Ewing's Sarcoma, Briefly - Everything You Need To Know - Dr. Nabil Ebraheim
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- Опубліковано 6 вер 2024
- Dr. Ebraheim’s educational animated video briefly describes the condition of Ewing's Sarcoma.
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Ewing’s Sarcoma, Briefly- Everything You Need to Know
There are some characteristics for Ewing’s Sarcoma that will help us in remembering this malignant bone tumor. Ewing’s Sarcoma occurs more in males between the ages of 5-30 years old. Ewing’s Sarcoma occurs in the diaphysis of bone about 50% of the time. It occurs mostly in the femur, the tibia, the pelvis and also in the spine. The shaft of the fibula is a special place for Ewing’s Sarcoma. X-ray will show a “moth eaten” appearance. The tumor is permeative. The tumor has an “onion skin” or “sunburst” appearance on x-ray due to periosteal reaction. The x-rays may show Codman triangles when the tumor breaks into the cortex and the newly formed reactive bone formation in an attempt to infiltrate outside the bone, invading the soft tissue. MRI will show infiltration of the marrow and a large soft tissue component. The tumor will have small, round, blue cells. The nuclei are prominent and there is minimal cytoplasm. The cells may arrange in a pseudorosette fashion.
Genetics
• 11;22 translocation
o Leads to the formation of a fusion protein EWS/ FLI-1
Ewing’s Sarcoma mimics infection. The patient will complain of pain, fever, tenderness, or a mass or swelling. Sedimentation rate could be high. The white blood cell (WBC) count could be high. You need to do a bone marrow biopsy to rule out metastasis to the marrow.
Immunostaining:
CD99 + MIC2 + Vimentin + Periodic acid- Schiff (PAS) = Contains Glycogen
The tumor is negative for cytokeratin test and reticulin test, which tests for lymphoma.
Treatment of Ewing’s Sarcoma
All malignant bone tumors will be treated with wide resection, regardless if it is a high grade or a low grade malignant tumor. When it is a high grade malignant tumor, you will add chemotherapy to the wide resection. Ewing’s Sarcoma in particular can also respond to radiation therapy. In brief, the treatment protocol for Ewing’s Sarcoma is chemotherapy and local control of the tumor, either by wide resection, by radiation therapy, or by both. You will use the chemotherapy before the wide resection. The surgical resection can be used when the lesion can be removed with wide margins. The radiation therapy treatment has problems of its own, but it is used for local control of the tumor in areas where limb salvage is not possible (e.g. pelvis). Radiation is also used if the patient has a positive post-resection margin or in case of advanced disease with metastatic lesions. Radiation can also be used in surgically inaccessible sites or when there is a poor chemotherapy response.
I am 5 and half years ewings sarcoma survivor of right hand proximal humerus. Treatment done in Tata Memorial Hospital Mumbai, India. Chemotherapy, Surgery and Radiation. Infection after 10 months of Surgery so undergone another surgery now from then it is 5 years no problem till date hope this continues.
Although I lost my ball and socket joint so no movement only elbow movement but I least my limb is saved.
My best wishes for undergoing Treatment. I wish everyone should get a good treatment and doctor.
My granny just got it. Doctors were shocked as it is seen in younger people. She's also from Mumbai. Hope you're doing well. Stay strong
I lost my 13 year old daughter to Ewing sarcoma. No treatment worked for her. She was so cooperative in treatment with a hope to live. In 10 months time, she left us.
My son's surviving ewing sarcoma.
So sorry for your loss. I was told that the doctors don't know as much about it as other cancers, and there's no definite cure. She is probably waiting for you in heaven where there's eternal life. It says in the Bible that our days are numbered before we're born. It's just a matter of how. We are all here to learn to love each other and our creator. She must have been special to have learned it Young.
So sorry for your loss, unfortunate that childhood cancers get so little funding into further research for better treatments.
@@chariz1593 strange that the doctors told you that, there's definitely a definitive cure for ewing sarcoma, however the word "cure" is used very loosely when talking about all cancers so perhaps that why they told you that. I was told that I would be considered "cured" 10 years after finishing treatment as I am considered in remission for the 10 years following treatment as they watch for signs of it relapsing.
I'm so sorry for your lost ma'am
I have ewing sarcoma in the pelvis it has grown alot of tumour i will be having surgery in turkey it may be cancer pray for me all .
How are you bro now
My brother also has in pelvic
Which treatment you took
A little bit of relief, I unfortunately was diagnosed with this in 2018, and it went to my lungs. All good now, but I always wanted to know the factors that may have caused it.
What is your symptoms?
@@305_jetromercene4 none of your business lol.
Hi, I'm so pleased to here your success story. My partner is currently battled ES in his lungs, no success with chemo. Do you mind sharing what treatment you had? Was it just chemo. Thx :)
@@sbishxx had 10 (five minute) sessions of radiation to end it.
@@dewgames1862 Strange attitude to take.
Sir sun ray appearance is seen in osteogenic sarcoma .
You’re the best. Script, graphics and narration. Nec Plus Ultra! Merci, Bangkok-Johnny from
Thailand
Amazing lectures sir Kindly upload all bone tumor lectures
p97w
I have Ewing sarcoma on the floor of my mouth. Was told it is 1 of 60 cases reported. Would you be interested in reviewing my pathology report?
Thanks for the video also
I know this is an old comment but I am interested in the pathology of your case
Sir, kindly upload other bone tumours
what an excellent and inclusive explanation. Thank you sooo much!
This was very helpful, thank you
Thanks it's really helpful, What about stages in evening sarcoma?
Well explained 👏
so nicely explained.thank you sir
My brother also has es in pelvic. Which treatment is best? Please help me
Thank you. Could you please explain the 2 arms of the induction therapy?
It's good to know there's a treatment for it. Is it possible to have it in the ribs and spine? I was told by a neurologist surgeon there was no real way to find out if a person has it, and no real cure for it. Thanks.
شكرا على الشرح الجميل والأسلوب الراقي
Congratulations, very helpful.
thank you sir
Thanks for nice helpful video
Thank You , Sir
I’m so fucking scared .
Thank u
Good information, thanks 🙏🙏
Cod man triangle and sun burst appearance are seen in osteosarcoma not in ewing sarcoma right??
The dr's told me this is what I have, but its not in the bone its in the tissue of my buttocks.
So far they want a month of kemo and light radiation, then surgery a month later. 🤦
nice
I’ve had Ewing’s in my spine, lungs 2x and nose and sinuses
I have Ewing sarcoma in pelvis .prognosis,palitative treatment ...morphine.
worked ?
How are you bro now
I'm also lost my 3and half yrs son
I am scared huhu
he died
thats how it is sometimes
bhai this is osteosarcoma
Thank you