Intention-to-treat (ITT) and other forms of data analysis
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- Опубліковано 9 лип 2024
- This video deals with epidemiological study designs called observational studies.It gives an overview of the following types of observational studies: cohort studies, case-control studies, cross-sectional studies, case studies and case series, and ecological studies.
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This was excellent, exactly what I was looking for. Thank you!
your videos are very good and have a wide message thank you
Cochrane is a collaboration of international researchers on a common platform to share opinions, case studies & their research studies for reference.
But what's the difference between per protocol & completers-only analysis? Sounds like same, as in both cases who adhered to initial randomly allocated group & present till end of the study are been considered.!
4:12imputation methods
I am still confused how if we don't know the outcome of the dropped out subjects? For example, 100 subjects in control group vs 100 subjects in experimental group are followed for survival after 5 years. If there are 10 dropped out subjects in experimental group and (for the sake of simplicity) the rest of them is alive, how should we calculate the survival rate of experimental group?
PP analysis: 90/90 = 100%
ITT analysis: 90/100?
And how about if I study their mortality rate?
PP analysis: 0/90 = 0%
ITT analysis: 10/100 = 10% (we count the dropped out subjects as "failure") or 0/100 (because we only include the dropped out as they were randomized, without any outcome)?
Thank you
Excellent explanation
Thanks very much. Bery useful
A very easy to learn way
Thank you so much
“The advantages of randomization…” are presumably for the experimenter who wants to follow his intentions. Unfortunately all kinds of disappointing outcomes have good intentions. But, if the patient died before they took the pill they are not in the experiment. In fact, intention to treat requires that you report that death is an outcome of the trial which may be a test of dental carries prevention. Proponents of using intention to treat will never answer objections like that. They might have to say that that was not the outcome. To determine the outcome, they will examine the teeth of the corpse.
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