Toxicology (Part-13) Insecticide Poisoning and Organophosphorus Poisoning Treatment | Antidote Drugs
Вставка
- Опубліковано 20 сер 2024
- Participate in the FREE online test for this lecture = forms.gle/5BtQ...
Download "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Test and other GPAT Materials - play.google.co...
Organophosphate compounds are used as commercial insecticides (disulfoton, phorate, dimethoate, ciodrin, dichlorvos, dioxathion, ruelene, carbophenothion, supona, TEPP, EPN, HETP, parathion, malathion, ronnel, coumaphos, diazinon, trichlorfon, paraoxon, potasan, dimefox, mipafox, schradan, sevin, and dimetonor) in chemical warfare (nerve gases such as tabun and sarin) and are applied as aerosols or dusts. They can be rapidly absorbed through skin and mucous membranes or by inhalation.
Organophosphates are also used in ophthalmology - echothiopate is used to treat glaucoma.
mechanism of Toxicity = Acetylcholine is the neurotransmitter at the cholinergic synaptic areas. And acetylcholinesterase enzyme degrades acetylcholine following stimulation of a nerve. Organophosphates are acetylcholinesterase inhibitors and they form a stable irreversible covalent bond to the enzyme. Organophosphates mediated inhibition of acetylcholinesterase causes acetylcholine to accumulate and results in initial excessive stimulation followed by depression.
In cholinergic junctions of the nervous system including postganglionic parasympathetic junctions (sites of muscarinic activity), autonomic ganglia and the neuromuscular junctions (sites of nicotinic activity) and certain synapses in the CNS all get affected by overstimulation by excessive acetylcholine.
Sign and Symptoms- (1) Muscarinic signs = (SLUDGE) salivation, lacrimation, urination, diaphoresis, gastrointestinal upset, emesis and progressing to bronchospasm, bronchorrhea, blurred vision, bradycardia or tachycardia, hypotension, confusion, and shock.
(2) Nicotinic effects = Skeletal muscle initially exhibits fasciculation (involuntary irregular, violent muscle contractions) followed by the inability to repolarize cell membranes resulting in weakness and paralysis. Severe reactions can lead to ventilatory failure and death (cholinergic crisis).
(1) Termination of the exposure including removing all soiled clothing. Gently cleanse with soap and water to hydrolyze organophosphate solutions. (2) Airway control and adequate oxygenation. Intubation may be necessary in cases of respiratory distress due to laryngospasm, bronchospasm, bronchorrhea, or seizures. Immediate aggressive use of atropine may eliminate the need for intubation. Succinylcholine should be avoided because it is degraded by AChE and may result in prolonged paralysis (3) Continuous cardiac monitoring and pulse oximetry should be established; an ECG should be performed. Torsades de Pointes should be treated in a standard manner. The use of intravenous magnesium sulfate has been reported as beneficial for organophosphate toxicity. The mechanism of action may involve acetylcholine antagonism or ventricular membrane stabilization. (4) Irrigate the eyes of patients who have had ocular exposure using isotonic sodium chloride solution or lactated Ringer’s solution. Morgan lenses can be used for eye irrigation.
(5) IV atropine- it is a competitive inhibitor. (6) IV pralidoxime- it reactivates acetylcholinesterase.
Get in touch with the solution by just clicking following links-
Facebook Group- / solutionpharamcy
Facebook Page- / pharmavideo
New channel (Pharmacy Dictionary) - / @pharmacydictionary
Instagram- / solutionpharmacy
E-Mail for official and other work - solutionpharmacy@gmail.com
LinkedIn- / pushpendrakpatel
#solutionpharmacy #Pharmacologyclass #GPATonlinetest
Gyaan Prakaasya Guru Milya, So Jini Beesari Jai. Aap jaise guru jisko mil jaaye uske karm hi achhe honge love u alot sir ji🥰🥰🥰👏👏💖
Thank you so much my dear
Great sir.👌 I am doing veterinary. This topic very important for us bcz frequent poising is observed in animal...
Thank you so much
#solutionpharmacy
Sir great job. .
I'm from Pakistan
♥️Love from Pakistan♥️
Thank you so much
Wonderful lecture thank u sir
Thank you so much
Sir,you are brilliant.
Thank you so much dear manish jo
Thanks sir for this wonderful video, sir I think nicotinic symptom me Bradycardia hoga Tachycardia nhi
Wonderful lecture ... Thank you sir.
Thank you
Great level teaching, you are a dedicated teacher, Super Sir
Thank you for your kind feedback and love
Kindly sir treatment mn dose bhi mention krdiya kren, btw u delivered lecture in very easy wordings.
Thank you. Actually discussing dose in online is not permitted
Great job. Have you worked with any antidote to pyrethin that can combat its exposure? Thank you!!
I never met a teacher like you ❤
I enjoy learning from you🤩
Thank you so much for your kind feedback. Tc
Pura concept bahut hi achhe se aa gya samjh me 👏👏👏
Great. Thank you for feedback
Sir you are very similar to jay shah am i right non pharmcological question? What a method of teaching. Nice sir love you
Great work Sir. Your way of explanation is very interesting .
Thank you so much
Nice video sir. Best way of teaching 🙏🙏🙏
Thank you
Bahut behtreeen
Thank u so much-
Sir
Thank you sir love from Nepal❤️
Great lecture sir . u r very Good teacher 😍😍
Thank you so much
Thank you ,love you sir...
My pleasure
Waooooow. Bro ❤️❤️ thnku dear 🎊 💐
Can we write this op poisoning in medicine exam (final year subject)
Best notes गुरु 📝❤️
Great Sir...
Thank you
Thnku sir ❤️
Sir... Tremendous.. Exam goin on.. Thanks a lot.
Thank you. Wishing you all the best
Very informative lecture sir
Thank you
Very nice video, keep it up
Thank you
Nice explanation sir
My pleasure. Thank you for your feedback.
Apankara. Asribad
Nice explaination 👍
Hello sir mujhe apke padhane ka tarika achha lagta h satisfaction milta ansr se or sir apse ek request hai ki pharmacology me classification ko yaad rakhne k liye koi coding,mnemonics bataiye
Brahman Boy Thank you. Aready upoloaded. Please check mnemonics
Nice sir
So great
Thank you
Nice video sir
Thank you
Awesome 🔥👍
Thank you
Nice
Thanku so much sir🥰
Most welcome
thank u so much,sir
My pleasure
In our house we spray organophosphorus insecticides for terminite . Is it dangerous. What is affect withdrawal period of this insecticides
Very nice Vedio sir
Thank you
1 lecture
Sir apne whiteboard presentation me batya hai ki Tachycardia and Mydriasis are nicotinic effects...
As per my knowledge there are no any nicotinic receptor in heart and eye....Then sir how it is ? Please explain....🙏
Sir mere Ghar me zink phosphaid zaher hawa ke zariye faila Hain use deactivate kaise kare Ghar me sabke pet dard karte hain
Sir how tachycardia and hypertension because vasodilation take place because of more ach
Pls any one answer thi ?
Nice explanation
Thank you
Sir voh jaher pani se bhi nahi nikalta kya kare?
Sir phos kill name ka monocrotophas peenese mauth hojayegi reply pls .galti peeyatho agar
Actylcholine bradycardia krta ha if receptors bind hota ha apne bataya tachycardia
Given reference from where we have taken notes.
Toxicology me kis type k questions ate hai
Thanks sir,sir suggestions tha medical report per bhi review dejiye
Altamash Ansari Wo to abhi shayad possible nhi ho paye
1st view sir
Is mouth to mouth or mouth to nose resuscitation safe in poisoning ?
Depebds on type of poison
Op poisoning say death hoti Hai ya sab Bach jatay hain??
Time par treatment hua to bachaya jaa sakta hai
@@solutionpharmacy Jo vent py Jata Hai wo bhi Bach Jata Hai.
Kon se college ke ho sir batayo
Monalisa sahu welcome
كيف الكتابه انجليزي والشرح لغه عمياء ؟،،،،،!!
Whats this. I cant understand anything. Title in english, so the lecturer must speak english too!
Dear sir. Really sorry for this. Contenr is in hindi and english both but for pure english - Please visit our new channel for upcoming lectures in English (From 01/12/2020). Link- ua-cam.com/users/PharmacyDictionaryBySolutionPharmacy
Yeah lol.
Wil it also cause Parkinson disease.
Chances are there
Sir M.O.A I am not understand 😔
7:00
Sir kindly make notes in pdf
Download "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Test and other GPAT Materials - play.google.com/store/apps/details?id=co.bolton.nqilv
Sir b. Pharma 1st semester ka Human Anatomy and physiology ka video nahi hai kya
Nhi
Nice video
#rubulboy
👌👍🌺
🙏🙏🙏🙏🙏🙏🙏🙏🙏
Sir maine apke solution pharmacy group se Q&A notes pdf form me leli h.... Yah notes reliable h kya qc department ke liye... With analysis, instrumental analysis, pharmaceutical chemistry yah 3 book me prefer kr raha hu
Wo hamare notes nhi hai so cant say
Sir room keh andar mask kyu pehe nah heh?
Watch the video first and then comment
Sir online test me ek question thik nahi laga mujhe jisme effect nicotinic ke pucha h par symptoms muscarinic ke diye h ... last wala question h sir i am sorry sir par confuse hun to puch liya
KM POOJA wahi to question tha. Answer to dekhiye
@@solutionpharmacy sir jo symptoms aapne lecture me bataye h vo is question se match nahi kar rahe h nicotinic and muscarinic , i think mujhe hi kahi na kahi confusion h , sorry sir to say that again , mene lecture 2 barr dekha confusion ko door karne ke liye
KM POOJA Haa aap sahi kah rahi hain. Maine check kia actually wo last option me none of them above ki jagah all of the avove ho gaya tha. Jisko correct kar lia. Thank you for rectification
@@solutionpharmacy thank you sir 😊
Very sad this isn’t in English...
So sorry. Please visit our new channel for upcoming lectures in English (From 01/12/2020). Link- ua-cam.com/users/PharmacyDictionaryBySolutionPharmacy
Sir please reply dijiye
too extensive for an small concept
Hope everyone would have same level of intelligence as yours. Concept is concept it is not small or large, that depends on the individual set of mind.
2nd
English is an international Language, cant you use english.
Our pharmacology lectures in English. Link- Complete Pharmacology Topics (English)
ua-cam.com/play/PLOsge3l7t_CTpZW0qDKEHoYyYBTYPozex.html
Channel list - ua-cam.com/users/PharmacyDictionaryBySolutionPharmacy