Professor Tyler jack is great in his teaching skill , I have seen the cancer lectures about 3 times and I am in love with the way you teach . Thanks I want more such lectures , thanks a lot sir , this complement is from india
I really don't get the part around 26 min, when he says that if you introduce tumorous cells into a mouse, it causes cancer. I thought you couldn't pass a cancer, because the immune system will destroy any outside cells anyway, and the body won't give these stranger cells blood and nutrients. if it was the case (that you can introduce cancer to another individual), then cancer could be contagious , and it's not, so there is something I really don't understand. I hope my question is clear because english is not my mother tongue.
Depends on the mouse. It can be immunodeficient or immunocompromised mice so they don't react to foreign molecules as you would expect. He was explaining that they isolated the "DNA" no cancer cells from the bladder, so then they tried to give immortalized cells this DNA to see if the DNA have cancer genes that promote the disease. Cancer is characterized by the ability to grow in more than one layer and also to create tumors when injected into animal models. So after introducing this "cancer DNA" into the immortalized mouse cells (no cancer cells, no tumorogenic, etc) they saw that they started forming many layers and thought that was cancer and was confirmed by the experiment of introducing the cells into a mouse to see if they form a tumor.
Diseases are contagious bcz of the way they are transmitted to other people........if we own introduce the wild type agent of non contagious disease into some healthy individual..it would definitely cause the disease.....it does not mean the disease is contagious.
He could have taken those same laboratory immortalized cells from that mice only - then did the Petri dish experiment and then reintroduced the cells back into same mice body. Or he might have given an immunosuppressant - Cyclosporin A
This may have a relation to the Warburg effect. You need to explore the fact that mitochondria also have DNA. The damage due to environment by asbestos, for example can cause ANAEROBIC GLYCOLYSIS. THE EFFECTS ON RAPID INCREASE OF INEFFICIENT USE OF GLUCOSE CAN THEN RESULT IN OXIDATION. REFER TO ROS: REACTIVE OXYGEN SPECIES. THE EFECTS CAN SOMETIMES MIGRATE TO THE DNA IN THE NUCLEUS. NOTE THAT NORMALY THE PRODUCTION OF ATP USES OXYGEN PHOSPHORYLATION. IN CANCER CELLS THAT IS BLOCKED. THAT CAUSES THE GREATER EFFICIENT ATP THAT IS PRODUCED. BY OXPHOR TO BE BLOCKED. NOTE: THE NATIONAL INSTITUTES OF HEALTH LIBRARY NOW STRESSES THAT OTTO WARBURG NEEDS A NEW HEARING. HIS VIEWS THAT THE MITOCHONDRIA CAUSE CANCER WAS CORRECT ALL ALONG. STUDYING ANAEROBIC GLYCOLISIS AND BLOCKED OXYDATIVE PHOSPHORYLATION MAY BE THE ROOT CAUSE OF CANCER.
I didn't not get the point......why we call them tumor suppressor genes in spite of the fact that they are responsible for causing cancer if they get mutated???
Tumor suppressor genes usually suppress the proliferation of cells. So as long as they're not mutated, they suppress the formation of cancer. However, if they lose their function there is no "molecular break" to prevent cancer from forming
Read up on the Warburg Effect And ANAEROBIC GLYCOLISIS. ALSO HOW THE OXYDATIVE PHOSPHORYLATION IS BLOCKED IN CANCER. MITOCHONDRIAL DNA IN THE CRISTA INNER CHAMBERS PRODUCE ATP. ALSO REFER TO THE KREBBS CYCLE. THESE ARE KEYS TO HOW CANCER CAN SPREAD TO THE DNA IN THE NUCLEUS. NIH NOW IS THINKING ATP PRODUCTION VIA ANAEROBIC GLYCOLISIS IS KEY TO CAUSING CANCER.
Professor Tyler jack is great in his teaching skill , I have seen the cancer lectures about 3 times and I am in love with the way you teach . Thanks I want more such lectures , thanks a lot sir , this complement is from india
Thank you
Thank you very much MIT, im a colombian medic student, keep the great work.
Thanks ❤️🤍
Great video! Loving it!
This is helpful ❤️🤍
Nice 👏👏👏
I really don't get the part around 26 min, when he says that if you introduce tumorous cells into a mouse, it causes cancer. I thought you couldn't pass a cancer, because the immune system will destroy any outside cells anyway, and the body won't give these stranger cells blood and nutrients. if it was the case (that you can introduce cancer to another individual), then cancer could be contagious , and it's not, so there is something I really don't understand. I hope my question is clear because english is not my mother tongue.
Depends on the mouse. It can be immunodeficient or immunocompromised mice so they don't react to foreign molecules as you would expect. He was explaining that they isolated the "DNA" no cancer cells from the bladder, so then they tried to give immortalized cells this DNA to see if the DNA have cancer genes that promote the disease.
Cancer is characterized by the ability to grow in more than one layer and also to create tumors when injected into animal models. So after introducing this "cancer DNA" into the immortalized mouse cells (no cancer cells, no tumorogenic, etc) they saw that they started forming many layers and thought that was cancer and was confirmed by the experiment of introducing the cells into a mouse to see if they form a tumor.
Knock out mouse models
Diseases are contagious bcz of the way they are transmitted to other people........if we own introduce the wild type agent of non contagious disease into some healthy individual..it would definitely cause the disease.....it does not mean the disease is contagious.
He could have taken those same laboratory immortalized cells from that mice only - then did the Petri dish experiment and then reintroduced the cells back into same mice body.
Or he might have given an immunosuppressant - Cyclosporin A
This may have a relation to the Warburg effect.
You need to explore the fact that mitochondria also have DNA.
The damage due to environment by asbestos, for example can cause
ANAEROBIC GLYCOLYSIS.
THE EFFECTS ON RAPID INCREASE OF INEFFICIENT USE OF GLUCOSE CAN THEN RESULT IN OXIDATION.
REFER TO ROS: REACTIVE OXYGEN SPECIES.
THE EFECTS CAN SOMETIMES MIGRATE TO THE DNA IN THE NUCLEUS.
NOTE THAT NORMALY THE PRODUCTION OF ATP USES
OXYGEN PHOSPHORYLATION.
IN CANCER CELLS THAT IS BLOCKED.
THAT CAUSES THE GREATER EFFICIENT ATP THAT IS PRODUCED. BY
OXPHOR TO BE BLOCKED.
NOTE: THE NATIONAL INSTITUTES OF HEALTH LIBRARY NOW STRESSES
THAT OTTO WARBURG NEEDS A NEW HEARING. HIS VIEWS THAT THE MITOCHONDRIA CAUSE CANCER WAS CORRECT ALL ALONG.
STUDYING ANAEROBIC GLYCOLISIS
AND BLOCKED OXYDATIVE PHOSPHORYLATION MAY BE THE ROOT CAUSE OF CANCER.
Richard Gere giving a lecture on cancer?
nice
wow
LIKE
I didn't not get the point......why we call them tumor suppressor genes in spite of the fact that they are responsible for causing cancer if they get mutated???
Tumor suppressor genes usually suppress the proliferation of cells.
So as long as they're not mutated, they suppress the formation of cancer. However, if they lose their function there is no "molecular break" to prevent cancer from forming
Read up on the Warburg Effect
And ANAEROBIC GLYCOLISIS.
ALSO HOW THE OXYDATIVE PHOSPHORYLATION IS BLOCKED
IN CANCER.
MITOCHONDRIAL DNA IN THE CRISTA
INNER CHAMBERS PRODUCE ATP.
ALSO REFER TO THE KREBBS CYCLE.
THESE ARE KEYS TO HOW CANCER CAN SPREAD TO THE DNA IN THE NUCLEUS. NIH NOW IS THINKING
ATP PRODUCTION VIA ANAEROBIC GLYCOLISIS IS KEY TO CAUSING CANCER.
@@samyek2222 not always