Rheumatoid Arthritis Pathophysiology (signs and symptoms)
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- Опубліковано 29 лис 2024
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![Rheumatoid Arthritis [Symptoms, Early Signs, Stages & BEST Treatment]](http://i.ytimg.com/vi/CTtIMGqTwXQ/mqdefault.jpg)
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Brilliant. I have had RA for 24 years and also a medical professional. People with RA know all too well the agony and frustration of living with this multifaceted disease that some may minimize into almost a trivial process. I appreciate your video as it eludes to anything but that. Thank you for your thorough explanation and demonstration.
Very nice video but what is the treatment of this Arthritus
People can see how it moves the bones, criples amd deteriorates them. How could they not think its anything but extremely painful?
Thank you 👍
How are you at present? How you managed your RA? What kind of treatment you went through? Can you plz lemme know I would be grateful for that .
Cupping therapy in your hand can help
You explain everything 100 times better than my professors in med school! this video helped me a lot! Thank you!!!!
AHAHAHAH Pethana!!
***** με ποιο πραγμα ακριβως?
***** ποια συνωνυμια? :P
Εχω μια συμφοιτητρια Elena KK κι ημουν σιγουρος οτι ηταν αυτη.
***** ααα οκ
You're a very important man for a Med student, from anywhere in the world, with a very unique gift of drawing and conversing. Please take care of yourself :)
And just as always, awesome work!
😂😂😂😂😂” please take care of yourself “
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Come and thank me later ✌️✌️
how u doing now mate
I've nearly finished the pathology book and read articles but still felt like I hadn't grasped the entire pathophysiology behind some diseases, including RA. Thanks for this Amazing overview
Can u be my bf
"
You explain everything 100 times better than my professors in med school! this video helped me a lot! Thank you!!!! " I couldnt have said it better than below comment...thank you Armando, your the absolute best at making medicine understandable.
From a patient stand point doctors should listen to their patients have compassion and BELIEVE them.
thank you for this video, i just spent 5 hours reading review papers and text books trying to understand it and you did it so beautifully in 15 minutes. Thank you - you are amazing.
Same here l was searching about the pathogenesis in different books and in internet but yes i finally understand it after watching this video. Sry for my bad english
same! I dont have a biology background until undergraduate but this video is soooo well made and easy to understand
Awesome video which I will have to re watch numerous times.
I have never come across a better teacher all my life
Thanks for the information. I was diagnosed with RA 6 months ago and I have been trying to learn as much as I can. Unfortunately I’m not very educated so a lot of this went over my head, however, the diagrams did help!
OMG 😮
I have an exam about RA tomorrow and your explanation helps me alot
thank very much sir!
❤ But good explanation But But what helps the pain ❓❓❓❓❓
This makes a lot of sense... both from testing and symptoms to reasons for swelling. Much appreciated!
-Macrophages start by releasing cytokines, TNF-alpha , IL-1 , IL-6 that lead to inflammation.
- cytokines stimulate fibroblasts (synoviocytes) , which results in activation, and proliferation.
- Synoviocytes will stimulate RankL expression, which will lead to the stimulation of osteoclasts with the aid of cytokines. Which will lead to bone erosion .
- Proliferation of fibroblasts also result in creating proteases, which leads to cartilage breakdown (degradation), cartliges also secrete proteases.
- When the fibroblasta are activated, they can travel from joint to joint, and this is how you get symmetrical arthritis. (Like in right and left hands).
- T-cells, (immunity cells) which are thoroughly present in the synovium are resposible for promoting inflammation by secreting IL-17 (cytokine) which promotes macrophage activity so it....etc.
- They also help in expression of RankL that .....etc.
- Plasma cells are responsible for inflammation too. Through cytokines and antibodies.
- Neutrophils in the synovial fluid also contribute to inflammation because they release proteases and active oxygen species which will affect in bone and cartilage erosion.
- Immune complexes (antibodies) which are a feature of rheumatoid arthritis , they bind to one another and promote inflammation
- Angiogenesis is affected by increasing the vascular pemeability by cytokines which will result in migration of all these cells into the joint.
- Rheumatoid arthritis also affects other organs due to increased inflammatory cytokines , skin: nodule formation, liver: anemia, cardiovascular diseases: stroke, myocardial infarction.
- Rheumatoid arthritis occurrence has unknown reasons but there are theories that suggest that genetics, smoking, and specific bacteria ( porphyromonas gingivalis) that are present pre RA are responsible for the appearance of the disease, these can lead to modifications in body’s antigens, which will make them seem foreign to the immune cells leading to an immune response, or by injury that leads to inflammation, and then lead to antigen modification. this is the first step of the pathogenesis of Rheumatoid arthritis..
Highly appreciable 👍
@@growingsoul3028lie not true
u helped me when I took anatomy & again then with physiology & once again, here ur helping me to understand exactly what is happening with my hands/joints as I have recently been diagnosed w/RA. thank you so very much!
Allopathy can’t cure you. And overtime you will be made to depend on immune suppressants, then comes the complications of the medicine, then surgery and you will be ultimately exhausted of hospital visits! Start on traditional or alternative medicine, follow a healthy food and lifestyle. I was earlier diagnosed as having rheumatoid arthritis, SLE. Now, I got my RA test become negative with homoeopathy. Rheumatologist and an Orthopedician were completely surprised as according to allopathy, once RA factor becomes positive, it will remain so forever. I too was surprised and enquired the lab to recheck if there was some mistake, they gave the sample to another lab and I got the same negative result. I have been on homoeopathy for many years. Take care. I’m still on crutches but improving over time. Much better than 5 years back. And that pain which was there every second even at rest has turned out to be almost nil at rest... but still have it while moving and is tolerable. My movements were greatly restricted to the extent that someone should help to even turn around in bed but now I can do it myself and from past 1 month, though a little difficult I am able to get up myself and go to toilet with the crutches. I had severe digestion problems too that I always vomited some of what I ate every time but now... there is almost no vomiting but still have belches. Hoping to return to complete normalcy soon. I am not on any other medication. Wish you get well soon.
Exceptional clarity. Images and words provide a clarity not possible with other pedagogies.
First year medical school here ; You just saved my life. A M A Z I N G video and thank you soooo much :)
You are an Awesome teacher, never understood my doctor, but I learned a lot listening. I have the swan neck. My doc told me I had a permanent hitch hiker thumb. I understood now what she was talking about. Thank up for helping me understand this disease. May God bless you always
I think this might be my favourite video on UA-cam, wow. Thanks.
Great video Armando!!
Very nice lecture on the path physiology of R A. Very easy to understand. Thanks.I have R A for 20 years. Your lecture explains lot of my questions .Thanks.
How is life with RA??
How do you perform ur daily activities??
Be blessed sir!! We medicos owe you for providing such beautiful explanation n pics to memorize!! 😇
This disease is so hard to understand and explain. Thank you for the very detailed breakdown!
I was tasked to discuss the pathophysiology of RA and I couldn't understand a thing. This helped me to thoroughly understand it. Thanks, mate!
You have no idea how much this just helped me!! Thank you for this absolutely beautiful presentation.
Clear and simple explanation of a complex disease. Well done!
Wow, just wow, thanks dude, you're awesome, you helped me so much for my med school work, greetings from Mexico
Well-explained with beautiful, easy-to-understand illustrations. Thank you!
Excellent,simple illustration . Thank you
I only have some basic nursing knowledge and this is so easy for me to understand - you're an excellent teacher. I have this disease myself. Thanks for this video!
your lectures are life saving. thank you for your time!!
For the record as a sufferer of RA, your joints will be in pain regardless of inflammation. My doctor seems to think there is no pain without inflammation.
Exactly! And it is so hard to convince them. -But all your blood test seems normal arghhh :)
Living in the hell of pain and yet to be diagnosed but your comment scared this chicken even more. Thanks for the video.
@@curious.soul. my experience had doctors scratching their head for a year before they diagnosed me as sero-negative RA. They havent given me time to explain, they just run tests and have me leave with 4 prescriptions to medications that dont seem to work for me. Eventually I stopped seeing doctors lol.
@@curious.soul. best thing to do is keep moving. Move those joints because they're suppose to move. If its suppose to move and doesnt WD40 if it moves and its not suppose to Duct tape.
@@DWNelson90 As of now I'd be happy if I can make through the day independently. But point taken about the moving part once it gets a bit better. Thank you for your words. Hope you feel better soon.
This made so much more sense to me in the context of bringing together immune and inflammatory responses. Thank you!!
Bravo!! Coming from a non medical student! Idk what T alphas, etc are but I'll rewatch this video until I've looked up all the terminology. I enjoyed your video although ofc I didn't understand everything, I could tell it was excellent explanation at least and got the gist (did have to look up a few definitions ofc).
I saw this video so many times. No it's much more clear..
Thank you. ❤🎉😊
I missed ur lectures in 2006 ..that's when i joined med school..
This video was seriously the best!! Everything was explained simply!
Awesome! He should put a picture of the final drawing to print :)
Basshar Dabboussi he does for 15 dollars lol check his site
Basshar Dabboussi amazing teaching skills!
excellent, as usual
Zu Nobi
. . ഹൃദയത്തിൽ സ്പർശിക്കുന്ന ഈ ഇടയിൽ ഇറങ്ങിയ ചുരുക്കം ചില ഗാനങ്ങളിൽ ഒന്ന്, എന്തായാലും ഒരുപാടിഷ്ട്ടമായി.
Very impressive and easy to understand the whole picture of Rheumatoid arthritis. Thanks!
This is beautiful! I understand RA so much more better now. Thank you soooooooooo much!
You are so valuable man bro I m watching this video in Turkey and normally my English is not so good you speak fast but I can understand nearly everythink actually you explain perfect please dont stop that send video
I have RD and I thank you for a concise video that helped me understand my dis~ease😢
Thanks for great video! , I hope you will prepare same video on Seronegative rheumatoid arthritis, and difference between seronegative and seropositive RA in immunological response .
fabulous explanation
what a wonderful explanation. thanks again from Yemen Aden.
Amazing video and linking of the markers -> tissue -> symptoms!
So so helpful, thank you for this detailed and visually appealing explanation!
Brilliant teacher wish you best of luck sir
Excellent!!! It is really a very clear presentation. THANKS VERY MUCH.
wow what a superb vid! Easy to understand with great drawings. Much appreciated
you are the best (from Alegria)
Thanks, the video is awesome (and even clearer than many medical textbooks)!
Spot on!!! Immunology simple, nice! (I would omit 5:46 fibroblast migration and extraarticular involvement basically everything pass 13:30)
Great sir .. I really like your explanation and way of teaching
best video!!!!!! concise precise, covering everything except treatment and lab inv... pls make a second video to cover those parts tooo
Thanks alot for this brilliant and concise presentation , It takes much effort and time .
you should scan your notes and upload them so that we can print them that would be so helpful
Please make a video on Juvenile Idiopathic Arthritis. It will be very helpful.
wow thanks so much for this brilliant explanation of how RA is triggered and develops.
what a video... awesome sir great explanation..!!!! thank you..!!!!👌👌
Great video. Really helps me with my studies.
awesome..... it really helps me a lot...
but please don't use yellow marker / pen in your videos ... thanks
Thank you very much ! I'm listening to you from France, I have understood all of the video, it was really clear thanks !
Ur explaination is best est of all. After a lot of struggle I found it. 😍
Beautifully explained!!!
Uric care tablets reduces Kapha doshas impacting high URIC ACID levels of the body and acts as a potent diuretic. It helps reduce the pain while passing urine and clear the obstruction of urine. It is also used to treat cough, oedema, asthma and various kidney problems. It contains ingredients like gokhru, imali kshar, yavakshar, kalmi shora, nausadar, swarna gairik etc. This formulation possesses hypotensive, antimicrobial, aphrodisiac and diuretic properties.
dude. weldone.you are realy realy amazing in presentation.despite the simplified coherent,conclusive information,your voice tones is too natural and not push on yourself thus makes listener relax and enjoy. thank you very much.
Excellent video! I have RA and am also coincidentally taking pathophysiology next semester. What a great opportunity to learn about my disorder while also preparing for the depth of pathophys
May I ask what textbook you’re using for this information?
Thank you. I just had an MRI that pretty much indicates RA, so I'm trying to learn about it.
Exelant explanation very Good information for RA patients
i don`t have any word to say about your way of delivery, content ,,,,,,
but i would like to say awesome....
thanks a lot........ plz update more videos for helping us
Fantastic work and easily understood! Thanks a lot.
What about weight gain, swelling & exssesive heat & sweating? Will it ever go away? Is there a cure? I’m 50 yr old woman
The yellow marker is hard to read. Can you kindly use a more visible marker? You’re doing a great job though. Thank you
your drawing skills are so good!
Thanks for making use of all of these great abilities in order to help people
I think about the great efforts make to accomplish this organized smart work
Please continue this great work
Made*
Thank you very much.
From 🇩🇿
What a great informative video, thanks for sharing!
Simple and goodexplanation. What about the treatment?
Pls help as I have started suffering from it.
Really great explanation and summary! Thanks :)
you have made an extraordinary job describing RA. Now, what hope is there for those who suffer with this terrible disea?
Thank you, essentially.
Very helpful thank you! Do you have a pdf version of your whiteboard drawing?
Excellent explanation as always!
Question...........I've had 3 "flares" of rheumatoid arthritis in the past 15 years. Each "flare" came about five years apart and lasted approx. five months. The 3 flares were worse each time with a wider array of symptoms and the symptoms themselves being more pronounced. There was about five years of "remission" between each "flare." The last of the 3 "flares" was BAD. HORRENDOUS. AWFUL.............In addition to the pain and swelling I also encountered the "malaise" where you just feel awful. The malaise is almost like having the flu 24/7 but a little different. Along with all the terrible RA symptoms you feel terrible too............you feel like someone vomited in the back of your car on a July day. That's all I can liken it too..................I have 2 questions: {1} When my rheumatoid arthritis is in "remission" can I still have symptoms in the background...........still effecting me although it is not a full blown "flare?" {2} Can I have the "malaise" piece of my RA and not have the swelling and joint pain piece? {I've felt lousy for awhile now...........kinda like I did when I had that last flare as far as the "malaise" but I'm not experiencing the other symptoms.} Thank you.
Dear doctor, is bone repair in rheumatoid arthritis possible? my aunt's femur bone is broken and is not healing since 2014. Is it possible that her bone will ever heal?
Dear doctors, please reply.
absolutely wonderful as always - nice preparation for my exam this afternoon. Always a joy to watch these videos. So clear and informative.
Thanks a lot this will help me in my upcoming individual presentation
Thanks a lot!
Armando Thank you so much !!
This video has helped me a lot. Thanks
Thanks for this video will helping to study . Thankyou so much
You are just amazing!! Thank you so much for making it so easy!😊
Your videos are incredibly useful. Thank you so much :)
you are doing a great job. as usual, Thx a lot
Can you explain the seronegative RA and why we don't have the antibodies?
very well said sir! thank you for the nutritive information.
This is the best video ever! I love u