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Powerhouse of the Cell
United States
Приєднався 25 кві 2020
Powerhouse of the Cell (formerly Primo Science) aims to achieve two goals:
1) To teach science though animations: From my 5+ years of tutoring high school students, I found that it was often challenging to visualize biological and chemical processes through a textbook or blackboard. Powerhouse serves to create a visual resource for students and educators to use to facilitate learning and improve performance.
2) To teach science through experimentation: After doing research in college, my peers and I realized that it was challenging to translate the material learned from classes into the laboratory. While courses often focus on already-discovered processes and mechanisms, science in the real world (not just in the laboratory) requires creative thinking and critical analysis. Powerhouse teaches the stories of famous biological discoveries to help students expand their view of science.
Videos are created and animated by Harrison Ngue, student at Harvard University.
1) To teach science though animations: From my 5+ years of tutoring high school students, I found that it was often challenging to visualize biological and chemical processes through a textbook or blackboard. Powerhouse serves to create a visual resource for students and educators to use to facilitate learning and improve performance.
2) To teach science through experimentation: After doing research in college, my peers and I realized that it was challenging to translate the material learned from classes into the laboratory. While courses often focus on already-discovered processes and mechanisms, science in the real world (not just in the laboratory) requires creative thinking and critical analysis. Powerhouse teaches the stories of famous biological discoveries to help students expand their view of science.
Videos are created and animated by Harrison Ngue, student at Harvard University.
But what is CRISPR-Cas9? An animated introduction to Gene Editing. #some2
This CRISPR animation visualizes how the CRISPR/Cas immune system was identified in bacteria and how the CRISPR/Cas9 system was developed for genome editing. This CRISPR animation also covers the history of gene editing, including zinc finger nucleases (ZFN), transcription activator-like effector nuclease (TALE nucleases, TALEN). A history of Jennifer Doudna, Emmanuelle Charpentier, Francisco Mojica, David Liu, and their contributions are described, such as the development of base editing and prime editing. We also go beyond just cutting DNA and discuss how CRISPR turns gene expression on (CRISPR activation, CRISPRa) and off (CRISPR inhibition, CRISPRi) to fluorescently tagging particular sequences (e.g. GFP). This animation explores some of the exciting possibilities of CRISPR-Cas9 biotechnology, including designer babies, genetically modified humans, the end of diseases, and genetic engineering.
But what is CRISPR-Cas9? An animated introduction to Gene Editing.
This video was made by Harrison Ngue, student at Harvard University, as the final project for the course Chemistry 177: The Chemistry, Biology, and Societal Implications of Genome Editing, taught by Professor David Liu and Aditya Raguram. Special thanks to both for providing feedback on this video!
Contents:
0:00 What is Gene Editing?
2:35 Discovery of CRISPR
5:31 CRISPR-Cas9 Technology
7:01 PAM Sequence
8:03 Modern Gene Editing
These biology animations and chemistry animations are largely made using Adobe Premiere Pro and Adobe After Effects, along with the 3blue1brown custom Python library, Manim. Icons, drawing, and chemical structures were designed using BioRender and ChemDraw.
Music:
Pure Water by Meydän
Link: ua-cam.com/video/BU85yzb0nMU/v-deo.html
Forever Sunrise - by Jonny Easton
Link: ua-cam.com/video/9Xndx7nhGAs/v-deo.html
Check out his channel
Link: ua-cam.com/users/jonnyeaston
------------------
Powerhouse of the Cell (formerly Primo Science), founded by Harrison Ngue, aims to teach science using animation and a visuals-first approach. If you want to stay posted on new videos, subscribe.
Though this channel does not yet have Patreon, an equally valuable form of support is to simply share the videos!
Twitter: Powerhouse_YT
But what is CRISPR-Cas9? An animated introduction to Gene Editing.
This video was made by Harrison Ngue, student at Harvard University, as the final project for the course Chemistry 177: The Chemistry, Biology, and Societal Implications of Genome Editing, taught by Professor David Liu and Aditya Raguram. Special thanks to both for providing feedback on this video!
Contents:
0:00 What is Gene Editing?
2:35 Discovery of CRISPR
5:31 CRISPR-Cas9 Technology
7:01 PAM Sequence
8:03 Modern Gene Editing
These biology animations and chemistry animations are largely made using Adobe Premiere Pro and Adobe After Effects, along with the 3blue1brown custom Python library, Manim. Icons, drawing, and chemical structures were designed using BioRender and ChemDraw.
Music:
Pure Water by Meydän
Link: ua-cam.com/video/BU85yzb0nMU/v-deo.html
Forever Sunrise - by Jonny Easton
Link: ua-cam.com/video/9Xndx7nhGAs/v-deo.html
Check out his channel
Link: ua-cam.com/users/jonnyeaston
------------------
Powerhouse of the Cell (formerly Primo Science), founded by Harrison Ngue, aims to teach science using animation and a visuals-first approach. If you want to stay posted on new videos, subscribe.
Though this channel does not yet have Patreon, an equally valuable form of support is to simply share the videos!
Twitter: Powerhouse_YT
Переглядів: 350 934
Відео
Nature's Tiny Factories: Fatty Acid Synthesis and Assembly Line Enzymes
Переглядів 9 тис.2 роки тому
Pallas Chou and Harrison Ngue created this video as a resource for Chemistry 27: Organic Chemistry of Life at Harvard University in Spring 2022, taught by Professor Emily Balskus. In this organic chemistry animation, we take a look at one of the most beautiful enzyme mechanisms: assembly line machinery, including fatty acid synthesis (FAS), polyketide synthesis (PKS), and non-ribosomal peptide ...
This is the Biology They Won't Teach You (Chapter 2) #some3
Переглядів 9 тис.4 роки тому
History of DNA. What is DNA? DNA visualisation visualized DNA animation. An exploration into the history of science of the discovery of DNA, including Watson and Crick, Rosalind Franklin's X-ray crystallography Photo 51. Other notable scientists include Matthias Jakob Schleiden, Rudolf Virchow, Otto Bütschli, Friedrich Miescher, Phoebus Levene, Erwin Chargaff, Oswald Avery, McCarty, and MacLeod...
But what is DNA? A visual introduction to DNA structure.
Переглядів 9 тис.4 роки тому
But what is DNA? A visual introduction. Excerpt from The Essence of Biology, Chapter 2: DNA Structure and Discovery. DNA visualisation visualized DNA animation A simple visual animation as an introduction to DNA structure (deoxyribonucleic acid). We cover the four DNA nucleotides (Adenine, Thymine, Cytosine, Guanine) and how they interact to form a double helix, as discovered by James Watson, F...
The Most Important Concept in Biology (Chapter 1)
Переглядів 14 тис.4 роки тому
Essence of biology, chapter 1 We cover the Central Dogma of Molecular Biology, DNA to RNA to Protein, and its importance in biology, biochemistry, and genetics. We look into the enzymatic processes that comprise Gene Expression and Protein Synthesis, including DNA Replication, Transcription, and Translation. Included is a brief introduction to mutations, gene regulation, genomics, transcriptomi...
Can You Answer this Harvard Homework Problem? | Primo Science
Переглядів 5 тис.4 роки тому
We go through a Harvard University LS50 (Life Sciences 50) problem set question about chemical reaction systems that includes biology, chemistry, math, linear algebra, calculus, and differential equations, including specific concepts such as transcription factors, the Intermediate Value Theorem, eigenvalues and eigenvectors, solving differential equations, dynamical systems, and more. Music Att...
Nice
'Buh wut is uh.?' I had to replay that section at :25 seconds at least three times to understand what you said. Your diction is horrendous. Also, the word is 'recognize', not 'recanize'. Might be interesting if the narration and music wasn't so awful.
9:35 ❤ Thanks a ton 🙏🏻
❤
Frankenstein's sons are disrupting natural order ..
❤🎉
Is it just me or did he have a hiccup at 0:23?
Good video
Okay, sooo if genome means the entire set of genes. Then, my guess is, that transcriptome should mean the entire set of trancripted mRNA. Translatome should be the entire set of steps or actions that make proteins and proteome then, should be the entire set of proteins that are formed. Now... if I say that there is an an entire set of proteins, and the cells need only some specific ones... then those not needed should be in a dormant state or inactive... That will relate it to genome regulations as well. So, there must be some other factor, which determines which mRNA from the transcriptome would get translated, which steps or actions from the entire set of translations- translatome would be chosen and fnally, which proteins will become active. There can be more than one factors as well, according to my assumption.
thank you for such an informative video , your video is such a high quality .
All i can think of it rh neg blood groups. Its definitely intervention mutation by the annunakis. 😮 I found this topiv because of my fascination with the rh factor topic
Type o is the universal donor o neg can only hav o neg it's repellent to virus and pox. It's healing blood. They already mastered it
oh my god i am speechless right now thankyou so much 🙂
Where did the CRISPR system originally come from? The first hint of their existence was made in 1987, when an unusual, repetitive DNA sequence was discovered in the genome of Escherichia coli. This sequence was later defined as CRISPR. The discovery occurred during an analysis of genes involved in phosphate metabolism.
So they can splice the Y male chromosome, and edit it into the female XX chromosome making it a third strand. This inturn produces a 3rd species of human. ½ male/female. This is demonic skull and bones 322 3= 3rd strand of dna 2= XY (male) 2= XX (female) 322
Fok1.... LoL
I've never seen anything related to CRISPR-Cas9 and I have to do a presentation about this method applied to crop improvement, based off of a paper. I wasn't understanding anything until I found this video. It really made the method so clear to me. Thanks a lot!
Well explained
do you recommend taking this course? I’m deciding between this and the typical lpsa/ls1b/ps11 track and don’t know if it’s worth it. I don’t want to take something that’ll tank my GPA but this does wipe out a lot of prereqs for med school
Makanya kami paleng ta'suka dengan kreator?,, memanipulasi otak, mracuni pikiran, merugikan keuangan, membohongi semua orang, global ,, makanya kami akan lepaskan particle anti kreator sistimatic stregls🌀🛰️🌀🛰️🌀🛰️🍥🛰️💎🛰️☀️🛰️☯️🛰️💥💥💥💥💥💥🌟👁️👁️👽☢️☢️😎
Bagi kami semua hanyalah tyori dan tyori yg ta'ada kepastian!,, jadi mau dibuat tyori apasaja tetap mengikuti/ haselnya tetap sama. Ibaratnya anda bicara dengan alat bantu telfon ,, sejauh manapon jika anda bicara A ya haselnya A dan seterosnya,, hanya buat cape' aja?? karna sebelom bicara anda juga sudah punya konsep....🎉🎉🎉🌀💎❤❤❤❤❤❤❤
😃😃😃 ini masihnya sangat sederhana,, karna semua murni Energi multy guna & sistimatic!!,, artinya ta'usah miker sudah pasti terwujod/ sistimatic muncol?? , contoh ??,, anda bicara apa / siapa?,, muncol sistimatic,, sebab!,, ucapan & penglihatan kami,, weaphond!. itulah sebabnya kami menghindari bicara langsong??,, takot terjadi emosi los kontrol sistimatic!!,, (💥💥💥💯) >>>EVRYBADI MULTYDIMENSI🎉🌟✳️💎🌀🌀🌀💲💰💸🤑💥💯🏬🏬🏬🏬🛤️🛤️🛤️🛤️🌴🌴🌴🌾🌾🌾🌾🐂🐂🐂🐏🐏🐏🐓🐓☀️💥💯%🌟👽👁️👁️☢️☢️☢️☢️☢️😎🌍🌎🌏🌐🛰️💖🛰️💖🛰️💖🛰️💖🍥🍥🍥☯️☯️☯️
Anyone who watches this and doesnt believe there is a designer of this world is clearly not reflecting!
It's interesting that they would think the repeating pattern was the important bit and not the unique information between them. From a computer science perspective (I know I know) those seem like headers and footers. It's like they really kick themselves by calling the unique data spacers
HBB gene 🧬 biological treatment honey 😂❤
That was so well explained. Thank you so much!
Cas9 is a human being who was experimented on without consent...
🇿🇦🥰
Your videos are short with the most important details.. make more to clear our minds .. thank you 😮😮❤
The music is such a turn off so loud and irritated
Was this first called a Protein Sequencer in the near past?
1. You literally just described a gene editing technology that can undo any "irreparable consequences" to genetic issues 2. We already used it to make kids nigh-immune to HIV with no consequences. 3. How the hell can correcting a known harmful genetic mutation by making it a known safe and widespread version cause irreparable consequences? Stop being a coward and siding with the selfish morons who would perpetuate preventable suffering out of sheer ignorance, distrust of science, and the inability to use their brain at the lowest level of critical thinking.
"If we change the dna it might be bad because the dna will be changed and we wouldn't be able to do anything about it because we can't sequence, edit, or make backups of DNA..." "...Wait, what?" People against curing genetic disease with germline engineering are ignorant, cowardly, and rather nope away from topics they don't understand and pretend they do it out of caution or humility than think through the issue to save lives and reduce suffering at an unprecedented scale by preventing preventable disease.
Excellent vedio
Its your closing statement for me❤ thanks for making this “complex technology” much easier to understand.
I'm just a housewife and grandma who's been fascinated by CRISPR Cas9 since the beginning. I even read Code Breaker. I'm so excited to now hear that this is being used to cure sickle cell, blindness, and deafness. Amazing.
Wow! That’s the book I am currently reading 😊
The Nobel Prize is no longer a distinction of honour and integrity.
THANK YOU , YOU HAVE EXPLAINED THIES GENIUS CONCEPT IN A REALLY GOOD WAY. THANKS
Beautiful, I love it. Thank you
I wonder how it actually reads the instructions? Guess i might find it out in the next videos,thanks for making this! I love it!
Hello, i want to ask you something, could CRISPR Technology be a solution for clinefertel syndrome (47 xxy)?
Very well explained excellent❤
24y5m WiFi is working well Considering.. Did you make this during the heat wave?
Hey bro I don't know how to contact you so I will try it here. I have a VERY important presentation in school and its also about CRISPR-Cas9 so I had the question if you could send me the animations you did in this video so I can put them into my powerpoint? That would skyrocket my grade and help me a lot. is there a way I could dm you on instagram or something so we could figure a way out how you can send it to me? Thank you for your help.
People don’t realize the amount of knowledge that was put into this video…
Thank you so much! I'm thrilled you appreciate the effort that went into it :)
wait so basically cas9 is like fanum and the DNA is kai and crispr is the fanum tax
on god
on fanum
based
Awesome video man!
Thank you for watching and commenting!
Plz come back man the world needs you😢😮
Thank you so much for the love and support! More videos are definitely on the way - each video just takes upwards of 200 hours to finish so the process unfortunately takes longer than any of us would like haha
@@PowerhouseCell I understand 😅🙏
I appreciate the support nonetheless! :)
Dammn that last sentence "maybe that scientist who will accomplish these feats in the future is watching this video right now." felt really emotional for some reason. Thanks
It could be true! Keep doing what you're doing :)
This “God mentality” from the generation that thinks making eunics of men somehow turns them into actual women. But a very good vide to describe what science is doing today.
nice
Glad you enjoyed!