Schizophrenia May Be an Autoimmune Condition

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  • Опубліковано 28 вер 2024
  • Schizophrenia affects 20 million people worldwide, and we don’t exactly know how it develops, or what causes it yet. However, some research has found that it might be an autoimmune condition.
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КОМЕНТАРІ • 641

  • @grannykiminalaska
    @grannykiminalaska 4 роки тому +299

    My family is filthy with autoimmune diseases. This could explain my sister's schitzophrenia. 😔

    • @danmueller4021
      @danmueller4021 4 роки тому +25

      Living in northerly latitudes could do it as well. Lack of sunlight is a major risk factor for the development of autoimmune diseases

    • @andi5262
      @andi5262 4 роки тому +1

      Kim in Alaska Same.

    • @mythreepants
      @mythreepants 4 роки тому +3

      *Be a factor

    • @danmueller4021
      @danmueller4021 4 роки тому +1

      @@mythreepants *Is a factor

    • @mem1701movies
      @mem1701movies 4 роки тому +6

      VITAMIN D supplements?

  • @allisond.46
    @allisond.46 4 роки тому +235

    "We don't know what it is, and we don't know what's causing it."
    Welcome to the world of mental health.

    • @pluspiping
      @pluspiping 3 роки тому +11

      "...But you're definitely faking it / making it up for attention"
      The followup response to every woman in the health care system.
      Heck, I've been accused of faking having an autoimmune disease, and faking having mental illnesses, so now I can get accused of faking the connection between autoimmune disease AND mental illnesses! Fun stuff.

    • @redlilwitchy6088
      @redlilwitchy6088 3 роки тому +1

      Yep. Sigh.

    • @3nertia
      @3nertia 3 роки тому +8

      More like welcome to the symptoms of capitalism a.k.a. systemic exploitation heh

    • @stellaancimer8505
      @stellaancimer8505 Рік тому +4

      But we have pills for you

    • @kellybarnett7578
      @kellybarnett7578 Рік тому

      Western medicine at its finest

  • @doctor_owl
    @doctor_owl 4 роки тому +110

    This is really fascinating!! As someone with multiple autoimmune conditions, I'm glad modern medicine is continuing to look into these factors. The immune system is complicated, and we barely understand how the human brain even works, so I wouldn't be surprised.
    I have narcolepsy and a few recent studies have hypothesized that it may actually be an autoimmune condition. I caught H1N1 when I was 16yrs old and got extremely sick. Almost immediately afterwards, I suddenly developed GI symptoms. A few weeks and a few tests later, I was diagnosed with severe ulcerative colitis (a type of IBD similar to chrons disease). Nobody else in my family has any autoimmune conditions.
    I've spent the last decade battling chronic illness and ended up having multiple major surgeries since the meds didn't work. My narcolepsy symptoms started in childhood but I wasn't diagnosed until a few years ago. My GI doctor is the one who first told me the theory that infections can trigger autoimmune conditions. Many systems in the body are connected in ways we don't fully understand!

    • @lily_lxndr
      @lily_lxndr 4 роки тому +6

      That thing about narcolepsy as an autoimmune condition is super interesting! I think I have it too (in the process of getting diagnosed but it's expensive), would you be able to link those studies you mentioned?

    • @gregorymalchuk272
      @gregorymalchuk272 4 роки тому

      Has any medication helped your narcolepsy?

    • @doctor_owl
      @doctor_owl 4 роки тому +4

      @@gregorymalchuk272 Gregory Malchuk Yes! There's only a few medications approved to treat narcolepsy in the US: Stimulants such as Adderall and Modafinil are the most common. There's also Xyrem which helps us get more restful sleep and can lessen the severity of cataplexy. They've been pretty successful for me. However those only mask the symptoms - they don't fix the root of the problem. Recent studies have found low hypocretin (orexin) levels in the cerebral-spinal fluid of patients with narcolepsy. This is the same effect commonly seen in sleep deprived individuals, so the current understanding is that narcolepsy essentially causes chronic sleep deprivation. It's not available as a prescription yet, but I started taking supplemental hypocretin (nasal spray) about a month ago and have noticed pretty significant improvement. Hopefully it will become more widely available in the near future!

    • @ahmed-lz3dl
      @ahmed-lz3dl 9 місяців тому

      An Arab doctor named Fayed Muhammad improved the condition of autoimmune diseases by following a healthy diet

    • @helloworld7818
      @helloworld7818 6 місяців тому

      My doctor prescribed me mint oil pills and they worked nice for my intestines. I don't know if they'll do the same for you, but I had pain in my colon and it diminished since taking those.

  • @nariu7times328
    @nariu7times328 4 роки тому +64

    Now we need the US medical system to keep up. My friend has such a hard time getting consistent treatment ...

    • @lttrhd
      @lttrhd Рік тому

      US medical system sucks. It works only for rich

  • @humanaesthetic
    @humanaesthetic 4 роки тому +78

    If true, this would change the current treatment paradigm of 1st and 2nd generation antipsychotics; that's awesome.
    Edit: oof I just want to make a small suggestion for a correction: microglia is said like "My-Crow-Glee-Yuh

    • @Descanlin
      @Descanlin 4 роки тому +2

      @@rbarajas86 ? He's usually pretty good.

    • @IanGrams
      @IanGrams 4 роки тому +8

      I suspect he checked online. Oddly both Oxford and Merriam-Webster list it as he pronounced it. I tend to lean towards how it's commonly used in my experience, but it's also not technically wrong if two separate dictionaries list it as such. Guess it's just another "gif".

    • @jeffreym68
      @jeffreym68 4 роки тому +1

      @@IanGrams Interesting. Folks in my field also pronounce it as M.Cruz suggested. I've never heard it any other way until this video.

    • @infinityphoenix1
      @infinityphoenix1 4 роки тому +3

      Ian Grams when he said microglia like that it sounded to me like a more formal/fancy/“correct” way of saying it, like you said it is the dictionary pronunciation. personally I prefer the other ”micro-glia” pronunciation because it makes it more obvious for people with basic knowledge of glial cells (I’m in undergrad psych atm) to know what you’re talking about lol

    • @IanGrams
      @IanGrams 4 роки тому +2

      @@jeffreym68 same here in the neuro courses I took. I'm rather curious how that disconnect between "proper" and common pronunciation came about now.

  • @stanburton6224
    @stanburton6224 4 роки тому +8

    I hypothesize that schizophrenia isnt a single disease, but may be a group of diseases that result in similar symptoms, but with different causes. Which would help explain the rule of thirds.

  • @gtbkts
    @gtbkts 4 роки тому +25

    Commenting for support

  • @lunacouer
    @lunacouer 4 роки тому +14

    I think it might not just be schizophrenia though? My psychiatrist explained to me that inflammation is involved in all mental illnesses.
    Either way, it's good news that the research is getting so broad. We need them to look in every nook and cranny.

  • @tkoborny
    @tkoborny Рік тому +2

    With actual physical abnormalities in the brain shouldn’t schizophrenia be considered a neurological disease not a mental health disorder?

  • @mijiah
    @mijiah 4 роки тому +26

    This is so interesting. The idea that this may not even be a mental disorder is revolutionary for helping people with schizophrenia, but helping destigmatize the disorder as a whole. I really hope there’s new developments in this and that we’re closer to helping people who have, in my opinion, one of- if not the most crippling disorders.

    • @grmpEqweer
      @grmpEqweer 4 роки тому +12

      Well, it's still a mental illness.
      But there's definitely physical brain changes involved. It very well could be the immune system attacking certain neural structures.
      ...All mental illnesses involve structural, degenerative brain changes, in fact.
      When ignorant people say "it's all in your head!" Well, yeah. And diabetes is all in your pancreas.😛 We people with mental illness issues have actual physical degenerative problems with our brains. We're not just whiners. Well, maybe a little whining. But it's a real physical illness.

    • @mschrisfrank2420
      @mschrisfrank2420 4 роки тому +3

      Having a cause in the body doesn’t mean it isn’t a mental disorder. But it does demystify it in a way that can help others understand better.

    • @mijiah
      @mijiah 4 роки тому +1

      Chris Frank Totally worded that wrong haha... I guess I had a blonde moment. But I’m not blonde so uh. Yeah no I’m just dumb. Thank you for correcting me! I appreciate you being nice about it!

    • @mijiah
      @mijiah 4 роки тому

      Get the pitchforks ! Yeahhhhhh. Had a big caveman brain moment there... oops. Thanks for correcting me nicely! Think this whole social distancing has finally gotten to me lol. But, it’s so funny that in the year of our lord 2020 people still say “it’s all in your head.” Like, yeah no sh*t Karen, it’s a MENTAL disorder, but that doesn’t mean I can just walk my PTSD off. Ughhhhhh

    • @luzdaviola
      @luzdaviola 9 місяців тому

      Could it be from heavy metal toxicity? Mercury? Aluminium? Lack of nutrients and things like glycine?

  • @ReginaldCarey
    @ReginaldCarey 4 роки тому +54

    Umm, did you mean micro-glia (small glial cells) as opposed to microg-lia?

    • @atheistsgod
      @atheistsgod 4 роки тому +7

      Agreed. My crow glee a (or al).

    • @ReginaldCarey
      @ReginaldCarey 4 роки тому +5

      Other brain diseases look strikingly like autoimmune damage. Look at multiple sclerosis - where myelin sheaths surrounding axons degrade and die. the amyloid plaques of Alzheimer’s which are associated with the disease.

    • @malavoy1
      @malavoy1 4 роки тому +9

      I'm sure their editing team is a bit understaffed right now or they would have caught it ;P

    • @TheElusiveReality
      @TheElusiveReality 4 роки тому +2

      That's also what I was thinking lol

    • @nicholass7449
      @nicholass7449 4 роки тому +8

      I thought the same thing, but google pronounced it like he did. However, my neuroscience professor pronounces it like micro-glia.

  • @christinafaulder
    @christinafaulder 7 місяців тому

    Wow! I’m blown away, this has put me on a good path, thank you 🌟💗🌟

  • @anatoliedragnea8983
    @anatoliedragnea8983 Рік тому +1

    My dearest wish is to stop having hallucinations psychic draws and no voices that arent real as well not fearing that something has controll over my body. These are the worst symptoms that i can remember at the moment.

  • @pluspiping
    @pluspiping 3 роки тому +1

    I swear, the next person who tries to tell me, "It's all in your head / have you tried thinking more positive / just be happier / just put in some effort," going to fricking GET IT. Shut up and be glad your immune system doesn't hate and attack you, GLADYS

  • @sentarenee4589
    @sentarenee4589 8 місяців тому

    My tonsils they're abnormal since I was little but if I don't eat and work out the blood refreshes and it's gone

  • @CRWM987
    @CRWM987 4 роки тому +1

    I want to hear more about this

  • @DebbieMassey-ph1ok
    @DebbieMassey-ph1ok 9 місяців тому

    Oh I hope your right,My son has this please keep testing he doesn't deserve this. most people think he's a drug user I know he's not.

  • @Thessalin
    @Thessalin 4 роки тому +2

    Wow. I work in law enforcement, so I deal with folks dealing with this. This is huge. I really hope we can make some headway through this.
    Is there any word on the worm studies about auto-immune disorders they had been doing? I have a coworker who has Crone's and when she's feeling bad, I always offer her some tasty tasty worms.

    • @SuviTuuliAllan
      @SuviTuuliAllan 4 роки тому +2

      Worms!?

    • @Thessalin
      @Thessalin 4 роки тому +1

      @@SuviTuuliAllan Yes worms! Not earthworms, but hook worms or pins worms. Maybe other types of parasitic worms. The hypothesis was they have an anti-inflammatory chemical to keep themselves from being eaten by the body, which can help people with auto-immune disorders. I saw something about the study on the BBC years and years ago. Never saw any serious follow up sadly. I had hoped it would work or generate new drugs.

    • @Nosirrbro
      @Nosirrbro 4 роки тому +5

      It’s quite unfortunate that the field which deals with people with mental disorders the second most is law enforcement

    • @Thessalin
      @Thessalin 4 роки тому +2

      @@Nosirrbro Amen to that.

  • @pierrevillemaire-brooks4247
    @pierrevillemaire-brooks4247 4 роки тому +1

    Does this mean that people with allergies are more prone to develop schizophrenia ?
    What about the roll of glial cells in the brain ?

  • @darthsidius9631
    @darthsidius9631 4 роки тому +1

    This is HUGE

  • @like90
    @like90 4 місяці тому

    I'm autistic and my brain does synaptic pruning less so I have way too many synaptic pathways.

  • @nofacee94
    @nofacee94 Місяць тому

    and all the problems caused by medication make the science much harder

  • @SteveParkin
    @SteveParkin 4 роки тому

    I don't know what it is but I like this presenter's style.

  • @LadyLenaki
    @LadyLenaki 4 роки тому +4

    I know that gluten can exacerbate certain mental illnesses, including schizophrenia, bipolar, and dementia.

  • @MayaGasterMoll
    @MayaGasterMoll Місяць тому

    damn... i've always said it like two words: micro glia i didn't know u were sposed to pronounce it like that

  • @berryberrykixx
    @berryberrykixx 4 роки тому +2

    I wonder if this could apply to other mental health conditions as well?

    • @GLaDTheresCake
      @GLaDTheresCake 4 роки тому

      @@sentientfetus3894 Why does autism spectrum disorder strike you as a likely candidate? I strikes me as one that probably isn't neurodegenerative at all actually. Since it's definitely present from birth (or at least a very early age, though diagnosis can't come until later since it's heavily tied to complex social behaviour). The DSM has historically grouped schizophrenia and ASD together a bit, even going so far as to make them mutually exclusive, something I have always been extremely hesitant of, but this confirms my critique more in my eyes. People with ASD aren't necessarily anti social in the broad way schizophrenics seem to be, and the lack of hallucinations and lack of required presence of damage to the brain is very telling too I'd say.

    • @lucifaerislifeandstuff5181
      @lucifaerislifeandstuff5181 4 роки тому

      @@GLaDTheresCake the mutually exclusivity of autism and schizophrenia comes from them affecting different parts of the brain differently

  • @ayammusic7719
    @ayammusic7719 4 роки тому +2

    What if they take dmt.?

  • @smavi4133
    @smavi4133 Рік тому +1

    I read about this like 20 years ago - even then they wrote that this is an actually old hypothesis but NOW it is taken seriously and is a major paradigm shift for the treatment of psychiatric ailments. And how many immune system based treatments have been brought out recently? 0.

  • @moses6486
    @moses6486 4 роки тому

    Very interesting, our body is running countless feedback loops in delicate dynamics.

  • @luzdaviola
    @luzdaviola 9 місяців тому

    Could it be from heavy metal toxicity? Mercury? Aluminium? Lack of nutrients and things like glycine?

  • @DavidRichfield
    @DavidRichfield 4 роки тому +3

    4:20 it's pronounced Micro-Glia, not Mi-croglia!

    • @bdf2718
      @bdf2718 4 роки тому +1

      Mine are my-crog-lee-a. Yours are your-crog-lee-a. His are his-crog-lee-a. Hope this helps.

    • @userou-ig1ze
      @userou-ig1ze 4 роки тому +2

      @@bdf2718 this was almost funny.

    • @withhernosestuckinabook2507
      @withhernosestuckinabook2507 4 роки тому +1

      I thought it was funny.

  • @chickensandw1tch
    @chickensandw1tch 2 роки тому

    yeah but still trippy voices with personalities start talking to you like what

  • @raspberrytaegi
    @raspberrytaegi 4 роки тому +1

    fascinating!

  • @kingsinthos8218
    @kingsinthos8218 4 роки тому +1

    Is it lupus?

  • @shaos3316
    @shaos3316 5 місяців тому

    My anhedonia and avolition get worse when I have milk, maybe it is bcs milk worsen my autoimmune condition

  • @skilltreebusybee
    @skilltreebusybee 2 роки тому

    Well I guess we have a better idea on why MHC geans are altered .
    Clostridium bacteria has aflatiotions with schizophrenia is it possible a friend of that strain is involved?

  • @MT-ll3tu
    @MT-ll3tu 4 роки тому +2

    Wouldn't shock me that the causes for Depression, Schizophrenia and more are low key brain damage. Wasn't there a dude who had a very exotic treatment for cancer, Discovered it cured his Schizophrenia?. At what point are they not disorders but symptoms of something else?.

    • @knockhello2604
      @knockhello2604 3 роки тому +1

      I was also thinking about this

    • @MT-ll3tu
      @MT-ll3tu 3 роки тому

      @@knockhello2604 It opened a can of worms, There are people that got there bipolar 2 fixed by getting a poop transplant. Heck I've even seen people have there Deperession go way either quick or slowly by getting rid of unneeded stress.

  • @autumnmanning4397
    @autumnmanning4397 3 роки тому

    This is an Amazing video.!!and I know this is hella petty of me, but its pronounced micro-glia- not -mi-grog-lia-. I'm sorry but it's messin' me up yo. lol

  • @DanielSMatthews
    @DanielSMatthews 4 роки тому +13

    There is one simple but dangerous experiment to test the hypothesis, and if it is correct to also cure schizophrenia, knock out the person's immune system and replace it with a new once via a bone marrow transplant.

    • @grmpEqweer
      @grmpEqweer 4 роки тому +2

      Huh. That's an interesting idea.

    • @LoneIrbis
      @LoneIrbis 4 роки тому +4

      It's possible though that the damage caused to the brain by the time schizophrenia develops is irreversible, then fixing immune system either with meds or transplant won't make any difference for those who already has this diagnosis.
      More potential, however, might be in prophylactic treatment for those who has predisposition for autoimmune and/OR schizophrenia - as it's also proved to have genetic markers (a combination of several of them, in fact).
      On another note, this whole correlation might also be explained by genetic relation between autoimmune predisposition and schizophrenia, i.e. not a direct link by one causing another, but just that people tend to get them in a pack in their genes.

    • @gregorymalchuk272
      @gregorymalchuk272 4 роки тому

      Immune suppression is a lot easier than stem cell transplantation.

  • @SLAYERSARCH
    @SLAYERSARCH Місяць тому

    and they help push people to become as such

  • @dr.casebolt
    @dr.casebolt 4 роки тому +1

    Micro-GLEE-uh, not mi-CROG-leah

  • @ragrle
    @ragrle 4 роки тому

    Just because you have a foot out of the cave does not mean you're not a Cave Man.

  • @KSWfarms
    @KSWfarms 4 роки тому

    Oh great I really need another autoimmune condition. *le sigh*

  • @MrCharlesdick
    @MrCharlesdick 2 роки тому

    seems like a clinical trial should be done testing Skyrizi in schizophrenia patients. Mechanistically that makes sense.

  • @LAChantrose
    @LAChantrose 4 роки тому +342

    Wow. My daughter is Schizoaffective, and she was recently diagnosed with an autoimmune disorder (we think it may be RA, we're going to the rheumatologist soon). This is eye opening.

    • @SuviTuuliAllan
      @SuviTuuliAllan 4 роки тому +5

      @@sentientfetus3894 Stronger cells, eh? Suuuure.

    • @SuviTuuliAllan
      @SuviTuuliAllan 4 роки тому +6

      @@sentientfetus3894 Where you getting this information? Do you know what autoimmunity means?

    • @ZombieBarioth
      @ZombieBarioth 4 роки тому +13

      @Sentient Fetus
      What makes no sense are your musings. Testosterone has nothing to do with your immune system, its a growth hormone that influences things like mood. Hormone imbalances cause issues like irritability or depression.
      Autoimmunity isn't stronger or more cells, its your body's response to system. Ann autoimmune disorder means your body is prone to overreacting or misidentifying threats.
      Yes, autism has been linked to autoimmune disorders as well, but an overactive one, that is to say things like allergies or sensitivities.

    • @mem1701movies
      @mem1701movies 4 роки тому +4

      Sentient Fetus I read that vitamin d might help with symptoms. As people get less sun now and told the sun was bad...autism spiked. Vitamin D is a hormone that affects everything in the body

    • @francischimenti1374
      @francischimenti1374 4 роки тому +7

      Is she having abdomen, lower and mid back pain(especially at the peak of inhaling for the mid back pain) too? Nausea and pain when hungry AND after eating? I'm also Schizoeffective and suffering Crohn's disease like symptoms the docs THOUGHT was rheumatoid arthritis too. It's important they diagnose it soon.

  • @thesuccessfulone
    @thesuccessfulone 4 роки тому +340

    Depression also is tied to inflammation in the brain. Maybe the neurodegeneration of various parts also link to brain inflammation

    • @crywhit4619
      @crywhit4619 4 роки тому

      Makes sense

    • @illiengalene2285
      @illiengalene2285 4 роки тому +4

      Multiple sclerosis is also highly linked with depression.

    • @KatGlos
      @KatGlos 4 роки тому +8

      It makes sense. I believe most mental illnesses are at least in part caused by physiological illnesses.

    • @cyanrosespirit
      @cyanrosespirit 4 роки тому +8

      @@KatGlos That's a connection that should go without saying- your brain is as much a part of your body as anything else. An illness in the body is an illness in the body. Brain cancer, depression, lung cancer- they're all equally physiological in origin.

    • @koditv551
      @koditv551 4 роки тому +5

      A 2012 study of 6 common antidepressants act as an anti inflammatory on the microglia in the brain. The papers conclusion was that part of the efficacy of antidepressants was do to the anti inflammatory properties

  • @yulebones
    @yulebones 4 роки тому +240

    This is an incredible paradigm shift and gives me hope for so many disorders.

    • @sas3dx
      @sas3dx 4 роки тому +3

      @ForestofTooMuchFood proof?

    • @cobalius
      @cobalius 4 роки тому

      I feel the same about this

    • @AFrostyDonut
      @AFrostyDonut 4 роки тому +2

      @@sas3dx it's true, I was the herbicide

    • @koditv551
      @koditv551 4 роки тому +2

      The research has been mounting for over 20 years, a 2008 paper titled "From inflammation, to sickness, and depression" is a good read

    • @luzdaviola
      @luzdaviola 9 місяців тому

      Could it be from heavy metal toxicity? Mercury? Aluminium? Lack of nutrients and things like glycine?

  • @zvihassan6094
    @zvihassan6094 4 роки тому +69

    Truly interesting!

  • @skyla611
    @skyla611 4 роки тому +205

    This is an extremely important topic. I have some minor inflammatory issues currently affecting my skin, but my mother has schizophrenia. I always wondered in inflammation and immune issues played a part.

    • @Skund79
      @Skund79 4 роки тому +3

      Scary

    • @skyla611
      @skyla611 4 роки тому +15

      Skund it is a little scary. This is giving me the push I need to try addressing inflammation through diet. Anything to help lower my risk of developing.

    • @Skund79
      @Skund79 4 роки тому +5

      @@skyla611 I wish you the best for your future!

    • @skyla611
      @skyla611 4 роки тому +1

      Skund thanks!

    • @Anglesso
      @Anglesso 4 роки тому +9

      There was this woman was diagnosed with schizophrenia but her doctor noticed something and it was a tiny inflammation in the brain. They were able to get rid of it and so she didn’t actually have “schizophrenia,” but at this point we don’t have a solid base of what schizophrenia actually is.

  • @grauekatze
    @grauekatze 4 роки тому +178

    I really like Anthony's clear and calm way of speaking.

    • @bdf2718
      @bdf2718 4 роки тому +1

      You didn't cringe at "my-crog-lee-a"?

    • @grauekatze
      @grauekatze 4 роки тому +1

      @@bdf2718 evidently didn't even notice. No one ever pronounces words the way I learned them in school (non native speaker) anyway, so meh?

    • @bdf2718
      @bdf2718 4 роки тому

      @@grauekatze Hmmm, your username looks German, and Germans tend not to use classical Greek and Roman words to construct new words - we have a television but Germans have a Fernsehapparat. Even so, "micro" (from Greek, via Latin) is an SI prefix even Germans are familiar with. I don't know what "glia" is in German.

    • @ezion67
      @ezion67 4 роки тому +1

      Second that, other SciShow hosts should take him as an example.

    • @DoctorX17
      @DoctorX17 4 роки тому +2

      If you close your eyes, he kinda sounds like LeVar Burton

  • @mschrisfrank2420
    @mschrisfrank2420 4 роки тому +50

    My great-uncle had paranoid schizophrenia, and there are autoimmune diseases all over that side of my family-ulcerative colitis, lupus, etc.

    • @luzdaviola
      @luzdaviola 9 місяців тому +1

      Could it be from heavy metal toxicity? Mercury? Aluminium? Lack of nutrients and things like glycine?

  • @breyjames5025
    @breyjames5025 4 роки тому +32

    This is a little bit of a weird story but hear me out. A little back knowledge to begin, my mother has her bachelors degree in biology, so she is educated to make an intelligent hypothesis. Continuing on, I had an ex bf whose step father suddenly had extreme behavior changes and schizophrenic like symptoms. Well their house was covered in house cat excretions and bodily fluids. One of the cats was really weird and my mom had the idea that the step fathers behavior changes were related to the state of the house because of toxoplasmosis, which is spread through cat feces. Toxoplasmosis can cause psychological symptoms. And that's how this relates to this video, that schizophrenic symptoms could be caused by an autoimmune response to some bacteria/infection or virus, or parasite.

    • @jihon3363
      @jihon3363 2 роки тому +1

      How did the story end, did he recover? It's strange that they recognize schizophrenia is caused by inflamation and immediately think autoimmune disease instead of maybe brain parasite.

    • @elsagrace3893
      @elsagrace3893 Рік тому

      @@jihon3363 brain parasites hardly ever happen. Schizophrenia is common enough. I think you have brain parasites 😂

    • @gristen
      @gristen Рік тому +3

      @@jihon3363 they didnt mention it in this video, but they believe its caused by autoimmune disorders because there have been many documented cases of long term psychiatric patients that only recovered after receiving treatment for lupus. the most famous and breakthrough case being that of april burrell. the washington post has a good article about her recovery if youre curious

    • @eyeswideopen7777
      @eyeswideopen7777 10 місяців тому

      Opioids can cause schizophrenia

  • @krush454
    @krush454 5 місяців тому +10

    As a schizophrenic, I just like that one thing is said and I wish it would be acknowledged more. Schizophrenia treatments reduce symptoms it doesn't stop them. Its a treatment not a cure. I still hear and see things I know aren't there and I'm on a heavy medication regiment. People think the pills make them go away, but it, for me at least, just makes them more manageable.

    • @akshorts2115
      @akshorts2115 5 місяців тому

      if you don't mind have you ever had any suicidal thoughts do you also get suicidal thoughts about jumping off a high place 😔 please tell me truth i am suicidal 🙏 i am sorry if it hurts your feelings 😢

    • @krush454
      @krush454 5 місяців тому +1

      @@akshorts2115 I don't have personal suicidal feelings, but there are 2 distinct voices that do encourage me to hurt myself or even end myself. I want to help you if I can, suicidal thoughts are terrible and we all need help sometimes

    • @akshorts2115
      @akshorts2115 5 місяців тому

      @@krush454 hi thanks for your reply just wanted to ask u what would be your method of u have suicidal thoughts 🤔 just asking I am sorry if it's offensive to you

    • @akshorts2115
      @akshorts2115 5 місяців тому

      @@krush454 just wanted to ask u have u ever had suicidal thoughts about jumping off the building do u feel scared about it❓

  • @bulkeh
    @bulkeh 4 роки тому +27

    This is very interesting to me. I had a client who has psoriasis in addition to schizophrenia and both seemed to flare up at the same time.

    • @maxaffe3195
      @maxaffe3195 5 місяців тому +3

      it is so sad that since 1950 there have been almost no advancements

  • @ThatQatPerson
    @ThatQatPerson 4 роки тому +6

    I wish medical science would stop treating psyche like it isn't part of the large organ in our heads. If an auto-immune disease can cause my type 1 diabetes, psoriasis and lupus then why couldn't it do the same to the brain?

  • @cellogirl11rw55
    @cellogirl11rw55 4 роки тому +14

    I have Bipolar Disorder, and I also have an autoimmune disorder, called Hashimoto's Disease, which I inherited from my mother, who also has postpartum depression and Seasonal Affective Disorder. Makes me wonder. . .

  • @fredworthmn
    @fredworthmn 4 роки тому +16

    Been dealing with memories of a person with this condition for about a week. Back in the 60's and 70's these things were considered character weaknesses and people were locked up and shunned like this lady I was trying to remember. Those who have this condition today can function in society with the meds and for most sufferers they get along adequately.
    Sadly, when I did remember her name and her brothers name, they had both died within the last 2 years. The lady was never able to live on her own because of this condition. Maybe the insight in this video would have helped her!

  • @cyclenut
    @cyclenut 3 роки тому +11

    I have childhood onset schizophrenia. I also have multiple personalities and an extremely high IQ. All is clinically diagnosed. My Schizophrenia showed signs before 3 years old.
    If schizophrenia is brain disintegration, it is a direct conflict because of high IQ and extremely good memory.
    Also, schizophrenia maybe heredity. My mother also had schizophrenia. Both my mother and I showed no signs of any autoimmune conditions.
    As a child, abuse brought out my schizophrenia. Other wise it is mild.

    • @EpinereinUrbex
      @EpinereinUrbex Рік тому +4

      I totally relate to that. Everything you said. I got diagnosed with schizoaffective. Every meds given to me gives unbearable side effects. Taking various supplements and going easy on autoimmune inducing foods helps a lot

    • @bilkishbegum6681
      @bilkishbegum6681 Рік тому

      @@EpinereinUrbextry niacin with vitamin c. Check out dr Abram hoffer

  • @GrimIkatsui
    @GrimIkatsui 4 роки тому +24

    Growing up I used to worry I might develop schizophrenia. Instead I got multiple sclerosis, an auto-immune disease that attacks the brain and spine. I've had some minor hallucinations and delusions as a result and I often wondered how different it really was from schizophrenia. Apparently not much.

    • @amandah.2202
      @amandah.2202 Рік тому

      I’m curious do you remember your childhood if so how much minor trauma occurred before age of ten … how was relationship with parents and there parenting styles

    • @GrimIkatsui
      @GrimIkatsui Рік тому +2

      @@amandah.2202 My parents were loving and attentive, but my mother's nature is the opposite of emotionally supportive so I didn't trust her or like physical contact from her by the age of 5. I spent a fair amount of time at a daycare facility run by my mother's friend, where I experienced some minor sexual traumas at the hands of boys in their early teens.

    • @eyeswideopen7777
      @eyeswideopen7777 10 місяців тому

      Did you live with mold in the house

    • @GrimIkatsui
      @GrimIkatsui 10 місяців тому +1

      @@eyeswideopen7777 No. That said, I'm starting to think stress and dietary habits (binge eating) along with a genetic predisposition are the cause of my problems.

    • @eyeswideopen7777
      @eyeswideopen7777 10 місяців тому

      @@GrimIkatsui yea I hear they need to eat healthy. Have you had it for a long time

  • @maxinealexander9709
    @maxinealexander9709 4 роки тому +11

    I read an article in MIT's magazine saying that it's because microglia, which sort of "clean up" unused neurons and act like janitors for the brain, are "cleaning up" pathways in the brain that they shouldn't. They spoke of how the cause was likely genetic. And they spoke about how they couldn't just remove microglia because, besides the necessary cleaning not being performed, they secrete an enzyme that neuronal tissue can't function without. It was quite fascinating and has stuck with me for years. I had to have read it around 4 years ago.

  • @naomilovenpeace
    @naomilovenpeace 4 роки тому +38

    Since autoimmune diseases are much more likely to developed in women I wonder why, if this is true, men and women have relatively equal rates of schizophrenia.

    • @KCH55
      @KCH55 4 роки тому +16

      Or maybe men are less to be diagnosed bc they less likely shows symptoms (asymptomatic) or bc schizophrenia has a generic connection. I remember heart disease used thought of more male disease but females tend to show it differently.

    • @BlckSWANWhtRbbt
      @BlckSWANWhtRbbt 4 роки тому +11

      There is evidence that a mother having an immune reaction to a cold or flu while pregnant can cause it as well. The birth months rates of those with schizophrenia show significant births in winter months respective of hemisphere.

    • @silviafox78
      @silviafox78 4 роки тому

      Maybe this is why men say most women are crazy... It's just that the ones that are actually schizophrenic are not too much crazier to the men as any other woman they've met and so they don't realize there is something actually going on.

    • @silviafox78
      @silviafox78 4 роки тому +2

      @Brook Heyes - I don't doubt that happens. However I believe when a man meets a schizophrenic woman once they will forever see emotional outbursts as a sign of what they see as crazy behavior. 1 bad egg ruins the omelet, as they say.

    • @bdf2718
      @bdf2718 4 роки тому +5

      Some immune system genes are on the X chromosome. Women have XX, men have XY. It's thought to be why women tend to be healthier, and live longer, than men. But it also means they have increased risk of an immune system gene that lead to auto-immune diseases.

  • @ericacook2862
    @ericacook2862 4 роки тому +34

    Working nights in a mental health facility, I'll say the most common thing I see between patients with the traits associated with schizophrenia is sleep disruption, or lack of sleep. Once people have come in, it's not uncommon for them to have been up for over a week without ever even trying to sleep. We'll get people who insist that they need no more than 2 hours of sleep a day, and will do everything to fight going to sleep. This isn't 100%, but usually when people do not benefit from sleep while showing signs of schizophrenia they wind up having bipolar disorder. I believe we will not get a proper grasp of what's going on with patients who present symptoms of schizophrenia until we explore the correlation between it and sleep disruption. It could be autoimmune, it could be a development in utero, but all of it has something to do with sleep. We have patients who fit the schizoaffective guidelines who will be at our facility for days, weeks, even months, without ever sleeping more than 3 hours a day. We've had patients who have never slept more than a half hour a day. The brain is not designed to function like that. Every single one of them insist that they don't need to sleep.

    • @stolenrelic
      @stolenrelic 4 роки тому

      I wonder if delusions during bipolar are also caused by a temporary increase in autoimmune activity.

    • @Nosirrbro
      @Nosirrbro 4 роки тому +3

      I would think that the symptoms of schizophrenia would probably make a normal sleep cycle far harder to achieve than for the average population. I would wonder if it’s simply because other factors cause them not to sleep well (and then think they don’t need it) or if the root cause is some biological disturbance that makes them directly feel like they don’t need sleep.

    • @koditv551
      @koditv551 4 роки тому +5

      It is more likely that the lack of sleep is a consequence of a perturbation of the systems in the brain. Sleep problems are quite in ME/CFS as well

    • @eyeswideopen7777
      @eyeswideopen7777 10 місяців тому +1

      Were they sexually abused before

    • @motorcyclesandmakeup1297
      @motorcyclesandmakeup1297 10 місяців тому +1

      I went through a scary time when I thought I didn’t need to sleep , I think that made me worse . It’s true

  • @robertschlesinger1342
    @robertschlesinger1342 4 роки тому +12

    Interesting and worthwhile video. Be sure to download the supporting scientific papers linked with the video.

  • @NewMessage
    @NewMessage 4 роки тому +48

    That is just mind boggling.
    No pun intended.

  • @thewatcher7823
    @thewatcher7823 3 місяці тому +2

    Going along with this theory, it could be implied that the gut plays a role in schizophrenia as well, as the gut is linked with both the brain and the immune system in ways that's still being looked into.
    If someone can have leaky gut, it seems possible to have a leaky blood-brain barrier to, among other things.
    Thankyou for the video.

  • @all3ykat79
    @all3ykat79 3 роки тому +7

    my sister was given vitamin d shots for deficiency, and it resolved her autoimmune food allergies. sunlight is good for my psoriasis. and vitamin d, from sunlight, can delay or reduce symptoms of MS. I hope scientists consider this as a possible compliment to nsaids and psych meds.

  • @michaeljames5936
    @michaeljames5936 3 роки тому +5

    There is a lot of evidence accumulating about 'inflammation' and any number of mental health disorders, but it shouldn't be forgotten that in the midst of our seeking infections and auto-antibodies, that chronic stress is a major cause of inflammation. In particular, living in an environment with a lot of expressed criticism and a loss of community are hugely influential in causing depression and schizophrenia. (Finally, I've witnessed many false dawns in the search for 'The' cause of mental illness, so I'll remain cautious in my optimism.)

  • @josephtulberg9520
    @josephtulberg9520 5 місяців тому +2

    I usually feal the best right before I get sick. Then the next day when I get sick I have rilly bad mental health. The day before I get sick I think that my bran is better because my immune system is fighting the sickness instead of my brain. I hope this is helpful

  • @franklinayala4879
    @franklinayala4879 2 роки тому +4

    Dr. Georgia Ede has put this hypotheses to work doing a nutritional psychology

  • @regular-joe
    @regular-joe 4 роки тому +20

    Anthony is quickly blossoming into one of the best hosts on this channel - very exciting! (Please give him the support in preproduction with pronouncing unfamiliar words).

    • @IanGrams
      @IanGrams 4 роки тому

      I've always said micro-glia but strangely both Oxford and Merriam-Webster list it as he pronounced it. Now I'm wondering how that disconnect came about.

  • @aprilburton3018
    @aprilburton3018 4 місяці тому +1

    New research shows Schizophrenia might be a metabolic disorder. The keto diet seems to have a very positive effect, to the point of eliminating symptoms in some people, or at the very least being able to reduce medication with the help of their doctor. Don't reduce medication on your own. My grandmother, brother, son, and nephew all have or had Schizophrenia. Blessings and Grace to all those who suffer this horrible disease. 🙏 ❤

  • @silviafox78
    @silviafox78 4 роки тому +6

    I wonder if any food allergies can be related to this as some food allergies can cause long-term inflammation and what seems to be an autoimmune response.

    • @birde6393
      @birde6393 3 роки тому +1

      i know some people w/ celiac disease display schizophrenia-like symptoms if they consume gluten :o so maybe????

  • @subspace666
    @subspace666 4 роки тому +1

    if Schizophrenia is autoimmune then it would mean drugs cause autoimmune conditions...

  • @Jadead23
    @Jadead23 4 місяці тому +1

    We have a lot of autoimmune illness in my family, I've been diagnosed with one, and my mother has schizophrenia

  • @jimdim851
    @jimdim851 4 роки тому +4

    Is inflammation from allergies (for example hay fever) included in the inflammation that may cause schizophrenia? And are allergies an autoimmune disease?

  • @earthmamma85
    @earthmamma85 Рік тому +8

    Mediterranean, lower carb diet will help everyone with autoimmune, and mental disorders. Too many carbs cause inflammation… constantly eating carbs keeps inflammation high.

  • @janschescke8102
    @janschescke8102 3 роки тому +23

    I have schizophrenia, working out really helps me ALOT!!!

    • @cyberrunner6529
      @cyberrunner6529 3 роки тому +1

      How are you doing now hope you are happy

    • @shield-u8f
      @shield-u8f 2 роки тому

      Sounds great, I have it too, what type of sports do you do?

    • @Slidehhy
      @Slidehhy Рік тому +1

      It is hard to work out with no energy

  • @TrevorJrHotkiss11
    @TrevorJrHotkiss11 4 роки тому +4

    There are also statistics that say those with schizophrenia have a higher rate of epilepsy, and vice versa.

  • @AmericanGreg
    @AmericanGreg 2 роки тому +2

    I recommend checking out Dr. Brooke Goldner. I'm beginning to try out her plant-based hyper-nutrition rapid recovery healing protocol, which incorporates a lot of omega-3 fats from things like chia and flax seeds as well as avocados and nutrients from a lot of cruciferous vegetables (minimal fruits - during the 6 week healing period). Also, she eliminates the foods that create the inflammation (animal products).

  • @10LettersIsTooLong
    @10LettersIsTooLong 4 роки тому +5

    Now is not the time to tell me I may have an autoimmune condition. (Seriously though, great video!)

    • @francischimenti1374
      @francischimenti1374 4 роки тому +1

      I feel you man, I've suffered 15 years of psychotic breakdowns from my Schizoeffective disorder and it's been over a year that I've suffered and exhibited Crohns disease like symptoms(an inflammatory disease of the bowels). I get covid 19, I'm screwed. It'll be a tragic and pointless end to leave for my beloved partner and family.
      Stay safe and take extra care.

  • @JungleJargon
    @JungleJargon 3 роки тому +2

    Have fun with that… not hardly anything to do with the immune system. Let me know what progress you are having… it a belief mechanism. It’s dilating pupils. It’s thought responses an reactions.

  • @subspace666
    @subspace666 4 роки тому +1

    if Schizophrenia is autoimmune then it would mean drugs cause autoimmune conditions...

  • @andrewj22
    @andrewj22 4 роки тому +3

    Kudos for the one small step towards scientifically literate reporting at 2:32 ("Whether that's because inflammation causes schizophrenia or the other way around isn't clear") but you forgot the other very likely possibility that neither causes the other, but instead that both inflammation and schizophrenia are caused by an unidentified third factor.

  • @maxwell4546
    @maxwell4546 4 роки тому +9

    Perfectly timed, too.

  • @subspace666
    @subspace666 4 роки тому +1

    if Schizophrenia is autoimmune then it would mean drugs cause autoimmune conditions...

  • @akkawowa
    @akkawowa Рік тому +3

    Coeliac disease (an autoimmune disorder caused by gluten) is also linked to schizophrenia.

    • @thestu4602
      @thestu4602 11 місяців тому +1

      Great post, encourage people out there to checkout Coeliac, Gluten & schizophrenia online

  • @LOOregano
    @LOOregano 5 місяців тому +1

    Check out connection between mold and autoimmune issues.

  • @c.k.1530
    @c.k.1530 3 роки тому +2

    Research Toxoplasmosis

  • @subspace666
    @subspace666 4 роки тому +2

    if Schizophrenia is autoimmune then it would mean drugs cause autoimmune conditions...

    • @BadBigBody
      @BadBigBody 3 місяці тому

      Why? Schizophrenia isn’t caused by drugs, it seems to be hereditary

    • @subspace666
      @subspace666 3 місяці тому

      @@BadBigBody one doesn't exclude the other, mental disorders can have many causes even things that can seem trivial like diet.

  • @machfassett5749
    @machfassett5749 10 місяців тому +3

    I remember getting a bad infection when I was about three or four (I only remember bits and pieces--most of what I'm about to talk about is from my mom's recollection). I was in the emergency room once with a high fever and other symptoms, and they said it was a kidney infection, so I was sent home with antibiotics. Those didn't work, as evidenced by my later even higher fever, vomiting, etc. They eventually realized it was an infection in my toe that i got by ripping my toenail open on a stray piece of string on my parents' old comforter (I know--the chances of that happening).
    Since then, I've dealt with progressively worsening mental health. I remember being five or six and consciously thinking that all of the UA-camrs I watched were robots, and not really believing that anyone I didn't personally know and have a connection with was a real person, at least on a subconscious level. The world hasn't felt real for nearly a decade. Paranoia and negative symptoms of schizophrenia started cropping up around 7th or 8th grade, which is also when my physical health started noticeably declining, developing orthostatic intolerance and chronic fatigue. Since then, my schizophrenia and the decline of my physical health have been progressing in tandem--getting noticeably worse in the colder months (extra inflammation and chronic pain from hEDS as the temperature drops, and the vast majority of my worst psychotic episodes happening at the turn of autumn and then again in the darkest and coldest parts of the year) before improving somewhat, but always on an overall downhill slide.
    Quite honestly, it would make a good deal of sense if these things were connected in my case--I wonder what future research has to bring to the table!

    • @annwalker8907
      @annwalker8907 9 місяців тому +1

      Thank you for sharing, I pray for your healing. I’m reseating this for a family member. Look into orthomolecular medicine. With blood tests to see what vitamins you need you could find healing. I don’t know for sure, as my family member is not able to see there is a problem so helping has been hard.

    • @machfassett5749
      @machfassett5749 9 місяців тому +1

      @@annwalker8907 Unfortunately, extra vitamins won't help. The only noticeable deficiency I have is an iron deficiency, which I'm already taking supplements for--trust me, I've had plenty of blood tests, mostly administered by doctors who refused to believe it could be hEDS (a genetic disorder that causes collagen proteins to be folded incorrectly--collagen supplements don't help it in any fashion because it's just giving supplies to make collagen (any consumed collagen has to be broken down because it's too large of a molecule to be used as-is), which my body will make incorrectly regardless) because of its supposed (and likely false) "rarity".

  • @johnshoemaker5532
    @johnshoemaker5532 4 роки тому +3

    I have it and it sucks balls and i keep losing my mind!! But i have a great immune system i never get sick at all!! But i do throw up blood everyday!!

    • @francischimenti1374
      @francischimenti1374 4 роки тому

      You mean "You LOST your mind a LONG time ago, life has become literal improv ever since"? If so, keep on winging it dude. Never stop changing and evolving. The death of the "false ego"(entrance into (Inner)sanity) was not a failure but an awakening. We stopped being mere animals that day and became actual human beings, maybe more. You're not alone. 😑✊

    • @Lara-jp4xk
      @Lara-jp4xk 3 роки тому

      If U do throw up blood, that's a serious health problem that needs to be diagnosed by a doctor.

    • @johnshoemaker5532
      @johnshoemaker5532 3 роки тому

      It is i have gard my stomach always bleeds!

  • @eseguerito2629
    @eseguerito2629 4 роки тому +12

    “Cool so now i can have audio-visual halucinations AND COVID-19. Yeet.”
    - Someone braver than I.

  • @manso306
    @manso306 4 роки тому +2

    that's not how you pronounce microglia afaik
    it's micro-glia

  • @Layow.
    @Layow. 4 роки тому +3

    Woooow! This is my first time checking in on this channel, and Im amazed by the character that is narrating this episode. Very well done and easy to follow!

  • @ladame3382
    @ladame3382 4 роки тому +4

    and the immune system is connected with our gut, so we should examine it too

    • @Alice-si8uz
      @Alice-si8uz 4 роки тому +1

      And the gut is surprisingly important to mental health (as is diet).

    • @userou-ig1ze
      @userou-ig1ze 4 роки тому +1

      and the gut is connected with the brain! Which is connected with quantum entaglement. And that means with you! It seems we should examine you and your comment more closely! Let's not forget, everything is connected...

  • @Vixinaful
    @Vixinaful Рік тому +1

    "Structral brain differences" You can say that again, their holes of the center is huge, these are extreme brain damages! Strange thing is my parent has schizophrenia and I have an autoimmune condition but never had or have schizophrenia. And what do we do about the brain damages that are already there? We cant heal those..yet.

  • @beverliedunlap2770
    @beverliedunlap2770 4 роки тому +2

    I think this has merit but if this is true how is it explained that schizophrenia onset is most common in late teens and the twenties. Why a certain age?

  • @AnikaWells274
    @AnikaWells274 Місяць тому

    I've been a schizophrenia patient . I know why exactly it happened . I was initiating into Spirituality from online . Suddenly I began to feel like I had supernatural power . I can telecommunicate ..I can hear things from others what they are saying inside ... That's how it growed and turned into severe issue ... But I'm fine now , hope everyone else too

  • @shahnilakanwal1457
    @shahnilakanwal1457 2 місяці тому

    I have inflammation and vitamin b12 deficiency I’m struggling feel like I’m lost I don’t know what’s really

  • @Bella7bella
    @Bella7bella 11 місяців тому +1

    How can you help my sister. She really needs help for her schizophrenia or we are gonna lose her???

    • @thestu4602
      @thestu4602 11 місяців тому

      Please look at correlation between Gluten & schizophrenia, if she cuts this out it may just help! There are a couple of stories online of recovery from this where patient were having hallucinations & Auditory episodes when they consume this toxic garbage! Wish her well!