Our summer semester just started and I was already confused on how to calculate probabilities for these scenarios. Your video was excellent and very easy to follow! Really appreciate the tutorial!
Shomu's thanks you for the clearity. The confusions that i was having are now solves by following and watching your youtubes videos. Such honesty and straightforward person.
Man u r born to made genetics interesting and easy, thanku so much for unexpected explanation ...now got cleared how easily & quickly solve pedegree probability...☺️
Hi Shomu, first of all biiig appreciation for you and your work. I follow you for a few years now. My question is for the second pedigree (11:00 min) - why do you exclude autosomal recessive? My calculations lead to both possibilities - either x-linked recessive or autosomal recessive.
The video is amazing. I have a small problem in the second pedigree. In the 1st gen after affected male and undecided genotype female --> the left most female is a carrier no doubt because in the 2nd generation - son is affected, daughter is unaffected and this daughter's son is affected --> meaning 1st gen and 2nd gen females are carriers of the disease. The only person whose genotype can't be decided is the parental generation female (generation zero) and the right most female in the first gen. I could point out this because i understood the concepts from your videos sir. Thank you and keep up the good work!!!!!!!!!!!!
For the second question, how is it possible for the females to be XX if the father has to donate an X, and the only X the affected father can donate is an affected X, thus making the genotype of all unaffected females XaX
Thanks a lott sir... ☺️ Sorry to say sir... Bt in this video in 1st ques u said genotype of {1} nd {2} will be (Aa) as they r the parents of {3}... I think by mistake u said this... Bcz {5} is child of {1} & {2} which also has same genotype as that of {3}... So finally no further error occur in solution of ques... :) only a little bit mistake while explaining solution u said {3} as a child of {1} & {2}... Thanks again... It really help me a lott... 😃
Great video as always.. but you said gamate (3) as the daughter of 1 and 2.. but as per the pedigree its 4 who is the child of 1& 2 and 3 is marrying her 😶 hope you got my point
Thank you so much sir......😊😊 Now I'm clear with this concept......and u just made it easy......a whole hearted thank you......I hope that I won't loose any Mark regarding this concept..... Thank you sir thank u so much.....
Thank you Sir. Your explanation method is excellent. Query, At 11:35, how it is X-linked inheritance? Male to female is x-linked and male-male is Autosomal I think Sir. Please clarify the confusion
sir in the 2nd explanation ......you represents recessive disorder with capital A....... its better to represents recessive disorder with ...lowercase letter ..a.......it may create confusion for new students in pedrgee
Why does everyone in the comments say "sir"? Must be an Indian respect thing or something lol. Watching from the USA and you SO helpful!!! I've been watching all your genetics vids and they're better explanations than my professor. Your vids are very engaging, you would make a great professor. Thank you so much Shomu, sir ;D
Thank you very much,❤️❤️but in the begening of the video the given pidgree isX linked dominant, since the affected male 2 has an affected daughters 4, and the affected male 8 has an affected mother also non of the sons of 2 being affected,..???????
19:02 why we calculate the prob of xx ! we calculate the prob if the girl is affected so only xA xA so no need to calculate the prob of just x .. can someone please explain this to me !!
sir in last question..u have asked probability of being unaffected. but in the end u carved out the solution for probability being affected-25% and for unaffected must be 1-1/4=3/4=75% chance of unaffected. please correct me if am wrong
plz check itz X linked dominant.criss cross also and diseased father have diseased daughter and diseases daughter hv diseased son. how can it be autosomal plz specify?
Sir In 2nd que Unaffected children are there from affected parent this is character of Dominant na ?? But this is x linked recessive . How ?? Or for this criteria both parents must be affected ?? Please tell me .. I'm highly confused now ... Your videos are really helpful thanks for everything 😊❤️
Sir, if males are mostly affected where the father is affected, I think the pedigree pattern is autosomal recessive as against the X-linked recessive, because, there is no male to male transmission in X-linked recessive. Please Sir, I am a bit confused.
Hello sir. I saw a video where talk and explain 3 types of whiskies. I only saw that 1st one where u talk about Malt Whisky and I wouldn't find the rest or other parts. So please if u don't mind give links to them or something to watch them plz. tnx
Sir i have a doubt regarding this question pls clarify this- chance of having cystic fibrosis if one parent is affected and the other is normal ? a)25% b)50%. c)0% d)80%
Sir, how come that the probability of B getting disease is also 1/4 ? If the mother's genotype could be either Carrier ( XcX) or unaffected XX. I thought that it is 1/8
For the 1st problem ...... talking abt 3 having aa .....bcoz of 1 and 2 having Aa and Aa.......... Is it right? Since 3 is not an offspring of 1 and 2......
Galactosemia is a recessive human disease that is treatable by restricting lactose and glucose in the diet. A couple is heterozygous for the galactosemia gene. If the couple has 4 children, what is the probability that none of the four will have galactosemia?
+Debangshu Banerjee actually you can say the exact genotype of individual 3. As the daughter of individual 3 is 7 and 7 is normal, you k or for sure that both 3 and 7 have genotype aa.bcz it's the only way to have normal individual.
I believe that you missed their point. This is a fantastic video, but there is an error. Indv. 3 must be (aa), this is correct, but you use this individual to justify why parents 1&2 are (Aa). With your notations, we presume that Indv. 3 is an outsider. If you indeed meant that Indv. 3 is the offspring of 1&2, and the father of 7&8, then you need to use the double-line notation for a consanguineous mating. I hope that this helps. All the best.
Pleaaaaaase in the first example , how do we know that is autosomal 🥺🥺🥺🥺🥺💔💔💔 I considered it as related on sex , X dominant 🤷🤷🤷 disease and it was like " correct " 🥺💔 Please !!!!!
@@shomusbiologyofficial thank u for ur answer I appreciate that 🥺 I did it sir and it was correct believe me , if there is any way to contact u just tell me I will show you the genotypes ... I have exam tomorrow so please 👉👈 . I wanna erase the false idea I have ,!
This guy is so passionate while teaching. Thank you for your work!
You're welcome
Our summer semester just started and I was already confused on how to calculate probabilities for these scenarios. Your video was excellent and very easy to follow! Really appreciate the tutorial!
Thank you so much for appreciating my efforts
Shomu's thanks you for the clearity. The confusions that i was having are now solves by following and watching your youtubes videos. Such honesty and straightforward person.
Glad to hear that you're getting benefit from my lectures
Sir, when i watching your more and more vedio , you are becoming my favorite sir , more and more . Glad i have a teacher like you ♥️
Thank you so much for appreciating my efforts. Please subscribe and share
Thank you so much sir ..infinite likes .. God bless you with more talents
Man u r born to made genetics interesting and easy, thanku so much for unexpected explanation ...now got cleared how easily & quickly solve pedegree probability...☺️
All the best
I was struggling for whole day.. you resolved my problem just in few minutes..
Thank you very much somu sir!!
Charan sparsh 🙏
Thank you so much for appreciating my efforts
Hi Shomu, first of all biiig appreciation for you and your work. I follow you for a few years now.
My question is for the second pedigree (11:00 min) - why do you exclude autosomal recessive? My calculations lead to both possibilities - either x-linked recessive or autosomal recessive.
The video is amazing. I have a small problem in the second pedigree. In the 1st gen after affected male and undecided genotype female --> the left most female is a carrier no doubt because in the 2nd generation - son is affected, daughter is unaffected and this daughter's son is affected --> meaning 1st gen and 2nd gen females are carriers of the disease.
The only person whose genotype can't be decided is the parental generation female (generation zero) and the right most female in the first gen.
I could point out this because i understood the concepts from your videos sir.
Thank you and keep up the good work!!!!!!!!!!!!
Thank you so much sir ❤️
You are a kind, pure heart person ...great teacher ♥️
Thank you so much for appreciating my efforts. Glad to hear that you're getting benefit from my lectures
you're a good teacher sir
Thank you
Man, you're saving my life before exam
Thank you so much!!!
You're welcome
Sir how can you relate (male) in 2nd generation with affected parents? That boy is from another family.
no he did make a minor error but it’s ok
Though there z minor error, but we can consider same for 5 th individual, so problem solved
There is some mistake in explanation
For the second question, how is it possible for the females to be XX if the father has to donate an X, and the only X the affected father can donate is an affected X, thus making the genotype of all unaffected females XaX
I considered it as related on sex ! But he said it is autosomal !!! Please help me to understand that 🥺💔
Ok,but see this pedigree again ,you'll find the father is unaffected ,i.e. having normal XY .(in 2nd generation)
thank you sir... always feel sure i will learn from ur tutorials... very dependable and commendable
Thank you so much for appreciating my efforts
Thanks a lott sir... ☺️
Sorry to say sir... Bt in this video in 1st ques u said genotype of {1} nd {2} will be (Aa) as they r the parents of {3}... I think by mistake u said this... Bcz {5} is child of {1} & {2} which also has same genotype as that of {3}... So finally no further error occur in solution of ques... :) only a little bit mistake while explaining solution u said {3} as a child of {1} & {2}...
Thanks again... It really help me a lott... 😃
The only mistake is that he didn't use the word outbreed👌👌👌rest are awesome
Your videos are so helpful! Thank you for posting them! Pedigrees are like a second nature to me now
Thank you so much for appreciating my efforts
Best explanation sir. Your teaching is Awesome
Thank you so much for appreciating my efforts
Sir....... You are so great..... In tamilnadu for ur knowledge surely.. Will wiil be paid 60 lakh per year.. I am damm suree....
Thank you so much for appreciating my efforts
Wonderful explanation Sir.
You're welcome
Nice explanation helpful to solve probability problems
You're welcome
Thankyou soo much...This is really helpful
You're welcome
Thank you so much... You helped me for my bio midterms tomorrow Sir!!!
+Sharru Uzumaki thank you. Glad to help
Sir can you slowly explain your explanation in every problem in next video to let the viewers fully understand. ❤️
Thank you
Glad to hear that you're getting benefit from my lectures
Sir if this is the case of X link recessive then the genotype will me x^a y not x^A y
Thank you very much ❤️❤️
You're welcome
Soo helpful🥰
Thank you
Great video as always.. but you said gamate (3) as the daughter of 1 and 2.. but as per the pedigree its 4 who is the child of 1& 2 and 3 is marrying her 😶 hope you got my point
Yes u r right . They hv did wrong analysis
Thank you Sir!!
You're welcome
Thank you very much for making this lecture video!
Your method of explanation was easy to grasp and practice!
+Natasha Grabau thank you. Glad it helped
Thank you so much sir......😊😊 Now I'm clear with this concept......and u just made it easy......a whole hearted thank you......I hope that I won't loose any Mark regarding this concept..... Thank you sir thank u so much.....
Glad to hear that you're getting benefit from my lectures
Really helpful
Thank you
EXCELLENT LECTURE
Thank you. Glad you liked my lectures
great video too good explanation thnku
Glad to hear that you are getting benefit from the videos
Sir you are best
Thank you so much for appreciating my efforts
Thank you so much sir, finding/supposing the genotype of each in solving these problems is a new trick for me.
+Devika Gautam glad it helped
Thank you Sir. Your explanation method is excellent.
Query, At 11:35, how it is X-linked inheritance? Male to female is x-linked and male-male is Autosomal I think Sir.
Please clarify the confusion
I think it's y linked?? 🙄
@@jyotikaushik1149 there is no Y chrmsme in female
sir in the 2nd explanation ......you represents recessive disorder with capital A....... its better to represents recessive disorder with ...lowercase letter ..a.......it may create confusion for new students in pedrgee
thanks to you i got the best grade ✨✨✨❤️ thank you alot
You're welcome. Glad to hear that you're getting benefit from my lectures
Thanks Sir. ..it is really help me
thanks a lot sir. becoz in the help of this video i solve many problem.
THANK YOU SO MUCHH
Yup
Why does everyone in the comments say "sir"? Must be an Indian respect thing or something lol. Watching from the USA and you SO helpful!!! I've been watching all your genetics vids and they're better explanations than my professor. Your vids are very engaging, you would make a great professor. Thank you so much Shomu, sir ;D
Thank you so much for appreciating my efforts
It's very easy and helpful thank u sir
+masoom ali glad to hear that. Please subscribe and share
Thanks a lot....a great help
Love u From Pakistan ❤
One of the best teacher...
Sir can you please discuss the model question paper? especially section - A...
thank you!
a big thank you sir..........great video
+Reshma Samanta glad you liked my lectures
once again a great one 😊shomu sir
+ratan chowdhury thank you. Glad you liked my lectures
awesome video sir..it's really helpful..
+Indhuja Aries glad to hear that
You r great sir
love it helped me a lot
your videos helped me a lotttttt.. thank you..
+Debtanay Deasi you're welcome
Thank you so much.sir
You're welcome
Good video
Thank you
Sir can get vedios for ques on mendels law.... Trihybrid cross??
thank u so much sir...., it's really helped me
Clarified 👍👍
You're welcome
nyc vdo sir.. plz make nxt vdo on circadian rhythm... it's urgent..plz sir
+Rajiv Sharma okay. Thank you
welcome sir..
Thank you very much,❤️❤️but in the begening of the video the given pidgree isX linked dominant, since the affected male 2 has an affected daughters 4, and the affected male 8 has an affected mother also non of the sons of 2 being affected,..???????
Thanks for excellency.I have a question sir, what is the chance of carrier of A???
What is the chance of being carrier A
You are doing a great job but I want to point out that 3 and 6 are not the offsprings of 1 and 2 here , which u have explained in this video.
sir can u please make a video on cladogram interpretation or phylogeny related net problems
+ratan chowdhury yes. I will do that soon. Thank you for watching the lecture
Shomu's Biology Mst welcm sir
👏👏👏
superb..much needed video..thnk u so much sir fr dis!
+varsha peghwal glad to hear that. Please subscribe and share
Thank you sir
19:02 why we calculate the prob of xx ! we calculate the prob if the girl is affected so only xA xA so no need to calculate the prob of just x .. can someone please explain this to me !!
Sir,please upload a video on ATLEAST ONE/TWOstatement in probability.
+sushant shekhar will do that soon.
Thanks again!!
+Kankana Banerjee you're welcome
But video was very much helpful
You're welcome
Thanku
Waoo......sir tq so much
sir in last question..u have asked probability of being unaffected. but in the end u carved out the solution for probability being affected-25% and for unaffected must be 1-1/4=3/4=75% chance of unaffected. please correct me if am wrong
plz check
itz X linked dominant.criss cross also and diseased father have diseased daughter and diseases daughter hv diseased son.
how can it be autosomal
plz specify?
Sir eg 1 may be also xlinked dominant.....reply pls
sir do u have any book about bioinformatices....???
Sir In 2nd que
Unaffected children are there from affected parent this is character of Dominant na ?? But this is x linked recessive . How ??
Or for this criteria both parents must be affected ??
Please tell me .. I'm highly confused now ...
Your videos are really helpful thanks for everything 😊❤️
it's recessive because it's skipping generation and also the disease only affects male which is why its x-linked recessive.
Same doubt
Sir, if males are mostly affected where the father is affected, I think the pedigree pattern is autosomal recessive as against the X-linked recessive, because, there is no male to male transmission in X-linked recessive. Please Sir, I am a bit confused.
Hello sir. I saw a video where talk and explain 3 types of whiskies. I only saw that 1st one where u talk about Malt Whisky and I wouldn't find the rest or other parts. So please if u don't mind give links to them or something to watch them plz. tnx
Sir can you please give me the definition of autosomal why is it part of the pedigree
In the second example in the first gen the mother is unaffected and thus she had an unaffected male and affected male offspring.
Sir in the 2nd example, if only males are affected why it cant be Y linked inheritance.
5:48 how can u relate 3rd male to be the son of 1 and 2..!??
that's wrong!
Sir pls give me the notes about probability intro, type ,basic probability distribution pls sir
Sir, some times "penetrance" problem also comes. What is dominant with incomplete penetrance?
brilliant
Sir i have a doubt regarding this question pls clarify this- chance of having cystic fibrosis if one parent is affected and the other is normal ?
a)25% b)50%. c)0% d)80%
25%
Since there is only one gene affected out of four
thank u sir
+BHOPAL SAINI you're welcome
Sir, how come that the probability of B getting disease is also 1/4 ? If the mother's genotype could be either Carrier ( XcX) or unaffected XX. I thought that it is 1/8
Shomu you're a legend man.. your videos are very helpful. KEEP IT UP MAN. BIG LIKE FROM ME & SUB ;)
Sir why it should be not Xlinked dominant because the disease is transfer from mother(4) to son (8). I am confused
Sir why this disease is not x linked dominant as the disease is transferred from father to daughter snd from mother to son?
Tq
For the 1st problem ...... talking abt 3 having aa .....bcoz of 1 and 2 having Aa and Aa..........
Is it right? Since 3 is not an offspring of 1 and 2......
awesome
Galactosemia is a recessive human disease that is treatable by restricting lactose and glucose in the diet. A couple is heterozygous for the galactosemia gene. If the couple has 4 children, what is the probability that none of the four will have galactosemia?
Number 3 is outsider then can we guess a trait of parent by using his particular trait.???
hi when i cross the parents genotypes u gave (Aa) and (Aa) there is only one (aa) while in the pedigree we need two or even three,,,,,
how is that???
there is a mistake here sir...individual 3 is an outsider...so it can not be told for sure that it is aa....so whole calculation may vary here
+Debangshu Banerjee actually you can say the exact genotype of individual 3. As the daughter of individual 3 is 7 and 7 is normal, you k or for sure that both 3 and 7 have genotype aa.bcz it's the only way to have normal individual.
Shomu's Biology yes sir
I believe that you missed their point. This is a fantastic video, but there is an error. Indv. 3 must be (aa), this is correct, but you use this individual to justify why parents 1&2 are (Aa). With your notations, we presume that Indv. 3 is an outsider. If you indeed meant that Indv. 3 is the offspring of 1&2, and the father of 7&8, then you need to use the double-line notation for a consanguineous mating. I hope that this helps. All the best.
1st explanation is wrong. blunder at around 5:45
+Dhruv Mishra I am pretty sure it's not wrong. State your logic
3 is not the progeny of 1 and 2 otherwise the explanation is correct if you replace 3 by 5 in your explanation.
Exactly dhruv!! Its supposed to be 5, tht is the male child of the parents rather than the 3
lol i was confused at that part...luckily i read this comment
Pleaaaaaase in the first example , how do we know that is autosomal 🥺🥺🥺🥺🥺💔💔💔
I considered it as related on sex , X dominant 🤷🤷🤷 disease and it was like " correct "
🥺💔 Please !!!!!
Best way to understand is to put genotypes and check if that satisfies the pedigree
@@shomusbiologyofficial thank u for ur answer I appreciate that 🥺
I did it sir and it was correct believe me , if there is any way to contact u just tell me I will show you the genotypes ... I have exam tomorrow so please 👉👈 . I wanna erase the false idea I have ,!