Erythropoesis - Physiology ; Sites and Stages
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- Опубліковано 20 гру 2024
- Erythropoiesis is the process by which red blood cells (erythrocytes) are produced.
On average, the body produces an astounding 2.5 billion red cells/kg/day. Erythrocytes arise from a complex line of cells, and their rate of production is tightly regulated to ensure adequate but not excessive numbers of red blood cells are produced.
Sites of Erythropoiesis
The site of erythropoiesis changes throughout life. In the very early foetus, it occurs in the yolk sac. From 2 - 5 months’ gestation it occurs in the liver and spleen before finally establishing in the bone marrow from about 5 months’ gestation.
In children, erythropoiesis can occur in the bone marrow of most bones. However, in adults, it only occurs in the bone marrow of the vertebrae, ribs, sternum, sacrum, pelvis and proximal femur.
When erythropoiesis is inadequate in the bone marrow, this can trigger extramedullary haematopoiesis - i.e. haematopoiesis occurring outside the marrow. This is commonly seen in haemoglobulinopathies, in particular thalassaemias and myelofibrosis.
Stages of Erythropoiesis
The production of all blood cells begins with the haemocytoblast, a multipotent haematopoietic stem cell. Haemocytoblasts have the greatest powers of self-renewal of any adult cell. They are found in the bone marrow and can be mobilised into the circulating blood when needed.
Some haemocytoblasts differentiate into common myeloid progenitor cells, which go on to produce erythrocytes, as well as mast cells, megakaryocytes and myeloblasts.
The process by which common myeloid progenitor cells become fully mature red blood cells involves several stages. First, they become normoblasts (aka eryhthroblasts), which are normally present in the bone marrow only.
Secondly, they lose some organelles and their nucleus as they mature into reticulocytes, which can be thought of as immature red blood cells. Some of these are released into the peripheral circulation.
Finally, reticulocytes lose their remaining organelles as they mature into erythrocytes, which are fully mature red blood cells. These normally survive for around 120 days.
During this maturation process, there is nuclear extrusion - i.e. mature erythrocytes have no nucleus. Nucleated red blood cells present in a sample of bone marrow can indicates the release of incompletely developed cells. This can occur in pathology such as thalassaemia, severe anaemia or haematological malignancy.
Anyone else one hour before exam?
Bhai😂😂😂
same here
I'm five minutes before exam
✋
🤲😭🤣
Me 😂
I think u referred from Sembulingam physiology book 📖📚
Yess
Good explantion, thank you... Madam, I believe you are following Sembulingham Physiology
Thank you for explaining this topic very well
Very easy process explained ..tqs mam.
Beautifully explained
Super madam , very simple explanation
Very good explanation,thanks a lot 👏👏👏
Nice presentration very clearly undestand thanks 🥰
Gud explanation. Last summary was so useful🫂
Well explained mam.. thank you so much 🥰
Good lecture
Thanks for liking, keep watching❤
Which physiology author book is good for better understanding of concepts and reading
Very good explaining, the way you speed up while writing I appreciate it
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Starting physiology before 6 hour 😅😅😅😅😅 from ur lecture
Can I get notes?
Provide this in pdf form please
Very easy to understand....thanks a lot
I think I wld score good marks....tq mam
Mam please provide this in pdf format
Anyone one day before the exams ?
Thankyou ma'am it was really a good explanation❤ plz keep it up😊
Nice explanation
Great teaching methods 🎉
Mam Could you upload facial nerve anatomy
this really helped me mam thankyou so much.
Most welcome 😊, glad it helped keep watching❤
Amazing explanation mam♥️♥️
Thanks a lot 😊💗
Can I get ur notes pdf?
Akka chala bagga chepparu 😊😊
Thank you tammudu
Learning physiology in learning anatomy😂
Darun, neat and clean
Infact you murdered it,I really really enjoyed it,pls when is leukopoiesis and thrombopoiesis own coming out I will love to have same explanation of it in this erythropoiesis way ma
Really nice and understood
Thank you for best explanation
wwhat does Reticular network do\
Thank you mam very helpful video ❤❤
Most welcome 😊💗
The best video I was ever seen❤️
good job
Iski pdf h kya
Well explained mam 😊👍👍
Very well explained mam ❤️
Provide this in pdf
Thanks and I understand easily ❤
mam plz uplode leukopoiesis and thrombopoiesis video
Although the no. of pages is less in these chapter it takes 3 to 4 hours for conpletion of it
And i can only study one subject a day during that 4 hours (bc embryology are untouched)
And there are writing work like assignment observation in middle of it which consumes a lot of my time
How can i improve from this situation 😭 being a 1st year
I am making a lot of back log portions rn
Ps: should i read book first or watch video first.
Amazing 👌
Really helpfull. Thank you.
Mam konjam clarity video poduga pls
Pls not put background music in video.
Video is very helpfull thanks
Good explanation
Can we right this as an essay question
Same doubt 🤔
Yesss, you and elaborate each step as heading and with diagram in each step, with a total flowchart at start to impress the examiner
Assalamualaikum mam
Ap kahan se hu mam
Apne apna MBBS kahan se kiya
all hail to the queen of anatomy.
Means Alot.
Thank you so much.
Keep watching 💖
Thank you so much mam ❤
Most welcome 😊💗
Helped a lot, tysm ❤
Glad it helped!, keep watching❤
Amazing ❤ thank you
Superb❤️
Thank you maam
Good morning. I don’t know the answer to a question. Can you help?Why erythrocytes live 120 days, leukocytes and platelets live 2-5 days?
Why is that?
Because erythrocytes are in millions and platelets and WBC are in thousands and lakhs, so erythrocytes live more than wbc and platelets
RBC live only 120 days because- Rbc doesnot have nucleus it cannot synthesize proteins needed for vita pathways(energy production) in addition to this its membrane looses integrity, moreover due to deficiency of enzymes for maintaining high level of intracellular potassium while pumping sodium out of the cell- intracellular sodium increases and potassium decreases , selective permeability of membrane is lost, water enters the cell, the cells becomes spherical and are not able to squeeze through narrow spaces of spleen, therefore get trapped by macrophages and get lysed within macrophages.
Therefore the average RBC has sufficient enzyme function to live 120 days.
Reference:-
Rodak-Text book of hematology .
Chapter 8-erythrocyte production and destruction.
Mam plz iska pdf link dedo
Mam please provide this in pdf please
Good 👍
Thanks
Tq mam for explaining ❤
best vdeooo thank you
Most welcome, keep watching❤
superb🙋🙋
Was so easy , tq mam
Well done
Good job,😊
Thanks 😊 ma'am
Thank you
thank you mam
Mam please provide pdf
I am 2nd year student of bds. I want to pursue mbbs.. That's my only dream.. I am 21 now. Shall I once more try for neet?
What's your number and rank in neet exam .
Anyone else 1 week before exam ?
Ye nots mil skta h pdf ,ppt me reply
Very nice mam❤️
❤ like this class and thanks to the creator... from my heart 💜
Mam i request you do for 1st yr all topics & all chapters for all 3 subjects plz mammmmmmmmmmm😊😊😊😊😊😊😊😊😊😊😊
As soon as possible mam
No hating but it is rbc not rbs
Night before my internal exam 11th July,2022
2020?
Me again before my 3rd internal 2nd December, 2022
Pdf
Mam pdf
One night before exam😅
Tq ❤
Night before my bloid physiology card... physiotherapi student fact😊
Dont use background music
Legend paper wali raat daikhte hue😂
mam our slides in english u teach in english this is discusting plz teach in Hindi
Tq mam💖
Yes
I love you ❤
Tq so much mam 😇☺️
👏👏👏
Prierythorblast it's network is chromatin network 😂 no reticular network
Anyone else in exam
❤️
yep "RBS"
👍🥰
Tq mam
You're welcome, keep watching ❤️