LTP in depth involved AMPA and NMDA receptors. AMPA receptors act as ionotropic receptors, which causes influx of Na+ after binding with glutamate. This depolarisation will causes the NMDA receptor to eject its Mg2+ ion that's blocking the channel. And it also binds with glutamate to allow Ca2+ influx. This influx would result in upregulation of these AMPA/NMDA receptors through secondary messengers (kinases). Thus, increasing the strength, frequency and excitability of the post-synaptic neurones.
You are absolutely right. I think I must have misread something somewhere. Thanks for pointing that out for me. LTP is a result of NMDA-dependent AMPA upregulation.
+Martin Lim My anesthesia professor is using the terms inotropic receptor and metabotropic receptor. Do receptors fall into a binary where they are either inotropic or metabotropic?
Both allow substances to move in and/or out, but you need something to open it. However, how is different. Ionotropic is a direct-ligand binding receptor which allows ions to flow in. The metabotropic receptor however, when activated, causes a protein cascade which leads to activation (usually phosphorylation) of an channel protein. They both cause conformation changes, but metabotropic takes longer and lasts longer. Hope that helped.
This is false. Long Term Potentiation is not the only way to learn. You didn't even mention Long Term Depression (LTD), which is the whole another side of learning and creating new memories.
I usually love your videos but this is not even close to what the appropriate LTP explanation...make a 12 minute videos and go through high and low frequency signals and types of LTP and NMDAR & AMPAR
LTP in depth involved AMPA and NMDA receptors. AMPA receptors act as ionotropic receptors, which causes influx of Na+ after binding with glutamate. This depolarisation will causes the NMDA receptor to eject its Mg2+ ion that's blocking the channel. And it also binds with glutamate to allow Ca2+ influx. This influx would result in upregulation of these AMPA/NMDA receptors through secondary messengers (kinases). Thus, increasing the strength, frequency and excitability of the post-synaptic neurones.
+Martin Lim Is it both AMPA and NMDA? NMDA helps with the induction phase but I have a feeling only AMPA receptors are upregulated as a result of LTP
You are absolutely right. I think I must have misread something somewhere. Thanks for pointing that out for me. LTP is a result of NMDA-dependent AMPA upregulation.
+Martin Lim My anesthesia professor is using the terms inotropic receptor and metabotropic receptor. Do receptors fall into a binary where they are either inotropic or metabotropic?
Both allow substances to move in and/or out, but you need something to open it. However, how is different. Ionotropic is a direct-ligand binding receptor which allows ions to flow in. The metabotropic receptor however, when activated, causes a protein cascade which leads to activation (usually phosphorylation) of an channel protein. They both cause conformation changes, but metabotropic takes longer and lasts longer. Hope that helped.
@@mrjohnyt2932 Are you still here?
This video changed my life, thank you. I might want to become a neurosurgeon now.
KEEP GOING
This is not good. It´s very shallow, and explains more about action potential then LTP.
It's meant to be shallow, it's an MCAT review. "inch deep, mile wide" head ass boi
thanks alot i've been reading for hours about this but i just couldn't understand it till i watched this video ... u are amazing guys...keep going❤
More like this please! :D
Suggested lectures, readings etc would be great to put in the description.
That is actually so fascinating and funky and awesome hehe
This is false. Long Term Potentiation is not the only way to learn. You didn't even mention Long Term Depression (LTD), which is the whole another side of learning and creating new memories.
It's really hard to find a concrete definition of plasticity and LTP, and this video does exactly that in a very clear way. Thank you!
Well explained 👍🏽
the point is our neuron gets firing by the time you started to watch the video, so be grateful.
YOU ARE THE BEST
I love medicine.
Maybe it's time you took as dose of your own, punk.
I usually love your videos but this is not even close to what the appropriate LTP explanation...make a 12 minute videos and go through high and low frequency signals and types of LTP and NMDAR & AMPAR
I normally like your stuff but this is so basic.
LTD also involves in learning
Ehh?could you explain
learning about how I learn...crazy lol
THis is wrong. My teecher says that its because you need to grow more brain cells in you're neurons.
+Sém HAAhahaha. Ok then.
Exactly write. You also need to make sure AMPA receptors are released from the ligand binding to the brain cell.