Sodium borohydride Reduction on Ketone / Ketone to Alcohol
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- Опубліковано 15 жов 2024
- This video clearly will explain reduction of ketone to secondary alcohol by sodium borohydride. In this video we took 4-chlorobenzophenone as ketone.
Some abbreviations:
RB-Round bottom flask
RT-Room temperature
min-minutes
C-Celsius
LR-Laboratory grade
AR-Analytical grade
Some spelling correction:
Quinched ----Quenched
Some important Notes:
1. Please avoid commercial solvent of methanol for the reaction
2. Kindly use LR or AR grade solvent
3. After weighing sodiumborohydride, immediately transfer any closed container or vessel since it is hygroscopic in nature. Keep the sodiumborohydride always closed container once portionwise addition over each time.
4. Equivalent of Sodium borohydride depends upon nature of the ketone.
5. As soon as sodium borohydride addition over check the TLC immediately. Few reactions are completed 0 degree itself.
6. Kindly use 2N HCl for reaction mass quenching. If Ketone containing nitrogen group which can able to form HCl salt then you can skip the HCl workup. Instead you can add cold water to quench the reaction mass and extract the product with ethyl acetate.
7. Kindly use whatman 1 filter paper for filtration
Alternative workup:
If resulting alcohol nature is liquid then after pH adjustment you can extract the product by ethyl acetate or any other organic solvents. The resulting organic layer is washed with water, Sat.NaCl, dried on sodium sulphate and concentrated (Using rotary evaporator or distillation).
The above alternative workup applicable for solid alcohol also. In this case we can avoid filtration process.
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