As a freshman I got hopeless when I first encountered cell biology, cell signaling cascade etc. I am trying to pick things up and REALLY THANKS for making them easier to understand! :)
excellent-i am a high school physics teacher and biology, especially genetics amazes me- very clear- reminds me of photosynthesis a bit- i see themes and variations with the building blocks
You are brilliant! Please keep making videos, they are so helpful! I am in an 8 week Bio course and it is moving way too fast! 4 Chapters covered in 2 classes and then we get an exam. Its killer... Your videos are really helpful for those of us who are having to teach ourselves. Thank you!
#Signal #transduction is the process by which an extracellular signaling molecule activates a membrane receptor that in turn alters intracellular molecules creating a response. Transmembrane receptors span the cell membrane, with part of the receptor outside and part inside the cell. The chemical signal binds to the outer portion of the receptor, changing its shape and conveying another signal inside the cell. Some chemical messengers, such as testosterone, can pass through the cell membrane, and bind directly to receptors in the cytoplasm or nucleus. Sometimes there is a cascade of signals within the cell. With each step of the cascade, the signal can be amplified, so a small signal can result in a large response.Eventually, the signal creates a change in the cell, either in the expression of the DNA in the nucleus or in the activity of enzymes in the cytoplasm. -Creative BioMart
Phosphorylation is not synonymous with increased activity. In fact there are enzymes that are activated by dephosphorylation and inactivated by phosphorylation. Insulin in general dephosphorylates the enzymes it acts upon (despite initial tyrosine phosphorylation activity, it ultimately dephosphorylates and inactivates the target enzyme). For example, insulin stimulates glycogen synthase activity by dephosphorylating it. Check it out on wikipedia Keep it up !!!
Thank you so much! I finally understood signal transduction and 2nd messenger activation for AA based hormones. You made it make sense! Again thank you :-)
Sugarplum, you are amazing.....! thanks...have an exam later on tonight...So is it safe to say, In theory and very simplified, a simple bone fracture will trigger neurons to release hormones into the blood stream to reach the fracture site and bind to healthy osteoblasts and trigger transduction leading to bone cell division:}...? sorry for my lack of jargon, first year here....lol
when the protein is phosphorylated by the TK, does the energy that was stored in the bond of the P in ATP go into the bond between the Protein and P? Is this why it's exciting, because potential energy is being passed from the ATP to the Protein-P, leaving the lesser potential energy ADP? Now the protein is energized, it can do more than just change shape and facilitate, it can do that and do work?
@ThePenguinProf Love, love your videos! What book would you recommend for someone that needs to get more in depth about Signal Transduction? I have an exam coming up. Thank you so much! :)
very good movie i like it very much... but i must add that you kind forgot to mention that phosphorylation also inhibits protein function cfr. glycogen synthase!!! (as every rule has its exceptions :p)
I have work in my spanish encampierio, be grateful for me watching , I only learn englishio. Today much thanks very Much , think I will pass my amplieflier puke.
Good, thanks, Just cut the other talks, usually students are watching this on an exam night and are not really interested in other talks than the subject.
Taking an exam on this tomorrow as well. Yours is the ONLY good video I can find on youtube describing transduction. In your face Sal Khan!!! Thanks.
Studying for my exam (just 5 days left)! Thanks for making this video; very clear and you have a very pleasant voice to listen to!
you make everything look so easy!! besides i love the tone of your voice!! i can listen to you a million times!! thank you!!
As a freshman I got hopeless when I first encountered cell biology, cell signaling cascade etc. I am trying to pick things up and REALLY THANKS for making them easier to understand! :)
The most interesting explanation of the VERY dreary second messengers I've seen. Thanks!! Glad to have found your channel.
i have to give a seminar on this topic in an hour and this really helped, thank you.
this is the first time im actually happy to hear the word "phosphorylation" :)))) ^^ thx so much :) keep up the good work prof :)
Thank you very much! My lecturer made this seem far more complicated than necessary. This video was very helpful. Keep up the good work!
excellent-i am a high school physics teacher and biology, especially genetics amazes me- very clear- reminds me of photosynthesis a bit- i see themes and variations with the building blocks
You are amazing speaker, I absolutely loved your presentation, especially the vibrant commentary to go with it. I wish you were my lecturer!
Thank you for making this video. I have an exam tomorrow and it was extremely helpful. Thank you!!
Thank you so much! You have no idea how helpful this lesson was!
Very helpful.. You makes complicated things so easy.. Really appreciating your efforts..
+Dr Anamika Gupta Thank you so much!!!
You are brilliant! Please keep making videos, they are so helpful! I am in an 8 week Bio course and it is moving way too fast! 4 Chapters covered in 2 classes and then we get an exam. Its killer... Your videos are really helpful for those of us who are having to teach ourselves. Thank you!
Really helpful, cheers! got an exam on this tomorrow!!
i love this 1, it explain the signal transduction in simpler way
that was so much better than the lecture from my professor
You are so great!! Love the energy and enthusiasm.
#Signal #transduction is the process by which an extracellular signaling molecule activates a membrane receptor that in turn alters intracellular molecules creating a response. Transmembrane receptors span the cell membrane, with part of the receptor outside and part inside the cell. The chemical signal binds to the outer portion of the receptor, changing its shape and conveying another signal inside the cell. Some chemical messengers, such as testosterone, can pass through the cell membrane, and bind directly to receptors in the cytoplasm or nucleus. Sometimes there is a cascade of signals within the cell. With each step of the cascade, the signal can be amplified, so a small signal can result in a large response.Eventually, the signal creates a change in the cell, either in the expression of the DNA in the nucleus or in the activity of enzymes in the cytoplasm.
-Creative BioMart
Wow I love the way you taught .
Thank you! 😃
Phosphorylation is not synonymous with increased activity. In fact there are enzymes that are activated by dephosphorylation and inactivated by phosphorylation. Insulin in general dephosphorylates the enzymes it acts upon (despite initial tyrosine phosphorylation activity, it ultimately dephosphorylates and inactivates the target enzyme).
For example, insulin stimulates glycogen synthase activity by dephosphorylating it. Check it out on wikipedia
Keep it up !!!
I seriously love you!!!!! You're are a fantastic prof!!!! Im jealous of your students!!!!
Awesome. Thanks for the fastastic explainations!
you’re a gem, thank you so much
Thanks so much!
Terrific explanation!! Thank you!
This is perfect, thank you so much! I was looking for something like this forever
love it...really helpfull....you make such a complicated subject become so easy to understand..thank youuuu...:D
Simply explained.... Nice one
Thank you 🙂
Thank you so much! I finally understood signal transduction and 2nd messenger activation for AA based hormones. You made it make sense! Again thank you :-)
I live your videos very much! It's very interesting, telling and helpful.
I LOVE your vids, they are all so thorough and extremely helpful!! THANK YOU
extremely helpful, I am very grateful thankyou!
This was very helpful! Thank you!
Thank you Prof. Was really helpful. Do you have a video on the catalytic receptors for signal transduction?
very good explanation
Thank you !
Thank you so much. Very helpful!
Great video! Very informative! Thank you!
Thank you for the video. Question: in 6:41 a cAMP is illustrated. Is there a 3',5' phosphate binding? It does look like a 4',5' binding.
It's not the best drawing - but yes, it's 3',5'-cyclic adenosine monophosphate
@@Penguinprof Great, this helps. Thank you again.
Wow amazing explanation...: loved it
Glad it was helpful!
This was an amazing video! You explained everything very well! Thank You :)
Outstanding. You are amazing!!!
Sugarplum, you are amazing.....! thanks...have an exam later on tonight...So is it safe to say, In theory and very simplified, a simple bone fracture will trigger neurons to release hormones into the blood stream to reach the fracture site and bind to healthy osteoblasts and trigger transduction leading to bone cell division:}...? sorry for my lack of jargon, first year here....lol
you're saving me right now.
when the protein is phosphorylated by the TK, does the energy that was stored in the bond of the P in ATP go into the bond between the Protein and P? Is this why it's exciting, because potential energy is being passed from the ATP to the
Protein-P, leaving the lesser potential energy ADP? Now the protein is energized, it can do more than just change shape and facilitate, it can do that and do work?
Amazing content! Thank you!
I'm so glad it was helpful!
Love watching your videos 😻😻😻😻😻
@ThePenguinProf Love, love your videos! What book would you recommend for someone that needs to get more in depth about Signal Transduction? I have an exam coming up. Thank you so much! :)
very good movie i like it very much... but i must add that you kind forgot to mention that phosphorylation also inhibits protein function cfr. glycogen synthase!!! (as every rule has its exceptions :p)
I have work in my spanish encampierio, be grateful for me watching , I only learn englishio. Today much thanks very
Much , think I will pass my amplieflier puke.
thank you for making this.
Thanks a lot. But phosphorylation doesn't always cause activation, it could also cause deactivation of a receptor protein.
thank you so much for this video
amazing. thank you looking for more.
Thankkss! Really helpful video :)
Thank you for making this vid.
Thanks !! very relaxing and i understand :D
Enjoyed it!
Amazing video
+erangaj Thanks for watching!!!
soo helpful!! thank you:)
Thank you so much! This helped a lot :)
When you say lipid fevering do you mean hydrophobic or hyrophilic?
Thank you very much!
Thank you for the A-HA! moment :-)
I'm loving it.. keep up the good work. Thanks :-)
Why can't the ligase move across the membrane? Is it due to different polarities or size? :)
thank you for the clarification :)
5:00 though 😂
Ayman Azizuddin LOL ikr? "I know right, the names are so sexy" XD I love it
THANK YOU !!!
thank you
I realy liked the video and ur way of teaching is very nice & "really the words are too sexy"
So glad you found it helpful! Thanks for watching!
thank you soooooooooooooooomuch
ok that was awesome!
Awesome - thank you :-)
well i loved that
you're perfect!
great!!!
thanks so much ....
thanks maaamm
Lovvve you sooo much
pretty sure it is phos4Olation. but i'm no expert, tyvm great video :)
that was cool
+JaysonR0 Thanks!
you're welcome god blesss you
Good, thanks, Just cut the other talks, usually students are watching this on an exam night and are not really interested in other talks than the subject.
EcoGranite yes I have a final in 2 days
awesome! (y)
thats a biiggg needle