Selecting between anti-CD20 bispecific antibodies and anti-CD19 CAR T-cells in third-line NHL

Manali Kamdar, MD, University of Colorado Cancer Center, Denver, CO, discusses the role of anti-CD20 bispecific antibodies in treating non-Hodgkin lymphoma (NHL) and their sequencing with anti-CD19 CAR T-cells. Both are approved for third-line therapy. Dr Kamdar usually selects CAR T-cells in this setting due to longer follow-up data, proven central nervous system (CNS) efficacy, and concerns that using bispecific antibodies first might lead to T-cell exhaustion, reducing the effectiveness of subsequent CAR T-cell treatment. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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