I would have compared it to the Internet (ARPANET) of the 70s since we are just at the beginning of the revolution. We just need to make sure we don't become the world of Gattaca (movie).
As someone who is visually impaired, this got be in the feels. Knowing there are big strides being made to improve this is incredible and that there could be a working solution out there, is mind blowing and life changing! So happy for those who took part and saw major life changes 💪😃
The thing that sucks is...once the study is over, these people no longer had access to the gene therapy, so they went blind again. :\ Imagine getting your vision back and then having it taken away.
As a molecular biologist who has used CRISPR several times in my lab work, this is so cool! The tech to help lots of people already exists and the biggest barrier is just our fear of genome editing. Thanks for shining a light on this amazing breakthrough in medicine!
I don't fear it, I actually want this to be used as therapy to fix things that can't be fixed by ordinary medicine or ordinary methods, it seems CRISPR does the job.
@@Azmodaeus49 Yeah. Hope it eventually can be used to repair or rebuild nerves, tendons, cartilage, regrow ear hair cells, fix mental illnesses like depression, adhd etc. My life would be considerably better
It is a very valid fear. The technology has the potential to make the world a far better place...and the potential to make global thermonuclear war seem less scary.
@@rudrasingh6354 I'd love CRISPR to cure eczema that is my biggest dream, the science community ignores this condition way too much, I suffer from that skin condition and had it my whole life, I'd love the science community to put in more money and research into finding a cure for people around the world suffers from eczema and allergies, it is not fair that many diseases are being fixed and cured, but diseases or conditions like allergies and eczema are being ignored 😔
As a Biomedical engineer previously worked on genetics, I'd say it's legitimate to fear this tech. As it enables humans to program each other, and who knows what would bad actors do, and there always will be bad actors out there.
I know this comment is not likely to be seen by anyone as this video was published a couple months ago, but I was not expecting to tear up while watching one of your videos. I have that exact mutation for LCA, and this gene therapy research is super exciting for me. Especially the guy who mentioned seeing a sunset for the first time in a couple of years, as that is something I want to do. Thanks for bringing this to my attention CF, I'm definitely going to try making some calls to this particular researcher and ask him about the progress they've made thus far and see if there is any opportunity for me to get in one of their clinical trials. (:
Hands down one of the greatest technologies of the 21st Century. The applications are near-limitless! We need to tread carefully from an ethical perspective, but CRISPR gives us the power to address so many of the negative aspects of life that, until now, we have simply had to put up with. What a time to be alive!
They are not going to tread lightly, ethically, and they aren't going to use it for the common people. These are the same people who constantly talk about population control.
@@SoloRenegade All technology is as bad as you want it to be. Relax, nobody is trying to make super-soldiers with this. But curing genetic conditions that affect one's life and their descendants too, consider how many live one can improve.
@@chinmayjoshi3592 No, this is disgraceful and evil! Scientists do not have the right to mess with our genes just because you perceive my autism as a "problem". Autism is not a problem, you claim you value all humans equally, since you want to rub us out of existence you clearly do not see us as equal, you are full of discriminatory thoughts like Hitler doing eugenics. The problem is clearly your view of autism and other primarily genetic conditions. I love being autistic, I wouldn't give it up for the world. Molecular biologist Miroslav Radman writes, "Mutagenesis has traditionally been viewed as an unavoidable consequence of imperfections in the process of DNA replication and repair. But if diversity is essential to survival, and if mutagenesis is required to generate such diversity, perhaps mutagenesis has been positively selected for throughout evolution." Do you really want to bring us to extinction you discriminatory geneticists? Evelyn Fox Keller explains: "We now know that mechanisms for enduring genetic stability are a product of evolution. Yet a surprising number of mutations in which at least some of these mechanisms are disabled have been found in bacteria living under natural conditions. Why do these mutants persist? Is it possible that they provide some selective advantage to the population as a whole? Might the persistence of some mutator genes in a population enhance the adaptability of that population? Apparently so. New mathematical models of bacterial populations in variable environments confirm that, under such conditions, selection favors the fixation of some mutator alleles and furthermore, that their presence accelerates the pace of evolution." The mutants behind autism and other conditions like Down Syndrome offer some great advantages to the human race, diminishing the genes is a great risk because without those mechanisms there is no asurety of genetic stability pushing us in the direction of extinction. Psychologist Howard Gardner warns: "With the coming of age of genetics, the danger magnifies. Beyond doubt we will discover genes that are important for reading alphabetical scripts; and there is already evidence that a small set of genes may be related to reading problems. As with the brain evidence, such information can be helpful for early intervention; but it could easily be used for stigmatising purposes. Indeed, it might become relevant for marriage prospects, holding a job, securing insurance, or even eugenic purposes. And no doubt, especially in our interventionist society, individuals with a genetic predisposition for reading problems will look into different kinds of genetic engineering or therapy. It is possible that such interventions will work and have no negative side effects, but it is perhaps more likely that they will have unanticipated effects. And we might even want to consider which valued human abilities - eg. spatial or pattern recognition skills - might be placed at risk were we to target our interventions specifically at reading disorders." Do you really want to destroy all alternative perceptions and ways of thinking? Each time you idiots have tried playing God you have only caused harm. Who caused the climate change? Scientists playing God trying to control nature, did you Gods anticipate the climate change? You cause the problems you wish to be solved all because you view who you see as abnormal as a problem, even though you can't even define a "normal" human. Again, this is wicked and pure evil to think we don't deserve to be born just because we are different. Sort your discriminatory thoughts out.
My son (6yrs) progressively going blind. It's heartbreaking. He handles it better than his family. We've been waiting for good news. Thank you for this video
That's why I'm throwing money at this.,.If you want to help then your family are the right type of people to encourage others to invest in gene editing company's instead of charities that are supposed to fund cures but never do....(This company is called CRISPER but there are others and they will all contribute to curing diseases)... You could also research on reach out to company's about possible treatments (I find you can achieve more than asking doctors)
Can you try these below. I have a daughter who had sudden eyesight loss and Thank to God the Almighty, she is normal now. 1. Stop consuming all processed food, especially with high technology . 2. Go organic raw food or light cooking 3. drink plenty of free chemical water 4. Dont eat processed sugar at all, they arent sugar, they are poison, except they are simple processed, not ultra fine. 5. Be outdoor in the sun, especially morning sun and let him play and be active 6. no screen time at all 7. if you are a Theis believe in lord God, pray for Him. He is the absolute answer. He controls everything, as small as speckle dust.
I thought you were about to say "I'm not blind..but i'm really glad people around me can see me" XD Jokes aside, one of my brother is loosing his sight and a breathrough like this gives me hope!
As a biotechnology student: great video! We need to keep researching, but simultanously think about the ethics. 😃 Curious to see what the future holds.
Yup. The fear is well placed, especially since it can disrupt the biochemical ecosystem within cells. That natural selection shaped over millions of years, & cause unforeseen consequences later in life.
I know most of these stories already, but watching this still brings me to the brink of crying. It's beautiful, both in a human way but also in a science way
As a person with Retinitis Pigmentosa (where I lose rods and cones cells in my retina which eventually leads to blindness over time) am always glad to hear of advances in the field of curing eyesight. Love to those working on this technology and even knowing that the technology is new, I hope that one day I can see again like I used to.
@ghost mall I turned 40 this year and am able to manage somewhat. I can read using darkmode on my devices and have a scattering of central and peripheral vision that I use to get through the day. I do hope that we can both get treatments to restore our vision in our lifetime. I know it is hope but am hanging on to it.
I also have a form of RP like problems, though my retina specialist thinks it high Myopia, I have the bone spicule formation on my retina, and my parpheral vision is awful. I'm 28, turning 29 in December, this gives me hope.
@@rejoyy Retinitis pigmentosa experimental CRISPR treatments and studies are already underway. The fact that you are that old and still have some vision probably makes both of you good candidates. You should see if you can get involved in a trial.
I cannot even begin to fathom what it must feel like, for people who have been blind since birth (or shortly thereafter), to finally attain eyesight... It must be unimaginable.. Both the sensation of power, and scary in some way, because once you can see (or hear), there's no way to "turn it off", except closing your eyes. How can "we regular folk" imagine gaining a completely new sense we've never had before? And having it being opened permanently. It's so hard to imagine what that must be like.
It can take months or even years for their brains to learn how to use the visual information. To connect visual objects to the concept of those objects in the persons mind. Because, until then, they've had ideas about what these objects might be, but they didn't have any visual representation to base it on. Only by the other senses. Also, things like depth perception don't only happen because we have 2 eyes, but also because our brain knows how to use that information. When you can't see for long periods, your brain doesn't need to stimulate the parts of itself that deal with vision, so those parts of the brain don't grow, and can even atrophy over time. So, the visual stimulation is there, but a lot of these people have a hard time getting used to it. It can be overwhelming, and they might come into it slowly, a little at a time by wearing eye coverings and using their vision sparingly when they're curious about what something looks like. Some people come into it much more enthusiastically and get used to it more quickly. It all just depends on the person.
I remember watching a video on someone who was deaf, And they had an implant. When they could hear for the first time they cried, And so did I at their overwhelming joy and I'm not usually that emotional. Must be an incredible moment for these people to gain one of their major senses back, We all take basic things for granted. When I severely ripped a calf muscle and couldn't walk for 4 months, It made me appreciate things a lot more especially disabled people, Just trying to get up and go to the toilet or get a drink from fridge was a major effort and exhausting and that was just a muscle tear. Who would have thought a muscle you don't really notice or bother about could be so critical to basic tasks.
My father is colorblind. Its one of the more common ones that brown and green look similar to him. A company makes glasses that fix the error by doing some magic with the light. I got him a pair as a gift and the ass rejected them telling me not to waste my money. Do you know how furious I was? I put all this thought into getting him something that he never experienced in his life and he just slapped it away. Sadly he would have accepted a tshirt or tie, or cigars but I was really mad (and still am kind of) that he didn't even try them on.
Back in the late '80s I contacted an elderly customer to set up a service call. She was ecstatic because she had some sort of eye surgery a few days before and for the first time in her life could see. I wish I could describe her child like joy and wonder in everything around her.
As an engineer I am interested in the loss of the fix after a "brief" time... I am sure going from blindness to seeing for over a year will be just the starting place, but it speaks our growing, but infant level knowledge of genetics. Also, I am sure there a other genes that must be "touched" to finish fixing this condition for all people with it. I think about little things like man pattern baldness to huge things like CF and other life ending diseases that might end up with a therapy like this. My biggest worry is man managing it. Greed and the desire to fix/modify people's traits we see as inferior or damaged should not lessen the value we place on life and individuality. We are not God and should not think this makes us such. There is one God and as his children, He has given us the intelligence and wisdom to use this kind of knowledge carefully and cautiously. That said, let's go understand more and more of the genome and how to assess it and modify it for permanent benefits.
@@greateel3237 What is defined as a disease is my concern, can you recall homosexuality defined as a pathological disorder? Hitler and racial hygiene? Why were alternative races defined as diseases? Humans clearly cannot be trusted, they will no doubt abuse people with it with selfish motives. I am autistic and I don't want to be cured of the gifts that come with it, they should not have the right to change people without our consent, it is racism and discrimination. Molecular biologist Miroslav Radman writes, "Mutagenesis has traditionally been viewed as an unavoidable consequence of imperfections in the process of DNA replication and repair. But if diversity is essential to survival, and if mutagenesis is required to generate such diversity, perhaps mutagenesis has been positively selected for throughout evolution." Evelyn Fox Keller explains: "We now know that mechanisms for enduring genetic stability are a product of evolution. Yet a surprising number of mutations in which at least some of these mechanisms are disabled have been found in bacteria living under natural conditions. Why do these mutants persist? Is it possible that they provide some selective advantage to the population as a whole? Might the persistence of some mutator genes in a population enhance the adaptability of that population? Apparently so. New mathematical models of bacterial populations in variable environments confirm that, under such conditions, selection favors the fixation of some mutator alleles and furthermore, that their presence accelerates the pace of evolution." The mutants behind autism offer some great advantages to the human race, diminishing the genes is a great risk because without those mechanisms there is no asurety of genetic stability pushing us in the direction of extinction. Psychologist Howard Gardner warns: "With the coming of age of genetics, the danger magnifies. Beyond doubt we will discover genes that are important for reading alphabetical scripts; and there is already evidence that a small set of genes may be related to reading problems. As with the brain evidence, such information can be helpful for early intervention; but it could easily be used for stigmatising purposes. Indeed, it might become relevant for marriage prospects, holding a job, securing insurance, or even eugenic purposes. And no doubt, especially in our interventionist society, individuals with a genetic predisposition for reading problems will look into different kinds of genetic engineering or therapy. It is possible that such interventions will work and have no negative side effects, but it is perhaps more likely that they will have unanticipated effects. And we might even want to consider which valued human abilities - eg. spatial or pattern recognition skills - might be placed at risk were we to target our interventions specifically at reading disorders." We can see the vast majority of so called diseases for what they are; they are discriminatory social constructions, not an intention to objectively understand human biology. Were global warming, warmer oceans, production of epidemic diseases, climate change, increased natural hazards and more anticipated. I doubt it so I would say Howard Gardner has a good point, every time humans have tried to play God and control nature nature struck humans back with greater problems, the people trying to solve the problems are the people who caused the problems and are trying to solve those problems repeating the same mistake to cause more problems. Why do so called geniuses fail to recognise their own short comings, why aren't we trying to cure the majority's weaknesses and how sickening the majority is with its ableism?
I’m a huge technology optimist, I believe we should use it to its fullest capabilities wherever it initially seems “unnatural” or not. I’m for progress and innovation by almost any means. I love the lightning speed strides we’re making in tech, and none of it scares me. Not the AI, not the gene editing, not the “metaverse” and alternate digital realities, not even things like Elon Musks NeuraLink or the concept of being able to one day upload your consciousness. It all excites me and makes me extremely optimistic for the future.
There’s a reason it’s all happening so fast. Because it HAS TO. Same reason a deer is born almost able to stand from the get go. IT HAS TO. For survival reasons. But it also has to happen correctly. That’s what I have been working on my whole life but now no one listens….
Keep dreaming. The fastest vaccine/cure ever developed was for mumps in 1963.It took 4 years. Yet they “developed” this CONvid bs vaccine in 8 months? At least these days they only go for things that will make them the most profits. If anything especially in the last 2 years has told us is that THEY COULD CARE LESS ABOUT ANY OF US!!
It's all about 💰, I've been following crisper, talk to doctor's to get there opinions they scared to lose there income, no were in the news surprise Surprise
I actually saw one of the Nobel scientists for this technology, Dr Emmanuelle Charpenier, in lecture at the Freie University in Berlin! This was before she even won. She's an amazing speaker. The dean said that she'll be one of the youngest who could win the Nobel when he introduced her. And she did. So happy for ALL OF THIS ❤️
Don’t get your hopes up just yet. Big Pharma will charge an exorbitant amount for this, as they always do. 99.99% of us wouldn’t be able to afford it. Let’s be honest here.
@@kovy689 Pharma's probably already have the tech, most likely already have the cure for cancer & other diseases but a cure doesn't make money. Patching people up temporary is a good income stream, if they actually cured people they would be out of business ( FACT )
@@DespaceMan Not probably, they already DO have the solution for most diseases know to man. They just safeguard it to maximize profits. And if that wasn’t enough, a bonus would be the the dozens “charities” acting like a cure doesn’t exist to further siphon cash from generous donors. I laugh every time some rich dude donates to a charity that already has a cure.
As with any Tool it is always how you use it. Dynamite was invented for stone quarry works. It's not a question of the tool itself. It's always the ethical question what you wish reach and how. Not every how is responsibility.
And keeping it out of reach of idiots. The internet is a shining example of how poorly we have managed that. Spreading the stupid and making otherwise harmless idiots potentially dangerous to society (kids needlessly dying from measles springs to mind).
Yeah, every technology can be used for good or bad.. Hopefully people will use them for good thing, like for medical purpose.. (not for weird things.. sometimes people are too creative..)
Some say the end is near. Some say we'll see Armageddon soon. Certainly hope we will. I sure could use a vacation from this bullshit three-ring circus sideshow of freaks. Here in this hopeless fucking hole we call L.A. The only way to fix it is to flush it all away. Any fucking time. Any fucking day. Learn to swim, see you down in Arizona Bay. Fret for your figure And fret for your latte And fret for your lawsuit And fret for your hairpiece And fret for your Prozac And fret for your pilot And fret for your contract And fret for your car. It's a bullshit three-ring circus sideshow of freaks. Here in this hopeless fucking hole we call L.A. The only way to fix it is to flush it all away. Any fucking time. Any fucking day. Learn to swim, see you down in Arizona Bay. Some say a comet will fall from the sky. Followed by meteor showers and tidal waves. Followed by fault lines that cannot sit still. Followed by millions of dumbfounded dip shits. And some say the end is near. Some say we'll see Armageddon soon. Certainly hope we will I sure could use a vacation from this stupid shit, silly shit, stupid shit. One great big festering neon distraction, I've a suggestion to keep you all occupied. Learn to swim. Learn to swim. Learn to swim. 'Cause mom's gonna fix it all soon. Mom's comin' 'round to put it back the way it ought to be. Learn to swim. [repeat] Fuck L Ron Hubbard And fuck all his clones. Fuck all these gun-toting Hip gangster wannabes. Learn to swim. [repeat] Fuck retro anything. Fuck your tattoos. Fuck all you junkies And fuck your short memory. Learn to swim. [repeat] Fuck smiley glad-hands With hidden agendas. Fuck these dysfunctional Insecure actresses. Learn to swim. [repeat] 'Cause I'm praying for rain I'm praying for tidal waves I wanna see the ground give way. I wanna watch it all go down. Mom, please flush it all away. I wanna see it go right in and down. I wanna watch it go right in. Watch you flush it all away. Time to bring it down again. Don't just call me pessimist. Try and read between the lines. And I can't imagine why you wouldn't welcome any change, my friend. I wanna see it come down. Bring it down Suck it down. Flush it down. -Tool
Amazing! About 2 years ago, I did a presentation during my undergrad about LCA2 and its potential for treatment via gene therapy. At the time, it was the only LCA type to deliver ANY promising treatment results through gene therapy. Hearing about this development makes me so happy to see the progress being made in this field especially as an aspiring ophthalmologist!!
This is incredible! Ive been legally blind my entire life with a visual acuity of 6/96 (or 20/315 in feet). With that said there are still many who have it far worse and I still consider myself lucky to have the vision that I still have. But the limitations are massive. I'm unable to drive, I am very limited with my career choices ect. This could be absolutely massive in the coming years for millions of people around the world as this technology progresses. Not to mention the hundreds of millions of people affected within other medical fields. Fingers crossed 🤞
@@thesupreme1503 it is extremely rare for people to be completely blind to the point of no light perception. The USA classifies vision that is uncorrectable by conventional glasses worse than 20/200 as legally blind, or your field of view being less than 20°. But visual impairment is classified as starting 20/70.
There are always ways technology can be used for harm. That shouldn’t deter us from using it for good. This has the potential to do miraculous things. Thanks for another great video!
The production quality on this channel is AMAZING. Glad UA-cam recommended it. Also, I appreciate your transparency by presenting advantages as well as disadvantages.
I've been wanting this to hurry up with crispr studies since it was discovered. There's too much fear mongering around it. I'm convinced it's the future.
I'm am severely visually impaired myself after a generic disease caused my vision to plummet off a cliff a few years ago, just as I finished university. This really gives me hope, if I can get back even a small percentage of what I lost, I'll take it.
As a person who has aspirations to develop technologies of this sort in the future, this really makes me happy. One day we won’t treat symptoms but the very roots of the problems.
This is absolutely amazing! I know how hard it can be when your eyes don't work properly as my eyes haven't been working together properly for many years. I've recently been having eye therapy and and the result has been absolutely amazing, especially with my studies at the moment. While I'm not blind I completely understand the difficulties and impact that eyesight has on peoples lives.
@@nuggetonastick1804 tinnitus is the constant ringing in your ear that some people have. i personally got it from listening to too much loud music. since it cannot be transmitted, there is no vaccine.
This is very emotional for me because this isn’t just an advancement for blindness, but all genetically related diseases as well. God bless all of you, we’re lucky to have hope for the future.
Imagine shortening the curve towards progress by introducing AI to the Trials & Errors phase to identify potential caveats, and eliminate them before executing a CRISPR Procedure? My wife suffers with RP, so I will be on the lookout for progress there, and feel more hopeful that it will occur in a period where she can reap the benefits!
I have a friend suffering from a similar condition, he started losing sights as a teenager, especially in low light conditions, and after that his field of vision reducing further and further, i really hope this treatment gets developped and accessible to more people in the next years/decade, i was really excited when i heard the news. I'm really stoked on genetic edition, probably more than the people working in the fields, yes, fix up our quirks, make us better, no need to suffer the effect of defects that managed to make it through the filter of natural selection.
My wife was the second person to get this. Only two of the 4 so far have had improvements My wife may have the most improvement. She has gone through hell with all of the tests they put her though weeks of 8 hour days of testing and probing. Only one eye so far she had to have her cataract removed first now she has to get the second eye done.
Excellent introduction to CRISPR - I appreciate your well thought out presentation of the incredibly aspirational and controversial topic. Thank you for adding to the public discourse as you have.
I actually know a young woman who is a part of this amazing study….and we’re all so hopeful it will be successful and made available to all who need it. Amazing stuff!
I researched CRISPR technology for my English research project and I’m so glad I did. This is pretty fascinating and I’m curious as to what improvements and advances (and, of course, downfalls) this technology will bring in the future.
Starting with the good, could help cure cancer. The bad, abusive parents who might know about this might try to wield another level of control on their children by threatening to mess up their genes or forcing them to undergo things that the child does not want.
Your videos are so unbelievably well made. From the first time I saw your videos I was in awe of your soothing voice and great information that is easy to digest. You are helping make the world a better place, I truly believe that. Keep up the great work!
This is very powerful tech. Has the ability to do a lot of good or some insanely dark applications as well. Needs to continue to be strictly regulated.
For one with Stargardt's decease I am really exited for this technology, my condition isn't that bad yet, as I obviously can read and write still, but it is gonna get worse over time until I get legally blind, so this exites me greatly
Each technology is a tool. And it's up to us to decide how this tool is going to be used. Powerful tools such as CRISPR come with huge responsibility. We need to ensure that it's used with care
I only add this because the Narrator overstated the outcome of this LCA treatment. Dr. Eric Pierce, MD, Phd. at Mass Eye and Ear was correctly quoted and did not make the statements that the Narrator did. Dr. Pierce is highly recognized and gifted in the field of Inherited Retinal Diseases/Dystrophie, and I might add highly respected. "Leber 's Congenital Amaurosis Type 2. (There are about 19 phenotypes (outward symptoms) of LCA and 25+ genotypes (the DNA coding that causes disease) To receive that treatment you have to have genetic testing to prove you have a defect in the gene that makes the protein, RPE65 (produced in the Retinal Pigmented Epithelial cell which are in intimate contact with the light sensing Retinal Photoreceptors). LCA2 makes up a very small segment of the Retinitis Pigmentosa/Inherited Retinal Diseases Community. It happens to about 1 in 80,000 people. Where RP (IRD's) happens to 1 in 4,000 people. The sad thing is this is mainly a Blinding Retinal Disease that begins in babies. By the time they are 4 yrs old, the amount of Rod Photoreceptors in the Retina that have been destroyed are numerous. By the time they are around 20 yrs, most are legally blind. That is why it has been approved for use in very young children, to prevent photoreceptor destruction caused by the DNA carrying the wrong recipe for the visual protein RPE65. Before too many Photoreceptors die off. Once they die that are not replaced, and treatment at an older age will not restore the destroyed photoreceptors. The treatment may rescue some damaged cells and restore them to health, before they completely die, but does nothing for the dead photoreceptors. So the Narrator suggesting it restores vision is false hope. The corrected gene segment is placed inside of a small virus that does not cause diseases in humans. The corrected gene segment is taken up by the Adeno-Associated Virus and mixes in with the Virus's own genome (single stranded DNA), this virus is then reproduced over and over again in the Lab. Then, they inject this corrected DNA Segment of RPE65 carrying virus under the Retina during a surgical process. It is hoped that this modified Virus will then infect the Retinal Cells and the corrected gene segment will be added into the patient's DNA in their Retinas, allowing the patient's cells to make correct copies of RPE65 and hopefully stop further destruction of the photoreceptors (Rods and Cones). If the photoreceptor has already died or so far along in destruction, the medicine will not work. Because once a photoreceptor is dead, it is GONE! The body does not replace its Photoreceptors like it does, for example a skin cell. That is why this "luxturna(TM)" must be injected early in the course of the disease to make a real difference. The treatment is VERY expensive. With surg., anes, hospital cost, Surgeon's Bill, and the high cost of the medicine itself... it can be close to $1 Millions Dollars. There are a few Insurance Companies that will carried the cost of this procedure and I understand that the NHS will also cover it, if approved. But, otherwise the patient has to pay out of pocket for this therapy.
Learning about CRISPR has been one of the most uplifting things ever. I used to have a lot of dark, depressing thoughts about dysgenic pressure, and how maybe the Nazis were right in that we needed some heavy hand to replace evolution now that we no longer had natural selection to clean up our gene pool, how religion was standing in the way of preventing our de-evolution as a species, how there might be some great war over designer babies and genetic engineering, etc. But seeing this technology in action gives me hope for the future.
CRISPR is an amazing tool, but there will need to be proactive, lengthy, thorough conversations and some oversight about the ethics and use for the tool. Where there is interest in something so profoundly powerful as CRISPR, it is bound to attract those with less idealistic questionable motivations; especially when "genetic mass driving" is a very real action now.
The one percent of bad cases will stop so many from getting the help they want 😞 Plus the inevitable moral panic when religious boomers find out about it
@@jjcoola998 Why would religious boomers object to medical treatments that would help them? There's nothing in any "holy" text that prohibits gene editing. And if someone doesn't want their genes edited, then I'm fine with them not being treated with it.
To the *incredible person* that's seeing this, I wish you all the best in life❤ don't over blame yourself, accept things and go forward. Don't let others define what “success” is for you. Get up, learn the skills needed and get after it, all the keys to a happy life is in your hands. Keep pushing.
As someone who has vision problems for many years, this is so cool.. but I do agree we must approach w cautious but it also give me hope for the future when it comes to my vision.
Like all new technology, it is scary to hypothesize possible futures that it will be abused (similar to internet when it was first coming around), but overall it's a fantastic development for humanity.
CRISPR is incredible and has virtually limitless applications. Ultimately it doesn't matter if some people are up in arms about it's ethical implications, nothing can stop the research now, it has too much promise to be stopped.
Frikkin amazing. They're hot on the trail of reversing aging aswell. Imagine never growing old and only dying through disease or an accident. Oink oink
I would love to see a way for people to “sandbox” these tests and studies to mitigate risk. In the chance that something great is discovered, but later effects create a much worse situation. I don’t know if this is feasible, but it would create a safer environment. Thoughts?
You do realise your basically demanding people to exit themselves from the reproductive pool then, ala anyone getting crispr treatment to not have children
@@brenelec There may be many people who would trade that to cure a debilitating genetic disease. After all why would one want to have a kid and risk passing on the bad gene to their poor kid ? You'd rather adopt and save a life instead.
Very inspiring, well done doctors & scientists who developed CRISPR & CAS9 active gene editing techniques! Nobel Prize in the making! Revolutionary & Emergent Innovation in biotech & life-science #42
@@aiistyt They should care because unregulated capitalism is creating oligarchy in usa, destroying our safety nets and the environment of our planet. Elon is considered a super genius even tho never invented anything, was born into better financial safety nets and now majority of Americans think he's self made and they can become like him.
@@Pyasa.shaitan But capitalism isn’t unregulated. As a diabetic i really wouldn’t care who solved it. As for Musk, you’re correct he wasn’t born poor but he is responsible for disrupting both the car & space industries.
@@aiistyt i mean with the way megacorps jacked up insulin prices to such an extreme degree, you should be concerned that corporate oligarchy is fucking everyone over! seriously man insulin was meant to be cheap and widely available
@@aiistyt Okay but what's the objective of all that disruption when majority of humanity can't afford them ? Climate change will affect poor countries the most, majority of them don't have access to tesla. If by disruption you mean taking advantage of your employees labor and marketing yourself as a super genius then no that's fraud.
"Sarif was right about one thing. It's in our nature to want to rise above our limits. Think about it. We were cold, so we harnessed fire. We were weak, so we invented tools. Every time we met an obstacle, we used creativity and ingenuity to overcome it." -Deus Ex: Human Revolution
@@christopherrapczynski204 if turned into a bio weapon through means of a man-made virus, the damage could be astronomical. It could be as simple as designing the cas-9 protein in a way that it replaces a commonly found and critical gene in all humans with gibberish.
I've been waiting for this forever, since I really want my blind brethren to see again, and if I ever were to lose my eyesight, I want to know that it could be fixed. Also could this make a person taller?
I have a theory (and hear me out) that mushrooms may be a major key to improving vision. Early studies have showed some promise and I have personally observed Paul Stamets’ mushroom stack to have noticeably improved my vision above 20/20 and had friends who wear contacts say they almost didn’t need them while on this special stack, among the other noticeable benefits. Color appears more vivid, everything become sharper, peripheral vision seems improved. I’ve done tests where I go to my favorite restaurant and can read the employee monitors from over 20 feet away, also notice extremely small bugs on the ground that I don’t think I would’ve before. I really hope more this and the numerous other benefits are more widely studied in the future. My city decriminalized all mushrooms at the start of the year and I have since began studying mycology, the benefits, and growing for personal use. It costs $50 and some good soil to have an unlimited supply of such a relatively easy to grow substance that has profound impacts on life. I’d really like to hear other’s who have tried the Stamets Stack thoughts on this! Very good video, excited to see where the future of gene editing takes us.
Repairing a gene in a species is one thing. When we start splicing genes from other species that's where it becomes radically dangerous. There is literally no possibility of predicting the cumulative knockoff effects the more we do that. Covid-19 is a good example. I think we should have strong ethical guidelines that limit it to repairing broken genes not adding new genes.
I was outraged when the Chinese scientist was reined in and imprisoned for gene editing. It goes to show how incredibly asinine the average person is in understanding biology if making babies more resistant to HIV, something already present in 10-20% of people if European ancestry is seen as wrong.
@@18890426 *Of European ancestry. The gene that He Jiankui inserted into those girls is already known to be present in Europeans, though I didn't think that the prevalence was 10% to 20%.
Currently, I am visually impaired on my right eye, and legally blind on my left eye. I was always visually impaired, but was able to see, to the point I got my driving license for motorcycles at 16. Unfortunately, when I was 19, a new disease appeared: Coats disease. This disease made me lose my left eye vision, and almost all vision on my right eye. My right eye, with glasses, is currently at 10% - but fortunately a good 10%, meaning, my vision is clear, average peripheral vision, but with some ghosting and with the help of magnifying glass, either physical or virtual. Seeing this innovations gives me two big hopes: 1) I might be able to see clearer, better, and maybe - just maybe - I can drive again, one of my biggest dreams! 2) My future children, if by chance get some visual disease from my genes, can be improved through this new techniques / technologies. This, along with the COVID-19 vaccines, prove that science is crucial for our quality of life!
I think personally that within the decade we will see a change or series of changes just as revolutionary as software was for computing like with the invention of Microsoft Windows OS. Crispr could enable a suite of industries namely agriculture. It’s immediate use will be with cases of great urgency like trying to mitigate the negative socio-economic impact of climate change on crops that aren’t resistant to rising temperatures and increasingly turbulent climates. As well as preventing forest biomes from further deprecation due to human intervention like unwanted indirect deforestation, and nurturing species of trees on verge of becoming endangered where their presence in the environment is needed so that a healthy ecosystem is maintained. Another industry of immense commercial interest will perhaps be DNA computing when storing data on new forms of drives.
![The Rise of A.I. Companions [Documentary]](http://i.ytimg.com/vi/QGLGq8WIMzM/mqdefault.jpg)
CRISPR IS probably like the Internet in the 80s. We don’t understand it yet but once we do there are infinite possibilities
CRISPIER than thou
unlike the net, one hopes that dank memes will not be produced.
@@DeconvertedMan dank genes
I would have compared it to the Internet (ARPANET) of the 70s since we are just at the beginning of the revolution. We just need to make sure we don't become the world of Gattaca (movie).
A lot of scope for abuse too, thanks to the evil out there in society.
As someone who is visually impaired, this got be in the feels. Knowing there are big strides being made to improve this is incredible and that there could be a working solution out there, is mind blowing and life changing! So happy for those who took part and saw major life changes 💪😃
How are you able to comment ?
@@asimgiri4269 I thought you were the same person 😂 you have the same photo in the snow with a beannie
@@ZZ-vl5nd 😂😂
The thing that sucks is...once the study is over, these people no longer had access to the gene therapy, so they went blind again. :\ Imagine getting your vision back and then having it taken away.
@@asimgiri4269 there are tools the visually impaired could use to surf the internet
As a molecular biologist who has used CRISPR several times in my lab work, this is so cool! The tech to help lots of people already exists and the biggest barrier is just our fear of genome editing. Thanks for shining a light on this amazing breakthrough in medicine!
I don't fear it, I actually want this to be used as therapy to fix things that can't be fixed by ordinary medicine or ordinary methods, it seems CRISPR does the job.
@@Azmodaeus49 Yeah. Hope it eventually can be used to repair or rebuild nerves, tendons, cartilage, regrow ear hair cells, fix mental illnesses like depression, adhd etc. My life would be considerably better
It is a very valid fear. The technology has the potential to make the world a far better place...and the potential to make global thermonuclear war seem less scary.
@@rudrasingh6354 I'd love CRISPR to cure eczema that is my biggest dream, the science community ignores this condition way too much, I suffer from that skin condition and had it my whole life, I'd love the science community to put in more money and research into finding a cure for people around the world suffers from eczema and allergies, it is not fair that many diseases are being fixed and cured, but diseases or conditions like allergies and eczema are being ignored 😔
As a Biomedical engineer previously worked on genetics, I'd say it's legitimate to fear this tech. As it enables humans to program each other, and who knows what would bad actors do, and there always will be bad actors out there.
I know this comment is not likely to be seen by anyone as this video was published a couple months ago, but I was not expecting to tear up while watching one of your videos. I have that exact mutation for LCA, and this gene therapy research is super exciting for me. Especially the guy who mentioned seeing a sunset for the first time in a couple of years, as that is something I want to do. Thanks for bringing this to my attention CF, I'm definitely going to try making some calls to this particular researcher and ask him about the progress they've made thus far and see if there is any opportunity for me to get in one of their clinical trials. (:
hows everything going, are u getting this treatment?
Good luck! ✨
Hands down one of the greatest technologies of the 21st Century. The applications are near-limitless! We need to tread carefully from an ethical perspective, but CRISPR gives us the power to address so many of the negative aspects of life that, until now, we have simply had to put up with. What a time to be alive!
They are not going to tread lightly, ethically, and they aren't going to use it for the common people. These are the same people who constantly talk about population control.
CRISPR could also be worse than nuclear weapons.
@@SoloRenegade All technology is as bad as you want it to be. Relax, nobody is trying to make super-soldiers with this. But curing genetic conditions that affect one's life and their descendants too, consider how many live one can improve.
@@chinmayjoshi3592
No, this is disgraceful and evil!
Scientists do not have the right to mess with our genes just because you perceive my autism as a "problem".
Autism is not a problem, you claim you value all humans equally, since you want to rub us out of existence you clearly do not see us as equal, you are full of discriminatory thoughts like Hitler doing eugenics. The problem is clearly your view of autism and other primarily genetic conditions. I love being autistic, I wouldn't give it up for the world.
Molecular biologist Miroslav Radman writes, "Mutagenesis has traditionally been viewed as an unavoidable consequence of imperfections in the process of DNA replication and repair. But if diversity is essential to survival, and if mutagenesis is required to generate such diversity, perhaps mutagenesis has been positively selected for throughout evolution."
Do you really want to bring us to extinction you discriminatory geneticists?
Evelyn Fox Keller explains:
"We now know that mechanisms for enduring genetic stability are a product of evolution. Yet a surprising number of mutations in which at least some of these mechanisms are disabled have been found in bacteria living under natural conditions. Why do these mutants persist? Is it possible that they provide some selective advantage to the population as a whole? Might the persistence of some mutator genes in a population enhance the adaptability of that population? Apparently so. New mathematical models of bacterial populations in variable environments confirm that, under such conditions, selection favors the fixation of some mutator alleles and furthermore, that their presence accelerates the pace of evolution."
The mutants behind autism and other conditions like Down Syndrome offer some great advantages to the human race, diminishing the genes is a great risk because without those mechanisms there is no asurety of genetic stability pushing us in the direction of extinction.
Psychologist Howard Gardner warns:
"With the coming of age of genetics, the danger magnifies. Beyond doubt we will discover genes that are important for reading alphabetical scripts; and there is already evidence that a small set of genes may be related to reading problems. As with the brain evidence, such information can be helpful for early intervention; but it could easily be used for stigmatising purposes. Indeed, it might become relevant for marriage prospects, holding a job, securing insurance, or even eugenic purposes. And no doubt, especially in our interventionist society, individuals with a genetic predisposition for reading problems will look into different kinds of genetic engineering or therapy. It is possible that such interventions will work and have no negative side effects, but it is perhaps more likely that they will have unanticipated effects. And we might even want to consider which valued human abilities - eg. spatial or pattern recognition skills - might be placed at risk were we to target our interventions specifically at reading disorders."
Do you really want to destroy all alternative perceptions and ways of thinking?
Each time you idiots have tried playing God you have only caused harm. Who caused the climate change? Scientists playing God trying to control nature, did you Gods anticipate the climate change?
You cause the problems you wish to be solved all because you view who you see as abnormal as a problem, even though you can't even define a "normal" human.
Again, this is wicked and pure evil to think we don't deserve to be born just because we are different.
Sort your discriminatory thoughts out.
Amid all the generally bad news in 2020/2021, this stands out as truly heartwarming
No….it actually is the worst of em all, think about bioterrorism as well!!
@@serotonin2222 Lol Resident Evil
Don't you trust the covid vax and it's makers? LOL! (NOT!).
@@keenanrobinson7239 boulder punching a***ole go brr
It does indeed
My son (6yrs) progressively going blind. It's heartbreaking. He handles it better than his family. We've been waiting for good news. Thank you for this video
I wish the best for your son
Good Luck Todd
May God be with him and you. A number of us are following new approaches with cautious optimism
That's why I'm throwing money at this.,.If you want to help then your family are the right type of people to encourage others to invest in gene editing company's instead of charities that are supposed to fund cures but never do....(This company is called CRISPER but there are others and they will all contribute to curing diseases)... You could also research on reach out to company's about possible treatments (I find you can achieve more than asking doctors)
Can you try these below. I have a daughter who had sudden eyesight loss and Thank to God the Almighty, she is normal now.
1. Stop consuming all processed food, especially with high technology .
2. Go organic raw food or light cooking
3. drink plenty of free chemical water
4. Dont eat processed sugar at all, they arent sugar, they are poison, except they are simple processed, not ultra fine.
5. Be outdoor in the sun, especially morning sun and let him play and be active
6. no screen time at all
7. if you are a Theis believe in lord God, pray for Him. He is the absolute answer. He controls everything, as small as speckle dust.
I'm not blind..but I'm really really glad people around me can see what I can.
I thought you were about to say "I'm not blind..but i'm really glad people around me can see me" XD Jokes aside, one of my brother is loosing his sight and a breathrough like this gives me hope!
As a biotechnology student: great video! We need to keep researching, but simultanously think about the ethics. 😃 Curious to see what the future holds.
Yup. The fear is well placed, especially since it can disrupt the biochemical ecosystem within cells. That natural selection shaped over millions of years, & cause unforeseen consequences later in life.
I know most of these stories already, but watching this still brings me to the brink of crying. It's beautiful, both in a human way but also in a science way
As a person with Retinitis Pigmentosa (where I lose rods and cones cells in my retina which eventually leads to blindness over time) am always glad to hear of advances in the field of curing eyesight.
Love to those working on this technology and even knowing that the technology is new, I hope that one day I can see again like I used to.
@ghost mall I turned 40 this year and am able to manage somewhat. I can read using darkmode on my devices and have a scattering of central and peripheral vision that I use to get through the day.
I do hope that we can both get treatments to restore our vision in our lifetime. I know it is hope but am hanging on to it.
I also have a form of RP like problems, though my retina specialist thinks it high Myopia, I have the bone spicule formation on my retina, and my parpheral vision is awful.
I'm 28, turning 29 in December, this gives me hope.
@@rejoyy Retinitis pigmentosa experimental CRISPR treatments and studies are already underway. The fact that you are that old and still have some vision probably makes both of you good candidates. You should see if you can get involved in a trial.
@@gregorymalchuk272 am residing in India. Not sure if CRISPR will accept Indian citizens.
@@rejoyy CRISPR is just the name for a gene editing technique that has only been available since 2012.
This is huge! Great time to be alive.
Yeah it's all roses until China develop a gene-specific virus based on all the DNA that they've been collecting from all over the world.
.
@@01DOGG01 nice tinfoil hat :d
@@01DOGG01 They already did that remember?
I want to be put in cryogenesis and wake up in 100 years. It's going to be lit
I cannot even begin to fathom what it must feel like, for people who have been blind since birth (or shortly thereafter), to finally attain eyesight... It must be unimaginable.. Both the sensation of power, and scary in some way, because once you can see (or hear), there's no way to "turn it off", except closing your eyes.
How can "we regular folk" imagine gaining a completely new sense we've never had before? And having it being opened permanently. It's so hard to imagine what that must be like.
It can take months or even years for their brains to learn how to use the visual information. To connect visual objects to the concept of those objects in the persons mind. Because, until then, they've had ideas about what these objects might be, but they didn't have any visual representation to base it on. Only by the other senses. Also, things like depth perception don't only happen because we have 2 eyes, but also because our brain knows how to use that information.
When you can't see for long periods, your brain doesn't need to stimulate the parts of itself that deal with vision, so those parts of the brain don't grow, and can even atrophy over time. So, the visual stimulation is there, but a lot of these people have a hard time getting used to it. It can be overwhelming, and they might come into it slowly, a little at a time by wearing eye coverings and using their vision sparingly when they're curious about what something looks like.
Some people come into it much more enthusiastically and get used to it more quickly. It all just depends on the person.
I remember watching a video on someone who was deaf, And they had an implant. When they could hear for the first time they cried, And so did I at their overwhelming joy and I'm not usually that emotional.
Must be an incredible moment for these people to gain one of their major senses back, We all take basic things for granted.
When I severely ripped a calf muscle and couldn't walk for 4 months, It made me appreciate things a lot more especially disabled people, Just trying to get up and go to the toilet or get a drink from fridge was a major effort and exhausting and that was just a muscle tear. Who would have thought a muscle you don't really notice or bother about could be so critical to basic tasks.
My father is colorblind. Its one of the more common ones that brown and green look similar to him. A company makes glasses that fix the error by doing some magic with the light. I got him a pair as a gift and the ass rejected them telling me not to waste my money. Do you know how furious I was? I put all this thought into getting him something that he never experienced in his life and he just slapped it away. Sadly he would have accepted a tshirt or tie, or cigars but I was really mad (and still am kind of) that he didn't even try them on.
Back in the late '80s I contacted an elderly customer to set up a service call. She was ecstatic because she had some sort of eye surgery a few days before and for the first time in her life could see. I wish I could describe her child like joy and wonder in everything around her.
@@MrShwaggins change is hard and scary for some people. how can history get past people like us.
As an engineer I am interested in the loss of the fix after a "brief" time... I am sure going from blindness to seeing for over a year will be just the starting place, but it speaks our growing, but infant level knowledge of genetics. Also, I am sure there a other genes that must be "touched" to finish fixing this condition for all people with it. I think about little things like man pattern baldness to huge things like CF and other life ending diseases that might end up with a therapy like this. My biggest worry is man managing it. Greed and the desire to fix/modify people's traits we see as inferior or damaged should not lessen the value we place on life and individuality. We are not God and should not think this makes us such. There is one God and as his children, He has given us the intelligence and wisdom to use this kind of knowledge carefully and cautiously. That said, let's go understand more and more of the genome and how to assess it and modify it for permanent benefits.
what else do we need to understand or learn to assess involving our DNA?
@@greateel3237
What is defined as a disease is my concern, can you recall homosexuality defined as a pathological disorder? Hitler and racial hygiene? Why were alternative races defined as diseases? Humans clearly cannot be trusted, they will no doubt abuse people with it with selfish motives.
I am autistic and I don't want to be cured of the gifts that come with it, they should not have the right to change people without our consent, it is racism and discrimination.
Molecular biologist Miroslav Radman writes, "Mutagenesis has traditionally been viewed as an unavoidable consequence of imperfections in the process of DNA replication and repair. But if diversity is essential to survival, and if mutagenesis is required to generate such diversity, perhaps mutagenesis has been positively selected for throughout evolution."
Evelyn Fox Keller explains:
"We now know that mechanisms for enduring genetic stability are a product of evolution. Yet a surprising number of mutations in which at least some of these mechanisms are disabled have been found in bacteria living under natural conditions. Why do these mutants persist? Is it possible that they provide some selective advantage to the population as a whole? Might the persistence of some mutator genes in a population enhance the adaptability of that population? Apparently so. New mathematical models of bacterial populations in variable environments confirm that, under such conditions, selection favors the fixation of some mutator alleles and furthermore, that their presence accelerates the pace of evolution."
The mutants behind autism offer some great advantages to the human race, diminishing the genes is a great risk because without those mechanisms there is no asurety of genetic stability pushing us in the direction of extinction.
Psychologist Howard Gardner warns:
"With the coming of age of genetics, the danger magnifies. Beyond doubt we will discover genes that are important for reading alphabetical scripts; and there is already evidence that a small set of genes may be related to reading problems. As with the brain evidence, such information can be helpful for early intervention; but it could easily be used for stigmatising purposes. Indeed, it might become relevant for marriage prospects, holding a job, securing insurance, or even eugenic purposes. And no doubt, especially in our interventionist society, individuals with a genetic predisposition for reading problems will look into different kinds of genetic engineering or therapy. It is possible that such interventions will work and have no negative side effects, but it is perhaps more likely that they will have unanticipated effects. And we might even want to consider which valued human abilities - eg. spatial or pattern recognition skills - might be placed at risk were we to target our interventions specifically at reading disorders."
We can see the vast majority of so called diseases for what they are; they are discriminatory social constructions, not an intention to objectively understand human biology.
Were global warming, warmer oceans, production of epidemic diseases, climate change, increased natural hazards and more anticipated. I doubt it so I would say Howard Gardner has a good point, every time humans have tried to play God and control nature nature struck humans back with greater problems, the people trying to solve the problems are the people who caused the problems and are trying to solve those problems repeating the same mistake to cause more problems.
Why do so called geniuses fail to recognise their own short comings, why aren't we trying to cure the majority's weaknesses and how sickening the majority is with its ableism?
I’m a huge technology optimist, I believe we should use it to its fullest capabilities wherever it initially seems “unnatural” or not. I’m for progress and innovation by almost any means. I love the lightning speed strides we’re making in tech, and none of it scares me. Not the AI, not the gene editing, not the “metaverse” and alternate digital realities, not even things like Elon Musks NeuraLink or the concept of being able to one day upload your consciousness. It all excites me and makes me extremely optimistic for the future.
There’s a reason it’s all happening so fast. Because it HAS TO. Same reason a deer is born almost able to stand from the get go. IT HAS TO. For survival reasons. But it also has to happen correctly. That’s what I have been working on my whole life but now no one listens….
this is absolutely mind boggling. it feels like we’re living in the future. next thing we know, cancer will be cured. what a time to be alive
Keep dreaming. The fastest vaccine/cure ever developed was for mumps in 1963.It took 4 years. Yet they “developed” this CONvid bs vaccine in 8 months? At least these days they only go for things that will make them the most profits. If anything especially in the last 2 years has told us is that THEY COULD CARE LESS ABOUT ANY OF US!!
It's all about 💰, I've been following crisper, talk to doctor's to get there opinions they scared to lose there income, no were in the news surprise Surprise
Cancer was cured decades ago
Jeebus these responses are sad.
We are always living in the future.
I actually saw one of the Nobel scientists for this technology, Dr Emmanuelle Charpenier, in lecture at the Freie University in Berlin! This was before she even won. She's an amazing speaker. The dean said that she'll be one of the youngest who could win the Nobel when he introduced her. And she did. So happy for ALL OF THIS ❤️
Holly molly
@@venky3867 Holy Moly*
Don’t get your hopes up just yet. Big Pharma will charge an exorbitant amount for this, as they always do.
99.99% of us wouldn’t be able to afford it. Let’s be honest here.
@@kovy689 Pharma's probably already have the tech, most likely already have the cure for cancer & other diseases but a cure doesn't make money. Patching people up temporary is a good income stream, if they actually cured people they would be out of business ( FACT )
@@DespaceMan Not probably, they already DO have the solution for most diseases know to man. They just safeguard it to maximize profits.
And if that wasn’t enough, a bonus would be the the dozens “charities” acting like a cure doesn’t exist to further siphon cash from generous donors. I laugh every time some rich dude donates to a charity that already has a cure.
As with any Tool it is always how you use it. Dynamite was invented for stone quarry works. It's not a question of the tool itself. It's always the ethical question what you wish reach and how. Not every how is responsibility.
And keeping it out of reach of idiots. The internet is a shining example of how poorly we have managed that. Spreading the stupid and making otherwise harmless idiots potentially dangerous to society (kids needlessly dying from measles springs to mind).
Yeah, every technology can be used for good or bad.. Hopefully people will use them for good thing, like for medical purpose.. (not for weird things.. sometimes people are too creative..)
Some say the end is near.
Some say we'll see Armageddon soon.
Certainly hope we will.
I sure could use a vacation from this bullshit three-ring circus sideshow of freaks.
Here in this hopeless fucking hole we call L.A.
The only way to fix it is to flush it all away.
Any fucking time. Any fucking day.
Learn to swim, see you down in Arizona Bay.
Fret for your figure
And fret for your latte
And fret for your lawsuit
And fret for your hairpiece
And fret for your Prozac
And fret for your pilot
And fret for your contract
And fret for your car.
It's a bullshit three-ring circus sideshow of freaks.
Here in this hopeless fucking hole we call L.A.
The only way to fix it is to flush it all away.
Any fucking time. Any fucking day.
Learn to swim, see you down in Arizona Bay.
Some say a comet will fall from the sky.
Followed by meteor showers and tidal waves.
Followed by fault lines that cannot sit still.
Followed by millions of dumbfounded dip shits.
And some say the end is near.
Some say we'll see Armageddon soon.
Certainly hope we will
I sure could use a vacation from this stupid shit, silly shit, stupid shit.
One great big festering neon distraction,
I've a suggestion to keep you all occupied.
Learn to swim.
Learn to swim.
Learn to swim.
'Cause mom's gonna fix it all soon.
Mom's comin' 'round to put it back the way it ought to be.
Learn to swim. [repeat]
Fuck L Ron Hubbard
And fuck all his clones.
Fuck all these gun-toting
Hip gangster wannabes.
Learn to swim. [repeat]
Fuck retro anything.
Fuck your tattoos.
Fuck all you junkies
And fuck your short memory.
Learn to swim. [repeat]
Fuck smiley glad-hands
With hidden agendas.
Fuck these dysfunctional
Insecure actresses.
Learn to swim. [repeat]
'Cause I'm praying for rain
I'm praying for tidal waves
I wanna see the ground give way.
I wanna watch it all go down.
Mom, please flush it all away.
I wanna see it go right in and down.
I wanna watch it go right in.
Watch you flush it all away.
Time to bring it down again.
Don't just call me pessimist.
Try and read between the lines.
And I can't imagine why you wouldn't welcome any change, my friend.
I wanna see it come down.
Bring it down
Suck it down.
Flush it down.
-Tool
Oh my god when that amazing man with cerebral palsy said he tried not to let it affect his work ethic… just want him to be happy. Touched my heart.
Amazing! About 2 years ago, I did a presentation during my undergrad about LCA2 and its potential for treatment via gene therapy. At the time, it was the only LCA type to deliver ANY promising treatment results through gene therapy. Hearing about this development makes me so happy to see the progress being made in this field especially as an aspiring ophthalmologist!!
This man never misses !!
This is incredible! Ive been legally blind my entire life with a visual acuity of 6/96 (or 20/315 in feet). With that said there are still many who have it far worse and I still consider myself lucky to have the vision that I still have.
But the limitations are massive. I'm unable to drive, I am very limited with my career choices ect.
This could be absolutely massive in the coming years for millions of people around the world as this technology progresses. Not to mention the hundreds of millions of people affected within other medical fields.
Fingers crossed 🤞
How can you be illegally blind?
look at me being an asshole to a blind person I must be going to heaven
@@thesupreme1503 It is just classification of the level of blindness. There is not such thing as " illegally blind".
@@DarkGT hey man I feel u bro my visual acuity in feet is also 20/275 so I know what ur going thru
@@thesupreme1503 it is extremely rare for people to be completely blind to the point of no light perception. The USA classifies vision that is uncorrectable by conventional glasses worse than 20/200 as legally blind, or your field of view being less than 20°. But visual impairment is classified as starting 20/70.
@@frostman9661 ah nice thanks for the information
There are always ways technology can be used for harm. That shouldn’t deter us from using it for good. This has the potential to do miraculous things.
Thanks for another great video!
Simply Amazing!Simply Amazing!Simply Amazing! Entire World and nations should support this Amazing research and way forward!
The production quality on this channel is AMAZING. Glad UA-cam recommended it. Also, I appreciate your transparency by presenting advantages as well as disadvantages.
One of my biggest fears on this planet. Kudos and looking forward to the day when everyone can see without any problems.
I’m blind and really looking forward to the day where blindness would be a thing of history
Wait fully blind?
@@marsillinkow how is he going to read this?
@@marsillinkow Hes not gonna see your comment
@@itsaaronlolz 😂😂
@@itsaaronlolz lmao
I've been wanting this to hurry up with crispr studies since it was discovered. There's too much fear mongering around it. I'm convinced it's the future.
I'm am severely visually impaired myself after a generic disease caused my vision to plummet off a cliff a few years ago, just as I finished university. This really gives me hope, if I can get back even a small percentage of what I lost, I'll take it.
Thank you for everyone who is work in this field
As a person who has aspirations to develop technologies of this sort in the future, this really makes me happy. One day we won’t treat symptoms but the very roots of the problems.
This is absolutely amazing! I know how hard it can be when your eyes don't work properly as my eyes haven't been working together properly for many years. I've recently been having eye therapy and and the result has been absolutely amazing, especially with my studies at the moment. While I'm not blind I completely understand the difficulties and impact that eyesight has on peoples lives.
@ghost mall Not trying to be snotty? So you're a natural.
Now hoping to see a solution for tinnitus and hearing loss emerging
@@nuggetonastick1804 i think you're thinking of tetanus, tinnitus is not a virus or something.
@@owndampu1731 lol.
Hell yeah that would be great.
@@nuggetonastick1804 tinnitus is the constant ringing in your ear that some people have. i personally got it from listening to too much loud music. since it cannot be transmitted, there is no vaccine.
Hearing loss is due to physical damage at a scale far bigger than individual genes.
This is very emotional for me because this isn’t just an advancement for blindness, but all genetically related diseases as well. God bless all of you, we’re lucky to have hope for the future.
These videos showcasing scientific breakthroughs are the reason I'm subscribed to your channel.
This is fantastic. Dagogo can you start adding chapters so we can start where we left when we come back?
It's 14 minutes long, just put it in 2× speed
@@julianbello8376 just get a plugin that does that
Imagine shortening the curve towards progress by introducing AI to the Trials & Errors phase to identify potential caveats, and eliminate them before executing a CRISPR Procedure? My wife suffers with RP, so I will be on the lookout for progress there, and feel more hopeful that it will occur in a period where she can reap the benefits!
Ive been watching you everyday for the past 2 weeks, ive been waiting for a new one!
As an Eye Doctor this is incredibly exciting!
I have a friend suffering from a similar condition, he started losing sights as a teenager, especially in low light conditions, and after that his field of vision reducing further and further, i really hope this treatment gets developped and accessible to more people in the next years/decade, i was really excited when i heard the news.
I'm really stoked on genetic edition, probably more than the people working in the fields, yes, fix up our quirks, make us better, no need to suffer the effect of defects that managed to make it through the filter of natural selection.
My wife was the second person to get this. Only two of the 4 so far have had improvements My wife may have the most improvement. She has gone through hell with all of the tests they put her though weeks of 8 hour days of testing and probing. Only one eye so far she had to have her cataract removed first now she has to get the second eye done.
Excellent introduction to CRISPR - I appreciate your well thought out presentation of the incredibly aspirational and controversial topic. Thank you for adding to the public discourse as you have.
I’m sure it depends on how old the patients are as well. The treatment will likely work better on a child than a senior citizen.
I think there are so so many possibilities in science. People are afraid of change. Absolutely love this progress.
Mr Bing,
You wouldn't love the progress if you were the one been targeted to lose the right to live.
I actually know a young woman who is a part of this amazing study….and we’re all so hopeful it will be successful and made available to all who need it. Amazing stuff!
I researched CRISPR technology for my English research project and I’m so glad I did. This is pretty fascinating and I’m curious as to what improvements and advances (and, of course, downfalls) this technology will bring in the future.
Starting with the good, could help cure cancer. The bad, abusive parents who might know about this might try to wield another level of control on their children by threatening to mess up their genes or forcing them to undergo things that the child does not want.
@@rnbsteenstar Spot on.
Your videos are so unbelievably well made. From the first time I saw your videos I was in awe of your soothing voice and great information that is easy to digest. You are helping make the world a better place, I truly believe that. Keep up the great work!
This is very powerful tech. Has the ability to do a lot of good or some insanely dark applications as well. Needs to continue to be strictly regulated.
I’m a bio-technician, disabled from visual impairment from damage to my optic nerve. I will need to regrow my nerves. I’m hopeful 🥰👍
Remember hearing about crispr 4 years ago. So happy it's moving forward.
The explanation of CRISPR at the start is really great and succinct, wonderfully edited, thanks.
Edit: Great caution advisory, I like it. 👍🏻
@@Kelly-vs8cm in English, this translates as, “After all, carrots are the best!” You into carrots?
CRISP-R is *the future!* Someone should notify Roanoke Gaming about this!
Haha that channel (or references to it) seem to be everywhere i go on UA-cam
@@jjcoola998 bots
can they reverse my failures with crispr
Mood 2021
9mm bullet can
@@vaidasspu that boy ain't right
@@-TK- that boy needs therapy
what we take for granted , it made me cry could barely type , thanks mate for restoring my fate in science a bit
FINALLY a video about cutting edge medical technology
For one with Stargardt's decease I am really exited for this technology, my condition isn't that bad yet, as I obviously can read and write still, but it is gonna get worse over time until I get legally blind, so this exites me greatly
Also have stargardts. Would love to Share experiences. Couldnt find a way to message privately
@@skred3fr what would you like to ask about? I'm up for sharing
Each technology is a tool. And it's up to us to decide how this tool is going to be used. Powerful tools such as CRISPR come with huge responsibility. We need to ensure that it's used with care
I see it as a major breakthrough, Genetic engineering has always fascinated me . Although it may have it's downsides
I love the progress in gene editing. Where ever did the breakthrough it is step forward in fixing other gene syndroms like my little girl have.
The sunset and sunrise can be seen for those who never seen before... we appreciate the continuously work of researchers around the globe.
It’s a great time to be alive.
Yeah!
Said a little girl in Afghanistan 😥
I'm positively thrilled about this!
However, as a cancer patient I might be a bit biased. ;)
Understandable. I don't have anything like cancer or blindness but I am very excited to see this in action.
I love how science is trying to do such incredible things!
I only add this because the Narrator overstated the outcome of this LCA treatment. Dr. Eric Pierce, MD, Phd. at Mass Eye and Ear was correctly quoted and did not make the statements that the Narrator did. Dr. Pierce is highly recognized and gifted in the field of Inherited Retinal Diseases/Dystrophie, and I might add highly respected.
"Leber 's Congenital Amaurosis Type 2.
(There are about 19 phenotypes (outward symptoms) of LCA and 25+ genotypes (the DNA coding that causes disease)
To receive that treatment you have to have genetic testing to prove you have a defect in the gene that makes the protein, RPE65 (produced in the Retinal Pigmented Epithelial cell which are in intimate contact with the light sensing Retinal Photoreceptors).
LCA2 makes up a very small segment of the Retinitis Pigmentosa/Inherited Retinal Diseases Community. It happens to about 1 in 80,000 people. Where RP (IRD's) happens to 1 in 4,000 people.
The sad thing is this is mainly a Blinding Retinal Disease that begins in babies. By the time they are 4 yrs old, the amount of Rod Photoreceptors in the Retina that have been destroyed are numerous. By the time they are around 20 yrs, most are legally blind.
That is why it has been approved for use in very young children, to prevent photoreceptor destruction caused by the DNA carrying the wrong recipe for the visual protein RPE65. Before too many Photoreceptors die off. Once they die that are not replaced, and treatment at an older age will not restore the destroyed photoreceptors. The treatment may rescue some damaged cells and restore them to health, before they completely die, but does nothing for the dead photoreceptors. So the Narrator suggesting it restores vision is false hope.
The corrected gene segment is placed inside of a small virus that does not cause diseases in humans. The corrected gene segment is taken up by the Adeno-Associated Virus and mixes in with the Virus's own genome (single stranded DNA), this virus is then reproduced over and over again in the Lab.
Then, they inject this corrected DNA Segment of RPE65 carrying virus under the Retina during a surgical process.
It is hoped that this modified Virus will then infect the Retinal Cells and the corrected gene segment will be added into the patient's DNA in their Retinas, allowing the patient's cells to make correct copies of RPE65 and hopefully stop further destruction of the photoreceptors (Rods and Cones).
If the photoreceptor has already died or so far along in destruction, the medicine will not work. Because once a photoreceptor is dead, it is GONE! The body does not replace its Photoreceptors like it does, for example a skin cell.
That is why this "luxturna(TM)" must be injected early in the course of the disease to make a real difference.
The treatment is VERY expensive. With surg., anes, hospital cost, Surgeon's Bill, and the high cost of the medicine itself... it can be close to $1 Millions Dollars. There are a few Insurance Companies that will carried the cost of this procedure and I understand that the NHS will also cover it, if approved. But, otherwise the patient has to pay out of pocket for this therapy.
Wow - amazing - hope this will be used greatly and safely to help many people.
Dagogo: "Cheers guys"
Me: (Is he gonna say it? IS HE GONNA SAY IT?!?)
Dagogo: "Have a good one"
Me: Ofcours he is! :)
omfg, that is huge
Absolutely, papa flammy
I agree papa flammy
I was waiting for your another episode
And the waiting ends here..
I burst into tears when reaching 08:46 how i’ve taken the eyesight for granted, how we cannot know how something f e e l s until we actually feel it
Learning about CRISPR has been one of the most uplifting things ever. I used to have a lot of dark, depressing thoughts about dysgenic pressure, and how maybe the Nazis were right in that we needed some heavy hand to replace evolution now that we no longer had natural selection to clean up our gene pool, how religion was standing in the way of preventing our de-evolution as a species, how there might be some great war over designer babies and genetic engineering, etc. But seeing this technology in action gives me hope for the future.
CRISPR is an amazing tool, but there will need to be proactive, lengthy, thorough conversations and some oversight about the ethics and use for the tool. Where there is interest in something so profoundly powerful as CRISPR, it is bound to attract those with less idealistic questionable motivations; especially when "genetic mass driving" is a very real action now.
The one percent of bad cases will stop so many from getting the help they want 😞
Plus the inevitable moral panic when religious boomers find out about it
@@jjcoola998 Why would religious boomers object to medical treatments that would help them? There's nothing in any "holy" text that prohibits gene editing. And if someone doesn't want their genes edited, then I'm fine with them not being treated with it.
@Shimmy Shai Sorry, but you sound sort of paranoid. Also, what on Earth would it mean to make babies "whiter"? What do you mean by that?
have you heard of optogenetics and or Prime Editor? The latter is like Cripr but newer? Maybe worth looking into
Wow I’ve never heard of this!
I did! I even did a scoping review paper on this topic which was praised by my supervisor
To the *incredible person* that's seeing this, I wish you all the best in life❤ don't over blame yourself, accept things and go forward. Don't let others define what “success” is for you. Get up, learn the skills needed and get after it, all the keys to a happy life is in your hands. Keep pushing.
Positive use of science for a better life; just love it.
As someone who has vision problems for many years, this is so cool.. but I do agree we must approach w cautious but it also give me hope for the future when it comes to my vision.
We're slowing becoming close to the Kryptonians
What's next - a Johnny Depp look-alike talking from a computer, healing other people and creating a hive mind?
Like all new technology, it is scary to hypothesize possible futures that it will be abused (similar to internet when it was first coming around), but overall it's a fantastic development for humanity.
As long as it is as accessible as the Internet, I have faith that it'll be more good than bad
It will be abused, that is the issue with any progress we make. However the good things that come out outweigh this. This is why we progress.
As a visually impaired, this is such wonderful news that it might one day reach all of the countries and have the opportunity for us to see again
CRISPR is incredible and has virtually limitless applications. Ultimately it doesn't matter if some people are up in arms about it's ethical implications, nothing can stop the research now, it has too much promise to be stopped.
"When science is on the march, nothing can stand in its way!" - Paul Bartel
Frikkin amazing. They're hot on the trail of reversing aging aswell. Imagine never growing old and only dying through disease or an accident.
Oink oink
I would love to see a way for people to “sandbox” these tests and studies to mitigate risk. In the chance that something great is discovered, but later effects create a much worse situation. I don’t know if this is feasible, but it would create a safer environment. Thoughts?
Definitely agree! Creating something like a "safe tests environment" would be a priority to ensure safe advancements.(QA Engineer here)
That would of be a great idea for the covid injections too !
You do realise your basically demanding people to exit themselves from the reproductive pool then, ala anyone getting crispr treatment to not have children
@@brenelec There may be many people who would trade that to cure a debilitating genetic disease. After all why would one want to have a kid and risk passing on the bad gene to their poor kid ? You'd rather adopt and save a life instead.
Malicious intent is an even bigger worry. Global thermonuclear war would seem like a picnic in a worst case scenario
I hope they make it affordable. Eyesight is a human right.
This is like going to the library and learn the basics on a subject , but even better. Nice content
Very inspiring, well done doctors & scientists who developed CRISPR & CAS9 active gene editing techniques! Nobel Prize in the making! Revolutionary & Emergent Innovation in biotech & life-science #42
One doesn’t experience self-transcendence, the illusion of self only dissipates:🎈
Hope the credit goes to scientist for this innovative idea and not some billionaire.
I understand what you’re saying but I doubt people with sight problems will care
@@aiistyt
They should care because unregulated capitalism is creating oligarchy in usa, destroying our safety nets and the environment of our planet. Elon is considered a super genius even tho never invented anything, was born into better financial safety nets and now majority of Americans think he's self made and they can become like him.
@@Pyasa.shaitan But capitalism isn’t unregulated. As a diabetic i really wouldn’t care who solved it. As for Musk, you’re correct he wasn’t born poor but he is responsible for disrupting both the car & space industries.
@@aiistyt i mean with the way megacorps jacked up insulin prices to such an extreme degree, you should be concerned that corporate oligarchy is fucking everyone over! seriously man insulin was meant to be cheap and widely available
@@aiistyt
Okay but what's the objective of all that disruption when majority of humanity can't afford them ? Climate change will affect poor countries the most, majority of them don't have access to tesla. If by disruption you mean taking advantage of your employees labor and marketing yourself as a super genius then no that's fraud.
This is awesome and scary AF!
"Sarif was right about one thing. It's in our nature to want to rise above our limits. Think about it. We were cold, so we harnessed fire. We were weak, so we invented tools. Every time we met an obstacle, we used creativity and ingenuity to overcome it." -Deus Ex: Human Revolution
I am thrilled for the people being helped
Finally all those girls will finally notice me!
As incredibly important as this technology is, it has the potential to make global thermonuclear war seem like a picnic by comparison
What?
@@christopherrapczynski204 if turned into a bio weapon through means of a man-made virus, the damage could be astronomical. It could be as simple as designing the cas-9 protein in a way that it replaces a commonly found and critical gene in all humans with gibberish.
I've been waiting for this forever, since I really want my blind brethren to see again, and if I ever were to lose my eyesight, I want to know that it could be fixed. Also could this make a person taller?
Yes😂😂
making an adult taller would be astronomically difficult but if embryos or babies were edited I think it would be possilbe
Awesome video man, this made me cry 😭 I’m so happy for the benefit that it will do for those people that need help.
I have a theory (and hear me out) that mushrooms may be a major key to improving vision. Early studies have showed some promise and I have personally observed Paul Stamets’ mushroom stack to have noticeably improved my vision above 20/20 and had friends who wear contacts say they almost didn’t need them while on this special stack, among the other noticeable benefits. Color appears more vivid, everything become sharper, peripheral vision seems improved. I’ve done tests where I go to my favorite restaurant and can read the employee monitors from over 20 feet away, also notice extremely small bugs on the ground that I don’t think I would’ve before. I really hope more this and the numerous other benefits are more widely studied in the future. My city decriminalized all mushrooms at the start of the year and I have since began studying mycology, the benefits, and growing for personal use. It costs $50 and some good soil to have an unlimited supply of such a relatively easy to grow substance that has profound impacts on life. I’d really like to hear other’s who have tried the Stamets Stack thoughts on this!
Very good video, excited to see where the future of gene editing takes us.
This is fantastic. Meanwhile technology should always be there to give people options, not to enforce an ableist standard.
Repairing a gene in a species is one thing. When we start splicing genes from other species that's where it becomes radically dangerous. There is literally no possibility of predicting the cumulative knockoff effects the more we do that. Covid-19 is a good example. I think we should have strong ethical guidelines that limit it to repairing broken genes not adding new genes.
I wonder if the military has not yet tried this yet, e.g. introducing cat eye gene to improve night vision of soldiers.
I was outraged when the Chinese scientist was reined in and imprisoned for gene editing. It goes to show how incredibly asinine the average person is in understanding biology if making babies more resistant to HIV, something already present in 10-20% of people if European ancestry is seen as wrong.
If Europeansancestry is seen as wrong? What do you mean by that ？
@@18890426 *Of European ancestry. The gene that He Jiankui inserted into those girls is already known to be present in Europeans, though I didn't think that the prevalence was 10% to 20%.
Currently, I am visually impaired on my right eye, and legally blind on my left eye.
I was always visually impaired, but was able to see, to the point I got my driving license for motorcycles at 16.
Unfortunately, when I was 19, a new disease appeared: Coats disease.
This disease made me lose my left eye vision, and almost all vision on my right eye.
My right eye, with glasses, is currently at 10% - but fortunately a good 10%, meaning, my vision is clear, average peripheral vision, but with some ghosting and with the help of magnifying glass, either physical or virtual.
Seeing this innovations gives me two big hopes:
1) I might be able to see clearer, better, and maybe - just maybe - I can drive again, one of my biggest dreams!
2) My future children, if by chance get some visual disease from my genes, can be improved through this new techniques / technologies.
This, along with the COVID-19 vaccines, prove that science is crucial for our quality of life!
I think personally that within the decade we will see a change or series of changes just as revolutionary as software was for computing like with the invention of Microsoft Windows OS. Crispr could enable a suite of industries namely agriculture. It’s immediate use will be with cases of great urgency like trying to mitigate the negative socio-economic impact of climate change on crops that aren’t resistant to rising temperatures and increasingly turbulent climates. As well as preventing forest biomes from further deprecation due to human intervention like unwanted indirect deforestation, and nurturing species of trees on verge of becoming endangered where their presence in the environment is needed so that a healthy ecosystem is maintained. Another industry of immense commercial interest will perhaps be DNA computing when storing data on new forms of drives.