HER2 IHC Interpretation Guide (Examples and Challenging Scenarios)

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  • Опубліковано 22 гру 2024

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  • @omerali2690
    @omerali2690 3 роки тому +5

    Thanks a lot sir. I know there are not many views but your presentations are extremely helpful and valuable for us, trainees.

  • @Lisa_5591
    @Lisa_5591 2 роки тому

    Thank you! My biopsy showed ER/PR both strong positive
    HER2 Negative. Just had an SMX 7/27 and IHC showed Her2 2+ so equivocal, plus ER/PR positive again. Currently awaiting FiSH results. I'm hopeful it's negative. I had DCIS with lumpectomy and radiation for my 1st dx back in 2000.

  • @bhanumatilab7886
    @bhanumatilab7886 2 роки тому +1

    Excellent session on HER 2 IHC interpretation..Full of practical tips for routine practice. Highly grateful to you Dr. Alexander Damron

  • @guruspath4291
    @guruspath4291 2 роки тому +1

    Very informative. Thanks doc!

  • @madhuk5449
    @madhuk5449 11 місяців тому

    Fantastic presentation

  • @SandhyaRamachandran
    @SandhyaRamachandran 3 роки тому +1

    Dr.Damron, thank u so much! Extremely well explained..I always found Her 2 challenging.
    At 10:01, “Barely perceptible at Low Power” ..I am assuming it to be 4X obj that you are referring to? (since at 14:01 u hv shown a 4X obj.image)

  • @OmarJaber-g4s
    @OmarJaber-g4s Рік тому

    thanks for the nice lecture. I have a case of well differentiated carcinoma, grade1 with tubular features that is showing a moderaTe basal/bassolateral staining. would you call it 2+ and send it for FISH?

    • @adamronMD
      @adamronMD  Рік тому

      The only time we really should consider basolateral staining in the breast equivocal is in micropapillary carcinomas. If you are seeing this pattern in a tubular carcinoma then it is not complete and should be scored as 1+

  • @umarsadique6207
    @umarsadique6207 Рік тому

    it was very interesting thanks a lot Dr.

  • @حانیهرفیعپور
    @حانیهرفیعپور 2 роки тому +1

    Thanks a lot it was very helpful

  • @samiahoucinat9492
    @samiahoucinat9492 2 роки тому

    Dear professor the picture show strong staining focally. even it is incomplete in more than 10 % but it doesn’t fit in definition of score 1+because it is not faint. Can we call it equivocal. As it doesn’t fit all n o. Not in 1. Not in3.

  • @EL-fe2of
    @EL-fe2of 11 місяців тому

    Hello Dr. Damron, after neoadjuvent therapy on a her2+ grading, a pathology report read residual cells 20 showing degenerative qualities, almost pcr, how close were these cells to destroyed, and how this few still remaining in your opinion? Less than 1mm in tumor bed -(or to any other qualified opinion) Thanks

  • @samiahoucinat9492
    @samiahoucinat9492 2 роки тому

    I mean some cases look 1+but they are not faint they are strong don’t exactely fit in definition of 1+should we better call them equivocal thank you so much for your excellent le tures

  • @MaryamAzizi-jf5lr
    @MaryamAzizi-jf5lr 9 місяців тому

    In cases with weak / moderate intensity but incomplete and in less than 10 percent of tumor cells… what score do you give to this one.. it’s not in the CAP, I could find it

  • @avanaavan2575
    @avanaavan2575 Рік тому +1

    Thanks Sir for this highly informative lecture :)

  • @Slnagurung
    @Slnagurung 2 роки тому

    Hi Dr Damron. How will we be able to differentiate the location of HER2 staining? such as cytoplasmic, membranous or nuclear. I am finding it hard! Could you please explain? thank you

    • @sumanapaul2174
      @sumanapaul2174 2 роки тому

      I guess as HER2 is a receptor,it should be present in membrane.

    • @adamronMD
      @adamronMD  2 роки тому

      The HER2 staining we score is based on membrane staining. Any cytoplasmic staining should not influence your score!

  • @avanaavan2575
    @avanaavan2575 2 роки тому

    Hello what do you recommend for me to start with as a beginner through breast pathology??? I have little basic information about pathology. Thanks

    • @adamronMD
      @adamronMD  2 роки тому

      The Molavi surgical pathology book is a great beginner book for basic histology!

    • @avanaavan2575
      @avanaavan2575 Рік тому

      @@adamronMD THANKS A LOT FOR YOUR RESPONCE :)

  • @praneethbablu2511
    @praneethbablu2511 10 місяців тому

    thank you!!

  • @moniashek2137
    @moniashek2137 3 роки тому

    Thank you!

  • @pezoserge2672
    @pezoserge2672 3 роки тому +1

    Thanks a lot

  • @sujathabalija2254
    @sujathabalija2254 3 роки тому

    Excellent thank you

  • @givepeace2007
    @givepeace2007 10 місяців тому

    Moses Nabem Agwa

  • @sujathabalija2254
    @sujathabalija2254 3 роки тому +1

    Excellent thank you