Yes Yes Yes!!! These video’s have been a tremendous asset for myself during nursing school. The breakdown, detail, and simplicity of the delivery of content is priceless. Why pay for other services and learning aids when Khan Academy offers them for FREE!!! My instructor should just play this series in lieu of lecture. This is so easy to understand and really ties in readings, powerpoints, etc. Thank you Khan Academy!!!
Lactic acid does not cause metabolic acidosis, it is a buffer against it. Metabolic acidosis arises when cytosol ATP demand exceeds respiratory production capacity, decoupling glycolysis from oxidative phosphorylation. ATP is hydrolysed to form ADP + P + H, in the case where VmaxO2 > 100% the protons produced during hydrolysis are not recycled stoichiometrically via oxidative phosphorylation (ADP + P + H -> ATP). Eventually the proton buildup will exceed the cells buffering capacity via inorganic phosphate, Creatine phosphate hydrolysis and proton efflux causing a decrease in pH. Pyruvate -> lactate step does not generate additional donor protons, lactate is produced as an acid salt meaning it will accept protons, buffering against those produced in the G3P D.H. step of glycolysis (Pyruvate + NADH + H -> Lactate + NAD). Lactic acid can be used as an indicator of metabolic acidosis but it is certainly not a cause of it.
Yes Yes Yes!!! These video’s have been a tremendous asset for myself during nursing school. The breakdown, detail, and simplicity of the delivery of content is priceless. Why pay for other services and learning aids when Khan Academy offers them for FREE!!! My instructor should just play this series in lieu of lecture. This is so easy to understand and really ties in readings, powerpoints, etc. Thank you Khan Academy!!!
Omg. He explains great anc it sticks better than all those review courses.
WOW! this was exactly what I needed!
very well explained ! thank you !
You really explain well!! THANK you very much! 👏👏👏👍
This is easy to understand. Thanks
youre amazing. your videos are amazing. thank you!!
Excellent material. But something is wrong with the audio...
Lactic acid does not cause metabolic acidosis, it is a buffer against it. Metabolic acidosis arises when cytosol ATP demand exceeds respiratory production capacity, decoupling glycolysis from oxidative phosphorylation. ATP is hydrolysed to form ADP + P + H, in the case where VmaxO2 > 100% the protons produced during hydrolysis are not recycled stoichiometrically via oxidative phosphorylation (ADP + P + H -> ATP). Eventually the proton buildup will exceed the cells buffering capacity via inorganic phosphate, Creatine phosphate hydrolysis and proton efflux causing a decrease in pH.
Pyruvate -> lactate step does not generate additional donor protons, lactate is produced as an acid salt meaning it will accept protons, buffering against those produced in the G3P D.H. step of glycolysis (Pyruvate + NADH + H -> Lactate + NAD). Lactic acid can be used as an indicator of metabolic acidosis but it is certainly not a cause of it.
Awesome videos.. so helpful
thank you ;)
Great