This is an excerpt from my virtual slide session for the University of North Carolina (UNC) pathology residents on 4.8.2021. Full video of the entire session is available for free here: kikoxp.com/posts/5306. WSI Digital slide for this case: kikoxp.com/posts/5131. Gross photo: kikoxp.com/posts/5132.
@@JMGardnerMD Rutgers New Jersey Medical School, Newark. We have three Bone and ST Pathologists: Seena Aisner, Valerie Fitzhugh and David Suster, his father is a famous Pathologist. He uses to teach us a lot like you pretty good
Doctor, I lost my cousin, male, 40 years old, indian (south asian decent) 4 days ago to this. His chondrosarcoma started in left acetabulum and doctors performed internal hemipelvictomy and removed the affected part in June this year. However in 3 months after june, pet scan showed new tumours which were not there earlier. He had new bigger tumours in C2 C3 C7 D2 D3 glutal muscle, most of the abdomain. Second surgey removed spinal tumours but 1 week later he stopped breathing due to lung tumour and suffered heart attack, he was put on ventilator and passed away the next day. Surgeries happened in Pune India. No cancer heredity in family, no blood sugar, no addictions, no blood pressure. Are the causes identified for this type of cancer?
I’m so very sorry for your loss. For most patients, chondrosarcoma arises randomly…Not because of any lifestyle, family history, or other risk factor. There are some patients who have rare syndromes like Maffucci syndrome, Ollier disease, or hereditary exostosis that predispose patients to getting chondrosarcoma. But those are very rare. The vast majority of chondrosarcoma patients have no risk factor or syndrome and get it through random chance as far as we understand currently. Best wishes for health and peace and healing for you and your family.
This is really informative video! since i am from Engineering background, i understood just little bit :) I have one question und it would be really helpfull if you could answer! since Childhood, i was diagnosed with Multiple Hereditary exostosis. when i was young at age 18 year i had to remove some exostosis with help of surgery. after that untill now(age 28) it was going well. but last year i had felt bumpy area near my right leg knee. so i wnat to see doctor and it was big that why doctor suggested me to go for surgery. but once doctor got report form pathologist. He told me i have deffensiated Chorndrosarkoma. i would like to ask you. Is this kind of disease tend to transfer to other organ of body! I am little bit sacred. If you find time and answer to my question. i would really appreciate! Thank you:) !
I’m sorry to hear of your diagnosis. What you are describing sounds like a secondary chondrosarcoma arising from an exostosis/osteochondroma. There is a higher chance of this happening in people with multiple hereditary exostosis. It’s really important to know the exact wording of the pathology report. Did it say “dedifferentiated chondrosarcoma” And mention high grade/grade 3? Or was it a low grade/grade 1 well differentiated chondrosarcoma? Unfortunately, Dedifferentiated chondrosarcoma is a high grade cancer that can spread to the lungs or other places in the body. Was the tumor completely removed during surgery with negative/clear margins? Have they already done a chest CT scan to check if it has spread to your lungs? Is your doctor an orthopedic surgeon with experience treating sarcoma? It’s usually a good idea to see a specialist who has experience treating sarcomas since they are rare tumors. Please discuss all of this with your doctor to make sure that it applies to your situation and your pathology results. Best wishes for health and healing.
@@JMGardnerMD Thank you so much for your Reply! since it very dificult for me to understand pathology report, that's why, i have thought, it would be better if i put whole Pathology report. (originaly it was in german language , but i have transleated in to English) Histomorphologically, a total of three non-orientable tissue sections can be seen. The biggest of the three described osteochondromatous tissue pieces shows a perichondral connective tissue Cap with underlying cartilage cap with a maximum width of 20 mm. In the area of the transition to the spongy lamellar bone underneath it shows a endochondral ossification. The chondroid lesion consists of only minimally atypical chondroid cells without binuclearity. In the basal sections at the transition to A vitality of the chondroid tissue can be seen focally in the bone core. None show up necrotic tissue parts. The lesion appears completely removed in the healthy without lesionary parts in the bony specimen resection margin. The medium-sized exophytic configured lesion shows a perichondral connective tissue cap with underlying portions chrondroid tissue with a maximum thickness of 2 mm. The third piece of tissue shows a flat one Configuration with a part of a 2 mm wide cartilage cap that can also be seen focally adjacent spongy lamellar bone and portions of fat marrow recognizable therein. The chondroid tissue of the two smaller pieces of tissue unremarkable. In the synopsis of radiological findings and histomorphological findings, a malignant progression of the described cartilage cap can be detected due to the 20 mm wide cartilage cap osteochrondromatous lesion cannot be ruled out. In this case it would be a secondary peripheral highly differentiated chondrosarcoma (G1) on the basis of an osteochondroma. A clinical-radiological correlation of findings should be carried out as a matter of urgency. Thank you so much for Information! :)
This is an excerpt from my virtual slide session for the University of North Carolina (UNC) pathology residents on 4.8.2021. Full video of the entire session is available for free here: kikoxp.com/posts/5306. WSI Digital slide for this case: kikoxp.com/posts/5131. Gross photo: kikoxp.com/posts/5132.
Awesome. Thanks Sir. No matter how many times I said thanks, it will always be less. 💚💚
Cool case. We got one similar like that but did not have de differentiation. We have a very good ortho service in our program. Thank you very much
Dediff chondrosarcoma is pretty rare in my experience. I’ve only seen a few cases. Where is your program located?
@@JMGardnerMD Rutgers New Jersey Medical School, Newark. We have three Bone and ST Pathologists: Seena Aisner, Valerie Fitzhugh and David Suster, his father is a famous Pathologist. He uses to teach us a lot like you pretty good
Doctor, I lost my cousin, male, 40 years old, indian (south asian decent) 4 days ago to this. His chondrosarcoma started in left acetabulum and doctors performed internal hemipelvictomy and removed the affected part in June this year. However in 3 months after june, pet scan showed new tumours which were not there earlier. He had new bigger tumours in C2 C3 C7 D2 D3 glutal muscle, most of the abdomain. Second surgey removed spinal tumours but 1 week later he stopped breathing due to lung tumour and suffered heart attack, he was put on ventilator and passed away the next day. Surgeries happened in Pune India. No cancer heredity in family, no blood sugar, no addictions, no blood pressure.
Are the causes identified for this type of cancer?
I’m so very sorry for your loss. For most patients, chondrosarcoma arises randomly…Not because of any lifestyle, family history, or other risk factor. There are some patients who have rare syndromes like Maffucci syndrome, Ollier disease, or hereditary exostosis that predispose patients to getting chondrosarcoma. But those are very rare. The vast majority of chondrosarcoma patients have no risk factor or syndrome and get it through random chance as far as we understand currently. Best wishes for health and peace and healing for you and your family.
You are a great doctor. How many lives will you have saved with your correct diagnoses? Dios te bendiga Jerad.
This is really informative video! since i am from Engineering background, i understood just little bit :) I have one question und it would be really helpfull if you could answer! since Childhood, i was diagnosed with Multiple Hereditary exostosis. when i was young at age 18 year i had to remove some exostosis with help of surgery. after that untill now(age 28) it was going well. but last year i had felt bumpy area near my right leg knee. so i wnat to see doctor and it was big that why doctor suggested me to go for surgery. but once doctor got report form pathologist. He told me i have deffensiated Chorndrosarkoma. i would like to ask you. Is this kind of disease tend to transfer to other organ of body! I am little bit sacred. If you find time and answer to my question. i would really appreciate! Thank you:) !
I’m sorry to hear of your diagnosis. What you are describing sounds like a secondary chondrosarcoma arising from an exostosis/osteochondroma. There is a higher chance of this happening in people with multiple hereditary exostosis. It’s really important to know the exact wording of the pathology report. Did it say “dedifferentiated chondrosarcoma” And mention high grade/grade 3? Or was it a low grade/grade 1 well differentiated chondrosarcoma? Unfortunately, Dedifferentiated chondrosarcoma is a high grade cancer that can spread to the lungs or other places in the body. Was the tumor completely removed during surgery with negative/clear margins? Have they already done a chest CT scan to check if it has spread to your lungs? Is your doctor an orthopedic surgeon with experience treating sarcoma? It’s usually a good idea to see a specialist who has experience treating sarcomas since they are rare tumors. Please discuss all of this with your doctor to make sure that it applies to your situation and your pathology results. Best wishes for health and healing.
@@JMGardnerMD Thank you so much for your Reply! since it very dificult for me to understand pathology report, that's why, i have thought, it would be better if i put whole Pathology report. (originaly it was in german language , but i have transleated in to English)
Histomorphologically, a total of three non-orientable tissue sections can be seen. The biggest of the three described osteochondromatous tissue pieces shows a perichondral connective tissue Cap with underlying cartilage cap with a maximum width of 20 mm. In the area of the transition to the spongy lamellar bone underneath it shows a endochondral ossification. The chondroid lesion consists of only minimally atypical chondroid cells without binuclearity. In the basal sections at the transition to A vitality of the chondroid tissue can be seen focally in the bone core. None show up necrotic tissue parts. The lesion appears completely removed in the healthy without lesionary parts in the bony specimen resection margin. The medium-sized exophytic configured lesion shows a perichondral connective tissue cap with underlying portions chrondroid tissue with a maximum thickness of 2 mm. The third piece of tissue shows a flat one
Configuration with a part of a 2 mm wide cartilage cap that can also be seen focally
adjacent spongy lamellar bone and portions of fat marrow recognizable therein. The
chondroid tissue of the two smaller pieces of tissue unremarkable.
In the synopsis of radiological findings and histomorphological findings, a malignant progression of the described cartilage cap can be detected due to the 20 mm wide cartilage cap osteochrondromatous lesion cannot be ruled out. In this case it would be a secondary peripheral highly differentiated chondrosarcoma (G1) on the basis of an osteochondroma. A clinical-radiological correlation of findings should be carried out as a matter of urgency.
Thank you so much for Information! :)