - IDA: management 00:16:47 - IDA: most common cause of failure to respond to oral iron 00:17:14 - Anaemia of Chronic Disease (ACD): introduction + definition 00:17:54 - ACD: causes of ACD 00:18:10 - ACD: also known as Anaemia of Inflammation (AI) 00:18:33 - ACD: pathophysiology of ACD 00:21:30 - ACD: thinking laterally - why does hepcidin synthesis increase in ACD? 00:22:40 - ACD: investigations 00:25:08 - ACD: treatment

Recommended watching speed x1.25 00:00:18 - Importance of understanding anaemia 00:00:31 - Anaemia definition 00:01:03 - General clinical features of anaemia 00:04:23 - making an anaemia diagnosis using proxies (haemoglobin and haematocrit) 00:06:01 - why using proxies (Hb concentration and Hct) can be unreliable in diagnosing anaemia 00:06:16 - examples when Hb concentration is unreliable at making a diagnosis of anaemia (acute blood loss, pregnancy, dehydration, and polycythaemia) 00:10:27 - anaemia classification using the MCV (the easiest and simplest way of classifying anaemia)

Recommended watching speed: 1.25x 00:00:12 - definition and purpose of red cell indices 00:00:42 - Red Cell Count (RBC) 00:01:29 - Mean Corpuscular Volume (MCV) 00:02:55 - Mean Corpuscular Haemoglobin (MCH) 00:03:49 - Mean Cell Haemoglobin Concentration (MCHC) 00:04:55 - Haemoglobin concentration 00:05:06 - Red Cell Width Distribution (RDW) 00:05:38 - Defining anisocytosis and poikilocytosis

Recommended watch speed: 1.25x or 1.5x 00:00:05 - importance of anaphylaxis 00:00:26 - anaphylaxis definition 00:01:02 - the 3 key diagnostic characteristics of anaphylaxis 00:01:29 - pathogenesis - type 1 hypersensitivity reaction 00:01:45 - pathogenesis - quick recap of the hypersensitivity reactions (with key mnemonics) 00:03:08 - pathogenesis - going through the NeedToKnow steps to understand the clinical features 00:04:59 - pathogenesis - mast cell degranulation and TRYPTASE 00:05:53 - pathogenesis - other mechanisms: Complement Activation 00:06:47 - pathogenesis - THE IMPORTANCE OF HISTAMINE 00:08:27 - the clinical features of anaphylaxis 00:08:56 - pathogenesis: IMPORTANT - the effects of HISTAMINE on the respiratory and cardiovascular system and how this produces specific clinical features 00:15:30 - Clinical features explained - logically understanding the clinical features based on the pathogenesis 00:20:32 - Clinical features - what are the first clinical features to present (usually)? 00:20-48 - Investigations 00:22:16 - Management 00:22:29 - management - cardiorespiratory arrest 00:22:56 - management - patient NOT in cardiorespiratory arrest with explanation 00:25:18 - management - what is an anaphylactic biphasic reaction and how can it be prevented? 00:26:17 - management - what we want to reverse from the pathogenesis 00:26:46 - ADRENALINE

00:00:20 - Types of iron 00:01:08 - Iron intake, requirements for growth, general requirements 00:01:56 - The most common iron we ingest 00:02:32 - Iron absorption and its requirements 00:04:30 - Ferrireductase 00:05:01 - Diagrammatic illustration of iron ingestion and absorption 00:06:07 - Role of gastric acid in iron physiology 00:06:25 - Iron physiology - the enterocyte 00:10:20 - Ferroportin 00:11:05 - Transferrin 00:13:02 - Hepcidin - production, function, regulation, and stimulation 00:18:02 - Iron stores - ferritin and haemosiderin 00:20:10 - Clinical significance of iron physiology

Nice content 👍!!loved it. Well explained.

00:00:27 - Defining Haemoglobin what it’s composed of 00:00:54 - Structure: Haem - protoporphyrin + iron 00:01:36 - Structure: Globin + types 00:03:04 - Haemoglobin synthesis 00:03:20 - Synthesis: location 00:03:43 - Synthesis of protoporphyrin - the rate limiting step and vitamin B6 00:04:40 - Synthesis of haem - 00:07:09 - Types - what causes the variability? 00:07:50 - Types - foetal/fetal haemoglobin (HbF) 00:12:21 - Types - Adult haemoglobin (HbA) and normal variant HbA2 00:16:00 - difference in affinity between HbF and HbA 00:16:57 - Function of haemoglobin 00:17:16 - Function - oxygen transport 00:18:26 - Function - oxygen: the oxygen-haemoglobin dissociation curve 00:22:54 - Function - changes to the oxygen-haemoglobin dissociation curve 00:23:20 - right shift of the oxygen-haemoglobin dissociation curve 00:24:13 - The Bohr Effect 00:25:10 - 2,3-DPG (2,3-diphosphoglyceric acid) 00:25:25 - left shift of the oxygen-haemoglobin dissociation curve 00:26:32 - factors that cause a left shift of the oxygen-dissociation curve 00:26:53 - why HbF causes a left shift 00:27:07 - left shift: carbon monoxide poisoning 00:28:40 - Function - carbon dioxide transport