Cell Biology | Zellweger Syndrome, Refsum's Disease, Adrenoleukodystrophy

Поділитися
Вставка
  • Опубліковано 13 чер 2024
  • Official Ninja Nerd Website: ninjanerd.org
    Ninja Nerds!
    In this lecture Professor Zach Murphy will be teaching you about the structure and function of peroxisomes. After discussing the normal function of peroxisomes, we will go into USMLE step 1 disorders related to peroxisomal deficiencies. These will include Zellweger syndrome, Refsum's disease, and Adrenoleukodystrophy. We hope you enjoy this lecture and be sure to support us below!
    Thanks to NN Community Friend @123awesome321 for the time stamps!
    0:14 - Overview
    0:32 - VLCFA, BCFA, & Peroxisome's ABCD1 Transporters
    1:59 - F1: Beta-Oxidation of VLCFA Pathway (OHOT)
    3:39 - F2: Alpha-Oxidation of BCFA Pathway
    4:36 - F3: Ethanol Metabolism
    5:49 - F4: Bile Acid Activation & Metabolism
    6:37 - F5: Cholesterol Synthesis
    8:11 - F6: Plasmalogen Synthesis
    9:30 - F7: Catalase Activity for Reducing H2O2 Buildup
    12:07 - Zellweger Syndrome
    14:45 - Refssum's Disease
    17:06 - Adrenoleukodystrophy (ALD)
    19:12 - Comment, Like, SUBSCRIBE!
    Join this channel to get access to perks:
    / @ninjanerdofficial
    APPAREL |
    www.amazon.com/s?k=ninja+nerd...
    DONATE
    PATREON | / ninjanerdscience
    PAYPAL | www.paypal.com/paypalme/ninja...
    SOCIAL MEDIA
    FACEBOOK | / ninjanerdlectures
    INSTAGRAM | / ninjanerdlectures
    TWITTER | / ninjanerdsci
    @NinjaNerdSci
    DISCORD | / discord
    #ninjanerd #Peroxisomes #CellBiology

КОМЕНТАРІ • 187

  • @F22_Raptors
    @F22_Raptors 3 роки тому +94

    If there is a nobel prize for education, you are definitely the no.1 candidate

  • @abrarkhan9674
    @abrarkhan9674 3 роки тому +25

    Zach, I was a cab driver u turned me into a doctor. Thank you zach

    • @alih6953
      @alih6953 3 роки тому +1

      congratz mate on becoming a doctor!

  • @arizonablossom8635
    @arizonablossom8635 3 роки тому +15

    Preparing for usmle step1 and all your lec are amazing this topic is high yield for step 1 usmle,thanks a lot for your great work.

  • @BloxWorldTV
    @BloxWorldTV 2 роки тому +9

    This was the most amazing explanation of PBD. My daughter is 10 and was diagnosed with zellweger may 2016. The resources parents have to learn about the disease are trash compared to this. You definitely have a gift

    • @tashahollander9121
      @tashahollander9121 2 роки тому

      Hey Robin. My son has a single enzyme disorder. (AMACR deficiency ) He does explain it all so well.

  • @ginaaponte8893
    @ginaaponte8893 2 роки тому +1

    Very informative in an easy to follow format!! Great job Zach

  • @MEZ4RCI
    @MEZ4RCI 3 роки тому +2

    finally an explanation of this disorders. I had searched for them two years ago but couldn't find a good resource back then

  • @fadeskywards1245
    @fadeskywards1245 3 роки тому +9

    Wow, I love how you were willing to make a video on diseases with intracellular organelle dysfunctions as their etyologies. Make a video on different types of dyslipidemia if you already haven't. Thanks again for being awesome!

  • @maureenonyango8198
    @maureenonyango8198 Рік тому

    the best teacher ever ...am really grateful for your assistance and simplifying issues

  • @ranadam5568
    @ranadam5568 3 роки тому +2

    Already know these but will always watch your vids to refresh my memory ♥️

  • @MinhNguyen-we9cl
    @MinhNguyen-we9cl 3 роки тому

    Dude you re just an amazing teacher. You help me a lot going through medical years. Thank you so much for your great work!!!

  • @michaelbraccia4556
    @michaelbraccia4556 3 роки тому

    I love learning about these diseases. Thank you

  • @deepaktripathy4930
    @deepaktripathy4930 Рік тому

    amazing sir, you are the machine that make the complex thing to so simple,not only understandable but last in memory for ever.🙏🙏

  • @bluedolphin4574
    @bluedolphin4574 2 роки тому

    Great video. Thank you. Please make more videos about diseases. They are highly appreciated.

  • @abwaankhadar9659
    @abwaankhadar9659 Рік тому +1

    Expert in medico lessons and professional teacher 🙏

  • @mrsamandabernier
    @mrsamandabernier 3 роки тому

    You're the most underrated channel on UA-cam. Amazing.

  • @salaheddinehouache1015
    @salaheddinehouache1015 3 роки тому

    I really appreciate your work Ninja crew, I'm waiting to watch your videos of every single organel... Good luck

  • @m.ziauddin14
    @m.ziauddin14 3 роки тому +1

    Excellent sir. You are a hero of medical

  • @diligesoderunt380
    @diligesoderunt380 3 роки тому

    Thank you so much Zach. You’re my hero

  • @samisadeq
    @samisadeq 2 роки тому

    EXCELLENT EXPLANATION! THANK YOU.

  • @eilianejad9178
    @eilianejad9178 2 роки тому

    This channel is a gold mine.

  • @ThatGuy_Biscuit
    @ThatGuy_Biscuit 3 роки тому

    I love this topic! Thank you sir zach! ❤️

  • @pridemhlanga6950
    @pridemhlanga6950 2 роки тому

    viewing this all the way from zimbabwe!!!!thanks alot ......really helps

  • @carlospelaez2866
    @carlospelaez2866 Рік тому

    Mate! i have a project on peroxisomes, and im mexican so i read 5 articles, consulted 3 books, watched like 5 videos all in spanish, and your video is AMAZING, putting EVERYTHING together beautifully.
    NEW SUB

  • @zahraaamjad2952
    @zahraaamjad2952 2 роки тому +1

    You make medschool SOOOOOO much easier, ZACH!!!!!

  • @granola1210
    @granola1210 3 роки тому

    Thank you so much for all your videos❤️❤️🥰

  • @abdelgadireshaq3990
    @abdelgadireshaq3990 3 роки тому +2

    We can't thank you enough guys for this amazing work
    Thank you so much ✨

  • @alibekaltay631
    @alibekaltay631 3 роки тому

    Don't stop man, you are doing great thing

  • @Maryam-zx6iw
    @Maryam-zx6iw 2 роки тому

    Perfect explanation

  • @123Iamawesome321
    @123Iamawesome321 2 роки тому +3

    Table of Contents:
    @0:14 Overview
    @0:32 VLCFA, BCFA, & Peroxisome's ABCD1 Transporters
    @1:59 F1: Beta-Oxidation of VLCFA Pathway (OHOT)
    @3:39 F2: Alpha-Oxidation of BCFA Pathway
    @4:36 F3: Ethanol Metabolism
    @5:49 F4: Bile Acid Activation & Metabolism
    @6:37 F5: Cholesterol Synthesis
    @8:11 F6: Plasmalogen Synthesis
    @9:30 F7: Catalase Activity for Reducing H2O2 Buildup
    @12:07 Zellweger Syndrome
    @14:45 Refssum's Disease
    @17:06 Adrenoleukodystrophy (ALD)
    @19:12 Comment, Like, SUBSCRIBE!

  • @thebest-yi3ro
    @thebest-yi3ro 3 роки тому +2

    ufff!!! I don't know whenever u r video pops up I feel blessed... u amazing man.. 🌹

  • @m.s.e.4192
    @m.s.e.4192 2 роки тому

    Simply excellent!!!

  • @binshx5774
    @binshx5774 2 роки тому

    I love ur clarifying!

  • @tutututi8299
    @tutututi8299 11 місяців тому

    i cant believe that boring stuff wold appear so simple nd it actually did make sense :). THANKS A LOT :)

  • @nanaokonsam4805
    @nanaokonsam4805 7 місяців тому

    You made things super easy

  • @jannmikoingelrabagogamingc6012
    @jannmikoingelrabagogamingc6012 3 роки тому

    Zach you are amazing!

  • @akhtarparas3238
    @akhtarparas3238 3 роки тому

    Amazing sir please keep making videos on molecular biology ❤❤lots of love and respect ❤

  • @bushrajamil1443
    @bushrajamil1443 2 роки тому

    LOVE YOUR VIDEOS! MAY GOD BLESS YOU!

  • @simpleliving4049
    @simpleliving4049 3 роки тому +2

    I love you sir for marking topic easy. LOVE 💕 FROM INDIA 🇮🇳

  • @ashujha5154
    @ashujha5154 9 місяців тому +1

    Love you BRO-TEACHER

  • @xaaboopinkly
    @xaaboopinkly 3 роки тому

    Huge thanks sir!

  • @guna7558
    @guna7558 3 роки тому

    Zach,your videos r very much helpful....thank you so much for being our mentor.I have a request....please make video on apoptosis n cancer,protein sorting.

  • @farisomran1892
    @farisomran1892 Рік тому

    I loveed this topic thanks 😊

  • @kennethdaniella-ab7963
    @kennethdaniella-ab7963 10 місяців тому

    Best teacher ever

  • @userkotoriyusitetotpsevdonim
    @userkotoriyusitetotpsevdonim 3 роки тому

    Thank you very much 😃❤🙏🏻

  • @SunilVerma-sj8fx
    @SunilVerma-sj8fx 2 роки тому

    Excellent sir

  • @abdullahabdullah3722
    @abdullahabdullah3722 2 роки тому

    God bless you and your team man !

  • @sarahaseeb3839
    @sarahaseeb3839 Рік тому

    The best explanation (HERE)❤

  • @user-sm5zq7cp7n
    @user-sm5zq7cp7n 2 роки тому

    You are amazing guys !!

  • @solij9961
    @solij9961 Рік тому

    Thank you 🙏

  • @Praise_ye_Yahweh
    @Praise_ye_Yahweh Місяць тому

    Thank you.

  • @prasenjitdas7694
    @prasenjitdas7694 3 роки тому

    Nice explanation ❤️

  • @GopalKumar-wn6ns
    @GopalKumar-wn6ns 2 роки тому

    Thanks a lot 🙏

  • @deekshithbangera779
    @deekshithbangera779 2 роки тому

    Amazing sir love you✨💖

  • @CLICK_SUBSCRIBE_BUTTON
    @CLICK_SUBSCRIBE_BUTTON Рік тому

    Thumbs up for zach hardworking ✌️

  • @niyadeo7970
    @niyadeo7970 7 місяців тому

    Amazing!

  • @dorcasb2194
    @dorcasb2194 3 роки тому +1

    Kindly do a video series on how to read and interpret X-rays and other radiographs. Thanks

  • @aliamer2868
    @aliamer2868 3 роки тому

    Great job

  • @BruinChang
    @BruinChang 3 роки тому +1

    Much appreciations from Taiwan!!

  • @artworld2720
    @artworld2720 3 роки тому

    Love you ninga nerds team

  • @TheUlumpa
    @TheUlumpa 3 роки тому

    Zach is love ❤

  • @melissalanigan6221
    @melissalanigan6221 3 роки тому

    Thanks Gain ur a genius amazing info

  • @kairananda8330
    @kairananda8330 7 місяців тому

    your videos are great,

  • @immy0119
    @immy0119 3 роки тому

    Name something that Zach can't ..I can wait forever!!!

  • @arfaaamer1707
    @arfaaamer1707 3 роки тому

    Amazing 👌
    Extremely helpful & Awesome 👍

  • @jamalabdinasir3697
    @jamalabdinasir3697 Рік тому

    thanks Dr

  • @rohanhittalamani7028
    @rohanhittalamani7028 Рік тому

    when teaching is a passion 🙂

  • @sadiqahmad988
    @sadiqahmad988 3 роки тому

    i am from pakistan .you are the first doctor easiest my way for mbbs

  • @linaviolon4105
    @linaviolon4105 2 роки тому

    Even if we study medecin in french in my country but you are helping us so much thank you

  • @riyastodaily
    @riyastodaily 3 роки тому

    Excellent explanation...

  • @abdelgadireshaq3990
    @abdelgadireshaq3990 3 роки тому +1

    Can you please make video about necrosis and apoptosis and differences between them?

  • @thefrancesco502
    @thefrancesco502 2 роки тому

    thank you very mutch

  • @buthainafazza836
    @buthainafazza836 Рік тому

    thank youu!!

  • @hawraaalhilali1092
    @hawraaalhilali1092 2 роки тому

    thank you!!!!

  • @atulsinghtech52
    @atulsinghtech52 Рік тому

    Amazing

  • @nenelach4473
    @nenelach4473 Рік тому

    ช่วยชีวิตผมมาก thank you very much ❤🙏

  • @chikeagbo3531
    @chikeagbo3531 3 місяці тому

    Beautiful

  • @user-gh4nt4ve6l
    @user-gh4nt4ve6l 2 роки тому

    thanks

  • @18bhavyanchandrach18
    @18bhavyanchandrach18 3 роки тому

    Please do videos on neoplasia it will be very helpful can't thank u enough u help us go through toughest phase from covid. Pandemic with out much effect by helping us through these videos love from India ninja nerd

  • @tavataniyapramote2689
    @tavataniyapramote2689 2 роки тому

    didnt know anyone could explain things this well

  • @mziaulislam1692
    @mziaulislam1692 Рік тому +1

    Much Love From Peshawar Pakistan 🇵🇰🥀

  • @nandembarane8862
    @nandembarane8862 3 роки тому

    Thanks man from 🇿🇦🇿🇦

  • @prabhatipanda6365
    @prabhatipanda6365 8 місяців тому

    Ty sir

  • @ikramshehzad6936
    @ikramshehzad6936 3 роки тому

    Lov u man.. plz makes vedios on microbiology

  • @victorias1839
    @victorias1839 3 роки тому +2

    omg, your t-shirt! got me laughing so much when I realized it's Schrutes Farms! Lmao!
    but seriously, thank you so much for the lecture

  • @hamzenouh4911
    @hamzenouh4911 3 роки тому

    first year medical exam. thank you

  • @soltanahaddad1545
    @soltanahaddad1545 Рік тому

    The BEST💥❤️

  • @shahiramohammadi7284
    @shahiramohammadi7284 3 роки тому +1

    Zach our medical hero🦸🏻‍♂️

  • @Chandra-tw2bp
    @Chandra-tw2bp 2 роки тому

    We are following you sir

  • @Mohammad-xe2qw
    @Mohammad-xe2qw 3 роки тому

    Best Of The Best

  • @chaimaa4303
    @chaimaa4303 2 роки тому

    fantasticc❤❤❤

  • @sudikshachopra1936
    @sudikshachopra1936 3 роки тому

    you are awesome!!

  • @JK-md4or
    @JK-md4or 2 місяці тому

    bangin my man

  • @aqibbashir5349
    @aqibbashir5349 3 роки тому

    Zach ,you r amazing

  • @michaellee6079
    @michaellee6079 Рік тому

    You should do an explicit MCAT prep course

  • @ayushtanwar6074
    @ayushtanwar6074 2 роки тому

    Zach I I am jealous of your skills man amazing....if I got a chance I'll steal them from yours

  • @easyenglish1415
    @easyenglish1415 3 роки тому

    first thank you siencehero and then please upload biology video more and rapid like this i have cell biology exam 3 mounth later and i really need your help.
    your ninja fan🙏🌹

  • @RobertSelig
    @RobertSelig 3 роки тому

    Dr Zach, you are the best! That acetyl aldehyde that the body makes is still very toxic(brain fog, candida, alcohol) so to break acetaldehyde down into acetate, Mo the most unpronounceable element on the table is needed for this enzyme aldehyde dehydrogenase to work or we get the symptoms of acetaldehyde symptoms. Can you talk about the metal cofactors on how they are critical for these enzymes to work since Mo is the most deficient mineral I see on Hair tissue mineral analysis?

  • @alialsalami7934
    @alialsalami7934 3 роки тому

    Thank you alot

  • @asala3087
    @asala3087 3 роки тому +1

    Thank zack still am waiting eye development

  • @mandeepsingh6010
    @mandeepsingh6010 3 роки тому +1

    Kent state bio department needs you