The impact of high and low burden TP53 mutations on risk and treatment decision in CLL

Maher Salamoon, MD, Al-Baironi Hospital, Damascus, Syria, discusses the impact of TP53 mutations on risk stratification and treatment decisions in newly diagnosed chronic lymphocytic leukemia (CLL). High-burden TP53 mutations correlate with poor outcomes and reduced drug response. Chemoimmunotherapy is now avoided in these patients; alternatives include ibrutinib, or venetoclax plus obinutuzumab. Early TP53 testing by next-generation sequencing (NGS) at diagnosis is recommended for all patients with CLL to guide treatment approaches. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.
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