You're a very important man for a Med student, from anywhere in the world, with a very unique gift of drawing and conversing. Please take care of yourself :) And just as always, awesome work!
Do anyone still doubt natural herbs? I've seen the great importance of natural herbs and the wonderful work they have done in people's lives. I wonder why people still spend their money on surgery, injections and drugs each time they are sick. Natural herbs can cure all kinds of illness including herpes, diabetics, asthma, Cancer, hepatitis, etc. I've seen it with my own eyes. I was cured of Arthritis and my Sister and her Husband were cured of herpes by dr Osemuahu who uses natural herbs to cure different kind of illness. Even Dr. Osemuahu proved to the whole world that natural herbs can cure all diseases and he cured countless of people using natural herbs. I know is hard to believe but am a living testimony. There is no harm in trying herbs. Contact Dr Osemuahu(whatsap no): +2349053317809 or email: dr.o.osemuahu@gmail.com Come and thank me later ✌️✌️
Brilliant. I have had RA for 24 years and also a medical professional. People with RA know all too well the agony and frustration of living with this multifaceted disease that some may minimize into almost a trivial process. I appreciate your video as it eludes to anything but that. Thank you for your thorough explanation and demonstration.
I've nearly finished the pathology book and read articles but still felt like I hadn't grasped the entire pathophysiology behind some diseases, including RA. Thanks for this Amazing overview
" You explain everything 100 times better than my professors in med school! this video helped me a lot! Thank you!!!! " I couldnt have said it better than below comment...thank you Armando, your the absolute best at making medicine understandable.
u helped me when I took anatomy & again then with physiology & once again, here ur helping me to understand exactly what is happening with my hands/joints as I have recently been diagnosed w/RA. thank you so very much!
Allopathy can’t cure you. And overtime you will be made to depend on immune suppressants, then comes the complications of the medicine, then surgery and you will be ultimately exhausted of hospital visits! Start on traditional or alternative medicine, follow a healthy food and lifestyle. I was earlier diagnosed as having rheumatoid arthritis, SLE. Now, I got my RA test become negative with homoeopathy. Rheumatologist and an Orthopedician were completely surprised as according to allopathy, once RA factor becomes positive, it will remain so forever. I too was surprised and enquired the lab to recheck if there was some mistake, they gave the sample to another lab and I got the same negative result. I have been on homoeopathy for many years. Take care. I’m still on crutches but improving over time. Much better than 5 years back. And that pain which was there every second even at rest has turned out to be almost nil at rest... but still have it while moving and is tolerable. My movements were greatly restricted to the extent that someone should help to even turn around in bed but now I can do it myself and from past 1 month, though a little difficult I am able to get up myself and go to toilet with the crutches. I had severe digestion problems too that I always vomited some of what I ate every time but now... there is almost no vomiting but still have belches. Hoping to return to complete normalcy soon. I am not on any other medication. Wish you get well soon.
-Macrophages start by releasing cytokines, TNF-alpha , IL-1 , IL-6 that lead to inflammation. - cytokines stimulate fibroblasts (synoviocytes) , which results in activation, and proliferation. - Synoviocytes will stimulate RankL expression, which will lead to the stimulation of osteoclasts with the aid of cytokines. Which will lead to bone erosion . - Proliferation of fibroblasts also result in creating proteases, which leads to cartilage breakdown (degradation), cartliges also secrete proteases. - When the fibroblasta are activated, they can travel from joint to joint, and this is how you get symmetrical arthritis. (Like in right and left hands). - T-cells, (immunity cells) which are thoroughly present in the synovium are resposible for promoting inflammation by secreting IL-17 (cytokine) which promotes macrophage activity so it....etc. - They also help in expression of RankL that .....etc. - Plasma cells are responsible for inflammation too. Through cytokines and antibodies. - Neutrophils in the synovial fluid also contribute to inflammation because they release proteases and active oxygen species which will affect in bone and cartilage erosion. - Immune complexes (antibodies) which are a feature of rheumatoid arthritis , they bind to one another and promote inflammation - Angiogenesis is affected by increasing the vascular pemeability by cytokines which will result in migration of all these cells into the joint. - Rheumatoid arthritis also affects other organs due to increased inflammatory cytokines , skin: nodule formation, liver: anemia, cardiovascular diseases: stroke, myocardial infarction. - Rheumatoid arthritis occurrence has unknown reasons but there are theories that suggest that genetics, smoking, and specific bacteria ( porphyromonas gingivalis) that are present pre RA are responsible for the appearance of the disease, these can lead to modifications in body’s antigens, which will make them seem foreign to the immune cells leading to an immune response, or by injury that leads to inflammation, and then lead to antigen modification. this is the first step of the pathogenesis of Rheumatoid arthritis..
You are an Awesome teacher, never understood my doctor, but I learned a lot listening. I have the swan neck. My doc told me I had a permanent hitch hiker thumb. I understood now what she was talking about. Thank up for helping me understand this disease. May God bless you always
thank you for this video, i just spent 5 hours reading review papers and text books trying to understand it and you did it so beautifully in 15 minutes. Thank you - you are amazing.
Same here l was searching about the pathogenesis in different books and in internet but yes i finally understand it after watching this video. Sry for my bad english
I only have some basic nursing knowledge and this is so easy for me to understand - you're an excellent teacher. I have this disease myself. Thanks for this video!
You are so valuable man bro I m watching this video in Turkey and normally my English is not so good you speak fast but I can understand nearly everythink actually you explain perfect please dont stop that send video
Bravo!! Coming from a non medical student! Idk what T alphas, etc are but I'll rewatch this video until I've looked up all the terminology. I enjoyed your video although ofc I didn't understand everything, I could tell it was excellent explanation at least and got the gist (did have to look up a few definitions ofc).
dude. weldone.you are realy realy amazing in presentation.despite the simplified coherent,conclusive information,your voice tones is too natural and not push on yourself thus makes listener relax and enjoy. thank you very much.
Thanks for great video! , I hope you will prepare same video on Seronegative rheumatoid arthritis, and difference between seronegative and seropositive RA in immunological response .
Very nice lecture on the path physiology of R A. Very easy to understand. Thanks.I have R A for 20 years. Your lecture explains lot of my questions .Thanks.
i don`t have any word to say about your way of delivery, content ,,,,,, but i would like to say awesome.... thanks a lot........ plz update more videos for helping us
Thanks for making use of all of these great abilities in order to help people I think about the great efforts make to accomplish this organized smart work Please continue this great work
Excellent video! I have RA and am also coincidentally taking pathophysiology next semester. What a great opportunity to learn about my disorder while also preparing for the depth of pathophys May I ask what textbook you’re using for this information?
You explain everything 100 times better than my professors in med school! this video helped me a lot! Thank you!!!!
AHAHAHAH Pethana!!
***** με ποιο πραγμα ακριβως?
***** ποια συνωνυμια? :P
Εχω μια συμφοιτητρια Elena KK κι ημουν σιγουρος οτι ηταν αυτη.
***** ααα οκ
You're a very important man for a Med student, from anywhere in the world, with a very unique gift of drawing and conversing. Please take care of yourself :)
And just as always, awesome work!
😂😂😂😂😂” please take care of yourself “
Do anyone still doubt natural herbs? I've seen the great importance of natural herbs and the wonderful work they have done in people's lives. I wonder why people still spend their money on surgery, injections and drugs each time they are sick. Natural herbs can cure all kinds of illness including herpes, diabetics, asthma, Cancer, hepatitis, etc. I've seen it with my own eyes. I was cured of Arthritis and my Sister and her Husband were cured of herpes by dr Osemuahu who uses natural herbs to cure different kind of illness. Even Dr. Osemuahu proved to the whole world that natural herbs can cure all diseases and he cured countless of people using natural herbs. I know is hard to believe but am a living testimony. There is no harm in trying herbs. Contact Dr Osemuahu(whatsap no): +2349053317809 or email: dr.o.osemuahu@gmail.com
Come and thank me later ✌️✌️
All Thanks 🙏🏿 To #drode on UA-cam were I was able to Cure my Rheumatoid arthritis problem completely with Herbal medicine
how u doing now mate
Brilliant. I have had RA for 24 years and also a medical professional. People with RA know all too well the agony and frustration of living with this multifaceted disease that some may minimize into almost a trivial process. I appreciate your video as it eludes to anything but that. Thank you for your thorough explanation and demonstration.
Very nice video but what is the treatment of this Arthritus
People can see how it moves the bones, criples amd deteriorates them. How could they not think its anything but extremely painful?
Thank you 👍
How are you at present? How you managed your RA? What kind of treatment you went through? Can you plz lemme know I would be grateful for that .
Cupping therapy in your hand can help
I've nearly finished the pathology book and read articles but still felt like I hadn't grasped the entire pathophysiology behind some diseases, including RA. Thanks for this Amazing overview
"
You explain everything 100 times better than my professors in med school! this video helped me a lot! Thank you!!!! " I couldnt have said it better than below comment...thank you Armando, your the absolute best at making medicine understandable.
This makes a lot of sense... both from testing and symptoms to reasons for swelling. Much appreciated!
Awesome video which I will have to re watch numerous times.
I have never come across a better teacher all my life
First year medical school here ; You just saved my life. A M A Z I N G video and thank you soooo much :)
OMG 😮
I have an exam about RA tomorrow and your explanation helps me alot
thank very much sir!
Exceptional clarity. Images and words provide a clarity not possible with other pedagogies.
u helped me when I took anatomy & again then with physiology & once again, here ur helping me to understand exactly what is happening with my hands/joints as I have recently been diagnosed w/RA. thank you so very much!
Allopathy can’t cure you. And overtime you will be made to depend on immune suppressants, then comes the complications of the medicine, then surgery and you will be ultimately exhausted of hospital visits! Start on traditional or alternative medicine, follow a healthy food and lifestyle. I was earlier diagnosed as having rheumatoid arthritis, SLE. Now, I got my RA test become negative with homoeopathy. Rheumatologist and an Orthopedician were completely surprised as according to allopathy, once RA factor becomes positive, it will remain so forever. I too was surprised and enquired the lab to recheck if there was some mistake, they gave the sample to another lab and I got the same negative result. I have been on homoeopathy for many years. Take care. I’m still on crutches but improving over time. Much better than 5 years back. And that pain which was there every second even at rest has turned out to be almost nil at rest... but still have it while moving and is tolerable. My movements were greatly restricted to the extent that someone should help to even turn around in bed but now I can do it myself and from past 1 month, though a little difficult I am able to get up myself and go to toilet with the crutches. I had severe digestion problems too that I always vomited some of what I ate every time but now... there is almost no vomiting but still have belches. Hoping to return to complete normalcy soon. I am not on any other medication. Wish you get well soon.
Well-explained with beautiful, easy-to-understand illustrations. Thank you!
Be blessed sir!! We medicos owe you for providing such beautiful explanation n pics to memorize!! 😇
You have no idea how much this just helped me!! Thank you for this absolutely beautiful presentation.
I think this might be my favourite video on UA-cam, wow. Thanks.
This made so much more sense to me in the context of bringing together immune and inflammatory responses. Thank you!!
Clear and simple explanation of a complex disease. Well done!
-Macrophages start by releasing cytokines, TNF-alpha , IL-1 , IL-6 that lead to inflammation.
- cytokines stimulate fibroblasts (synoviocytes) , which results in activation, and proliferation.
- Synoviocytes will stimulate RankL expression, which will lead to the stimulation of osteoclasts with the aid of cytokines. Which will lead to bone erosion .
- Proliferation of fibroblasts also result in creating proteases, which leads to cartilage breakdown (degradation), cartliges also secrete proteases.
- When the fibroblasta are activated, they can travel from joint to joint, and this is how you get symmetrical arthritis. (Like in right and left hands).
- T-cells, (immunity cells) which are thoroughly present in the synovium are resposible for promoting inflammation by secreting IL-17 (cytokine) which promotes macrophage activity so it....etc.
- They also help in expression of RankL that .....etc.
- Plasma cells are responsible for inflammation too. Through cytokines and antibodies.
- Neutrophils in the synovial fluid also contribute to inflammation because they release proteases and active oxygen species which will affect in bone and cartilage erosion.
- Immune complexes (antibodies) which are a feature of rheumatoid arthritis , they bind to one another and promote inflammation
- Angiogenesis is affected by increasing the vascular pemeability by cytokines which will result in migration of all these cells into the joint.
- Rheumatoid arthritis also affects other organs due to increased inflammatory cytokines , skin: nodule formation, liver: anemia, cardiovascular diseases: stroke, myocardial infarction.
- Rheumatoid arthritis occurrence has unknown reasons but there are theories that suggest that genetics, smoking, and specific bacteria ( porphyromonas gingivalis) that are present pre RA are responsible for the appearance of the disease, these can lead to modifications in body’s antigens, which will make them seem foreign to the immune cells leading to an immune response, or by injury that leads to inflammation, and then lead to antigen modification. this is the first step of the pathogenesis of Rheumatoid arthritis..
I was tasked to discuss the pathophysiology of RA and I couldn't understand a thing. This helped me to thoroughly understand it. Thanks, mate!
This video was seriously the best!! Everything was explained simply!
You are an Awesome teacher, never understood my doctor, but I learned a lot listening. I have the swan neck. My doc told me I had a permanent hitch hiker thumb. I understood now what she was talking about. Thank up for helping me understand this disease. May God bless you always
Wow, just wow, thanks dude, you're awesome, you helped me so much for my med school work, greetings from Mexico
thank you for this video, i just spent 5 hours reading review papers and text books trying to understand it and you did it so beautifully in 15 minutes. Thank you - you are amazing.
Same here l was searching about the pathogenesis in different books and in internet but yes i finally understand it after watching this video. Sry for my bad english
same! I dont have a biology background until undergraduate but this video is soooo well made and easy to understand
All Thanks 🙏🏿 To #drode on UA-cam were I was able to Cure my Rheumatoid arthritis problem completely with Herbal medicine
I only have some basic nursing knowledge and this is so easy for me to understand - you're an excellent teacher. I have this disease myself. Thanks for this video!
This is beautiful! I understand RA so much more better now. Thank you soooooooooo much!
your lectures are life saving. thank you for your time!!
Excellent,simple illustration . Thank you
Very impressive and easy to understand the whole picture of Rheumatoid arthritis. Thanks!
Thanks, the video is awesome (and even clearer than many medical textbooks)!
wow what a superb vid! Easy to understand with great drawings. Much appreciated
So so helpful, thank you for this detailed and visually appealing explanation!
best video!!!!!! concise precise, covering everything except treatment and lab inv... pls make a second video to cover those parts tooo
Excellent!!! It is really a very clear presentation. THANKS VERY MUCH.
Great video Armando!!
I saw this video so many times. No it's much more clear..
Thank you. ❤🎉😊
Fantastic work and easily understood! Thanks a lot.
This disease is so hard to understand and explain. Thank you for the very detailed breakdown!
Amazing video and linking of the markers -> tissue -> symptoms!
Thanks alot for this brilliant and concise presentation , It takes much effort and time .
fabulous explanation
You are so valuable man bro I m watching this video in Turkey and normally my English is not so good you speak fast but I can understand nearly everythink actually you explain perfect please dont stop that send video
Thank you very much ! I'm listening to you from France, I have understood all of the video, it was really clear thanks !
what a wonderful explanation. thanks again from Yemen Aden.
Bravo!! Coming from a non medical student! Idk what T alphas, etc are but I'll rewatch this video until I've looked up all the terminology. I enjoyed your video although ofc I didn't understand everything, I could tell it was excellent explanation at least and got the gist (did have to look up a few definitions ofc).
This was just awesome! Great clip :)
Great video. Really helps me with my studies.
You are just amazing!! Thank you so much for making it so easy!😊
dude. weldone.you are realy realy amazing in presentation.despite the simplified coherent,conclusive information,your voice tones is too natural and not push on yourself thus makes listener relax and enjoy. thank you very much.
Thanks for great video! , I hope you will prepare same video on Seronegative rheumatoid arthritis, and difference between seronegative and seropositive RA in immunological response .
Really great explanation and summary! Thanks :)
What a great informative video, thanks for sharing!
Excellent explanation as always!
Great sir .. I really like your explanation and way of teaching
what a video... awesome sir great explanation..!!!! thank you..!!!!👌👌
Great video, your explanations are pretty nice!
great video, thanks for the help!
Your videos are incredibly useful. Thank you so much :)
thanks for all of the information. love your videos please make more
Very nice lecture on the path physiology of R A. Very easy to understand. Thanks.I have R A for 20 years. Your lecture explains lot of my questions .Thanks.
How is life with RA??
How do you perform ur daily activities??
I have RD and I thank you for a concise video that helped me understand my dis~ease😢
Beautifully explained!!!
Brilliant teacher wish you best of luck sir
Thank you, an awesome explanation with drawings
Thanks for the work put in
excellent, as usual
Zu Nobi
i don`t have any word to say about your way of delivery, content ,,,,,,
but i would like to say awesome....
thanks a lot........ plz update more videos for helping us
This video has helped me a lot. Thanks
very well said sir! thank you for the nutritive information.
wow thanks so much for this brilliant explanation of how RA is triggered and develops.
Exelant explanation very Good information for RA patients
absolutely wonderful as always - nice preparation for my exam this afternoon. Always a joy to watch these videos. So clear and informative.
Ur explaination is best est of all. After a lot of struggle I found it. 😍
you are doing a great job. as usual, Thx a lot
Thank you so much it is really helpful. I got lot of ideas from that video, for my review article.❤️❤️
Awesome! He should put a picture of the final drawing to print :)
Basshar Dabboussi he does for 15 dollars lol check his site
Basshar Dabboussi amazing teaching skills!
All Thanks 🙏🏿 To #drode on UA-cam were I was able to Cure my Rheumatoid arthritis problem completely with Herbal medicine
Very helpful thank you! Do you have a pdf version of your whiteboard drawing?
Thanks a lot this will help me in my upcoming individual presentation
Armando Thank you so much !!
what a champion!!! great video
Thanks for making use of all of these great abilities in order to help people
I think about the great efforts make to accomplish this organized smart work
Please continue this great work
Made*
your drawing skills are so good!
Excellent video! I have RA and am also coincidentally taking pathophysiology next semester. What a great opportunity to learn about my disorder while also preparing for the depth of pathophys
May I ask what textbook you’re using for this information?
This is the best video ever! I love u
Wow. Great video. Thanks a million
Excellent video, thank you so much
Thanks for this video will helping to study . Thankyou so much
Thank you for your amazing videos doctor
Wow im speechless! This is amazing :) it helped so much!
Arafa 07 should be asamed in using people’s pain to extract benefit
Hi Armando, I really enjoy your work. I would like to see your references at the end of the video. Thanks!
Thanks for such an amazing video.. U made my life easy 😍
I can relate everything as I'm experiencing the same thanks fr explaining..
I missed ur lectures in 2006 ..that's when i joined med school..
Love your videos thanks a lot for helping ❤️
Excellent video! Thanks a lot!!!
Great video. Thank you!
u r amazing.. u cleaned all the mess of my mind..thnx a lot.
You're amazing! Thank you :D
you are the best (from Alegria)
Fantastic video - brilliant