PyMOL ligand-protein interactions | PyMOL tutorial | Protein Data Bank | Basic Science Series

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  • Опубліковано 1 лют 2025

КОМЕНТАРІ • 73

  • @Shadow-bx8ri
    @Shadow-bx8ri 2 роки тому +4

    Your content and way of explaining is out of the world sir. Thanks a lot for clearing out long term doubt.

  • @DocScoop7
    @DocScoop7 10 місяців тому +1

    it was so helpful that i immediately subscribed the channel!! sending love from Shanghai

  • @Amir-jn5mo
    @Amir-jn5mo Рік тому +3

    Amazing video. I had no clue what to even do in pyMOL as it looked intimidating. Now I can easily clean up a protein and focus on presenting the binding pocket im interested in

  • @adampruska1738
    @adampruska1738 Рік тому +1

    Thank you very much. It was really helpful and speeded up my work efficiency with PyMol

  • @bangnikabang6501
    @bangnikabang6501 Рік тому

    oh my God. sir, I love you. everywhere else the instruction is so sparse and general. thank you !!!

  • @egowong317
    @egowong317 Рік тому +2

    This is very helpful - thank you very much Professor!

  • @gl0wsticks659
    @gl0wsticks659 2 місяці тому +1

    amazing video, thank you so much!

  • @marufislam3777
    @marufislam3777 Рік тому +2

    Thank you so much, sir. Can we get more tutorials as you said in this video? Like: "Finding the residues in the ligand binding pocket."

  • @nonlawat
    @nonlawat 3 місяці тому +1

    thanks so much!!!
    so easy to follow

  • @vamsivardhan5403
    @vamsivardhan5403 8 місяців тому +1

    The tutorial was absolutely fantastic and made to involve more but I could not find the link for the continuation of this video regarding labelling for each residue,, can anyone share the continuation of this video link plzz

    • @BasicScienceSeries
      @BasicScienceSeries  8 місяців тому +1

      Will try to make more useful more, stay tuned for more 🙏🏻🙏🏻Thank you

  • @manognak7406
    @manognak7406 4 місяці тому +1

    HELLO Sir, thanks for this amazing tutorial. How will we know what chains to delete in the protein molecule? ( If the chains are non identical). Is there any criteria for that? Also, can a ligand be in its 2D form for docking?

    • @BasicScienceSeries
      @BasicScienceSeries  4 місяці тому +1

      Well by manually selecting the chains and then go to remove object

  • @robertmuller1881
    @robertmuller1881 Рік тому +1

    Very clear - thank you

  • @uos.chemist1437
    @uos.chemist1437 3 місяці тому +1

    Dear I have performed docking using pyrx and visualized using discovery studio. but I want to visualized through pymol+lingplot. What I do.
    Share any video or details
    Thanks

    • @BasicScienceSeries
      @BasicScienceSeries  3 місяці тому +1

      That's a great question, let me search on it and hopefully I ll bring a video on it soon 🙏🏻🙏🏻

  • @vigneshpandi5722
    @vigneshpandi5722 6 місяців тому +1

    Thanks 😊

  • @sarinasarina3973
    @sarinasarina3973 2 роки тому +1

    thank you sir. everything is going well except when tap the bottom"S" at the underside bar no sequence information occured.

    • @BasicScienceSeries
      @BasicScienceSeries  2 роки тому +1

      So nice of you : ) Thank you so much for your kind support and for your comment as well.. It should work if you are not able to get the sequence, try reinstalling the software again.

  • @dhruvipatel4144
    @dhruvipatel4144 Рік тому +1

    Hello sir, how do we get XYZ coordinates of a particular ligand and it's interaction with other molecules on the PDB?

  • @Yellownealy
    @Yellownealy Рік тому +1

    Can you do protein-protein binding affinity? Like binding sites of an antibody to a particular cell-surface protein?

  • @manishmishra9177
    @manishmishra9177 2 роки тому +7

    show sticks, byres all within 5 of ligand
    For those who coudn't see the screen like me. copy paste this cmd

    • @BasicScienceSeries
      @BasicScienceSeries  2 роки тому +2

      Use laptop if you want to watch the video it won't be helpful with mobile phones. Thanks for your comment 🙏🏼

    • @manishmishra9177
      @manishmishra9177 2 роки тому

      @@BasicScienceSeries Can you make a video on how to calculate the volume of substrate binding site? Thanks in advance... :)

    • @ikaoktavianawati4736
      @ikaoktavianawati4736 Рік тому

      Thanks, it helps alot. English is not my first language, so it sounds unclear to me.

  • @israthumayunslifeinchina4996
    @israthumayunslifeinchina4996 8 місяців тому +1

    show sticks, by res all within 5 ligand
    i was write according to your information but residues not coming, in your video it is also not clear, can you please give me detail

    • @BasicScienceSeries
      @BasicScienceSeries  7 місяців тому +1

      Can you provide more details on the issue what command you are following ??

  • @matthewadihonneyamos8723
    @matthewadihonneyamos8723 2 роки тому +1

    thank you, sir!!

  • @imenfathallah5788
    @imenfathallah5788 2 роки тому +1

    thank you for this video

  • @karenluiselang3423
    @karenluiselang3423 3 роки тому +3

    Dear, what's the comand for select the residues close to the ligant? Thank you very much.

    • @BasicScienceSeries
      @BasicScienceSeries  3 роки тому +2

      Check this on out, number of commands with examples: pymolwiki.org/index.php/Selection_Algebra

    • @ikaoktavianawati4736
      @ikaoktavianawati4736 Рік тому

      yes, since the picture is not clear enough to see 😢

  • @amalelfoly5944
    @amalelfoly5944 Рік тому +1

    could you please write the command of show sticks you used

  • @luluingram3735
    @luluingram3735 3 роки тому +1

    life saver

  • @fatimagenetics
    @fatimagenetics Рік тому +1

    i need to watch next part,,,
    kindly provide me i haven't found

  • @waqi409
    @waqi409 Рік тому +1

    The command is not clearly visible mention in the comments, please

    • @BasicScienceSeries
      @BasicScienceSeries  Рік тому

      Please check the comment section, if it is not posted already, let me know thanks 🙏🏼

  • @alchemista947
    @alchemista947 2 роки тому +1

    when i select chain the ligand also selected i dont know why

    • @BasicScienceSeries
      @BasicScienceSeries  2 роки тому +2

      Thank you so much for your kind support and for your comment as well.. You need to select the residue option not the chain option at the bottom of the right corner. Play around I am sure you will figure it out. Which molecular you are exploring...

  • @aneeshaanilkumar3935
    @aneeshaanilkumar3935 10 місяців тому

    Sir How to design anti drug conjugation

  • @Fordance100
    @Fordance100 7 місяців тому +1

    Good video. Fonts are too small.

  • @fatimagenetics
    @fatimagenetics Рік тому +1

    provide me link of next video

  • @JohnathonDubourg-g6k
    @JohnathonDubourg-g6k 4 місяці тому +1

    Erica Extensions

  • @JenniferHernandez-r9p
    @JenniferHernandez-r9p 3 місяці тому +1

    Kevon Corners

  • @AmyAnderson-f6g
    @AmyAnderson-f6g 3 місяці тому +1

    Boehm Spring

  • @TrudyMarquez-c3p
    @TrudyMarquez-c3p 4 місяці тому

    Crist Forges

  • @SharlaClonch-k1f
    @SharlaClonch-k1f 4 місяці тому +1

    Moshe Trail