Malaria dynamics within the mosquito

The 12th Annual Undergraduate Research Conference at the Interface of Biology and Mathematics
Date: October 31 - November 1, 2020
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Featured Speaker: Olivia Prosper, Mathematics, University of Tennessee, Knoxville
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Abstract:
The malaria parasite Plasmodium falciparum requires a vertebrate host and a female Anopheles mosquito to complete a full life cycle, with sexual reproduction occurring in the mosquito. While parasite dynamics within the vertebrate host, such as humans, has been studied using mathematical models, less is understood about dynamics within the mosquito, a critical component of malaria transmission dynamics. This sexual stage of the parasite life cycle allows for the production of genetically novel parasites. In the meantime, a mosquito's biology creates bottlenecks in the infecting parasites' development. We developed a two-stage stochastic model of the generation of parasite diversity within a mosquito and were able to demonstrate the importance of heterogeneity amongst parasite dynamics across a population of mosquitoes on estimates of parasite diversity. A key epidemiological parameter related to the timing of onward transmission from mosquito to vertebrate host is the extrinsic incubation period (EIP). Using simple models of within-mosquito parasite dynamics fitted to empirical data, we investigated factors influencing the EIP.