I’m replying in February 2024. I’m curious how your schooling has progressed in the time since your post. Still heading to med school? I’m so glad to see people with dreams and ambitions. Best of luck to you!
Amazing. Thank you for sharing this with us. Looking forward to discussing this more with my students. The advances over the last 3 years have been astounding.
Virology unfortunately has become the new cash cow of the Qaukes and Pseudoscientists......These mferz are Criminals. To Build a Biohazard, Bill us for the Antidote-Vaccine and prance on towards a victory parade or Nobel Prize for doing such Beneficial, Lasting Goood to Mankind even. These are AIDS-carring, Rh Null Variation or some Disgusting Creature of Unknown Orgin/Aetiology. Aiding and Abetting this is unequivocally insanity and criminal, felonious enterprise. I ask of you to not Ecourage the Dogs lest you be one also. MD/PhD Finley, es muss besser sein am wenigstens. Heil!
By now you would have tested safety/efficacy in mouse model for lung pneumonia. Do you have results? Have you done clinical trail in human patients? Is phage treatment used in USA?
Any argument to get our scientific community to seriously consider something new, we are running out of other options... This video is a bit old so I wonder how their research has progressed.
This is NOT new: it was a competing approach to treating infections when antibiotics were discovered. It is 100+ years old tech, used mainly by former Soviet countries bc they could not obtain antibiotics, which were patented.
bell curve baby, Drake video is on the left side of it and the middle too. Far right side of it is what you are referring to. It would be more interesting for sure. In general.
What about Quorum Sensing (QS) and Its Role in the P. aeruginosa Biofilm? Do you think biofilm is the cause of bacteria resistance to drugs? Do you think Sulforaphane can inhibit QS P. aeruginosa Biofilm?
Would our immune system get rid of the phages? ive read that most phages are hunted from the environment. doesnt that means they are foreign particles?
Phages are most abundant in sewer waste believe it or not. Which may very well indicate that they come from living things like animals including humans. I'm no biologist myself but I find the idea very intriguing ua-cam.com/video/uoaanINMq3Q/v-deo.html
Wouldn’t our immune system try to eliminate those bacteriophages by recruiting memory cells, doctor? I don’t really know about the method of introducing the phages though.
bacteriophages have undergone years of evolution to only infect/reproduce within bacteria, so our immune system would not attack/identify them as harmful
no, covid is a virus, bacteriophages are bacteria eaters. but, since you sound interested, there is a thing called virophages, although we don't know much about them since they were only discovered in 2008. And from what I know, covid isn't a giant virus. virophages only seem to attack big viruses like mimiviruses and pandoraviruses. but they do act like bacteriophages. I am just a highschool student though, a horrible one, so don't be surprised if I am wrong. I just started researching virophages the other day using google of all places.
Recently, the FDA has approved phage therapy as a compassionate treatment for COVID-19 patients (Adaptive Phage Therapeutics, Inc., 2020), due to the high incidence of MDR secondary infections mentioned previously.
I assume you are talking about @15:46. It shows that after bacteria are treated with phages, the bacteria become susceptible to certain kinds of antibiotics.
To inhibit the spread of Phage resistant / antibiotic-sensitive bacteria - shouldn't both treatments be used synchronously or at least administer antibiotics immediately following the Phage? As opposed to waiting for the patient to exhibit further symptoms (or through blood tests) that indicate a phage resistant / evolved strain has developed? We obviously don't want that new bug spreading to anyone. Or is the thought process that, even if it is Phage resistant, at least it is antibiotic sensitive in others? Seems like you would want to kill the new bug with Patient Zero. But, I guess that's just too reasonable? 09:20 You make the assumption that the Phage may cause the target Bacteria to become vulnerable to previously ineffective antibiotics. The data that you PRESENTED supports this. But, are there any examples where this regression to antibiotic sensitivity did not occur? What options would be left in that situation? Are there any processes to identify different Phages that might be useful if that mutation occurs? I see the massive benefits of this. I understand why pharmaceutical companies haven't worked on this, as they probably can't copyright/patent a lot of the processes or living organisms. Being a business, their only concern is money - not making people better. So, it's really up to people that actually care about each other's health to spread this information. Are there any resources that you could recommend that would help a community-based organization to start a Phagen bank?
There's also phage.directory now. It looks like you could only help if you are actually a researcher. But since they among other things publish a weekly newsletter (all of the 24 so far can be found on the site under "Capsid & tail"), one could subscribe to that if one is interested in tracking the progress of phage therapy.
(On Monday of April 10, 2023). On the Matter of PhD Paul E. Turner from Yale University on the Phage Therapy (Virus-Infection Anti-MDR Desensitization): 1) Lethal Force to be used with caution. Antibiotics themselves should be last choice yet People subsist taking Antibiotic Chemotherapy that mostly creates an Immunosuppression Profile, and these People are walking Biohazards (Aside from the Cystic Fibrosis, Diathesis of Immunosuppression or even the HIVs). To Kill anything is killing. The Bacteria will fight back understandably. What is not understood in this case is how people can continue to expose us all to their Human Laboratory Biohazards Manufactured Pathogenosis. Could it be because these Thugs are only doing the Bidding of most Detestable Profiteers on Earth? In short, the Goal should be to Exclude these people from the Average Good Old Folk since their Genetic, Environmental Antibiotic Abuse is Dictating the Molecular Mean of us all. Pardon me, but neither HeLa Cells, Phage Therapy, like Free Walking Pathogenic People are to be common fare for us ALL. Forget that! 2) Virus are to be Reckoned with certainly, but to kill them (an impossibility), or Grow them, or Design them, as is this Virology's Ability, is sheer madness no different than the Extremist Approach of Relying on Antibiotic, an Flagrant Abuse. This should include Prophylaxis of Vaccination. The Guts to manufacture Disease and unleash them on to US, let alone the charging often Exorbitant Fees for Such "Service and Product". Currently, this is more pathological than Pseudomonas aeruginosa, Multidrug Resistant Bacteria or Genetic Diseases (Cystic Fibrosis, Sickle Cell Anemia) Combined. However, this Virology like Walking, Talking Breathing Pathogen Disseminators are to be Illegal (because they are) and Definitely, for the Well-being and Goodness of us all, Segregated (Incarceration possibility even) as Disease Control and Prevention (Supposed Task of the State [CDC] however has become an AIDS Promoting-Unleashing Criminal Enterprise Rather). PhD Turner, es nicht gut zu vermehren Krankenheiten oder verkehren in Wissenschaften der Daemon et al: Heil!
Why don't you just talk to the scientists at the Eliava Institute in Georgia....who have been studying phage since 1923. Starting from scratch makes no sense when phage therapy has been studied and used in ex Soviet countries for 100 years.
outstanding Dr. Turner, my major is biology applying to med school 2023 can't afford Yale
I’m replying in February 2024. I’m curious how your schooling has progressed in the time since your post. Still heading to med school?
I’m so glad to see people with dreams and ambitions. Best of luck to you!
Amazing. Thank you for sharing this with us. Looking forward to discussing this more with my students. The advances over the last 3 years have been astounding.
Virology unfortunately has become the new cash cow of the Qaukes and Pseudoscientists......These mferz are Criminals. To Build a Biohazard, Bill us for the Antidote-Vaccine and prance on towards a victory parade or Nobel Prize for doing such Beneficial, Lasting Goood to Mankind even. These are AIDS-carring, Rh Null Variation or some Disgusting Creature of Unknown Orgin/Aetiology. Aiding and Abetting this is unequivocally insanity and criminal, felonious enterprise. I ask of you to not Ecourage the Dogs lest you be one also. MD/PhD Finley, es muss besser sein am wenigstens. Heil!
great teacher! loved this presentation!
This Doc is teaching you Criminal Enterprise 101: Si Vis Pacem Fare Bellum!
Thank you for this charismatic presentation of an interesting topic 👍
By now you would have tested safety/efficacy in mouse model for lung pneumonia. Do you have results? Have you done clinical trail in human patients? Is phage treatment used in USA?
Any argument to get our scientific community to seriously consider something new, we are running out of other options... This video is a bit old so I wonder how their research has progressed.
This is NOT new: it was a competing approach to treating infections when antibiotics were discovered. It is 100+ years old tech, used mainly by former Soviet countries bc they could not obtain antibiotics, which were patented.
ua-cam.com/video/fYg9m4EGb38/v-deo.html
This is Dr. Paul giving a comprehensive overview of the current research 1 year ago 👍💗
Imagine if we lived in a world where this video had 10 billion views and Drake's shitty song "God's Plan" had 8 thousand views.
.
bell curve baby, Drake video is on the left side of it and the middle too. Far right side of it is what you are referring to.
It would be more interesting for sure. In general.
What about Quorum Sensing (QS) and Its Role in the P. aeruginosa Biofilm? Do you think biofilm is the cause of bacteria resistance to drugs? Do you think Sulforaphane can inhibit QS P. aeruginosa Biofilm?
please dont stop uploading i love biology
Yes! Never had money for school, but never stoped learning. I’d be rich if I were paid to watch you tube!
Would our immune system get rid of the phages? ive read that most phages are hunted from the environment. doesnt that means they are foreign particles?
Phages are most abundant in sewer waste believe it or not. Which may very well indicate that they come from living things like animals including humans. I'm no biologist myself but I find the idea very intriguing ua-cam.com/video/uoaanINMq3Q/v-deo.html
Wouldn’t our immune system try to eliminate those bacteriophages by recruiting memory cells, doctor? I don’t really know about the method of introducing the phages though.
bacteriophages have undergone years of evolution to only infect/reproduce within bacteria, so our immune system would not attack/identify them as harmful
Americans... Go to Georgia... they have been using it for nearly a Century.... They have the experience.
CRISPR Cas9 + phage therapy?
yeah I was also thinking about this
I'm not really a professional in science, but I am generally interested.
Mr.Turner,would that help my husband. He has bad lungs. (I can’t write it ,I have a stroke).
How is he?
that theory is real? of bacteria phage resistance become weak to antibiotics and so on?
I realise that creating the right phage lysin can take many years. Can they be used against covid 19?
Ian Brennan , no
@@ccmkoho can you ELI5?
Covid is a virus. Bacteriophages eat bacteria, not viruses
no, covid is a virus, bacteriophages are bacteria eaters. but, since you sound interested, there is a thing called virophages, although we don't know much about them since they were only discovered in 2008.
And from what I know, covid isn't a giant virus. virophages only seem to attack big viruses like mimiviruses and pandoraviruses. but they do act like bacteriophages.
I am just a highschool student though, a horrible one, so don't be surprised if I am wrong. I just started researching virophages the other day using google of all places.
Recently, the FDA has approved phage therapy as a compassionate treatment for COVID-19 patients (Adaptive Phage Therapeutics, Inc., 2020), due to the high incidence of MDR secondary infections mentioned previously.
I do not understand the chart he used.
I assume you are talking about @15:46. It shows that after bacteria are treated with phages, the bacteria become susceptible to certain kinds of antibiotics.
You can also use Endolysine from BP. There is no resistance reported.
fart in that mouth I will
To inhibit the spread of Phage resistant / antibiotic-sensitive bacteria - shouldn't both treatments be used synchronously or at least administer antibiotics immediately following the Phage? As opposed to waiting for the patient to exhibit further symptoms (or through blood tests) that indicate a phage resistant / evolved strain has developed? We obviously don't want that new bug spreading to anyone. Or is the thought process that, even if it is Phage resistant, at least it is antibiotic sensitive in others? Seems like you would want to kill the new bug with Patient Zero. But, I guess that's just too reasonable?
09:20 You make the assumption that the Phage may cause the target Bacteria to become vulnerable to previously ineffective antibiotics. The data that you PRESENTED supports this. But, are there any examples where this regression to antibiotic sensitivity did not occur? What options would be left in that situation? Are there any processes to identify different Phages that might be useful if that mutation occurs?
I see the massive benefits of this. I understand why pharmaceutical companies haven't worked on this, as they probably can't copyright/patent a lot of the processes or living organisms. Being a business, their only concern is money - not making people better. So, it's really up to people that actually care about each other's health to spread this information. Are there any resources that you could recommend that would help a community-based organization to start a Phagen bank?
Indeed synergie demonstrated in laboratory and some clinical cases. More research needed.
There's also phage.directory now. It looks like you could only help if you are actually a researcher.
But since they among other things publish a weekly newsletter (all of the 24 so far can be found on the site under "Capsid & tail"), one could subscribe to that if one is interested in tracking the progress of phage therapy.
Ssethtzeentach brought me here. Very educational.
What happens if virus jumps from bacteria to humans??? Because in previous lectures u said how amazing viruses are when it comes to survival
That is why drugs need to be tested and approved before they are sold.
@@allyourcode bro I was asking what happens if virus changes its host not about any kind of drugs.
Phages can infect only bacteria.
@@Rishab1702 Bacteriophages specifically target bacteria, they are pretty much unable to infect eukaryotic cells, such as our own.
Good Information 💯
(On Monday of April 10, 2023). On the Matter of PhD Paul E. Turner from Yale University on the Phage Therapy (Virus-Infection Anti-MDR Desensitization): 1) Lethal Force to be used with caution. Antibiotics themselves should be last choice yet People subsist taking Antibiotic Chemotherapy that mostly creates an Immunosuppression Profile, and these People are walking Biohazards (Aside from the Cystic Fibrosis, Diathesis of Immunosuppression or even the HIVs). To Kill anything is killing. The Bacteria will fight back understandably. What is not understood in this case is how people can continue to expose us all to their Human Laboratory Biohazards Manufactured Pathogenosis. Could it be because these Thugs are only doing the Bidding of most Detestable Profiteers on Earth? In short, the Goal should be to Exclude these people from the Average Good Old Folk since their Genetic, Environmental Antibiotic Abuse is Dictating the Molecular Mean of us all. Pardon me, but neither HeLa Cells, Phage Therapy, like Free Walking Pathogenic People are to be common fare for us ALL. Forget that! 2) Virus are to be Reckoned with certainly, but to kill them (an impossibility), or Grow them, or Design them, as is this Virology's Ability, is sheer madness no different than the Extremist Approach of Relying on Antibiotic, an Flagrant Abuse. This should include Prophylaxis of Vaccination. The Guts to manufacture Disease and unleash them on to US, let alone the charging often Exorbitant Fees for Such "Service and Product". Currently, this is more pathological than Pseudomonas aeruginosa, Multidrug Resistant Bacteria or Genetic Diseases (Cystic Fibrosis, Sickle Cell Anemia) Combined. However, this Virology like Walking, Talking Breathing Pathogen Disseminators are to be Illegal (because they are) and Definitely, for the Well-being and Goodness of us all, Segregated (Incarceration possibility even) as Disease Control and Prevention (Supposed Task of the State [CDC] however has become an AIDS Promoting-Unleashing Criminal Enterprise Rather). PhD Turner, es nicht gut zu vermehren Krankenheiten oder verkehren in Wissenschaften der Daemon et al: Heil!
Talks about heart transplant on Dr Khodadoust at @17:30
thank you sir
I liked this very much
Podcast 1052 doesn’t exist
What if you take garlic with meds?
Why don't you just talk to the scientists at the Eliava Institute in Georgia....who have been studying phage since 1923. Starting from scratch makes no sense when phage therapy has been studied and used in ex Soviet countries for 100 years.
21:20