What will happen if we use sodium amide in toluene instead of liquid ammonia? Will the reaction change if we have m-nitro bromo benzene as the reactant?
+ons laabidi the 2 carbons that have trible bond musn't have negative charge as these 2 carbons atoms hve 4 bonds and the are similar so the nucleophile with a negative charge can attack any one of them.
No, there is no need of an activating group means EWG here., bases stronger than those that normally are used. And incoming group does not always take the position vacated by leaving group.
Ibrahim Malki, during the formation of the benzyne intermediate, benzene, being a counjugated system, can have any alternating position of the pi bonds. So, 2 benzyne intermediates are possible.
You should have also discussed the selectivity of the products.
Benzyne? More like "Beautiful lectures, and watching them always makes me feel fine!" 👍
What will happen if we use sodium amide in toluene instead of liquid ammonia? Will the reaction change if we have m-nitro bromo benzene as the reactant?
how does a nucleophile attack a tripple bond which is also electron rich?
i didn't understand something how can the nucleophile attack the triple Bond when both have negative charges
+ons laabidi
the 2 carbons that have trible bond musn't have negative charge
as these 2 carbons atoms hve 4 bonds and the are similar
so the nucleophile with a negative charge can attack any one of them.
In the previous video, there were three conditions for the reaction. Do these still apply? Why or why not?
No, there is no need of an activating group means EWG here., bases stronger than those that normally are used. And incoming group does not always take the position vacated by leaving group.
I don't understand the explanation at 8:50-9:17
Ibrahim Malki, during the formation of the benzyne intermediate, benzene, being a counjugated system, can have any alternating position of the pi bonds. So, 2 benzyne intermediates are possible.